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The map label for this gene is pyn [H]

Identifier: 222095549

GI number: 222095549

Start: 1868528

End: 1869829

Strand: Direct

Name: pyn [H]

Synonym: BCQ_1889

Alternate gene names: 222095549

Gene position: 1868528-1869829 (Clockwise)

Preceding gene: 222095548

Following gene: 222095550

Centisome position: 35.84

GC content: 38.17

Gene sequence:

>1302_bases
ATGAGAATGGTAGATATTATTGCGAAAAAACGTGACGGTAAAGAATTAACGACTGAAGAAATCAAATTCTTTATTAATGG
ATATACAGACGGAAGTATTCCTGATTATCAAGTAAGTGCACTTGCAATGGCAATCTTCTTTAAAGATATGACAGATCGCG
AACGTGCAGATTTAACGATGGCAATGGTGGAGTCCGGAGAAACAATCGACTTATCAGCAATTGAAGGAATTAAAGTAGAC
AAACATTCAACTGGCGGTGTTGGTGATACAACAACATTAGTACTAGGACCATTAGTAGCTGCTTTAGATGTACCAGTAGC
AAAAATGTCTGGTCGTGGTTTAGGACATACGGGCGGAACAATTGATAAATTAGAAGCGGTAGAAGGATTCCACGTTGAAA
TTACGAAAGAGCAGTTCATTGATATTGTAAACCGTGACAAAGTAGCTGTTATTGGGCAAACAGGAAACTTAACACCTGCA
GACAAAAAGATTTATGCATTACGCGATGTAACAGGAACGGTTAACTCAATTCCTTTAATCGCAAGTTCAATTATGAGTAA
AAAAATTGCAGCTGGTGCTGACGCAATCGTACTTGATGTGAAAACAGGTGCTGGCGCATTTATGAAAACAGAAGAAGATG
CAAAAGAATTAGCACATGCAATGGTACGTATCGGAAATAATGTAGGACGTCAAACGATGGCTGTTATTTCAGATATGTCA
CAACCACTTGGTTTTGCAATTGGTAACGCTCTAGAAGTGAAAGAAGCGATTGATACGTTAAAAGGTGAAGGTCCAGAAGA
TTTAACAGAATTAGTACTCGTATTAGGAAGTCAGATGGTCGTACTTGCGAAAAAAGCAAATACATTAGAAGAAGCTCGTG
AAATGTTAATTGAAGTGATGAAGAACGGAAAAGCAACTGAGAAGTTTAAAGAGTTCTTAAGCAATCAAGGCGGAGATAGC
TCAATTGTAGACAATCCAGAAAAAATGCCACAAGCGAAGTATGTAATTGATGTACCTGCAAAAACTTCAGGTGTTATTTC
TAACATTGTTGCAGATGAAATCGGTATCGCAGCTATGCTACTTGGTGCTGGCCGTGCAACGAAAGAAGACGAAATTGATT
TAGCGGTAGGACTAATGTTACGTAAAAAAGTGGGCGATGCAGTAAAAGAAGGCGAGCCATTCGTAACAATCTATGCAAAT
CGCGAAAATGTAGAAGATGTAAAAGCTAAAATTTATGAGAACATTTCTATCGCTGAAACAGCAGAGGCTCCTAAATTAGT
GCATACAGTTATTACTGACTAA

Upstream 100 bases:

>100_bases
ATTACTTTTCGGTGCAACATTAGTAAGTTTCTTATCAGCAACAATCGTAGGCTTATTATTTTAATAGATTCATATCATAT
AAAAAGGAATGGTGATTGTA

Downstream 100 bases:

>100_bases
TCATCATTACACTTACTTTGAGGGGGAAATAATATGGATAAGAAAAAATATATTGAAGAAGCAAATAAGATGTTAGAAAA
AGCATATATTCCGTATTCAA

Product: pyrimidine-nucleoside phosphorylase

Products: NA

Alternate protein names: PYNP [H]

Number of amino acids: Translated: 433; Mature: 433

Protein sequence:

>433_residues
MRMVDIIAKKRDGKELTTEEIKFFINGYTDGSIPDYQVSALAMAIFFKDMTDRERADLTMAMVESGETIDLSAIEGIKVD
KHSTGGVGDTTTLVLGPLVAALDVPVAKMSGRGLGHTGGTIDKLEAVEGFHVEITKEQFIDIVNRDKVAVIGQTGNLTPA
DKKIYALRDVTGTVNSIPLIASSIMSKKIAAGADAIVLDVKTGAGAFMKTEEDAKELAHAMVRIGNNVGRQTMAVISDMS
QPLGFAIGNALEVKEAIDTLKGEGPEDLTELVLVLGSQMVVLAKKANTLEEAREMLIEVMKNGKATEKFKEFLSNQGGDS
SIVDNPEKMPQAKYVIDVPAKTSGVISNIVADEIGIAAMLLGAGRATKEDEIDLAVGLMLRKKVGDAVKEGEPFVTIYAN
RENVEDVKAKIYENISIAETAEAPKLVHTVITD

Sequences:

>Translated_433_residues
MRMVDIIAKKRDGKELTTEEIKFFINGYTDGSIPDYQVSALAMAIFFKDMTDRERADLTMAMVESGETIDLSAIEGIKVD
KHSTGGVGDTTTLVLGPLVAALDVPVAKMSGRGLGHTGGTIDKLEAVEGFHVEITKEQFIDIVNRDKVAVIGQTGNLTPA
DKKIYALRDVTGTVNSIPLIASSIMSKKIAAGADAIVLDVKTGAGAFMKTEEDAKELAHAMVRIGNNVGRQTMAVISDMS
QPLGFAIGNALEVKEAIDTLKGEGPEDLTELVLVLGSQMVVLAKKANTLEEAREMLIEVMKNGKATEKFKEFLSNQGGDS
SIVDNPEKMPQAKYVIDVPAKTSGVISNIVADEIGIAAMLLGAGRATKEDEIDLAVGLMLRKKVGDAVKEGEPFVTIYAN
RENVEDVKAKIYENISIAETAEAPKLVHTVITD
>Mature_433_residues
MRMVDIIAKKRDGKELTTEEIKFFINGYTDGSIPDYQVSALAMAIFFKDMTDRERADLTMAMVESGETIDLSAIEGIKVD
KHSTGGVGDTTTLVLGPLVAALDVPVAKMSGRGLGHTGGTIDKLEAVEGFHVEITKEQFIDIVNRDKVAVIGQTGNLTPA
DKKIYALRDVTGTVNSIPLIASSIMSKKIAAGADAIVLDVKTGAGAFMKTEEDAKELAHAMVRIGNNVGRQTMAVISDMS
QPLGFAIGNALEVKEAIDTLKGEGPEDLTELVLVLGSQMVVLAKKANTLEEAREMLIEVMKNGKATEKFKEFLSNQGGDS
SIVDNPEKMPQAKYVIDVPAKTSGVISNIVADEIGIAAMLLGAGRATKEDEIDLAVGLMLRKKVGDAVKEGEPFVTIYAN
RENVEDVKAKIYENISIAETAEAPKLVHTVITD

Specific function: The Enzymes Which Catalyze The Reversible Phosphorolysis Of Pyrimidine Nucleosides Are Involved In The Degradation Of These Compounds And In Their Utilization As Carbon And Energy Sources, Or In The Rescue Of Pyrimidine Bases For Nucleotide Synthesis. [C

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI166158925, Length=423, Percent_Identity=35.4609929078014, Blast_Score=268, Evalue=6e-72,
Organism=Homo sapiens, GI4503445, Length=423, Percent_Identity=35.4609929078014, Blast_Score=268, Evalue=6e-72,
Organism=Homo sapiens, GI166158922, Length=423, Percent_Identity=35.4609929078014, Blast_Score=268, Evalue=6e-72,
Organism=Escherichia coli, GI1790842, Length=404, Percent_Identity=46.7821782178218, Blast_Score=339, Evalue=2e-94,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR018090
- InterPro:   IPR000053
- InterPro:   IPR017872 [H]

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C [H]

EC number: =2.4.2.2 [H]

Molecular weight: Translated: 46325; Mature: 46325

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: PS00647 THYMID_PHOSPHORYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRMVDIIAKKRDGKELTTEEIKFFINGYTDGSIPDYQVSALAMAIFFKDMTDRERADLTM
CCHHHHHHCCCCCCCCCHHHHEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHEEH
AMVESGETIDLSAIEGIKVDKHSTGGVGDTTTLVLGPLVAALDVPVAKMSGRGLGHTGGT
EECCCCCEEEEEECCCEEECCCCCCCCCCHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCC
IDKLEAVEGFHVEITKEQFIDIVNRDKVAVIGQTGNLTPADKKIYALRDVTGTVNSIPLI
HHHHHHCCCCEEEECHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEEECCCCCCHHHHHH
ASSIMSKKIAAGADAIVLDVKTGAGAFMKTEEDAKELAHAMVRIGNNVGRQTMAVISDMS
HHHHHHHHHHCCCCEEEEEECCCCCCCEECHHHHHHHHHHHHHHCCCCCHHHHHHHHHHC
QPLGFAIGNALEVKEAIDTLKGEGPEDLTELVLVLGSQMVVLAKKANTLEEAREMLIEVM
CCHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHH
KNGKATEKFKEFLSNQGGDSSIVDNPEKMPQAKYVIDVPAKTSGVISNIVADEIGIAAML
HCCCHHHHHHHHHCCCCCCCCCCCCHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHH
LGAGRATKEDEIDLAVGLMLRKKVGDAVKEGEPFVTIYANRENVEDVKAKIYENISIAET
HHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHCCCCHHHH
AEAPKLVHTVITD
CCCCHHHHHHHCC
>Mature Secondary Structure
MRMVDIIAKKRDGKELTTEEIKFFINGYTDGSIPDYQVSALAMAIFFKDMTDRERADLTM
CCHHHHHHCCCCCCCCCHHHHEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHEEH
AMVESGETIDLSAIEGIKVDKHSTGGVGDTTTLVLGPLVAALDVPVAKMSGRGLGHTGGT
EECCCCCEEEEEECCCEEECCCCCCCCCCHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCC
IDKLEAVEGFHVEITKEQFIDIVNRDKVAVIGQTGNLTPADKKIYALRDVTGTVNSIPLI
HHHHHHCCCCEEEECHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEEECCCCCCHHHHHH
ASSIMSKKIAAGADAIVLDVKTGAGAFMKTEEDAKELAHAMVRIGNNVGRQTMAVISDMS
HHHHHHHHHHCCCCEEEEEECCCCCCCEECHHHHHHHHHHHHHHCCCCCHHHHHHHHHHC
QPLGFAIGNALEVKEAIDTLKGEGPEDLTELVLVLGSQMVVLAKKANTLEEAREMLIEVM
CCHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHH
KNGKATEKFKEFLSNQGGDSSIVDNPEKMPQAKYVIDVPAKTSGVISNIVADEIGIAAML
HCCCHHHHHHHHHCCCCCCCCCCCCHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHH
LGAGRATKEDEIDLAVGLMLRKKVGDAVKEGEPFVTIYANRENVEDVKAKIYENISIAET
HHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHCCCCHHHH
AEAPKLVHTVITD
CCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8550462; 8867804; 9384377; 10568751 [H]