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The map label for this gene is ykwA [H]

Identifier: 222095473

GI number: 222095473

Start: 1779232

End: 1780965

Strand: Direct

Name: ykwA [H]

Synonym: BCQ_1813

Alternate gene names: 222095473

Gene position: 1779232-1780965 (Clockwise)

Preceding gene: 222095472

Following gene: 222095474

Centisome position: 34.12

GC content: 39.56

Gene sequence:

>1734_bases
ATGAATAGAGGTAGGGATGTTATGAGCAAGTTTACAGTAGCTTCTAATGGTTCATTAGAAACGACATTAAGAGGAGTAGA
AGTATTATCAACACCACTTTTAAATAAAGGGGTCGCTTTCACGCAAGAAGAAAGAGAAGAATTAGGTTTAAAAGGGTTAT
TACCGCCAGCGGTTTTAACATTGGAAGAACAAGCACGTCGAGCATATGAACAATTTTGTTCTCAGCCGGATGATTTATTA
AAGAATGTATACTTAACAGCGTTACATGATCGAAATGAAGTATTATTTTATCGTATTTTAACAGATCATTTACGCGAAAT
GTTACCAATCGTATATACACCAACTGTCGGTGTAGCGATTCAAAGATATAGTCATGAATATCGTAAACCACGAGGTGTGT
ATTTATCAATTAACGATCCGTCAGGTATTGAGGAAGTATTTGCCAATATTGGTGCAACAGCAGAAAATATTGATTTAGTC
GTTGTAACAGATGGAGAAGGTATATTAGGAATTGGTGACTGGGGCGTTGGTGGTATTAACATCGCGATCGGAAAATTAGC
TGTTTATACAGCCGCAGTTGGAATCGATCCTAGCCGCGTATTACCGGTAATTTTAGATGTAGGTACAAATCGTGAAGAAT
TATTAGACAATCCATTTTATATTGGAAATCGTCACCCTCGTATAACAGGTGAAGCTTACGATGAATTTATTGATACATTT
GTACAAGCGGTAAATAAGCAATTCCCGAAAGCGCTTTTACATTGGGAAGACTTCAGTTCTCGTAATGCACGAAAAATTTT
AGATAAATATCGTCATGATATTTGTACGTTTAATGATGATATTCAAGGTACAGGTGCAGTTTCGCTTGCGGCTGTATTAT
CGGCAGTAAAAGCTTCTGGTGTACCGCTAAGTGAACACCGCGTTGTTGTGTTTGGTGCTGGTACGGCTGGAATCGGTATC
GCAGATCAAGTTAGAGATGCGATGGTCCGCGTAGGCGTATCAGAAGAAGAATCATATAAGCGTTTCTGGTGTATTGATCG
TAACGGATTAGTTACAGATAATATGGAAGATCTTCTTGATTTCCAAATGCCGTATGCAAGAAAAGAAGCGGAAGTAAGTG
AGTGGAAACAAAATGGTGTGATTGGACTTGCTGAAGTTGTGAAACATGTGAAACCGACAATTTTAATCGGTACATCAACC
GTTGCTGGTGCATTTAAAGAAGAAATTATTAAAGAAATGGCTTCTCACGTAGAAAGACCAATCATTTTACCAATGTCGAA
TCCGACGCCACTTGCTGAAGCAAAACCAGCCGATTTAATCGAGTGGACAGAAGGAAGAGCGTTAGTTGCAACAGGAAGTC
CATTTGAACCAGTTACATATAACGGTGTAACGTATGTGATTGGACAATCAAATAATGCACTTATTTTCCCAGGTCTTGGT
CTTGGAACAATTGTCGTACGTGCAAGCGTTATGACGGATGGAATGTTCGCAGCAGCAGCTGAAGCAGTTGCAAGTATGGT
TGATACAAGTCAGCCAGGAGCACCTATTTTGCCAGAAGTTGAAGAGCTACGTAATATCTCGGAAATGGTAGCAATTGAAG
TAGCGAAAGTTGCCGTTGCGGAAGGTGTTGCGAGAGAGAACTTAAGTGATAACGATATCAAGATTGCAGTGAAAGAAGCA
ATCTGGGAGCCTGAGTATCGCCAAATAAAAGCGGTAGAAAAGGTTAGAATATAG

Upstream 100 bases:

>100_bases
GACACACCCAGGGATTGCAGGAGCAACTCTTTTAAAGAAAAATTAAAAGAAGAGGGGGGACAAGCCCCTCTTTTTTGTTT
ACAATATAGAAATGCTATAT

Downstream 100 bases:

>100_bases
AAATAAAGCCCGTTTATAATATAAGCGGGCTTTCACTTTTATTACTGAAAAAAGAGTATAGGAAGTGGCACCTTTGAATT
GGAATCAATTATGGAAGAAA

Product: malate dehydrogenase

Products: NA

Alternate protein names: NAD-ME 3 [H]

Number of amino acids: Translated: 577; Mature: 577

Protein sequence:

>577_residues
MNRGRDVMSKFTVASNGSLETTLRGVEVLSTPLLNKGVAFTQEEREELGLKGLLPPAVLTLEEQARRAYEQFCSQPDDLL
KNVYLTALHDRNEVLFYRILTDHLREMLPIVYTPTVGVAIQRYSHEYRKPRGVYLSINDPSGIEEVFANIGATAENIDLV
VVTDGEGILGIGDWGVGGINIAIGKLAVYTAAVGIDPSRVLPVILDVGTNREELLDNPFYIGNRHPRITGEAYDEFIDTF
VQAVNKQFPKALLHWEDFSSRNARKILDKYRHDICTFNDDIQGTGAVSLAAVLSAVKASGVPLSEHRVVVFGAGTAGIGI
ADQVRDAMVRVGVSEEESYKRFWCIDRNGLVTDNMEDLLDFQMPYARKEAEVSEWKQNGVIGLAEVVKHVKPTILIGTST
VAGAFKEEIIKEMASHVERPIILPMSNPTPLAEAKPADLIEWTEGRALVATGSPFEPVTYNGVTYVIGQSNNALIFPGLG
LGTIVVRASVMTDGMFAAAAEAVASMVDTSQPGAPILPEVEELRNISEMVAIEVAKVAVAEGVARENLSDNDIKIAVKEA
IWEPEYRQIKAVEKVRI

Sequences:

>Translated_577_residues
MNRGRDVMSKFTVASNGSLETTLRGVEVLSTPLLNKGVAFTQEEREELGLKGLLPPAVLTLEEQARRAYEQFCSQPDDLL
KNVYLTALHDRNEVLFYRILTDHLREMLPIVYTPTVGVAIQRYSHEYRKPRGVYLSINDPSGIEEVFANIGATAENIDLV
VVTDGEGILGIGDWGVGGINIAIGKLAVYTAAVGIDPSRVLPVILDVGTNREELLDNPFYIGNRHPRITGEAYDEFIDTF
VQAVNKQFPKALLHWEDFSSRNARKILDKYRHDICTFNDDIQGTGAVSLAAVLSAVKASGVPLSEHRVVVFGAGTAGIGI
ADQVRDAMVRVGVSEEESYKRFWCIDRNGLVTDNMEDLLDFQMPYARKEAEVSEWKQNGVIGLAEVVKHVKPTILIGTST
VAGAFKEEIIKEMASHVERPIILPMSNPTPLAEAKPADLIEWTEGRALVATGSPFEPVTYNGVTYVIGQSNNALIFPGLG
LGTIVVRASVMTDGMFAAAAEAVASMVDTSQPGAPILPEVEELRNISEMVAIEVAKVAVAEGVARENLSDNDIKIAVKEA
IWEPEYRQIKAVEKVRI
>Mature_577_residues
MNRGRDVMSKFTVASNGSLETTLRGVEVLSTPLLNKGVAFTQEEREELGLKGLLPPAVLTLEEQARRAYEQFCSQPDDLL
KNVYLTALHDRNEVLFYRILTDHLREMLPIVYTPTVGVAIQRYSHEYRKPRGVYLSINDPSGIEEVFANIGATAENIDLV
VVTDGEGILGIGDWGVGGINIAIGKLAVYTAAVGIDPSRVLPVILDVGTNREELLDNPFYIGNRHPRITGEAYDEFIDTF
VQAVNKQFPKALLHWEDFSSRNARKILDKYRHDICTFNDDIQGTGAVSLAAVLSAVKASGVPLSEHRVVVFGAGTAGIGI
ADQVRDAMVRVGVSEEESYKRFWCIDRNGLVTDNMEDLLDFQMPYARKEAEVSEWKQNGVIGLAEVVKHVKPTILIGTST
VAGAFKEEIIKEMASHVERPIILPMSNPTPLAEAKPADLIEWTEGRALVATGSPFEPVTYNGVTYVIGQSNNALIFPGLG
LGTIVVRASVMTDGMFAAAAEAVASMVDTSQPGAPILPEVEELRNISEMVAIEVAKVAVAEGVARENLSDNDIKIAVKEA
IWEPEYRQIKAVEKVRI

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the malic enzymes family [H]

Homologues:

Organism=Homo sapiens, GI62420882, Length=546, Percent_Identity=42.1245421245421, Blast_Score=432, Evalue=1e-121,
Organism=Homo sapiens, GI62420880, Length=546, Percent_Identity=42.1245421245421, Blast_Score=432, Evalue=1e-121,
Organism=Homo sapiens, GI239049447, Length=546, Percent_Identity=42.1245421245421, Blast_Score=432, Evalue=1e-121,
Organism=Homo sapiens, GI4505143, Length=554, Percent_Identity=40.7942238267148, Blast_Score=423, Evalue=1e-118,
Organism=Homo sapiens, GI4505145, Length=570, Percent_Identity=39.1228070175439, Blast_Score=394, Evalue=1e-109,
Organism=Homo sapiens, GI270265879, Length=481, Percent_Identity=41.5800415800416, Blast_Score=363, Evalue=1e-100,
Organism=Escherichia coli, GI87081919, Length=555, Percent_Identity=46.8468468468468, Blast_Score=509, Evalue=1e-145,
Organism=Caenorhabditis elegans, GI17537199, Length=552, Percent_Identity=43.1159420289855, Blast_Score=435, Evalue=1e-122,
Organism=Saccharomyces cerevisiae, GI6322823, Length=578, Percent_Identity=45.3287197231834, Blast_Score=507, Evalue=1e-144,
Organism=Drosophila melanogaster, GI281362672, Length=550, Percent_Identity=40.5454545454545, Blast_Score=422, Evalue=1e-118,
Organism=Drosophila melanogaster, GI281362674, Length=550, Percent_Identity=40.5454545454545, Blast_Score=422, Evalue=1e-118,
Organism=Drosophila melanogaster, GI21356279, Length=550, Percent_Identity=40.5454545454545, Blast_Score=422, Evalue=1e-118,
Organism=Drosophila melanogaster, GI24646388, Length=527, Percent_Identity=40.0379506641366, Blast_Score=396, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24646386, Length=527, Percent_Identity=40.0379506641366, Blast_Score=396, Evalue=1e-110,
Organism=Drosophila melanogaster, GI78707242, Length=543, Percent_Identity=35.7274401473296, Blast_Score=363, Evalue=1e-100,
Organism=Drosophila melanogaster, GI78707238, Length=543, Percent_Identity=35.7274401473296, Blast_Score=363, Evalue=1e-100,
Organism=Drosophila melanogaster, GI281363505, Length=563, Percent_Identity=33.9253996447602, Blast_Score=360, Evalue=1e-99,
Organism=Drosophila melanogaster, GI78707236, Length=563, Percent_Identity=33.9253996447602, Blast_Score=360, Evalue=1e-99,
Organism=Drosophila melanogaster, GI281363503, Length=536, Percent_Identity=34.5149253731343, Blast_Score=356, Evalue=3e-98,
Organism=Drosophila melanogaster, GI78707232, Length=512, Percent_Identity=35.546875, Blast_Score=354, Evalue=7e-98,
Organism=Drosophila melanogaster, GI78707240, Length=519, Percent_Identity=36.4161849710983, Blast_Score=354, Evalue=8e-98,
Organism=Drosophila melanogaster, GI19922384, Length=573, Percent_Identity=28.6212914485166, Blast_Score=254, Evalue=1e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR001891
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M [H]

EC number: =1.1.1.38 [H]

Molecular weight: Translated: 63143; Mature: 63143

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS00331 MALIC_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRGRDVMSKFTVASNGSLETTLRGVEVLSTPLLNKGVAFTQEEREELGLKGLLPPAVLT
CCCCHHHHHHHEECCCCCHHHHHHHHHHHHCCHHCCCCCCCHHHHHHCCCCCCCCHHHHH
LEEQARRAYEQFCSQPDDLLKNVYLTALHDRNEVLFYRILTDHLREMLPIVYTPTVGVAI
HHHHHHHHHHHHHCCHHHHHHHHHHEEEECCCCEEEHHHHHHHHHHHCCEEECCCHHHHH
QRYSHEYRKPRGVYLSINDPSGIEEVFANIGATAENIDLVVVTDGEGILGIGDWGVGGIN
HHHHHHHCCCCCEEEEECCCCCHHHHHHHCCCCCCCEEEEEEECCCCEEEECCCCCCCEE
IAIGKLAVYTAAVGIDPSRVLPVILDVGTNREELLDNPFYIGNRHPRITGEAYDEFIDTF
EEHHHHEEHHHHCCCCHHHCEEEEEECCCCHHHHCCCCEEECCCCCCCCHHHHHHHHHHH
VQAVNKQFPKALLHWEDFSSRNARKILDKYRHDICTFNDDIQGTGAVSLAAVLSAVKASG
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCC
VPLSEHRVVVFGAGTAGIGIADQVRDAMVRVGVSEEESYKRFWCIDRNGLVTDNMEDLLD
CCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCHHHHHH
FQMPYARKEAEVSEWKQNGVIGLAEVVKHVKPTILIGTSTVAGAFKEEIIKEMASHVERP
HCCCCCCCHHHHHHHHHCCCEEHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHCCCC
IILPMSNPTPLAEAKPADLIEWTEGRALVATGSPFEPVTYNGVTYVIGQSNNALIFPGLG
EEEECCCCCCCCCCCCCCCEEECCCCEEEECCCCCCCEEECCEEEEEECCCCEEEECCCC
LGTIVVRASVMTDGMFAAAAEAVASMVDTSQPGAPILPEVEELRNISEMVAIEVAKVAVA
HHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
EGVARENLSDNDIKIAVKEAIWEPEYRQIKAVEKVRI
HHHHHCCCCCCCEEEEEHHHHCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MNRGRDVMSKFTVASNGSLETTLRGVEVLSTPLLNKGVAFTQEEREELGLKGLLPPAVLT
CCCCHHHHHHHEECCCCCHHHHHHHHHHHHCCHHCCCCCCCHHHHHHCCCCCCCCHHHHH
LEEQARRAYEQFCSQPDDLLKNVYLTALHDRNEVLFYRILTDHLREMLPIVYTPTVGVAI
HHHHHHHHHHHHHCCHHHHHHHHHHEEEECCCCEEEHHHHHHHHHHHCCEEECCCHHHHH
QRYSHEYRKPRGVYLSINDPSGIEEVFANIGATAENIDLVVVTDGEGILGIGDWGVGGIN
HHHHHHHCCCCCEEEEECCCCCHHHHHHHCCCCCCCEEEEEEECCCCEEEECCCCCCCEE
IAIGKLAVYTAAVGIDPSRVLPVILDVGTNREELLDNPFYIGNRHPRITGEAYDEFIDTF
EEHHHHEEHHHHCCCCHHHCEEEEEECCCCHHHHCCCCEEECCCCCCCCHHHHHHHHHHH
VQAVNKQFPKALLHWEDFSSRNARKILDKYRHDICTFNDDIQGTGAVSLAAVLSAVKASG
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCC
VPLSEHRVVVFGAGTAGIGIADQVRDAMVRVGVSEEESYKRFWCIDRNGLVTDNMEDLLD
CCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCHHHHHH
FQMPYARKEAEVSEWKQNGVIGLAEVVKHVKPTILIGTSTVAGAFKEEIIKEMASHVERP
HCCCCCCCHHHHHHHHHCCCEEHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHCCCC
IILPMSNPTPLAEAKPADLIEWTEGRALVATGSPFEPVTYNGVTYVIGQSNNALIFPGLG
EEEECCCCCCCCCCCCCCCEEECCCCEEEECCCCCCCEEECCEEEEEECCCCEEEECCCC
LGTIVVRASVMTDGMFAAAAEAVASMVDTSQPGAPILPEVEELRNISEMVAIEVAKVAVA
HHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
EGVARENLSDNDIKIAVKEAIWEPEYRQIKAVEKVRI
HHHHHCCCCCCCEEEEEHHHHCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377 [H]