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The map label for this gene is ilvA [H]

Identifier: 222095515

GI number: 222095515

Start: 1830978

End: 1832180

Strand: Direct

Name: ilvA [H]

Synonym: BCQ_1855

Alternate gene names: 222095515

Gene position: 1830978-1832180 (Clockwise)

Preceding gene: 222095514

Following gene: 222095517

Centisome position: 35.12

GC content: 35.16

Gene sequence:

>1203_bases
ATGAAGGATATCGTTATTAAAACACCGTTACAACGTGATACAGTTTTATCTGAGAAATATGATTGTGACGTTTATGTAAA
ACGAGAAGACTTACAATTAATTCGCTCTTTCAAAATTCGTGGTGCGTATAATCTAATTCAAAGTTTACCGAAAGTACAAT
TACAAAACGGTGTTGTTTGTGCAAGTGCTGGTAATCATGCGCAAGGAGTAGCTTATACGTGTAATTTATTGAAGATTCCG
TCAAAAATTTTCATGCCGACGACGACACCTAAACAAAAAGTGTCACAAGTACAATTTTTCGGTGGTGATTTTGCGGAAAT
TGTATTAGTTGGTGATACATTTGATAGCTCTTTCCAAGAAGCACAGCGTTATTGTGAAGAAAATAGAATGACATTTGTTC
ATCCGTTTGATGATCCGTACGTAGTTGCTGGTCAAGGGACAGTGGCAGTTGAAATTATGCATGATATGGAGAAACCGGTT
GATTATATCTTTACAGCAATTGGTGGTGGTGGATTAGCATCAGGTGTTGGTACATATGTGAAAGGTGTTAGTCCTGCTAC
ACAGGTCATTGGGGTAGAGCCAATGGGAGCTGCATCTATGAAAGAGGCTTTTCTTCAAAATGATAATGTCGCATTGGAGA
AAATAGATAGTTTTGTTGATGGGGCAGCGGTTAAAAAGGTAGGAAAGTTAACATTTGAAACTTGTAAAGATGTAATTGAT
GACATTGTTTTAGTACCAGAAGGAAAGGTTTGTACGACGATTTTAGAACTGTATAAGAAAAATGCGATTGTAGCTGAACC
AGCTGGTGCACTCTCTATTGCAGCGCTTGATTTATACAGAGATGAAATAAAAGGTAAAACAGTTGTTTGTACGCTAAGTG
GTGGAAATAATGATATTGATAGAATGCAAGAAATGAAAGAACGATCTCTCATTTATGAAGGATTAAAGCATTATTTCATC
ATTGAATTCCCACAGCGTTCAGGTGCGTTAAGAGAATTTCTTGATAAAGGATTAGGGCCAGAAGATGATATTACTCGCTT
TGAGTATATTAAGAAACATAATAAAGAAAATGGTCCAGCATTAGTCGGAGTAGAGTTAAAACATAAAGAAGATTATGAGC
AATTAATTACTCGTTTTAAAGAAAATAATATTCAATTTATGGAGCTTAATAAAAATCCTGTTTTGTTTGATTTGCTTATT
TAA

Upstream 100 bases:

>100_bases
TTTGATTGAGCCAATATAAAAGAGATAAGGATGATATGAAATGGTGCAAAAGGTAAAGGAGAGAGTGAAAATTGAAGATA
TCTTAATGGCTCATAATTGC

Downstream 100 bases:

>100_bases
TATAAGGAAAGGGTTGGCATCCAAATAAAAAAGATAGATACAAGCAAGGGAAATGCTGCTTGTTCTATCTTTTTTACAAT
TAAACTAAATAATTGCCATA

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 400; Mature: 400

Protein sequence:

