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The map label for this gene is pbp2 [H]

Identifier: 222096075

GI number: 222096075

Start: 2375766

End: 2377532

Strand: Reverse

Name: pbp2 [H]

Synonym: BCQ_2415

Alternate gene names: 222096075

Gene position: 2377532-2375766 (Counterclockwise)

Preceding gene: 222096083

Following gene: 222096071

Centisome position: 45.6

GC content: 32.37

Gene sequence:

>1767_bases
ATGTTACATACAAAAATAAAAAAATGGGGATTTTTTGCGGTTCTTTCTATTGTAGGTTTGATTTTACTAATTTTATTTAA
AATCAACTTCATTTCAATTACTATCGCAACTTCTTCAGCCGAAAGAGGAAAAATCTTTGATCAAAATGGTGTAATACTAG
CTACAAATAAGAAAGTTAAGTCTCTATATTGTACTTCTAATGATGAAAAGTTATCGAAACAAGATACATCAAACACATTA
GCTTTTTTCGATCAATTTTCAAGTAAGTTTCAACATGATATTTCTTCAGAGAGCATAAAATCTCAATTACAACAATCTTG
TAAAAAACAGACTATGCATGATATACCGTTATACTCTGATATAGCTGAGAATGAACTTGCATTCATAAACAAAAACAAAC
CGAATAATGTAATAATTAAAGATGAATGGATTCGATATTATCCTAAACATGAAATTGGTTCACAGGTAATTGGGTATGTA
GAAAGTAACCTTAATTCAAAGCATATGCCGGTTGGAAAAAGTGGGATTGAGCTGCAATATGAAGGTGATTTAAAAGGAAA
ACCGGGTAAAACTCTTATTTTTAAAATGAATAACAAAGAGTTCTTATGGAACATTCAAAAAGTACAAAAAGGTAAGGATA
TCAGGCTAGCTTTAGATTCTAAATTGCAACAAAAATCAGAGGAAGCATTACGATCACAAATTAAGAAATTACCTGATGCT
AAAGGTGGTTATGCTGTAGTGAGCAATGCAAAAACTGGCGCGATTTTAACTATGGCCAACTCAGCAGTTTTTGATCCAAA
TATATTACATACACATGTAACAACTAAAATAAATAACATAAAATCACTTTCGCAAAATAAAGCAATTCAAAAATTAAAAT
ATGGTGAGTCTTATGTAAATATGGCTTCTACTATAAAGCCACTTACTATTTTAATTGGATTAAACGAAAAGCTTTTTCAA
CCTGAAGATACGTATTTAGATAACGGTACTTTTGAGTATGATAATCAAAATAACATTACAAATGCACCCGGAACGCCAAC
AGGTGAGATTACACCGAGGCAGGCTATCATTAATTCATCTAACACATTTATGACAGCAAAAGTAGCTCTACCATTATTTA
ACCAACATAATGGAAATGTAGAAAAAGTGGCACATATATGGACAGATTATTTAATGCAATTCGGCCTACGTTCTAAAACC
GGGATTGATTTACCCTTTGAAGAAGACGGACAATATGAATTCCATCCCTCTAATAAGTTTGAAAATGGAATTTCCGCTTT
ATTAAATGCCTCTTGGGGAGGAAATGAAGTGCATACTCCTCTTCAACTTGCTCAATATGCAGCAACTTTAGCAAGTAAAG
GTGATAAATATAAACCACAAATCGTAAGTGCTATTATTGGTAAAGATGGTAAAGAAACAAAAAAGTTTAAACCAATTTTA
GAAAGTTCAAATCGTTACCCAATGAACTTTTGGAGTGTCATGCAAGGTGGAATGAGTCAAAATATAGAGGAGATTAAAAA
GTTGCCCTTCGACGTCGCTGGTAAAACAGGTATTACAGGTTTTCCAAATGAGCAAGCAAGAATGATCAATCATTCTCTAT
TCATTGCATATGCTCCTACCGAAGATCCACAGATTGCCGTTTCTGTCGTTATTCCTGGTAGTAATTCAGAAAAAAACATT
GCTGCTCTCGTTACATCAGAAATTTTAGAGTCCTGGAATACTCTTCAAAAAGAGAATAAAAACAAAAAGGAAGGTTCATT
AAAGTGA

Upstream 100 bases:

>100_bases
CTGTAGTACTTAATAGACAATCTAAATAATAAAGTTGTTCCACATTTACAAAAAAAATAATTAACTATAAGATGAAGTAG
GCTACAAAAGGGAGGATTTT

Downstream 100 bases:

>100_bases
ACCTTCCTTTTTTACCAAATAGAATCTATATTTATTATTTTCCATTCACCTTCATTATTCTTTTCAAACATAAATGAGTA
TTTAATGTCAGTTAAAACAT

Product: penicillin-binding protein 2

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 588; Mature: 588

Protein sequence:

>588_residues
MLHTKIKKWGFFAVLSIVGLILLILFKINFISITIATSSAERGKIFDQNGVILATNKKVKSLYCTSNDEKLSKQDTSNTL
AFFDQFSSKFQHDISSESIKSQLQQSCKKQTMHDIPLYSDIAENELAFINKNKPNNVIIKDEWIRYYPKHEIGSQVIGYV
ESNLNSKHMPVGKSGIELQYEGDLKGKPGKTLIFKMNNKEFLWNIQKVQKGKDIRLALDSKLQQKSEEALRSQIKKLPDA
KGGYAVVSNAKTGAILTMANSAVFDPNILHTHVTTKINNIKSLSQNKAIQKLKYGESYVNMASTIKPLTILIGLNEKLFQ
PEDTYLDNGTFEYDNQNNITNAPGTPTGEITPRQAIINSSNTFMTAKVALPLFNQHNGNVEKVAHIWTDYLMQFGLRSKT
GIDLPFEEDGQYEFHPSNKFENGISALLNASWGGNEVHTPLQLAQYAATLASKGDKYKPQIVSAIIGKDGKETKKFKPIL
ESSNRYPMNFWSVMQGGMSQNIEEIKKLPFDVAGKTGITGFPNEQARMINHSLFIAYAPTEDPQIAVSVVIPGSNSEKNI
AALVTSEILESWNTLQKENKNKKEGSLK

Sequences:

>Translated_588_residues
MLHTKIKKWGFFAVLSIVGLILLILFKINFISITIATSSAERGKIFDQNGVILATNKKVKSLYCTSNDEKLSKQDTSNTL
AFFDQFSSKFQHDISSESIKSQLQQSCKKQTMHDIPLYSDIAENELAFINKNKPNNVIIKDEWIRYYPKHEIGSQVIGYV
ESNLNSKHMPVGKSGIELQYEGDLKGKPGKTLIFKMNNKEFLWNIQKVQKGKDIRLALDSKLQQKSEEALRSQIKKLPDA
KGGYAVVSNAKTGAILTMANSAVFDPNILHTHVTTKINNIKSLSQNKAIQKLKYGESYVNMASTIKPLTILIGLNEKLFQ
PEDTYLDNGTFEYDNQNNITNAPGTPTGEITPRQAIINSSNTFMTAKVALPLFNQHNGNVEKVAHIWTDYLMQFGLRSKT
GIDLPFEEDGQYEFHPSNKFENGISALLNASWGGNEVHTPLQLAQYAATLASKGDKYKPQIVSAIIGKDGKETKKFKPIL
ESSNRYPMNFWSVMQGGMSQNIEEIKKLPFDVAGKTGITGFPNEQARMINHSLFIAYAPTEDPQIAVSVVIPGSNSEKNI
AALVTSEILESWNTLQKENKNKKEGSLK
>Mature_588_residues
MLHTKIKKWGFFAVLSIVGLILLILFKINFISITIATSSAERGKIFDQNGVILATNKKVKSLYCTSNDEKLSKQDTSNTL
AFFDQFSSKFQHDISSESIKSQLQQSCKKQTMHDIPLYSDIAENELAFINKNKPNNVIIKDEWIRYYPKHEIGSQVIGYV
ESNLNSKHMPVGKSGIELQYEGDLKGKPGKTLIFKMNNKEFLWNIQKVQKGKDIRLALDSKLQQKSEEALRSQIKKLPDA
KGGYAVVSNAKTGAILTMANSAVFDPNILHTHVTTKINNIKSLSQNKAIQKLKYGESYVNMASTIKPLTILIGLNEKLFQ
PEDTYLDNGTFEYDNQNNITNAPGTPTGEITPRQAIINSSNTFMTAKVALPLFNQHNGNVEKVAHIWTDYLMQFGLRSKT
GIDLPFEEDGQYEFHPSNKFENGISALLNASWGGNEVHTPLQLAQYAATLASKGDKYKPQIVSAIIGKDGKETKKFKPIL
ESSNRYPMNFWSVMQGGMSQNIEEIKKLPFDVAGKTGITGFPNEQARMINHSLFIAYAPTEDPQIAVSVVIPGSNSEKNI
AALVTSEILESWNTLQKENKNKKEGSLK

Specific function: Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=630, Percent_Identity=21.5873015873016, Blast_Score=116, Evalue=5e-27,
Organism=Escherichia coli, GI1786272, Length=565, Percent_Identity=24.070796460177, Blast_Score=89, Evalue=6e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460
- InterPro:   IPR017790 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 65685; Mature: 65685

Theoretical pI: Translated: 9.69; Mature: 9.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLHTKIKKWGFFAVLSIVGLILLILFKINFISITIATSSAERGKIFDQNGVILATNKKVK
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEEECCCCCCCEECCCCEEEEECCCEE
SLYCTSNDEKLSKQDTSNTLAFFDQFSSKFQHDISSESIKSQLQQSCKKQTMHDIPLYSD
EEEECCCCHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHH
IAENELAFINKNKPNNVIIKDEWIRYYPKHEIGSQVIGYVESNLNSKHMPVGKSGIELQY
HCCCCEEEEECCCCCEEEEECHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEE
EGDLKGKPGKTLIFKMNNKEFLWNIQKVQKGKDIRLALDSKLQQKSEEALRSQIKKLPDA
CCCCCCCCCCEEEEEECCCCEEEEHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCC
KGGYAVVSNAKTGAILTMANSAVFDPNILHTHVTTKINNIKSLSQNKAIQKLKYGESYVN
CCCEEEEECCCCCEEEEEECCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCHHHHH
MASTIKPLTILIGLNEKLFQPEDTYLDNGTFEYDNQNNITNAPGTPTGEITPRQAIINSS
HHHHCCEEEEEEECCHHHCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCHHHHCCCC
NTFMTAKVALPLFNQHNGNVEKVAHIWTDYLMQFGLRSKTGIDLPFEEDGQYEFHPSNKF
CCEEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCCCH
ENGISALLNASWGGNEVHTPLQLAQYAATLASKGDKYKPQIVSAIIGKDGKETKKFKPIL
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHH
ESSNRYPMNFWSVMQGGMSQNIEEIKKLPFDVAGKTGITGFPNEQARMINHSLFIAYAPT
HCCCCCCCHHHHHHCCCHHCCHHHHHHCCCCCCCCCCCCCCCCHHHHHCCCEEEEEECCC
EDPQIAVSVVIPGSNSEKNIAALVTSEILESWNTLQKENKNKKEGSLK
CCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MLHTKIKKWGFFAVLSIVGLILLILFKINFISITIATSSAERGKIFDQNGVILATNKKVK
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEEECCCCCCCEECCCCEEEEECCCEE
SLYCTSNDEKLSKQDTSNTLAFFDQFSSKFQHDISSESIKSQLQQSCKKQTMHDIPLYSD
EEEECCCCHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHH
IAENELAFINKNKPNNVIIKDEWIRYYPKHEIGSQVIGYVESNLNSKHMPVGKSGIELQY
HCCCCEEEEECCCCCEEEEECHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEE
EGDLKGKPGKTLIFKMNNKEFLWNIQKVQKGKDIRLALDSKLQQKSEEALRSQIKKLPDA
CCCCCCCCCCEEEEEECCCCEEEEHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCC
KGGYAVVSNAKTGAILTMANSAVFDPNILHTHVTTKINNIKSLSQNKAIQKLKYGESYVN
CCCEEEEECCCCCEEEEEECCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCHHHHH
MASTIKPLTILIGLNEKLFQPEDTYLDNGTFEYDNQNNITNAPGTPTGEITPRQAIINSS
HHHHCCEEEEEEECCHHHCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCHHHHCCCC
NTFMTAKVALPLFNQHNGNVEKVAHIWTDYLMQFGLRSKTGIDLPFEEDGQYEFHPSNKF
CCEEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCCCH
ENGISALLNASWGGNEVHTPLQLAQYAATLASKGDKYKPQIVSAIIGKDGKETKKFKPIL
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHH
ESSNRYPMNFWSVMQGGMSQNIEEIKKLPFDVAGKTGITGFPNEQARMINHSLFIAYAPT
HCCCCCCCHHHHHHCCCHHCCHHHHHHCCCCCCCCCCCCCCCCHHHHHCCCEEEEEECCC
EDPQIAVSVVIPGSNSEKNIAALVTSEILESWNTLQKENKNKKEGSLK
CCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]