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The map label for this gene is thrC [H]

Identifier: 222095618

GI number: 222095618

Start: 1938045

End: 1939103

Strand: Direct

Name: thrC [H]

Synonym: BCQ_1958

Alternate gene names: 222095618

Gene position: 1938045-1939103 (Clockwise)

Preceding gene: 222095617

Following gene: 222095619

Centisome position: 37.17

GC content: 39.47

Gene sequence:

>1059_bases
ATGTATAAAGGACTATTAAACGAATATGCTTCTTATTTACCGGTAAATGAAAACACACCTGATGTGAGCTTAATGGAAGG
AAATACACCCCTTATTCCGTTATTAAATATATCAAAACAATTAGGGATTCAGTTATATGGTAAGTACGAAGGAGCGAATC
CGACAGGTTCCTTTAAAGATCGTGGTATGGTAATGGCAGTCGCAAAGGCGAAAGAAGACGGTTCGGAGGCCATTATTTGC
GCATCGACAGGCAATACATCAGCATCGGCTGCCGCATACGCGGCACGCCTTGGAATGAAATGTATTATCGTAATACCGGA
AGGAAAGATTGCACATGGAAAATTAGCGCAAGCAGTTGCCTATGGTGCTGAAATCATTTCAATAGAAGGAAATTTTGATG
ATGCACTAAAGGCTGTAAGAAATATTGCTGCAGAAGAGCCAATCACATTAGTTAACTCGGTAAATCCTTATCGAATTGAA
GGGCAAAAAACAGCAGCATTTGAAATTTGTGACCAATTGCAAAGTGCACCAGATGTTTTAGCGATTCCTGTTGGGAATGC
TGGGAATATTACAGCGTACTGGAAGGGTTTCTGTGAATATGAGAAAGAAAAAGGATATAAGAAGCCAAGAATTCATGGAT
TTGAAGCGGAAGGAGCAGCTGCTATTGTAAAAGGGCATGTAATTGACGAGCCAGAAACAATTGCAACAGCGATTCGCATC
GGTAACCCAGCAAGTTGGTCATATGCAGTAGAGGCTGCTGAGCAATCTCACGGTGAAATAGATATGGTATCAGATGAAGA
AATTTTACATGCGTATAGATTATTAGCAAAATCGGAAGGGGTTTTCGCTGAGCCAGGATCAAATGCTTCATTAGCTGGCG
TAATGAAACATGTTCAATCTGGAAAAATCAAAAAAGGAGAAACAGTTGTTGCAGTTTTAACTGGAAACGGCTTGAAAGAT
CCTGATATCGCAATCTCTGCTAATACATTAGATATTGCAAGTGTTTCAAATAATATAGAACAAATTAAAGAGCATATTAA
AGGGGTGATTATGTCGTGA

Upstream 100 bases:

>100_bases
CATCAAACTTCAAAGTATCAATTCGAACGAGTTTTAGGAGCGATAGAAGATGTCGCAAGTGAAATAAACAGTTACTACAT
TATTGAGGAGGAAAAACAAT

Downstream 100 bases:

>100_bases
TACCATTAAGTATTCGTGTTCCTGCTAGTACAGCGAATGTTGGACCTGGATTCGATTCAGTAGGAATAGCTTTGTCATTA
TATTTACATGTAGTAGTTAA

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 352; Mature: 352

Protein sequence:

>352_residues
MYKGLLNEYASYLPVNENTPDVSLMEGNTPLIPLLNISKQLGIQLYGKYEGANPTGSFKDRGMVMAVAKAKEDGSEAIIC
ASTGNTSASAAAYAARLGMKCIIVIPEGKIAHGKLAQAVAYGAEIISIEGNFDDALKAVRNIAAEEPITLVNSVNPYRIE
GQKTAAFEICDQLQSAPDVLAIPVGNAGNITAYWKGFCEYEKEKGYKKPRIHGFEAEGAAAIVKGHVIDEPETIATAIRI
GNPASWSYAVEAAEQSHGEIDMVSDEEILHAYRLLAKSEGVFAEPGSNASLAGVMKHVQSGKIKKGETVVAVLTGNGLKD
PDIAISANTLDIASVSNNIEQIKEHIKGVIMS

Sequences:

>Translated_352_residues
MYKGLLNEYASYLPVNENTPDVSLMEGNTPLIPLLNISKQLGIQLYGKYEGANPTGSFKDRGMVMAVAKAKEDGSEAIIC
ASTGNTSASAAAYAARLGMKCIIVIPEGKIAHGKLAQAVAYGAEIISIEGNFDDALKAVRNIAAEEPITLVNSVNPYRIE
GQKTAAFEICDQLQSAPDVLAIPVGNAGNITAYWKGFCEYEKEKGYKKPRIHGFEAEGAAAIVKGHVIDEPETIATAIRI
GNPASWSYAVEAAEQSHGEIDMVSDEEILHAYRLLAKSEGVFAEPGSNASLAGVMKHVQSGKIKKGETVVAVLTGNGLKD
PDIAISANTLDIASVSNNIEQIKEHIKGVIMS
>Mature_352_residues
MYKGLLNEYASYLPVNENTPDVSLMEGNTPLIPLLNISKQLGIQLYGKYEGANPTGSFKDRGMVMAVAKAKEDGSEAIIC
ASTGNTSASAAAYAARLGMKCIIVIPEGKIAHGKLAQAVAYGAEIISIEGNFDDALKAVRNIAAEEPITLVNSVNPYRIE
GQKTAAFEICDQLQSAPDVLAIPVGNAGNITAYWKGFCEYEKEKGYKKPRIHGFEAEGAAAIVKGHVIDEPETIATAIRI
GNPASWSYAVEAAEQSHGEIDMVSDEEILHAYRLLAKSEGVFAEPGSNASLAGVMKHVQSGKIKKGETVVAVLTGNGLKD
PDIAISANTLDIASVSNNIEQIKEHIKGVIMS

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=322, Percent_Identity=28.8819875776398, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI295821200, Length=322, Percent_Identity=28.8819875776398, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI4557415, Length=322, Percent_Identity=28.8819875776398, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI11345492, Length=290, Percent_Identity=29.3103448275862, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI33469958, Length=277, Percent_Identity=25.6317689530686, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI1790207, Length=295, Percent_Identity=26.7796610169492, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI2367138, Length=223, Percent_Identity=28.2511210762332, Blast_Score=69, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI71991565, Length=306, Percent_Identity=27.1241830065359, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322631, Length=275, Percent_Identity=29.4545454545455, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24643623, Length=189, Percent_Identity=33.8624338624339, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI20129101, Length=189, Percent_Identity=33.8624338624339, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: 1344 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 37363; Mature: 37363

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYKGLLNEYASYLPVNENTPDVSLMEGNTPLIPLLNISKQLGIQLYGKYEGANPTGSFKD
CCCHHHHHHHHHCCCCCCCCCEEEEECCCCEEEEECCCHHCCEEEEEEECCCCCCCCCCC
RGMVMAVAKAKEDGSEAIICASTGNTSASAAAYAARLGMKCIIVIPEGKIAHGKLAQAVA
CCEEEEEEECCCCCCCEEEEEECCCCCHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHH
YGAEIISIEGNFDDALKAVRNIAAEEPITLVNSVNPYRIEGQKTAAFEICDQLQSAPDVL
CCEEEEEEECCHHHHHHHHHHHHCCCCEEEECCCCCEEECCCCHHHHHHHHHHHCCCCEE
AIPVGNAGNITAYWKGFCEYEKEKGYKKPRIHGFEAEGAAAIVKGHVIDEPETIATAIRI
EEECCCCCCEEHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCCCHHHEEEEEC
GNPASWSYAVEAAEQSHGEIDMVSDEEILHAYRLLAKSEGVFAEPGSNASLAGVMKHVQS
CCCCCCHHEEEHHHHCCCCEEEECCHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHC
GKIKKGETVVAVLTGNGLKDPDIAISANTLDIASVSNNIEQIKEHIKGVIMS
CCCCCCCEEEEEEECCCCCCCCEEEECCCEEEHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MYKGLLNEYASYLPVNENTPDVSLMEGNTPLIPLLNISKQLGIQLYGKYEGANPTGSFKD
CCCHHHHHHHHHCCCCCCCCCEEEEECCCCEEEEECCCHHCCEEEEEEECCCCCCCCCCC
RGMVMAVAKAKEDGSEAIICASTGNTSASAAAYAARLGMKCIIVIPEGKIAHGKLAQAVA
CCEEEEEEECCCCCCCEEEEEECCCCCHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHH
YGAEIISIEGNFDDALKAVRNIAAEEPITLVNSVNPYRIEGQKTAAFEICDQLQSAPDVL
CCEEEEEEECCHHHHHHHHHHHHCCCCEEEECCCCCEEECCCCHHHHHHHHHHHCCCCEE
AIPVGNAGNITAYWKGFCEYEKEKGYKKPRIHGFEAEGAAAIVKGHVIDEPETIATAIRI
EEECCCCCCEEHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCCCHHHEEEEEC
GNPASWSYAVEAAEQSHGEIDMVSDEEILHAYRLLAKSEGVFAEPGSNASLAGVMKHVQS
CCCCCCHHEEEHHHHCCCCEEEECCHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHC
GKIKKGETVVAVLTGNGLKDPDIAISANTLDIASVSNNIEQIKEHIKGVIMS
CCCCCCCEEEEEEECCCCCCCCEEEECCCEEEHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3186450; 8768250 [H]