>400_residues
MKDIVIKTPLQRDTVLSEKYDCDVYVKREDLQLIRSFKIRGAYNLIQSLPKVQLQNGVVCASAGNHAQGVAYTCNLLKIP
SKIFMPTTTPKQKVSQVQFFGGDFAEIVLVGDTFDSSFQEAQRYCEENRMTFVHPFDDPYVVAGQGTVAVEIMHDMEKPV
DYIFTAIGGGGLASGVGTYVKGVSPATQVIGVEPMGAASMKEAFLQNDNVALEKIDSFVDGAAVKKVGKLTFETCKDVID
DIVLVPEGKVCTTILELYKKNAIVAEPAGALSIAALDLYRDEIKGKTVVCTLSGGNNDIDRMQEMKERSLIYEGLKHYFI
IEFPQRSGALREFLDKGLGPEDDITRFEYIKKHNKENGPALVGVELKHKEDYEQLITRFKENNIQFMELNKNPVLFDLLI

Sequences:

>Translated_400_residues
MKDIVIKTPLQRDTVLSEKYDCDVYVKREDLQLIRSFKIRGAYNLIQSLPKVQLQNGVVCASAGNHAQGVAYTCNLLKIP
SKIFMPTTTPKQKVSQVQFFGGDFAEIVLVGDTFDSSFQEAQRYCEENRMTFVHPFDDPYVVAGQGTVAVEIMHDMEKPV
DYIFTAIGGGGLASGVGTYVKGVSPATQVIGVEPMGAASMKEAFLQNDNVALEKIDSFVDGAAVKKVGKLTFETCKDVID
DIVLVPEGKVCTTILELYKKNAIVAEPAGALSIAALDLYRDEIKGKTVVCTLSGGNNDIDRMQEMKERSLIYEGLKHYFI
IEFPQRSGALREFLDKGLGPEDDITRFEYIKKHNKENGPALVGVELKHKEDYEQLITRFKENNIQFMELNKNPVLFDLLI
>Mature_400_residues
MKDIVIKTPLQRDTVLSEKYDCDVYVKREDLQLIRSFKIRGAYNLIQSLPKVQLQNGVVCASAGNHAQGVAYTCNLLKIP
SKIFMPTTTPKQKVSQVQFFGGDFAEIVLVGDTFDSSFQEAQRYCEENRMTFVHPFDDPYVVAGQGTVAVEIMHDMEKPV
DYIFTAIGGGGLASGVGTYVKGVSPATQVIGVEPMGAASMKEAFLQNDNVALEKIDSFVDGAAVKKVGKLTFETCKDVID
DIVLVPEGKVCTTILELYKKNAIVAEPAGALSIAALDLYRDEIKGKTVVCTLSGGNNDIDRMQEMKERSLIYEGLKHYFI
IEFPQRSGALREFLDKGLGPEDDITRFEYIKKHNKENGPALVGVELKHKEDYEQLITRFKENNIQFMELNKNPVLFDLLI

Specific function: Catalyzes the formation of alpha-ketobutyrate from threonine in a two-step reaction. The first step is a dehydration of threonine, followed by rehydration and liberation of ammonia [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=309, Percent_Identity=31.7152103559871, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI33469958, Length=318, Percent_Identity=26.4150943396226, Blast_Score=79, Evalue=9e-15,
Organism=Homo sapiens, GI19923959, Length=318, Percent_Identity=29.2452830188679, Blast_Score=75, Evalue=7e-14,
Organism=Escherichia coli, GI1790207, Length=388, Percent_Identity=35.0515463917526, Blast_Score=206, Evalue=2e-54,
Organism=Escherichia coli, GI1789505, Length=306, Percent_Identity=37.5816993464052, Blast_Score=180, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI71991565, Length=334, Percent_Identity=34.1317365269461, Blast_Score=158, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI17537387, Length=401, Percent_Identity=29.925187032419, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17508781, Length=279, Percent_Identity=29.0322580645161, Blast_Score=102, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6320930, Length=365, Percent_Identity=36.1643835616438, Blast_Score=231, Evalue=2e-61,
Organism=Saccharomyces cerevisiae, GI6322631, Length=301, Percent_Identity=31.8936877076412, Blast_Score=155, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6319788, Length=302, Percent_Identity=27.8145695364238, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI21355833, Length=330, Percent_Identity=34.5454545454545, Blast_Score=150, Evalue=1e-36,
Organism=Drosophila melanogaster, GI24645328, Length=250, Percent_Identity=32.8, Blast_Score=101, Evalue=7e-22,

