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The map label for this gene is hisI [H]

Identifier: 222095144

GI number: 222095144

Start: 1458888

End: 1459193

Strand: Direct

Name: hisI [H]

Synonym: BCQ_1484

Alternate gene names: 222095144

Gene position: 1458888-1459193 (Clockwise)

Preceding gene: 222095143

Following gene: 222095145

Centisome position: 27.98

GC content: 34.31

Gene sequence:

>306_bases
ATGAAACCTAACTTTTCAAAAGGACTATTACCAGCAGTTGTAATTGAAGAAGGTACAAAAGAAGTTTTAATGCTAGCTTA
TATGAATGAAGAAGCATATGAAAAAACGCTAGAAACGAAAAGAACGTGGTTTTATTCTCGTTCAAGAAGGTCGTTATGGA
ATAAAGGAGAAACATCAGGTAATGTCCAACATGTGCAATCTCTTTATTTAGATTGTGATCAAGATGCAATTGTTGTTGTC
GTAAAGCAAGTAGGGCCTGCTTGCCATACGGGAGAAAAAACGTGTTTTCATTACAAAATTATATAG

Upstream 100 bases:

>100_bases
CAGTTGATGCAGCGTTAGCGGCATCAATCTTTCATTACGGTGAGGCGACAATAGGGGACGTAAAGAGAAAGTTAAGAAAT
GCAAACGTCGAGGTGCGGCT

Downstream 100 bases:

>100_bases
GGGGATACATATGAAAAACGCCTTTACATTACTATTCGAAACAATTAAAGAACGAAAGAGAAATCCACTTTCTGAATCCT
ATACAAATTACTTGTTTTTA

Product: phosphoribosyl-amp cyclohydrolase

Products: NA

Alternate protein names: PRA-CH [H]

Number of amino acids: Translated: 101; Mature: 101

Protein sequence:

>101_residues
MKPNFSKGLLPAVVIEEGTKEVLMLAYMNEEAYEKTLETKRTWFYSRSRRSLWNKGETSGNVQHVQSLYLDCDQDAIVVV
VKQVGPACHTGEKTCFHYKII

Sequences:

>Translated_101_residues
MKPNFSKGLLPAVVIEEGTKEVLMLAYMNEEAYEKTLETKRTWFYSRSRRSLWNKGETSGNVQHVQSLYLDCDQDAIVVV
VKQVGPACHTGEKTCFHYKII
>Mature_101_residues
MKPNFSKGLLPAVVIEEGTKEVLMLAYMNEEAYEKTLETKRTWFYSRSRRSLWNKGETSGNVQHVQSLYLDCDQDAIVVV
VKQVGPACHTGEKTCFHYKII

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-CH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=91, Percent_Identity=48.3516483516484, Blast_Score=103, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6319819, Length=91, Percent_Identity=38.4615384615385, Blast_Score=63, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002496
- ProDom:   PD002610 [H]

Pfam domain/function: PF01502 PRA-CH [H]

EC number: =3.5.4.19 [H]

Molecular weight: Translated: 11585; Mature: 11585

Theoretical pI: Translated: 8.06; Mature: 8.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPNFSKGLLPAVVIEEGTKEVLMLAYMNEEAYEKTLETKRTWFYSRSRRSLWNKGETSG
CCCCCCCCCCCEEEECCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
NVQHVQSLYLDCDQDAIVVVVKQVGPACHTGEKTCFHYKII
CHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCEEEEEEEC
>Mature Secondary Structure
MKPNFSKGLLPAVVIEEGTKEVLMLAYMNEEAYEKTLETKRTWFYSRSRRSLWNKGETSG
CCCCCCCCCCCEEEECCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
NVQHVQSLYLDCDQDAIVVVVKQVGPACHTGEKTCFHYKII
CHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA