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The map label for this gene is nhaC [H]

Identifier: 222095167

GI number: 222095167

Start: 1480161

End: 1481642

Strand: Direct

Name: nhaC [H]

Synonym: BCQ_1507

Alternate gene names: 222095167

Gene position: 1480161-1481642 (Clockwise)

Preceding gene: 222095166

Following gene: 222095168

Centisome position: 28.39

GC content: 37.65

Gene sequence:

>1482_bases
ATGCCTCGGCAGCGGACTCGATTTCAGAGTGCTGTGCCAAATCCAGCAAGCATATGCTTGAAAGATGAGAAGAGCGTTTC
TTATAGATGTATAAGACCTCTTCTCGTTGGAAGAGGTCTTTTGTTATTCATTAGAAAAAGGTTGAAACTAGGGAGAGATG
GTACTTTGAAAGAAACGAGAGGAAATGGTTTGGCATTATTACCACTTGGGATATTTTTGGCGCTATTTATTGGTTCTGGA
ATTATTACAGGTGATTTCTATAAATTGCCGATACTTGTAGCAATTTCAATTGCTGTAGGAGTCGCTTTAGCAATGAATCG
TAAAGAAAGTTTTCATGTAAAAGTGGAACGATTTGCTAAAGGTGCAGGGAACCCAGACATTATGATTATGGTTCTAATTT
TTGTACTGGCAGGAGCATTTTCTGAAACAGCAAAAGGGATGGGTGGCGTTGATTCTACAGTTAACTTAGCGTTATCAATT
TTACCACAAGGATTTATCGTAGCTGGCATTTTCGTTATAGGAGCATTTATTTCATTAGCGATGGGAACTTCAATGGGAAC
AATTGCTGCATTAGCACCAATTGCTGTAGGTATTAGTGGGCAAACTGATATCTCAATTGCACTTACGATGGCTACTGTTG
TTGGCGGAGCGATGTTTGGTGATAATTTATCATTTATTTCAGATACAACAATCGCAGCTGTACGTTCACAAGGAACAGAA
ATGAAAGATAAGTTTAAAACGAACTTTTTAATTGTATTACCAGCGGCTATTATTACAATCGTACTATTAGTAATCATTAC
TTTAGGAAGTGATACGCAGATTAAAGCGCATAGCTTTGACTGGATAAAGATTTTACCGTATGCAGGAGTACTTATTACAG
CGCTACTTGGTTGGAATGTACTTATCGTGTTAACTGGTGGAACTGTACTATCTGGGGTTATCGGTCTTTTAGATGGGAGT
TATACGTTAGAGAGTTTCTTTAAAAGTGTAACGACTGGAATGGGCGGTATGATGGAGTTAGTATTACTCGCTATTTTAAT
TGGCGGTATGGTCGAATTGATTCAATATAATGGTGGCATTCAATATTTAATGAATATTTTAACGCGTAACATTCGTTCAA
AAAAAGGAGCAGAGTTCGGTATAGCTGGTTTAGTAGGTATGACGAATATGTGTACAGCGAATAATACCATTTCTATTATC
TTTACAGGTCCGCTTGCGAAAAACATTGCAGATCAATATGAAATTGATCCTCGTAAATCAGCGAGTGTATTAGATCTTTT
CTCGTGCTGTGTGCAAGGGTTAATTCCGTATGGTGCGCAAATGTTAACAGCAGCAGGATTTGCGGCGTTATCTCCAATTG
AACTGTTACCATATGCGTTTTATCCAATCTTAGTTGGAGTATGTGGAATCATTTCTATATTAATTGGTTTCCCGAGGTTT
TCTAAAGTAGCGGAAAAGAAAGAGTATCATAAAACAGCATAA

Upstream 100 bases:

>100_bases
GACTTTTGTTTTGTAAGCGAGTAAAGTTAGGGAAGAAATTATTATTAAAAAATAAATATGAAACCTTCTTATAAAGAGAG
GCGGAGGGACTGGCCCTACG

Downstream 100 bases:

>100_bases
TGAAAATGAAGTGTATGAAAAGTAACGAAAGCCGTACAGAGAATGTTCTCTGTACGGCTTTTTATGTGCGGGAAAAGAGT
GAATGATCCCATGCTACCGT

Product: Na+/H+ antiporter

Products: NA

Alternate protein names: Sodium/hydrogen antiporter; Sodium/proton antiporter [H]

Number of amino acids: Translated: 493; Mature: 492

Protein sequence:

>493_residues
MPRQRTRFQSAVPNPASICLKDEKSVSYRCIRPLLVGRGLLLFIRKRLKLGRDGTLKETRGNGLALLPLGIFLALFIGSG
IITGDFYKLPILVAISIAVGVALAMNRKESFHVKVERFAKGAGNPDIMIMVLIFVLAGAFSETAKGMGGVDSTVNLALSI
LPQGFIVAGIFVIGAFISLAMGTSMGTIAALAPIAVGISGQTDISIALTMATVVGGAMFGDNLSFISDTTIAAVRSQGTE
MKDKFKTNFLIVLPAAIITIVLLVIITLGSDTQIKAHSFDWIKILPYAGVLITALLGWNVLIVLTGGTVLSGVIGLLDGS
YTLESFFKSVTTGMGGMMELVLLAILIGGMVELIQYNGGIQYLMNILTRNIRSKKGAEFGIAGLVGMTNMCTANNTISII
FTGPLAKNIADQYEIDPRKSASVLDLFSCCVQGLIPYGAQMLTAAGFAALSPIELLPYAFYPILVGVCGIISILIGFPRF
SKVAEKKEYHKTA

Sequences:

>Translated_493_residues
MPRQRTRFQSAVPNPASICLKDEKSVSYRCIRPLLVGRGLLLFIRKRLKLGRDGTLKETRGNGLALLPLGIFLALFIGSG
IITGDFYKLPILVAISIAVGVALAMNRKESFHVKVERFAKGAGNPDIMIMVLIFVLAGAFSETAKGMGGVDSTVNLALSI
LPQGFIVAGIFVIGAFISLAMGTSMGTIAALAPIAVGISGQTDISIALTMATVVGGAMFGDNLSFISDTTIAAVRSQGTE
MKDKFKTNFLIVLPAAIITIVLLVIITLGSDTQIKAHSFDWIKILPYAGVLITALLGWNVLIVLTGGTVLSGVIGLLDGS
YTLESFFKSVTTGMGGMMELVLLAILIGGMVELIQYNGGIQYLMNILTRNIRSKKGAEFGIAGLVGMTNMCTANNTISII
FTGPLAKNIADQYEIDPRKSASVLDLFSCCVQGLIPYGAQMLTAAGFAALSPIELLPYAFYPILVGVCGIISILIGFPRF
SKVAEKKEYHKTA
>Mature_492_residues
PRQRTRFQSAVPNPASICLKDEKSVSYRCIRPLLVGRGLLLFIRKRLKLGRDGTLKETRGNGLALLPLGIFLALFIGSGI
ITGDFYKLPILVAISIAVGVALAMNRKESFHVKVERFAKGAGNPDIMIMVLIFVLAGAFSETAKGMGGVDSTVNLALSIL
PQGFIVAGIFVIGAFISLAMGTSMGTIAALAPIAVGISGQTDISIALTMATVVGGAMFGDNLSFISDTTIAAVRSQGTEM
KDKFKTNFLIVLPAAIITIVLLVIITLGSDTQIKAHSFDWIKILPYAGVLITALLGWNVLIVLTGGTVLSGVIGLLDGSY
TLESFFKSVTTGMGGMMELVLLAILIGGMVELIQYNGGIQYLMNILTRNIRSKKGAEFGIAGLVGMTNMCTANNTISIIF
TGPLAKNIADQYEIDPRKSASVLDLFSCCVQGLIPYGAQMLTAAGFAALSPIELLPYAFYPILVGVCGIISILIGFPRFS
KVAEKKEYHKTA

Specific function: Is a secondary, electrogenic Na(+)/H(+) antiporter that catalyzes Na(+) uptake and proton efflux. Makes modest contributions to pH homeostasis in the alkaline range of pH but is not contributor to Na(+) resistance. Appears to have a repressive effect on g

COG id: COG1757

COG function: function code C; Na+/H+ antiporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaC Na(+)/H(+) antiporter family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004770
- InterPro:   IPR018461 [H]

Pfam domain/function: PF03553 Na_H_antiporter [H]

EC number: NA

Molecular weight: Translated: 52319; Mature: 52188

Theoretical pI: Translated: 9.75; Mature: 9.75

Prosite motif: PS00133 CARBOXYPEPT_ZN_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRQRTRFQSAVPNPASICLKDEKSVSYRCIRPLLVGRGLLLFIRKRLKLGRDGTLKETR
CCCCHHHHHHCCCCCHHEEEECCCCCHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCCC
GNGLALLPLGIFLALFIGSGIITGDFYKLPILVAISIAVGVALAMNRKESFHVKVERFAK
CCCEEEHHHHHHHHHHHCCCCEECCHHHHHHHHHHHHHHHHHHHHCCCCHHEEEHHHHHC
GAGNPDIMIMVLIFVLAGAFSETAKGMGGVDSTVNLALSILPQGFIVAGIFVIGAFISLA
CCCCCCHHHHHHHHHHHCCHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
MGTSMGTIAALAPIAVGISGQTDISIALTMATVVGGAMFGDNLSFISDTTIAAVRSQGTE
HCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHCCHHHHHHHHCCCH
MKDKFKTNFLIVLPAAIITIVLLVIITLGSDTQIKAHSFDWIKILPYAGVLITALLGWNV
HHHHHCCCEEEEHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCE
LIVLTGGTVLSGVIGLLDGSYTLESFFKSVTTGMGGMMELVLLAILIGGMVELIQYNGGI
EEEEECCHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCH
QYLMNILTRNIRSKKGAEFGIAGLVGMTNMCTANNTISIIFTGPLAKNIADQYEIDPRKS
HHHHHHHHHHHHHCCCCCCCHHHHHCCCCCEECCCEEEEEEECHHHHHHHHHCCCCCCCC
ASVLDLFSCCVQGLIPYGAQMLTAAGFAALSPIELLPYAFYPILVGVCGIISILIGFPRF
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
SKVAEKKEYHKTA
HHHHHHHHHCCCC
>Mature Secondary Structure 
PRQRTRFQSAVPNPASICLKDEKSVSYRCIRPLLVGRGLLLFIRKRLKLGRDGTLKETR
CCCHHHHHHCCCCCHHEEEECCCCCHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCCC
GNGLALLPLGIFLALFIGSGIITGDFYKLPILVAISIAVGVALAMNRKESFHVKVERFAK
CCCEEEHHHHHHHHHHHCCCCEECCHHHHHHHHHHHHHHHHHHHHCCCCHHEEEHHHHHC
GAGNPDIMIMVLIFVLAGAFSETAKGMGGVDSTVNLALSILPQGFIVAGIFVIGAFISLA
CCCCCCHHHHHHHHHHHCCHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
MGTSMGTIAALAPIAVGISGQTDISIALTMATVVGGAMFGDNLSFISDTTIAAVRSQGTE
HCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHCCHHHHHHHHCCCH
MKDKFKTNFLIVLPAAIITIVLLVIITLGSDTQIKAHSFDWIKILPYAGVLITALLGWNV
HHHHHCCCEEEEHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCE
LIVLTGGTVLSGVIGLLDGSYTLESFFKSVTTGMGGMMELVLLAILIGGMVELIQYNGGI
EEEEECCHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCH
QYLMNILTRNIRSKKGAEFGIAGLVGMTNMCTANNTISIIFTGPLAKNIADQYEIDPRKS
HHHHHHHHHHHHHCCCCCCCHHHHHCCCCCEECCCEEEEEEECHHHHHHHHHCCCCCCCC
ASVLDLFSCCVQGLIPYGAQMLTAAGFAALSPIELLPYAFYPILVGVCGIISILIGFPRF
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
SKVAEKKEYHKTA
HHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 10903309; 11274110 [H]