Paralogues:

None

Copy number: 1344 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR001721
- InterPro:   IPR011820 [H]

Pfam domain/function: PF00291 PALP; PF00585 Thr_dehydrat_C [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 44504; Mature: 44504

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDIVIKTPLQRDTVLSEKYDCDVYVKREDLQLIRSFKIRGAYNLIQSLPKVQLQNGVVC
CCCEEEECCCCCCHHHCCCCCCEEEEEHHHHHHHHHHHHCHHHHHHHHCCCEECCCCEEE
ASAGNHAQGVAYTCNLLKIPSKIFMPTTTPKQKVSQVQFFGGDFAEIVLVGDTFDSSFQE
ECCCCCCCCCEEEEEEEECCCHHCCCCCCCHHHHHHHHHCCCCEEEEEEEECCCCHHHHH
AQRYCEENRMTFVHPFDDPYVVAGQGTVAVEIMHDMEKPVDYIFTAIGGGGLASGVGTYV
HHHHHHHCCEEEEECCCCCEEEECCCEEEEEEHHHHHCHHHHHHHHCCCCHHHHHHHHHH
KGVSPATQVIGVEPMGAASMKEAFLQNDNVALEKIDSFVDGAAVKKVGKLTFETCKDVID
CCCCCHHHEEECCCCCHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
DIVLVPEGKVCTTILELYKKNAIVAEPAGALSIAALDLYRDEIKGKTVVCTLSGGNNDID
CEEECCCCHHHHHHHHHHHCCCEEECCCCCEEHHHHHHHHHHCCCCEEEEEECCCCCCHH
RMQEMKERSLIYEGLKHYFIIEFPQRSGALREFLDKGLGPEDDITRFEYIKKHNKENGPA
HHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCE
LVGVELKHKEDYEQLITRFKENNIQFMELNKNPVLFDLLI
EEEEEECCCCCHHHHHHHHHHCCEEEEEECCCCEEEEEEC
>Mature Secondary Structure
MKDIVIKTPLQRDTVLSEKYDCDVYVKREDLQLIRSFKIRGAYNLIQSLPKVQLQNGVVC
CCCEEEECCCCCCHHHCCCCCCEEEEEHHHHHHHHHHHHCHHHHHHHHCCCEECCCCEEE
ASAGNHAQGVAYTCNLLKIPSKIFMPTTTPKQKVSQVQFFGGDFAEIVLVGDTFDSSFQE
ECCCCCCCCCEEEEEEEECCCHHCCCCCCCHHHHHHHHHCCCCEEEEEEEECCCCHHHHH
AQRYCEENRMTFVHPFDDPYVVAGQGTVAVEIMHDMEKPVDYIFTAIGGGGLASGVGTYV
HHHHHHHCCEEEEECCCCCEEEECCCEEEEEEHHHHHCHHHHHHHHCCCCHHHHHHHHHH
KGVSPATQVIGVEPMGAASMKEAFLQNDNVALEKIDSFVDGAAVKKVGKLTFETCKDVID
CCCCCHHHEEECCCCCHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
DIVLVPEGKVCTTILELYKKNAIVAEPAGALSIAALDLYRDEIKGKTVVCTLSGGNNDID
CEEECCCCHHHHHHHHHHHCCCEEECCCCCEEHHHHHHHHHHCCCCEEEEEECCCCCCHH
RMQEMKERSLIYEGLKHYFIIEFPQRSGALREFLDKGLGPEDDITRFEYIKKHNKENGPA
HHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCE
LVGVELKHKEDYEQLITRFKENNIQFMELNKNPVLFDLLI
EEEEEECCCCCHHHHHHHHHHCCEEEEEECCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]