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The map label for this gene is mepA [H]

Identifier: 222095334

GI number: 222095334

Start: 1652680

End: 1654035

Strand: Direct

Name: mepA [H]

Synonym: BCQ_1674

Alternate gene names: 222095334

Gene position: 1652680-1654035 (Clockwise)

Preceding gene: 222095333

Following gene: 222095336

Centisome position: 31.7

GC content: 35.84

Gene sequence:

>1356_bases
ATGGAAGCAACAGAAAAGTTAAGAGAAAAACCGATAAAGAGCTTATTTATTTCGTATTTAATACCAGCCGTTCTAGGAAT
GGTATTAATGTCAGTTAACATTGTAATTGATGCGGTTATGATTAGTAGGGGAGTTGGAGCAAACGGATTAGCAGGAGTAA
ACGTGGCTATTCCAGCGTTTTCAATTTTCTTCTCTATTTCATTATGGATTGGGATGGGCGGGGCAACGTTATATTCCATT
GCATTAGGTGAAAATAAAATTGAAAGAGCAAGGTCTATTTTTACTCAATCCATGACGGTAGCAGTCATTATCGTAGGCGT
TTTAGCGGCGATTTGCTTATGGAGAATAGAAGACTTAGCATACTTATTCGGTGCAAACGAAGTGATTTTACCGTATGCAT
TAGAATATTTACACGTATTATTAACATTTGGAATGATATACGTTTTAGAAAATATTTTAAGTACATTTATACGAAATGAT
GGAAATCCTAATTTAGCAATGGCAGGTTTAGTTGTAACAGCTGTATTAAATATAGTGTTTGACTATATCTTTATTTTCAT
CTTTAAATGGGGCGTAACAGGAGCGGCTTCAGCAACTATTCTTTCGGCAGCGATTGGTTTCCTTGTATTATTAACGCACT
TCTTGAGAAAAAGTAGTATTTTAAAATGGACGAAATTCCATTTTGAATGGGATACAGTAAAACAAATTATGATAATCGGT
TTCCCGAGCTTTACAGCAGAAAGTACAGTAGCGATTGTAACGATTGGTTTTAATATTGCATTCGTTCAATATGCAGGAGA
AGTAGGAGTCGCTTCTTATGCGATGGTGAATAGTATTCATGCAATGACATTACTATTATTCTTTGGTGTAGGTGCTGCTT
TACAACCGATTGCTAGTTTCCATTATGGTGCAAATTTAGCAGAGAGACTTCGTGAAGGGTTGCAGTTTGCAGTGAAAATT
GCAGTTGTACTTGGAGGCGTTGCAATAATTGTCGGATTATTCTTCGGGAAATATATTATTGGTCTATTTGATGTCCAATC
TCCAGAGTTATTGGAGTTAACATTAACGGGTATTAGCCTGTTCTTTATCCAATACGTATTTTTAGGCTATAACATTGTAT
ATGGAGAGTACTTCCAATCAGTGCGACAAACGACAAAATCAGTACTTATTATAATGAGCCGAGGGTTACTATTTATTATT
CCATTATTATGGATTATGCCGAAATTATTTGGGATAAACGGAATTTGGCTCGTTATGCCAGTAGCGGAAGTATTGACAGC
GATTATCGTATTTACGATGAATCGTATGAAACATCCTGTTCCATTAAACATGGCAGGCGAGAAAGAAGCGATATAA

Upstream 100 bases:

>100_bases
CGATAAGTAAGTTACCTATTTTTCAAATTCTCTATTGACCTTCAAGTTACTTTAAGGTTTAAACTGAGAAAAGAGAGTTG
AAAAAAAGGAGCAAAATAGT

Downstream 100 bases:

>100_bases
TGAAGAAAATCCCCTTAAGCAAGTAAGGGGATTTTTTATTTTTTTAAACTGATAGCAAAAGATCCATCTGTTTCTTGAAC
AGACGCAAAGGCAACGTTTT

Product: mate efflux family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 451; Mature: 451

Protein sequence:

>451_residues
MEATEKLREKPIKSLFISYLIPAVLGMVLMSVNIVIDAVMISRGVGANGLAGVNVAIPAFSIFFSISLWIGMGGATLYSI
ALGENKIERARSIFTQSMTVAVIIVGVLAAICLWRIEDLAYLFGANEVILPYALEYLHVLLTFGMIYVLENILSTFIRND
GNPNLAMAGLVVTAVLNIVFDYIFIFIFKWGVTGAASATILSAAIGFLVLLTHFLRKSSILKWTKFHFEWDTVKQIMIIG
FPSFTAESTVAIVTIGFNIAFVQYAGEVGVASYAMVNSIHAMTLLLFFGVGAALQPIASFHYGANLAERLREGLQFAVKI
AVVLGGVAIIVGLFFGKYIIGLFDVQSPELLELTLTGISLFFIQYVFLGYNIVYGEYFQSVRQTTKSVLIIMSRGLLFII
PLLWIMPKLFGINGIWLVMPVAEVLTAIIVFTMNRMKHPVPLNMAGEKEAI

Sequences:

>Translated_451_residues
MEATEKLREKPIKSLFISYLIPAVLGMVLMSVNIVIDAVMISRGVGANGLAGVNVAIPAFSIFFSISLWIGMGGATLYSI
ALGENKIERARSIFTQSMTVAVIIVGVLAAICLWRIEDLAYLFGANEVILPYALEYLHVLLTFGMIYVLENILSTFIRND
GNPNLAMAGLVVTAVLNIVFDYIFIFIFKWGVTGAASATILSAAIGFLVLLTHFLRKSSILKWTKFHFEWDTVKQIMIIG
FPSFTAESTVAIVTIGFNIAFVQYAGEVGVASYAMVNSIHAMTLLLFFGVGAALQPIASFHYGANLAERLREGLQFAVKI
AVVLGGVAIIVGLFFGKYIIGLFDVQSPELLELTLTGISLFFIQYVFLGYNIVYGEYFQSVRQTTKSVLIIMSRGLLFII
PLLWIMPKLFGINGIWLVMPVAEVLTAIIVFTMNRMKHPVPLNMAGEKEAI
>Mature_451_residues
MEATEKLREKPIKSLFISYLIPAVLGMVLMSVNIVIDAVMISRGVGANGLAGVNVAIPAFSIFFSISLWIGMGGATLYSI
ALGENKIERARSIFTQSMTVAVIIVGVLAAICLWRIEDLAYLFGANEVILPYALEYLHVLLTFGMIYVLENILSTFIRND
GNPNLAMAGLVVTAVLNIVFDYIFIFIFKWGVTGAASATILSAAIGFLVLLTHFLRKSSILKWTKFHFEWDTVKQIMIIG
FPSFTAESTVAIVTIGFNIAFVQYAGEVGVASYAMVNSIHAMTLLLFFGVGAALQPIASFHYGANLAERLREGLQFAVKI
AVVLGGVAIIVGLFFGKYIIGLFDVQSPELLELTLTGISLFFIQYVFLGYNIVYGEYFQSVRQTTKSVLIIMSRGLLFII
PLLWIMPKLFGINGIWLVMPVAEVLTAIIVFTMNRMKHPVPLNMAGEKEAI

Specific function: Multidrug resistance efflux protein [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528
- InterPro:   IPR015522 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 49507; Mature: 49507

Theoretical pI: Translated: 8.35; Mature: 8.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEATEKLREKPIKSLFISYLIPAVLGMVLMSVNIVIDAVMISRGVGANGLAGVNVAIPAF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHH
SIFFSISLWIGMGGATLYSIALGENKIERARSIFTQSMTVAVIIVGVLAAICLWRIEDLA
HHHHHHHHHHCCCCHHHEEEHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YLFGANEVILPYALEYLHVLLTFGMIYVLENILSTFIRNDGNPNLAMAGLVVTAVLNIVF
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
DYIFIFIFKWGVTGAASATILSAAIGFLVLLTHFLRKSSILKWTKFHFEWDTVKQIMIIG
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHEEEHHHHHHHHEEE
FPSFTAESTVAIVTIGFNIAFVQYAGEVGVASYAMVNSIHAMTLLLFFGVGAALQPIASF
CCCCCCCCEEEEEEECCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
HYGANLAERLREGLQFAVKIAVVLGGVAIIVGLFFGKYIIGLFDVQSPELLELTLTGISL
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHH
FFIQYVFLGYNIVYGEYFQSVRQTTKSVLIIMSRGLLFIIPLLWIMPKLFGINGIWLVMP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHH
VAEVLTAIIVFTMNRMKHPVPLNMAGEKEAI
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MEATEKLREKPIKSLFISYLIPAVLGMVLMSVNIVIDAVMISRGVGANGLAGVNVAIPAF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHH
SIFFSISLWIGMGGATLYSIALGENKIERARSIFTQSMTVAVIIVGVLAAICLWRIEDLA
HHHHHHHHHHCCCCHHHEEEHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YLFGANEVILPYALEYLHVLLTFGMIYVLENILSTFIRNDGNPNLAMAGLVVTAVLNIVF
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
DYIFIFIFKWGVTGAASATILSAAIGFLVLLTHFLRKSSILKWTKFHFEWDTVKQIMIIG
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHEEEHHHHHHHHEEE
FPSFTAESTVAIVTIGFNIAFVQYAGEVGVASYAMVNSIHAMTLLLFFGVGAALQPIASF
CCCCCCCCEEEEEEECCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
HYGANLAERLREGLQFAVKIAVVLGGVAIIVGLFFGKYIIGLFDVQSPELLELTLTGISL
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHH
FFIQYVFLGYNIVYGEYFQSVRQTTKSVLIIMSRGLLFIIPLLWIMPKLFGINGIWLVMP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHH
VAEVLTAIIVFTMNRMKHPVPLNMAGEKEAI
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA