Click here to switch to the map view.

The map label for this gene is serA [C]

Identifier: 222095148

GI number: 222095148

Start: 1461110

End: 1461907

Strand: Direct

Name: serA [C]

Synonym: BCQ_1488

Alternate gene names: 222095148

Gene position: 1461110-1461907 (Clockwise)

Preceding gene: 222095147

Following gene: 222095151

Centisome position: 28.02

GC content: 39.47

Gene sequence:

>798_bases
GTGATTGATGCGGCACCTAATTTGAAGATTGTTGCAAACTACGGTGCTGGTTACGATAATATTGATTACTCATATGCCGA
AAAAAAAGGGATTGCGGTAACGAATACACCGAAAGTATCAACGGAAGCTACTGCAGAACTAACATTTGCACTTCTTTTGG
CAGCTGCACGTAGAATTCCTGAAGGTGATACGTTATGTCGTACAACTGGATTTAACGGATGGGCACCGTTATTTTTCTTA
GGCCGCGAAGTACATGGTAAGACAATTGGAATTATCGGCCTTGGAGAAATCGGAAAGGCAGTTGCAAAGCGTGCGAAAGC
GTTTGGAATGAATGTTTTATATACAGGACCAAATCGAAAGCCTGAAGCTGAAAGTGAACTGGAAGCAACATATGTAACAT
TGGAAGAGTTATTACAAACAGCAGACTTTATTACAATTAACTGTGCGTATAATCGGAAATTGCATCATATGATTGATGAA
GAACAGTTTAAAATGATGAAGAAAACAGCTTATATTATAAATGCTTCACGTGGACCAATTATGCATGAAGCGGCACTTGC
TCATGCATTAAAAACGAATGAAATTGAAGGGGCAGCGCTTGACGTGTTTGAATTTGAGCCGAAAATTACTGAAGAGCTAA
AAGGATTAAAGAATGTGGTACTTGCTCCTCACGTAGGAAATGCAACATTCGAAACGCGTGATGCGATGGCCGAAACGGCG
GTAAGAAATATTTTAGCTGTATTAAATGGCGAAGAAGCTGTAACGCCTGTCAATCAAAAAGTATTCGTTACAAAATAA

Upstream 100 bases:

>100_bases
GTACGATAAAGAGGAGTTAATTTCTTTAGATGAATTAACAGAGCGTGTAAAAGACAAAGATGCATTGTTAAGCCTACTTT
CTACAAAGGTGACAAAAGAA

Downstream 100 bases:

>100_bases
AAAGAAACCTTCCGATTCCGGAAGGTTTCTTTTTATTTTTCTTTATTTGCTCTTTTTGATGGTCTTTGTCTAAGGAATTG
AGATAGCATGTACAAAATAT

Product: 2-hydroxyacid dehydrogenase family protein; phosphoglycerate dehydrogenase

Products: glycerate; NADP; NADPH; glyoxylate; 2-Dehydro-D-gluconate; 5-ketogluconate; L-idonate [C]

Alternate protein names: NA

Number of amino acids: Translated: 265; Mature: 265

Protein sequence:

>265_residues
MIDAAPNLKIVANYGAGYDNIDYSYAEKKGIAVTNTPKVSTEATAELTFALLLAAARRIPEGDTLCRTTGFNGWAPLFFL
GREVHGKTIGIIGLGEIGKAVAKRAKAFGMNVLYTGPNRKPEAESELEATYVTLEELLQTADFITINCAYNRKLHHMIDE
EQFKMMKKTAYIINASRGPIMHEAALAHALKTNEIEGAALDVFEFEPKITEELKGLKNVVLAPHVGNATFETRDAMAETA
VRNILAVLNGEEAVTPVNQKVFVTK

Sequences:

>Translated_265_residues
MIDAAPNLKIVANYGAGYDNIDYSYAEKKGIAVTNTPKVSTEATAELTFALLLAAARRIPEGDTLCRTTGFNGWAPLFFL
GREVHGKTIGIIGLGEIGKAVAKRAKAFGMNVLYTGPNRKPEAESELEATYVTLEELLQTADFITINCAYNRKLHHMIDE
EQFKMMKKTAYIINASRGPIMHEAALAHALKTNEIEGAALDVFEFEPKITEELKGLKNVVLAPHVGNATFETRDAMAETA
VRNILAVLNGEEAVTPVNQKVFVTK
>Mature_265_residues
MIDAAPNLKIVANYGAGYDNIDYSYAEKKGIAVTNTPKVSTEATAELTFALLLAAARRIPEGDTLCRTTGFNGWAPLFFL
GREVHGKTIGIIGLGEIGKAVAKRAKAFGMNVLYTGPNRKPEAESELEATYVTLEELLQTADFITINCAYNRKLHHMIDE
EQFKMMKKTAYIINASRGPIMHEAALAHALKTNEIEGAALDVFEFEPKITEELKGLKNVVLAPHVGNATFETRDAMAETA
VRNILAVLNGEEAVTPVNQKVFVTK

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=254, Percent_Identity=40.5511811023622, Blast_Score=188, Evalue=4e-48,
Organism=Homo sapiens, GI23308577, Length=264, Percent_Identity=33.7121212121212, Blast_Score=163, Evalue=1e-40,
Organism=Homo sapiens, GI61743967, Length=254, Percent_Identity=37.7952755905512, Blast_Score=152, Evalue=2e-37,
Organism=Homo sapiens, GI4557497, Length=254, Percent_Identity=37.7952755905512, Blast_Score=152, Evalue=3e-37,
Organism=Homo sapiens, GI145580578, Length=272, Percent_Identity=35.6617647058824, Blast_Score=149, Evalue=2e-36,
Organism=Homo sapiens, GI4557499, Length=272, Percent_Identity=35.6617647058824, Blast_Score=149, Evalue=2e-36,
Organism=Homo sapiens, GI145580575, Length=271, Percent_Identity=35.7933579335793, Blast_Score=146, Evalue=1e-35,
Organism=Escherichia coli, GI87082289, Length=263, Percent_Identity=38.7832699619772, Blast_Score=180, Evalue=7e-47,
Organism=Escherichia coli, GI1789279, Length=241, Percent_Identity=33.6099585062241, Blast_Score=114, Evalue=6e-27,
Organism=Escherichia coli, GI1787645, Length=259, Percent_Identity=30.1158301158301, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1788660, Length=235, Percent_Identity=28.936170212766, Blast_Score=77, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17532191, Length=259, Percent_Identity=34.7490347490347, Blast_Score=151, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI25147481, Length=277, Percent_Identity=29.2418772563177, Blast_Score=115, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6324055, Length=236, Percent_Identity=37.7118644067797, Blast_Score=160, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6320925, Length=279, Percent_Identity=32.6164874551971, Blast_Score=140, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6322116, Length=279, Percent_Identity=32.6164874551971, Blast_Score=139, Evalue=6e-34,
Organism=Saccharomyces cerevisiae, GI6324964, Length=270, Percent_Identity=27.7777777777778, Blast_Score=76, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6321253, Length=281, Percent_Identity=25.2669039145907, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI28571528, Length=260, Percent_Identity=39.2307692307692, Blast_Score=159, Evalue=1e-39,
Organism=Drosophila melanogaster, GI28574286, Length=260, Percent_Identity=38.4615384615385, Blast_Score=159, Evalue=2e-39,
Organism=Drosophila melanogaster, GI45551003, Length=256, Percent_Identity=35.9375, Blast_Score=154, Evalue=5e-38,
Organism=Drosophila melanogaster, GI28574284, Length=256, Percent_Identity=35.9375, Blast_Score=154, Evalue=6e-38,
Organism=Drosophila melanogaster, GI24585514, Length=256, Percent_Identity=35.9375, Blast_Score=154, Evalue=6e-38,
Organism=Drosophila melanogaster, GI28574282, Length=256, Percent_Identity=35.9375, Blast_Score=154, Evalue=6e-38,
Organism=Drosophila melanogaster, GI45552429, Length=256, Percent_Identity=35.9375, Blast_Score=154, Evalue=6e-38,
Organism=Drosophila melanogaster, GI24646446, Length=248, Percent_Identity=36.2903225806452, Blast_Score=136, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24646448, Length=248, Percent_Identity=36.2903225806452, Blast_Score=136, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24646452, Length=248, Percent_Identity=36.2903225806452, Blast_Score=136, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24646450, Length=248, Percent_Identity=36.2903225806452, Blast_Score=136, Evalue=2e-32,
Organism=Drosophila melanogaster, GI62472511, Length=248, Percent_Identity=36.2903225806452, Blast_Score=135, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24585516, Length=259, Percent_Identity=29.7297297297297, Blast_Score=127, Evalue=5e-30,
Organism=Drosophila melanogaster, GI19921140, Length=249, Percent_Identity=33.3333333333333, Blast_Score=125, Evalue=3e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: NA

Molecular weight: Translated: 28944; Mature: 28944

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDAAPNLKIVANYGAGYDNIDYSYAEKKGIAVTNTPKVSTEATAELTFALLLAAARRIP
CCCCCCCEEEEEECCCCCCCCCCHHHHCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCC
EGDTLCRTTGFNGWAPLFFLGREVHGKTIGIIGLGEIGKAVAKRAKAFGMNVLYTGPNRK
CCCCEEEECCCCCCCHHHHCCCCCCCCEEEEEECHHHHHHHHHHHHHHCCEEEEECCCCC
PEAESELEATYVTLEELLQTADFITINCAYNRKLHHMIDEEQFKMMKKTAYIINASRGPI
CCCHHHHHHHHHHHHHHHHHCCEEEEEEEECCHHHHHHCHHHHHHHHHHEEEEECCCCCC
MHEAALAHALKTNEIEGAALDVFEFEPKITEELKGLKNVVLAPHVGNATFETRDAMAETA
HHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHEEECCCCCCCCCHHHHHHHHHH
VRNILAVLNGEEAVTPVNQKVFVTK
HHHHHHHHCCCHHCCCCCCEEEEEC
>Mature Secondary Structure
MIDAAPNLKIVANYGAGYDNIDYSYAEKKGIAVTNTPKVSTEATAELTFALLLAAARRIP
CCCCCCCEEEEEECCCCCCCCCCHHHHCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCC
EGDTLCRTTGFNGWAPLFFLGREVHGKTIGIIGLGEIGKAVAKRAKAFGMNVLYTGPNRK
CCCCEEEECCCCCCCHHHHCCCCCCCCEEEEEECHHHHHHHHHHHHHHCCEEEEECCCCC
PEAESELEATYVTLEELLQTADFITINCAYNRKLHHMIDEEQFKMMKKTAYIINASRGPI
CCCHHHHHHHHHHHHHHHHHCCEEEEEEEECCHHHHHHCHHHHHHHHHHEEEEECCCCCC
MHEAALAHALKTNEIEGAALDVFEFEPKITEELKGLKNVVLAPHVGNATFETRDAMAETA
HHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHEEECCCCCCCCCHHHHHHHHHH
VRNILAVLNGEEAVTPVNQKVFVTK
HHHHHHHHCCCHHCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: hydroxypyruvate; NADPH; glycolate; NADP; gluconate; 2,5-diketo-D-gluconate; 2-keto-L-gulonate [C]

Specific reaction: hydroxypyruvate + NADPH = glycerate + NADP glycolate + NADP = NADPH + glyoxylate NADP + gluconate = NADPH + 2-Dehydro-D-gluconate 2,5-diketo-D-gluconate + NADPH = 5-ketogluconate + NADP 2-keto-L-gulonate + NADPH = L-idonate + NADP [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA