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The map label for this gene is moaA [H]

Identifier: 222095767

GI number: 222095767

Start: 2078964

End: 2079884

Strand: Direct

Name: moaA [H]

Synonym: BCQ_2107

Alternate gene names: 222095767

Gene position: 2078964-2079884 (Clockwise)

Preceding gene: 222095765

Following gene: 222095768

Centisome position: 39.87

GC content: 36.05

Gene sequence:

>921_bases
ATGCCTGCTGAAGTGTTCGGACCTGATTATGCTTTTTTACAGGAAGAGTGTTTATTAACGTTTGATGAAATAGAAAGGTT
AGCGAGATTATTTATAAGTATGGGAGTTAATAAAATTAGGCTTACTGGCGGTGAACCTTTATTGCGTAAAGACTTACCGA
AGTTAATTGGAAGACTTGCAAAGCTAGAAGGCTTAAAAGATATTGGGCTCACAACAAACGGAATTCATTTAGCAAAACAA
GCTAAGGCGCTAAAAGAAGCAGGATTAAAGCGTGTAAATATTAGTTTAGATGCAATAGAGGATTGTGTCTTCCAAAAAAT
TAATGGAAGACATGTAAGTACGAAACCTGTACTGAAAGGAATTGAAGCAGCGAAGGAAGCTGGATTAGAAGTAAAGGTAA
ATATGGTCGTAAAAAAAGGGATGAATGATAGTCAAATTCTTCCTATGGCTCAGTATTTTAAAGAACAAGAAATACAGTTA
CGTTTCATTGAGTTTATGGATGTAGGCAGTACGAACGGATGGAACTTTGAACAAGTCGTTACGAAGGAACAATTAATAGA
GAAAATTAATCGTGTATATCCAATTGAACCTGTTAAACCTCGTTACTTTGGAGAAGTTGCGAAATTGTATCGATATGTAG
GAAGCGATGCCGAAGTTGGATTTATTACTTCAGTATCTGAGTCATTTTGTTCTTCTTGTACGAGAGCCCGTATTTCGGCA
GACGGCAAGTTTTATACGTGCTTATTTGGAGAAAAAGGAACGGATTTACGATCGCTTCTTCGAGAAAATATTTCTGATGC
ATCACTATTAAAAATTTTACAACATACATGGCGATATAGAACAGATCGATATTCAGATGAAAGAACGGCGGAAAGTACAA
ATAAACGTCAAAAAGTTGAGATGTCTTACATTGGTGGATAG

Upstream 100 bases:

>100_bases
GATATAGATGCACGAGAACATGAAAGATTCTTTAAAGCGACCACTTCAAGATTTACGCATTTCAGTTATTGATCGTTGTA
ATTTTAGGTGCACATATTGT

Downstream 100 bases:

>100_bases
CGAAAGGAGGATTCCTTATGCAAGAGCGATATTCAAGACAAGTATTGTTTTCTGGAATAGGTGAAATGGGACAAAGGAAA
ATAAGGGAAAAGCATGTGCT

Product: molybdenum cofactor biosynthesis protein a

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 306; Mature: 305

Protein sequence:

>306_residues
MPAEVFGPDYAFLQEECLLTFDEIERLARLFISMGVNKIRLTGGEPLLRKDLPKLIGRLAKLEGLKDIGLTTNGIHLAKQ
AKALKEAGLKRVNISLDAIEDCVFQKINGRHVSTKPVLKGIEAAKEAGLEVKVNMVVKKGMNDSQILPMAQYFKEQEIQL
RFIEFMDVGSTNGWNFEQVVTKEQLIEKINRVYPIEPVKPRYFGEVAKLYRYVGSDAEVGFITSVSESFCSSCTRARISA
DGKFYTCLFGEKGTDLRSLLRENISDASLLKILQHTWRYRTDRYSDERTAESTNKRQKVEMSYIGG

Sequences:

>Translated_306_residues
MPAEVFGPDYAFLQEECLLTFDEIERLARLFISMGVNKIRLTGGEPLLRKDLPKLIGRLAKLEGLKDIGLTTNGIHLAKQ
AKALKEAGLKRVNISLDAIEDCVFQKINGRHVSTKPVLKGIEAAKEAGLEVKVNMVVKKGMNDSQILPMAQYFKEQEIQL
RFIEFMDVGSTNGWNFEQVVTKEQLIEKINRVYPIEPVKPRYFGEVAKLYRYVGSDAEVGFITSVSESFCSSCTRARISA
DGKFYTCLFGEKGTDLRSLLRENISDASLLKILQHTWRYRTDRYSDERTAESTNKRQKVEMSYIGG
>Mature_305_residues
PAEVFGPDYAFLQEECLLTFDEIERLARLFISMGVNKIRLTGGEPLLRKDLPKLIGRLAKLEGLKDIGLTTNGIHLAKQA
KALKEAGLKRVNISLDAIEDCVFQKINGRHVSTKPVLKGIEAAKEAGLEVKVNMVVKKGMNDSQILPMAQYFKEQEIQLR
FIEFMDVGSTNGWNFEQVVTKEQLIEKINRVYPIEPVKPRYFGEVAKLYRYVGSDAEVGFITSVSESFCSSCTRARISAD
GKFYTCLFGEKGTDLRSLLRENISDASLLKILQHTWRYRTDRYSDERTAESTNKRQKVEMSYIGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI116734668, Length=257, Percent_Identity=42.0233463035019, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI22027536, Length=257, Percent_Identity=42.0233463035019, Blast_Score=197, Evalue=1e-50,
Organism=Escherichia coli, GI1786999, Length=290, Percent_Identity=33.1034482758621, Blast_Score=164, Evalue=6e-42,
Organism=Caenorhabditis elegans, GI17561210, Length=307, Percent_Identity=33.5504885993485, Blast_Score=163, Evalue=8e-41,
Organism=Caenorhabditis elegans, GI32566331, Length=306, Percent_Identity=32.6797385620915, Blast_Score=163, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI32566329, Length=307, Percent_Identity=32.5732899022801, Blast_Score=160, Evalue=5e-40,
Organism=Drosophila melanogaster, GI28574490, Length=270, Percent_Identity=36.2962962962963, Blast_Score=178, Evalue=3e-45,
Organism=Drosophila melanogaster, GI28574488, Length=257, Percent_Identity=37.7431906614786, Blast_Score=177, Evalue=1e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 34634; Mature: 34503

Theoretical pI: Translated: 8.87; Mature: 8.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAEVFGPDYAFLQEECLLTFDEIERLARLFISMGVNKIRLTGGEPLLRKDLPKLIGRLA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHH
KLEGLKDIGLTTNGIHLAKQAKALKEAGLKRVNISLDAIEDCVFQKINGRHVSTKPVLKG
HHCCCHHCCCCCCCHHHHHHHHHHHHCCCEEEECHHHHHHHHHHHHCCCCCCCHHHHHHH
IEAAKEAGLEVKVNMVVKKGMNDSQILPMAQYFKEQEIQLRFIEFMDVGSTNGWNFEQVV
HHHHHHCCCEEEEEEHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
TKEQLIEKINRVYPIEPVKPRYFGEVAKLYRYVGSDAEVGFITSVSESFCSSCTRARISA
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHCC
DGKFYTCLFGEKGTDLRSLLRENISDASLLKILQHTWRYRTDRYSDERTAESTNKRQKVE
CCCEEEEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHCCHHHEEE
MSYIGG
EHCCCC
>Mature Secondary Structure 
PAEVFGPDYAFLQEECLLTFDEIERLARLFISMGVNKIRLTGGEPLLRKDLPKLIGRLA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHH
KLEGLKDIGLTTNGIHLAKQAKALKEAGLKRVNISLDAIEDCVFQKINGRHVSTKPVLKG
HHCCCHHCCCCCCCHHHHHHHHHHHHCCCEEEECHHHHHHHHHHHHCCCCCCCHHHHHHH
IEAAKEAGLEVKVNMVVKKGMNDSQILPMAQYFKEQEIQLRFIEFMDVGSTNGWNFEQVV
HHHHHHCCCEEEEEEHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
TKEQLIEKINRVYPIEPVKPRYFGEVAKLYRYVGSDAEVGFITSVSESFCSSCTRARISA
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHCC
DGKFYTCLFGEKGTDLRSLLRENISDASLLKILQHTWRYRTDRYSDERTAESTNKRQKVE
CCCEEEEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHCCHHHEEE
MSYIGG
EHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA