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The map label for this gene is lldP [H]

Identifier: 222094969

GI number: 222094969

Start: 1295808

End: 1297307

Strand: Direct

Name: lldP [H]

Synonym: BCQ_1307

Alternate gene names: 222094969

Gene position: 1295808-1297307 (Clockwise)

Preceding gene: 222094968

Following gene: 222094970

Centisome position: 24.85

GC content: 37.8

Gene sequence:

>1500_bases
ATGGCCATATTGTTGGCACTTATCCCAATTATGATGATTTTCATTTGTTTATTTTTATTTAAACAAACGTCATTAAGGTC
CTCGTTAATTTCTTATGCTGTGTCTGTTGGAATCGTTTTACTCTCGCCAATGTTTCAATTAGGGATAAGTGAAACTGTGC
ACGCAACGATTAAAGGATGGTTAATTTGTTTTATTGTCGGGTACGTTTTATTTTTCGGTATTTTTTTATTTCACCTCATG
AACAAAATGGGGTACATCGACCAAGTAGCGCGTTTTTTAGAAGAAGTGACGCAAGATCGTTTATTACAAATGCTTCTTAT
GTGCTTTGGTATTTGCCCACTAATTGAATCGGTAAGTGGATTCGGAATTGGTTTTATGGTTGCAGCACCTATTTTTCTTT
CATTAGGTTATAAACCGTTCCAAGCTGTACTGCTCTCGTTTATCGGCTTACTAGCTAGTTCATGGGGGGCAATGGCAACT
GGTACGATTATCGGTTCGCAACTTATCAATATGCCGCTTACAACACTCGGTACAAATACAGCGCTATTAAGTATCCCGAT
GTTTGCTTATTTCGTCATTCTTTCTTTACACGTTGTTGGCGGCTGGCAGGCGGTTATTGAAAAGTGGAAGGAAGGATTCG
GTTTCTTTCTATTATTTTCTCTCGGAATCTATCTTTCTAACGCATACGTAAGTGTTGAACTAGCAGGTATACTAAGTTCT
ATCGTTACGATTACATTTGGCTTTCTTATCATTAAATTAAAAGGAAAAAGTGGGCAAAATCTTATAACAGAGCATGCGGC
TGCAACGGAGAGAGAAGTATCTATTATAAAAATTATTAGCCCTTATATATTTCTAACAGTTTGTATTTTACTTTCTCGCC
TCGTTCCAGCATTACATGATTTGTTCAGATCATATGTGGTTCTTGATTTGAAATCATACTCTTACAAACTAGAGTTACTA
TATTCACCAGGATTTTGGCTCGGTATGACTTGCTTATTTACTATTATTTTCTTCCGCATCCCGTCTAATATTATTAAACA
ATCACTCTCACAAACGATCAAACAATGGATTCCTTTTGCGATTACGACGACAATGTTTATCGCCATTTCAGAATTAATGG
GTGCATCTGGCATGCATTCATTACTGGCAAAAACGGCTGGTGAAACATTTGGAACATTTTTCGTTTTCGTTGCTCCGTTT
ATCGGTGGTATCGGTGGCTTTTTAACAGGTAGTAATGCAGGCTCAAATGCGATGTTCATAAAACTACAAATGCAAACGGC
GCAAAATGTAGCACTCCCGTGGCAATACGTCACAACATTGCAAAACACCGCATCATCAGTAGCGACGATCGCTTGCCCGT
CACGGATTACACTAGGTGCGTATTTATGTAACATTCCGTATCGTGAAAATGAACTATTAAAGAAGACGACGTTAATGATT
TTTGGTGCGGTGTTGCTTATAGTGGTAGAGGTTGTTGTTTGGTATATGTTGAGAAATTAA

Upstream 100 bases:

>100_bases
TCGGTTCCCTTTTTTGTATCTGTTGCAAAAACAATTGAAAAAAATCATATCTGTTATATAATAGTTAAAAATTGTATTTT
AAACGAAAAGAGATGATAAC

Downstream 100 bases:

>100_bases
AAATCCTCCTGACATAGGAGGATTTTTGTTATGAGTGGATAATGTTTTAAATATGAAAAGCTTCTACTAAATGAATAGGA
GATGAAATGTATGCCCCTAA

Product: L-lactate permease

Products: Proton [Cytoplasm]; lactate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 499; Mature: 498

Protein sequence:

>499_residues
MAILLALIPIMMIFICLFLFKQTSLRSSLISYAVSVGIVLLSPMFQLGISETVHATIKGWLICFIVGYVLFFGIFLFHLM
NKMGYIDQVARFLEEVTQDRLLQMLLMCFGICPLIESVSGFGIGFMVAAPIFLSLGYKPFQAVLLSFIGLLASSWGAMAT
GTIIGSQLINMPLTTLGTNTALLSIPMFAYFVILSLHVVGGWQAVIEKWKEGFGFFLLFSLGIYLSNAYVSVELAGILSS
IVTITFGFLIIKLKGKSGQNLITEHAAATEREVSIIKIISPYIFLTVCILLSRLVPALHDLFRSYVVLDLKSYSYKLELL
YSPGFWLGMTCLFTIIFFRIPSNIIKQSLSQTIKQWIPFAITTTMFIAISELMGASGMHSLLAKTAGETFGTFFVFVAPF
IGGIGGFLTGSNAGSNAMFIKLQMQTAQNVALPWQYVTTLQNTASSVATIACPSRITLGAYLCNIPYRENELLKKTTLMI
FGAVLLIVVEVVVWYMLRN

Sequences:

>Translated_499_residues
MAILLALIPIMMIFICLFLFKQTSLRSSLISYAVSVGIVLLSPMFQLGISETVHATIKGWLICFIVGYVLFFGIFLFHLM
NKMGYIDQVARFLEEVTQDRLLQMLLMCFGICPLIESVSGFGIGFMVAAPIFLSLGYKPFQAVLLSFIGLLASSWGAMAT
GTIIGSQLINMPLTTLGTNTALLSIPMFAYFVILSLHVVGGWQAVIEKWKEGFGFFLLFSLGIYLSNAYVSVELAGILSS
IVTITFGFLIIKLKGKSGQNLITEHAAATEREVSIIKIISPYIFLTVCILLSRLVPALHDLFRSYVVLDLKSYSYKLELL
YSPGFWLGMTCLFTIIFFRIPSNIIKQSLSQTIKQWIPFAITTTMFIAISELMGASGMHSLLAKTAGETFGTFFVFVAPF
IGGIGGFLTGSNAGSNAMFIKLQMQTAQNVALPWQYVTTLQNTASSVATIACPSRITLGAYLCNIPYRENELLKKTTLMI
FGAVLLIVVEVVVWYMLRN
>Mature_498_residues
AILLALIPIMMIFICLFLFKQTSLRSSLISYAVSVGIVLLSPMFQLGISETVHATIKGWLICFIVGYVLFFGIFLFHLMN
KMGYIDQVARFLEEVTQDRLLQMLLMCFGICPLIESVSGFGIGFMVAAPIFLSLGYKPFQAVLLSFIGLLASSWGAMATG
TIIGSQLINMPLTTLGTNTALLSIPMFAYFVILSLHVVGGWQAVIEKWKEGFGFFLLFSLGIYLSNAYVSVELAGILSSI
VTITFGFLIIKLKGKSGQNLITEHAAATEREVSIIKIISPYIFLTVCILLSRLVPALHDLFRSYVVLDLKSYSYKLELLY
SPGFWLGMTCLFTIIFFRIPSNIIKQSLSQTIKQWIPFAITTTMFIAISELMGASGMHSLLAKTAGETFGTFFVFVAPFI
GGIGGFLTGSNAGSNAMFIKLQMQTAQNVALPWQYVTTLQNTASSVATIACPSRITLGAYLCNIPYRENELLKKTTLMIF
GAVLLIVVEVVVWYMLRN

Specific function: Plays a role in L-lactate utilization [H]

COG id: COG1620

COG function: function code C; L-lactate permease

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lactate permease family [H]

Homologues:

Organism=Escherichia coli, GI1790031, Length=514, Percent_Identity=22.9571984435798, Blast_Score=99, Evalue=9e-22,
Organism=Escherichia coli, GI1789347, Length=316, Percent_Identity=23.7341772151899, Blast_Score=72, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003804 [H]

Pfam domain/function: PF02652 Lactate_perm [H]

EC number: NA

Molecular weight: Translated: 55050; Mature: 54919

Theoretical pI: Translated: 8.97; Mature: 8.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AILLALIPIMMIFICLFLFKQTSLRSSLISYAVSVGIVLLSPMFQLGISETVHATIKGW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH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HHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; lactate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + lactate [Periplasm] = Proton [Cytoplasm] + lactate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10508058 [H]