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The map label for this gene is fhs [H]

Identifier: 222095745

GI number: 222095745

Start: 2055363

End: 2057051

Strand: Direct

Name: fhs [H]

Synonym: BCQ_2085

Alternate gene names: 222095745

Gene position: 2055363-2057051 (Clockwise)

Preceding gene: 222095744

Following gene: 222095746

Centisome position: 39.42

GC content: 38.6

Gene sequence:

>1689_bases
ATGACAACTACTACAACAGTTAAATCCGACATTGAAATCGCACAAGAAGCAAGTATGAAGAAGATTCAAGAAATTGCAGC
TGAATTAAATATTTTAGAAGATGAATTAGAGCCATACGGTCATTATAAAGGTAAGTTATCTCTTGATATTTTTAAGCGCT
TACAGAATGAGAAAGACGGTAAAGTTGTTTTAGTAACAGCGATTAACCCAACTCCAGCTGGAGAAGGTAAATCAACAGTA
ACAGTTGGTTTAGGTCAAGCTTTTAATAAAATTGGTAAGAAAACAGTAATTGCACTTCGCGAACCATCTCTTGGACCAAC
GATGGGGCTAAAAGGCGGAGCAGCAGGTGGTGGATTTTCACAGGTTGTACCAATGGAAGACATTAACCTTCACTTTACTG
GAGATATCCATGCGATCACAACTGCTAATAACGCGTTAGCGGCGTTTATTGATAATCATATCCAACAAGGAAATACACTT
GGAATTGATACGCGTAAAATCGTTTGGAAACGATGTGTTGACTTAAATGATCGTGCCCTACGTAACGTAGTAATTGGTCT
TGGTGGACCGGTTCAAGGTGTACCACGTGAAGATGGTTTTGATATTACAGTAGCATCTGAAATTATGGCCGTATTCTGCC
TTGCAACAGATATTCAAGATTTAAAAGCACGTCTATCGCGCATCGTAGTTGCTTATAACTTTGCAAATCAACCTGTAACG
GTTAAAGATTTAGGTGTAGAAGGTGCGTTAACATTATTATTAAAAGATGCATTAAAGCCAAACTTAGTGCAAACGTTAGA
AAATACACCAGCTATCATTCATGGCGGACCATTTGCGAATATCGCTCACGGTTGTAACAGTGTTATCGCTACAACAATGG
CAGCAAAATTAGGTGATTATGTTATTACAGAAGCTGGATTTGGTGCAGATTTAGGTGCTGAGAAGTTTTTAGATATTAAA
GCTCGTGCAGCTGGCATTAAACCAGAAGCAGTTGTTATTGTTGCGACGATTCGTGCGCTTAAAATGCATGGTGGCGTAGC
AAAAGATCAATTAAAAGAAGAAAATGTAGATGCATTAGCAAAAGGTATGGAGAACTTACAGAAGCACGTTGAAACAATTC
AAAGCTTCGGTGTGCCTTTCGTAATTGCAATTAATAAATTCATTACAGATACAGATGCAGAAGTTGCATACTTACAAGAA
TGGTGTAATGAGCGTGGCTATGCGGTATCCTTAACAGAAGTTTGGGAGAAAGGTGGCCAAGGCGGAGTTGACCTTGCTGA
AAAAGTGTTAAAAGAAATTGAAAAAGGTGAAAACAACTACGCACCACTTTATGAATTAGAATTACCATTAGAAGAGAAAA
TTCGTACAATTGCTCAAAAAGTGTACGGCGCAAAAGATATTGAATTTGCTCCGAAAGCACGTAAGCAATTAGCTCAATAT
GAAGGCGAAGGTTGGAGTAACCTACCAATTTGTATGGCGAAAACACAATACTCTCTTTCTGACGATGCAACGAAATTAGG
TCGTCCATCTGACTTTATCGTTACAATTCGTGAGCTAAAACCATCTATTGGTGCAGGCTTTATCGTTGCGTTAACAGGGA
CAATGTTAACAATGCCAGGCCTTCCAAAACAACCAGCAGCACTACAAATGGATGTAAATGAAGATGGAAAAGCAGTAGGT
TTATTCTAA

Upstream 100 bases:

>100_bases
GCATAAAGAAATGAAAGAATTTTTAGGAGGTAAATAAGTGCAGAAAATACAAAAAACTGATACAATATCATCAGAACCAA
TTAAAGGGGGACTAGGGTAT

Downstream 100 bases:

>100_bases
AAGGTTGTAATTCATCTCGTTTATCTGTAAACTATATATACATCAAGTGGCGCCTTTCCATCGAAAGGCGCCTGTTTTTT
GGAGGAAATTATGTTTGATC

Product: formate--tetrahydrofolate ligase

Products: NA

Alternate protein names: Formyltetrahydrofolate synthetase; FHS; FTHFS [H]

Number of amino acids: Translated: 562; Mature: 561

Protein sequence:

>562_residues
MTTTTTVKSDIEIAQEASMKKIQEIAAELNILEDELEPYGHYKGKLSLDIFKRLQNEKDGKVVLVTAINPTPAGEGKSTV
TVGLGQAFNKIGKKTVIALREPSLGPTMGLKGGAAGGGFSQVVPMEDINLHFTGDIHAITTANNALAAFIDNHIQQGNTL
GIDTRKIVWKRCVDLNDRALRNVVIGLGGPVQGVPREDGFDITVASEIMAVFCLATDIQDLKARLSRIVVAYNFANQPVT
VKDLGVEGALTLLLKDALKPNLVQTLENTPAIIHGGPFANIAHGCNSVIATTMAAKLGDYVITEAGFGADLGAEKFLDIK
ARAAGIKPEAVVIVATIRALKMHGGVAKDQLKEENVDALAKGMENLQKHVETIQSFGVPFVIAINKFITDTDAEVAYLQE
WCNERGYAVSLTEVWEKGGQGGVDLAEKVLKEIEKGENNYAPLYELELPLEEKIRTIAQKVYGAKDIEFAPKARKQLAQY
EGEGWSNLPICMAKTQYSLSDDATKLGRPSDFIVTIRELKPSIGAGFIVALTGTMLTMPGLPKQPAALQMDVNEDGKAVG
LF

Sequences:

>Translated_562_residues
MTTTTTVKSDIEIAQEASMKKIQEIAAELNILEDELEPYGHYKGKLSLDIFKRLQNEKDGKVVLVTAINPTPAGEGKSTV
TVGLGQAFNKIGKKTVIALREPSLGPTMGLKGGAAGGGFSQVVPMEDINLHFTGDIHAITTANNALAAFIDNHIQQGNTL
GIDTRKIVWKRCVDLNDRALRNVVIGLGGPVQGVPREDGFDITVASEIMAVFCLATDIQDLKARLSRIVVAYNFANQPVT
VKDLGVEGALTLLLKDALKPNLVQTLENTPAIIHGGPFANIAHGCNSVIATTMAAKLGDYVITEAGFGADLGAEKFLDIK
ARAAGIKPEAVVIVATIRALKMHGGVAKDQLKEENVDALAKGMENLQKHVETIQSFGVPFVIAINKFITDTDAEVAYLQE
WCNERGYAVSLTEVWEKGGQGGVDLAEKVLKEIEKGENNYAPLYELELPLEEKIRTIAQKVYGAKDIEFAPKARKQLAQY
EGEGWSNLPICMAKTQYSLSDDATKLGRPSDFIVTIRELKPSIGAGFIVALTGTMLTMPGLPKQPAALQMDVNEDGKAVG
LF
>Mature_561_residues
TTTTTVKSDIEIAQEASMKKIQEIAAELNILEDELEPYGHYKGKLSLDIFKRLQNEKDGKVVLVTAINPTPAGEGKSTVT
VGLGQAFNKIGKKTVIALREPSLGPTMGLKGGAAGGGFSQVVPMEDINLHFTGDIHAITTANNALAAFIDNHIQQGNTLG
IDTRKIVWKRCVDLNDRALRNVVIGLGGPVQGVPREDGFDITVASEIMAVFCLATDIQDLKARLSRIVVAYNFANQPVTV
KDLGVEGALTLLLKDALKPNLVQTLENTPAIIHGGPFANIAHGCNSVIATTMAAKLGDYVITEAGFGADLGAEKFLDIKA
RAAGIKPEAVVIVATIRALKMHGGVAKDQLKEENVDALAKGMENLQKHVETIQSFGVPFVIAINKFITDTDAEVAYLQEW
CNERGYAVSLTEVWEKGGQGGVDLAEKVLKEIEKGENNYAPLYELELPLEEKIRTIAQKVYGAKDIEFAPKARKQLAQYE
GEGWSNLPICMAKTQYSLSDDATKLGRPSDFIVTIRELKPSIGAGFIVALTGTMLTMPGLPKQPAALQMDVNEDGKAVGL
F

Specific function: Unknown

COG id: COG2759

COG function: function code F; Formyltetrahydrofolate synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the formate--tetrahydrofolate ligase family [H]

Homologues:

Organism=Homo sapiens, GI36796743, Length=623, Percent_Identity=47.8330658105939, Blast_Score=513, Evalue=1e-145,
Organism=Homo sapiens, GI222136639, Length=625, Percent_Identity=45.28, Blast_Score=491, Evalue=1e-139,
Organism=Homo sapiens, GI310124614, Length=102, Percent_Identity=53.921568627451, Blast_Score=107, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17568737, Length=629, Percent_Identity=44.9920508744038, Blast_Score=481, Evalue=1e-136,
Organism=Caenorhabditis elegans, GI17568739, Length=629, Percent_Identity=44.9920508744038, Blast_Score=481, Evalue=1e-136,
Organism=Saccharomyces cerevisiae, GI6319558, Length=635, Percent_Identity=43.6220472440945, Blast_Score=491, Evalue=1e-139,
Organism=Saccharomyces cerevisiae, GI6321643, Length=626, Percent_Identity=43.9297124600639, Blast_Score=473, Evalue=1e-134,
Organism=Drosophila melanogaster, GI62472483, Length=622, Percent_Identity=43.0868167202572, Blast_Score=465, Evalue=1e-131,
Organism=Drosophila melanogaster, GI45551871, Length=622, Percent_Identity=43.0868167202572, Blast_Score=465, Evalue=1e-131,
Organism=Drosophila melanogaster, GI24645718, Length=622, Percent_Identity=43.0868167202572, Blast_Score=465, Evalue=1e-131,
Organism=Drosophila melanogaster, GI17137370, Length=622, Percent_Identity=43.0868167202572, Blast_Score=465, Evalue=1e-131,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000559
- InterPro:   IPR020628 [H]

Pfam domain/function: PF01268 FTHFS [H]

EC number: =6.3.4.3 [H]

Molecular weight: Translated: 60476; Mature: 60345

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: PS00722 FTHFS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTTTTVKSDIEIAQEASMKKIQEIAAELNILEDELEPYGHYKGKLSLDIFKRLQNEKDG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHCCCCCC
KVVLVTAINPTPAGEGKSTVTVGLGQAFNKIGKKTVIALREPSLGPTMGLKGGAAGGGFS
CEEEEEEECCCCCCCCCCEEEEEHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCCC
QVVPMEDINLHFTGDIHAITTANNALAAFIDNHIQQGNTLGIDTRKIVWKRCVDLNDRAL
CCCCCCCCCEEEECCEEEEEECCCHHHHHHHHHHHCCCEECCCHHHHHHHHHCCCCHHHH
RNVVIGLGGPVQGVPREDGFDITVASEIMAVFCLATDIQDLKARLSRIVVAYNFANQPVT
HHEEEECCCCCCCCCCCCCCCEEHHHHHHHHHHHHHCHHHHHHHHHHEEEEEECCCCCEE
VKDLGVEGALTLLLKDALKPNLVQTLENTPAIIHGGPFANIAHGCNSVIATTMAAKLGDY
EEECCCCHHHHHHHHHHCCCHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCE
VITEAGFGADLGAEKFLDIKARAAGIKPEAVVIVATIRALKMHGGVAKDQLKEENVDALA
EEECCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEHHHHHHHHCCCCCHHHHHHCCHHHHH
KGMENLQKHVETIQSFGVPFVIAINKFITDTDAEVAYLQEWCNERGYAVSLTEVWEKGGQ
HHHHHHHHHHHHHHHCCCCEEEEEHHHHCCCCHHHHHHHHHHCCCCCEEEHHHHHHCCCC
GGVDLAEKVLKEIEKGENNYAPLYELELPLEEKIRTIAQKVYGAKDIEFAPKARKQLAQY
CCHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
EGEGWSNLPICMAKTQYSLSDDATKLGRPSDFIVTIRELKPSIGAGFIVALTGTMLTMPG
CCCCCCCCCEEEEECCCCCCCCHHHCCCCCHHEEEHHHHCCCCCCCEEEEEHHHHHCCCC
LPKQPAALQMDVNEDGKAVGLF
CCCCCCEEEEECCCCCCEECCC
>Mature Secondary Structure 
TTTTTVKSDIEIAQEASMKKIQEIAAELNILEDELEPYGHYKGKLSLDIFKRLQNEKDG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHCCCCCC
KVVLVTAINPTPAGEGKSTVTVGLGQAFNKIGKKTVIALREPSLGPTMGLKGGAAGGGFS
CEEEEEEECCCCCCCCCCEEEEEHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCCC
QVVPMEDINLHFTGDIHAITTANNALAAFIDNHIQQGNTLGIDTRKIVWKRCVDLNDRAL
CCCCCCCCCEEEECCEEEEEECCCHHHHHHHHHHHCCCEECCCHHHHHHHHHCCCCHHHH
RNVVIGLGGPVQGVPREDGFDITVASEIMAVFCLATDIQDLKARLSRIVVAYNFANQPVT
HHEEEECCCCCCCCCCCCCCCEEHHHHHHHHHHHHHCHHHHHHHHHHEEEEEECCCCCEE
VKDLGVEGALTLLLKDALKPNLVQTLENTPAIIHGGPFANIAHGCNSVIATTMAAKLGDY
EEECCCCHHHHHHHHHHCCCHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCE
VITEAGFGADLGAEKFLDIKARAAGIKPEAVVIVATIRALKMHGGVAKDQLKEENVDALA
EEECCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEHHHHHHHHCCCCCHHHHHHCCHHHHH
KGMENLQKHVETIQSFGVPFVIAINKFITDTDAEVAYLQEWCNERGYAVSLTEVWEKGGQ
HHHHHHHHHHHHHHHCCCCEEEEEHHHHCCCCHHHHHHHHHHCCCCCEEEHHHHHHCCCC
GGVDLAEKVLKEIEKGENNYAPLYELELPLEEKIRTIAQKVYGAKDIEFAPKARKQLAQY
CCHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
EGEGWSNLPICMAKTQYSLSDDATKLGRPSDFIVTIRELKPSIGAGFIVALTGTMLTMPG
CCCCCCCCCEEEEECCCCCCCCHHHCCCCCHHEEEHHHHCCCCCCCEEEEEHHHHHCCCC
LPKQPAALQMDVNEDGKAVGLF
CCCCCCEEEEECCCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA