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The map label for this gene is cysG [H]

Identifier: 222095159

GI number: 222095159

Start: 1472186

End: 1472962

Strand: Direct

Name: cysG [H]

Synonym: BCQ_1499

Alternate gene names: 222095159

Gene position: 1472186-1472962 (Clockwise)

Preceding gene: 222095158

Following gene: 222095160

Centisome position: 28.23

GC content: 39.77

Gene sequence:

>777_bases
ATGGGAAAAGTATATATCGTTGGAGCGGGCCCTGGTGATCCAGACTTAATTACTGTAAAAGGGTTGAAATGTATTGAGAA
GGCAGATGTTATTTTATACGACCGTCTCGTAAATAAAGAGTTGCTTTCCTATGCAAAGCCTGGAGCCGATTTAATTTATT
GCGGAAAACTACCAAATTATCACACGATGAAGCAAGAGACAATTAACACGTTTCTTATTAAATATGCGAAAAAAGGAAAA
GTTGTAACGAGGCTTAAGGGAGGCGATCCATTTGTGTTTGGTAGAGGGGGAGAAGAAGCTGAAGCGTTAGCAAAGCAAGG
TGTACCATTTGAAATTGTTCCTGGTATTTCAGCTGGAATAGCTGCTCCTGCTTATGCAGGCATTCCAGTGACACATCGTG
ATGCAAGTGCAAGTTTTGCTATTGTGACAGGGCATAGAAAAGAAGATGCTGAAGAGGAAGTGAAGTGGGAAAATTTAGCG
AAAGGTGTAGAGACTTTAGCTGTATATATGGGGGTTAGCAATTTACCCTACATATGTGAACAACTGATAAAGCATGGAAA
AGATAAAAGTACGCCTGCTGCTATTATTGAGCGGGGAACGACATCTATGCAGCGCACAGTTGTTGGGACGTTAGGAACAA
TTGTAGATGTTGCGAAAAAAGAACAAATTCAAAATCCAAGCATGATTGTAATTGGAGAAGTCGTCCGTTTTAGAGAAAAA
ATTCATTGGTTTGAGAAACAGACAGAAAGTACGTATCAAGTAAGTGGAGTGTTATAA

Upstream 100 bases:

>100_bases
TTATTCATGAGTAAGGAACATTGAAATATGAAGAAATGAAAACTTCCATTCATATATAAGGATGGAAGTTTCACTTTAAT
AGTAGAAATGAGGAGAGATG

Downstream 100 bases:

>100_bases
AATGAAAGCCATCTTATATATATGTCATGGAAGTCGCTTGAAAGCAGCGAAAGAAGAAGCGGTTGCATTTATTACGTCAT
GTATGAACCGTGTAGAGGCA

Product: uroporphyrin-iii c-methyltransferase

Products: NA

Alternate protein names: Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM [H]

Number of amino acids: Translated: 258; Mature: 257

Protein sequence:

>258_residues
MGKVYIVGAGPGDPDLITVKGLKCIEKADVILYDRLVNKELLSYAKPGADLIYCGKLPNYHTMKQETINTFLIKYAKKGK
VVTRLKGGDPFVFGRGGEEAEALAKQGVPFEIVPGISAGIAAPAYAGIPVTHRDASASFAIVTGHRKEDAEEEVKWENLA
KGVETLAVYMGVSNLPYICEQLIKHGKDKSTPAAIIERGTTSMQRTVVGTLGTIVDVAKKEQIQNPSMIVIGEVVRFREK
IHWFEKQTESTYQVSGVL

Sequences:

>Translated_258_residues
MGKVYIVGAGPGDPDLITVKGLKCIEKADVILYDRLVNKELLSYAKPGADLIYCGKLPNYHTMKQETINTFLIKYAKKGK
VVTRLKGGDPFVFGRGGEEAEALAKQGVPFEIVPGISAGIAAPAYAGIPVTHRDASASFAIVTGHRKEDAEEEVKWENLA
KGVETLAVYMGVSNLPYICEQLIKHGKDKSTPAAIIERGTTSMQRTVVGTLGTIVDVAKKEQIQNPSMIVIGEVVRFREK
IHWFEKQTESTYQVSGVL
>Mature_257_residues
GKVYIVGAGPGDPDLITVKGLKCIEKADVILYDRLVNKELLSYAKPGADLIYCGKLPNYHTMKQETINTFLIKYAKKGKV
VTRLKGGDPFVFGRGGEEAEALAKQGVPFEIVPGISAGIAAPAYAGIPVTHRDASASFAIVTGHRKEDAEEEVKWENLAK
GVETLAVYMGVSNLPYICEQLIKHGKDKSTPAAIIERGTTSMQRTVVGTLGTIVDVAKKEQIQNPSMIVIGEVVRFREKI
HWFEKQTESTYQVSGVL

Specific function: Catalyzes both methylations at C-2 and C-7 of uroporphyrinogen III leading to precorrin-1 and precorrin-2; their oxidative esterification gives respectively factor I octamethyl ester and sirohydrochlorin [H]

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=246, Percent_Identity=47.9674796747967, Blast_Score=249, Evalue=2e-67,
Organism=Saccharomyces cerevisiae, GI6322922, Length=237, Percent_Identity=32.4894514767932, Blast_Score=123, Evalue=3e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR003043 [H]

Pfam domain/function: PF00590 TP_methylase [H]

EC number: =2.1.1.107 [H]

Molecular weight: Translated: 28108; Mature: 27977

Theoretical pI: Translated: 8.72; Mature: 8.72

Prosite motif: PS00839 SUMT_1 ; PS00840 SUMT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKVYIVGAGPGDPDLITVKGLKCIEKADVILYDRLVNKELLSYAKPGADLIYCGKLPNY
CCEEEEEECCCCCCCEEEECCCHHHHHCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCC
HTMKQETINTFLIKYAKKGKVVTRLKGGDPFVFGRGGEEAEALAKQGVPFEIVPGISAGI
CHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEECCCCCHHHHHHHCCCCEEEECCCCCCC
AAPAYAGIPVTHRDASASFAIVTGHRKEDAEEEVKWENLAKGVETLAVYMGVSNLPYICE
CCCCCCCCCEEECCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
QLIKHGKDKSTPAAIIERGTTSMQRTVVGTLGTIVDVAKKEQIQNPSMIVIGEVVRFREK
HHHHCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHH
IHWFEKQTESTYQVSGVL
HHHHHHHCCCEEEEECCC
>Mature Secondary Structure 
GKVYIVGAGPGDPDLITVKGLKCIEKADVILYDRLVNKELLSYAKPGADLIYCGKLPNY
CEEEEEECCCCCCCEEEECCCHHHHHCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCC
HTMKQETINTFLIKYAKKGKVVTRLKGGDPFVFGRGGEEAEALAKQGVPFEIVPGISAGI
CHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEECCCCCHHHHHHHCCCCEEEECCCCCCC
AAPAYAGIPVTHRDASASFAIVTGHRKEDAEEEVKWENLAKGVETLAVYMGVSNLPYICE
CCCCCCCCCEEECCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
QLIKHGKDKSTPAAIIERGTTSMQRTVVGTLGTIVDVAKKEQIQNPSMIVIGEVVRFREK
HHHHCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHH
IHWFEKQTESTYQVSGVL
HHHHHHHCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1906874 [H]