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The map label for this gene is mdmC [H]

Identifier: 222095610

GI number: 222095610

Start: 1931385

End: 1932056

Strand: Direct

Name: mdmC [H]

Synonym: BCQ_1950

Alternate gene names: 222095610

Gene position: 1931385-1932056 (Clockwise)

Preceding gene: 222095609

Following gene: 222095611

Centisome position: 37.04

GC content: 38.24

Gene sequence:

>672_bases
ATGAGTATGATTGAGAAGTGGACGGCTGTTGATCAATATATGAGTGATGTATTAATACCGAAAGATTCTACATTAGAAGA
AGTTCTTCAAGAAAATGCTACAGCTAATTTACCGGCACATGACGTATCACCGACGCAAGATAAGTTTTTACAATTATTAG
TACAAATTCAAGGAGCTCGAAATATTTTAGAGATTGGTACTCTAGGTGGATATAGCACCATATGGCTTGCAAGGGCATTG
CCATATGGTGGTCGGATTGTTACATTGGAAGCGAGTGAAAAACATGCTGAAATTGCACGTAGCAATATTGAACGTGCCAA
TTTGACTGATAAAATTGAAATACGAGTAGGATTAGCTTTAGATTCTTTACAGCAAATAGAAAATGAGAAGTATGAACCAT
TTGACTTTATCTTTATAGACGCTGATAAACAAAATAATCCTGCTTATTTTGAATGGGCGCTGAAACTATCACGTCCAGGG
ACTGTAATTATTGGGGATAACGTAGTACGTGAAGGAGAAGTTATTGACAATACGAGTAATGACCCTCGCGTACAAGGAAT
ACGTCGTTTCTATGAGCTAATAGCTGCTGAGCCGCGTGTAAGTGCTACAGCGCTTCAAACAGTCGGAAGTAAAGGGTACG
ATGGATTTGTAATGGCAGTCGTAAAAGAATAA

Upstream 100 bases:

>100_bases
AGATATCCCTTCTTTATATTTGTGTATAAAACAGAATTTTCGGTATAATCAAAAGTGAATGGTAGAAAAGCATTGAGAAA
TTGAAGGGGATGGTATTTCC

Downstream 100 bases:

>100_bases
CGAAAGGAGATAAATAGAATGAAAAAGATGTTTGAAAAATTATAACATGTATCGTATACAACACAGTTAGCCCGTGGACC
TCCAACATACTTAAAAATAT

Product: o-methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 223; Mature: 222

Protein sequence:

>223_residues
MSMIEKWTAVDQYMSDVLIPKDSTLEEVLQENATANLPAHDVSPTQDKFLQLLVQIQGARNILEIGTLGGYSTIWLARAL
PYGGRIVTLEASEKHAEIARSNIERANLTDKIEIRVGLALDSLQQIENEKYEPFDFIFIDADKQNNPAYFEWALKLSRPG
TVIIGDNVVREGEVIDNTSNDPRVQGIRRFYELIAAEPRVSATALQTVGSKGYDGFVMAVVKE

Sequences:

>Translated_223_residues
MSMIEKWTAVDQYMSDVLIPKDSTLEEVLQENATANLPAHDVSPTQDKFLQLLVQIQGARNILEIGTLGGYSTIWLARAL
PYGGRIVTLEASEKHAEIARSNIERANLTDKIEIRVGLALDSLQQIENEKYEPFDFIFIDADKQNNPAYFEWALKLSRPG
TVIIGDNVVREGEVIDNTSNDPRVQGIRRFYELIAAEPRVSATALQTVGSKGYDGFVMAVVKE
>Mature_222_residues
SMIEKWTAVDQYMSDVLIPKDSTLEEVLQENATANLPAHDVSPTQDKFLQLLVQIQGARNILEIGTLGGYSTIWLARALP
YGGRIVTLEASEKHAEIARSNIERANLTDKIEIRVGLALDSLQQIENEKYEPFDFIFIDADKQNNPAYFEWALKLSRPGT
VIIGDNVVREGEVIDNTSNDPRVQGIRRFYELIAAEPRVSATALQTVGSKGYDGFVMAVVKE

Specific function: 4-O-methyltransferase for the lactone ring of midecamycin and other macrolide antibiotics [H]

COG id: COG4122

COG function: function code R; Predicted O-methyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. Type 3 family [H]

Homologues:

Organism=Homo sapiens, GI31542747, Length=161, Percent_Identity=33.5403726708075, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI25148771, Length=198, Percent_Identity=30.3030303030303, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17565612, Length=208, Percent_Identity=29.8076923076923, Blast_Score=75, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002935 [H]

Pfam domain/function: PF01596 Methyltransf_3 [H]

EC number: NA

Molecular weight: Translated: 24884; Mature: 24753

Theoretical pI: Translated: 4.45; Mature: 4.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSMIEKWTAVDQYMSDVLIPKDSTLEEVLQENATANLPAHDVSPTQDKFLQLLVQIQGAR
CCHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCC
NILEIGTLGGYSTIWLARALPYGGRIVTLEASEKHAEIARSNIERANLTDKIEIRVGLAL
CEEEECCCCCHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHCCHHCCCCEEEEEEEEHHH
DSLQQIENEKYEPFDFIFIDADKQNNPAYFEWALKLSRPGTVIIGDNVVREGEVIDNTSN
HHHHHHHCCCCCCEEEEEEECCCCCCCCEEEEEEEECCCCEEEECCCEEECCCEECCCCC
DPRVQGIRRFYELIAAEPRVSATALQTVGSKGYDGFVMAVVKE
CHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCEEEEEEEC
>Mature Secondary Structure 
SMIEKWTAVDQYMSDVLIPKDSTLEEVLQENATANLPAHDVSPTQDKFLQLLVQIQGAR
CHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCC
NILEIGTLGGYSTIWLARALPYGGRIVTLEASEKHAEIARSNIERANLTDKIEIRVGLAL
CEEEECCCCCHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHCCHHCCCCEEEEEEEEHHH
DSLQQIENEKYEPFDFIFIDADKQNNPAYFEWALKLSRPGTVIIGDNVVREGEVIDNTSN
HHHHHHHCCCCCCEEEEEEECCCCCCCCEEEEEEEECCCCEEEECCCEEECCCEECCCCC
DPRVQGIRRFYELIAAEPRVSATALQTVGSKGYDGFVMAVVKE
CHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1629172 [H]