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The map label for this gene is yisK [H]

Identifier: 222094872

GI number: 222094872

Start: 1198394

End: 1199296

Strand: Direct

Name: yisK [H]

Synonym: BCQ_1210

Alternate gene names: 222094872

Gene position: 1198394-1199296 (Clockwise)

Preceding gene: 222094864

Following gene: 222094874

Centisome position: 22.98

GC content: 36.99

Gene sequence:

>903_bases
ATGTTGCGTTTGGTAACGGCGAAAAAAGAAGAAAAGGTATTTGTAGGTATTGTGGATGAAGAAGAAGAAAAGGTATTGCA
CTTAAGAGAAGCGCAAAGGCAAAAGGGAGAAAAGGTTACAATCCCTATTACAATGTTAGAATGTATTGAAAGAGGAACCG
AATGTGTTGAAAAAATGTGTGAAATTGTCAATTGGGCGAAGGAAAATGAAGGAACGGCGTATTACCCGTTAACTGAGGTG
AAAATATTAGCACCAATTCCAAGGCCAAGAAAGAATATTCTTTGCGTTGGAAAAAATTATCGTGAGCATGCGATGGAAAT
GGGCGGCGTAGAGTCAATTCCAGAAAATATAATGATCTTTACGAAAGCACCAACGACAGTGATTGGAATGGATGAAAAAA
TTAATAGTCATCCCCACGCAACAAATGAATTAGACTATGAAGGGGAACTAGCTATCGTCATTGGTAAGCGAGGGAAACAA
ATAAAAAAAGAAAAAGCGCTTGAGCATGTTTTTGGTTATACCATTATAAATGATATAACTGCTCGCGACATTCAAAGGAA
GCATAAGCAATTTTTCCTTGGAAAAAGTTTCGATACATTTTGTCCGATGGGACCGTATTTAATTCATAAATCGATGGTTA
GTGCGCCAAATGCATTACACATTGAAACGGTAGTAAATGGAGAAGTAAGACAAACTTCAAATACAAATAAAATGATTTTT
TCAATAGAAGAAATCATTTCAACGATAAGTAAAGGAATGACATTAGAACCAGGAGATATTATTGCAACAGGAACCCCGGC
TGGTGTTGGAAAAGGTTTCACACCACCGAAGTTTTTGCATGCCGGTGATGAAGTAGTTATTACAGTAGAAGGAATTGGTA
CTTTGCGAAATGTAGTGAAGTGA

Upstream 100 bases:

>100_bases
TATGAGAAGAATATTGTAAAAATTAGCGTGTATGAGAAGGTTTTTTTCTTACAGATGCGAATACAATTAAAAGGTATGAG
TTTTAGGATGGAGAGTGGAA

Downstream 100 bases:

>100_bases
AGTGAAGAAAAGAGCTATCTTATTACTAGATAGCTCTTTTCTATGGTCTTGGGTGATAGAGGTAATCGATAACGGAAAAA
GTGTAAAGACCAATGACTGC

Product: fumarylacetoacetate hydrolase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 300; Mature: 300

Protein sequence:

>300_residues
MLRLVTAKKEEKVFVGIVDEEEEKVLHLREAQRQKGEKVTIPITMLECIERGTECVEKMCEIVNWAKENEGTAYYPLTEV
KILAPIPRPRKNILCVGKNYREHAMEMGGVESIPENIMIFTKAPTTVIGMDEKINSHPHATNELDYEGELAIVIGKRGKQ
IKKEKALEHVFGYTIINDITARDIQRKHKQFFLGKSFDTFCPMGPYLIHKSMVSAPNALHIETVVNGEVRQTSNTNKMIF
SIEEIISTISKGMTLEPGDIIATGTPAGVGKGFTPPKFLHAGDEVVITVEGIGTLRNVVK

Sequences:

>Translated_300_residues
MLRLVTAKKEEKVFVGIVDEEEEKVLHLREAQRQKGEKVTIPITMLECIERGTECVEKMCEIVNWAKENEGTAYYPLTEV
KILAPIPRPRKNILCVGKNYREHAMEMGGVESIPENIMIFTKAPTTVIGMDEKINSHPHATNELDYEGELAIVIGKRGKQ
IKKEKALEHVFGYTIINDITARDIQRKHKQFFLGKSFDTFCPMGPYLIHKSMVSAPNALHIETVVNGEVRQTSNTNKMIF
SIEEIISTISKGMTLEPGDIIATGTPAGVGKGFTPPKFLHAGDEVVITVEGIGTLRNVVK
>Mature_300_residues
MLRLVTAKKEEKVFVGIVDEEEEKVLHLREAQRQKGEKVTIPITMLECIERGTECVEKMCEIVNWAKENEGTAYYPLTEV
KILAPIPRPRKNILCVGKNYREHAMEMGGVESIPENIMIFTKAPTTVIGMDEKINSHPHATNELDYEGELAIVIGKRGKQ
IKKEKALEHVFGYTIINDITARDIQRKHKQFFLGKSFDTFCPMGPYLIHKSMVSAPNALHIETVVNGEVRQTSNTNKMIF
SIEEIISTISKGMTLEPGDIIATGTPAGVGKGFTPPKFLHAGDEVVITVEGIGTLRNVVK

Specific function: Unknown

COG id: COG0179

COG function: function code Q; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAH family [H]

Homologues:

Organism=Homo sapiens, GI156231349, Length=262, Percent_Identity=42.7480916030534, Blast_Score=204, Evalue=7e-53,
Organism=Homo sapiens, GI40786394, Length=262, Percent_Identity=42.3664122137405, Blast_Score=202, Evalue=2e-52,
Organism=Homo sapiens, GI215422413, Length=185, Percent_Identity=42.7027027027027, Blast_Score=132, Evalue=5e-31,
Organism=Homo sapiens, GI66348062, Length=185, Percent_Identity=42.7027027027027, Blast_Score=131, Evalue=6e-31,
Organism=Homo sapiens, GI13654274, Length=185, Percent_Identity=42.7027027027027, Blast_Score=131, Evalue=6e-31,
Organism=Escherichia coli, GI1787428, Length=212, Percent_Identity=33.0188679245283, Blast_Score=117, Evalue=9e-28,
Organism=Caenorhabditis elegans, GI17557057, Length=183, Percent_Identity=39.8907103825137, Blast_Score=130, Evalue=8e-31,
Organism=Saccharomyces cerevisiae, GI6324161, Length=229, Percent_Identity=29.2576419213974, Blast_Score=92, Evalue=1e-19,
Organism=Drosophila melanogaster, GI28572127, Length=221, Percent_Identity=42.0814479638009, Blast_Score=184, Evalue=4e-47,
Organism=Drosophila melanogaster, GI24663695, Length=221, Percent_Identity=39.3665158371041, Blast_Score=152, Evalue=2e-37,
Organism=Drosophila melanogaster, GI28571789, Length=183, Percent_Identity=34.4262295081967, Blast_Score=94, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002529
- InterPro:   IPR011234 [H]

Pfam domain/function: PF01557 FAA_hydrolase [H]

EC number: NA

Molecular weight: Translated: 33500; Mature: 33500

Theoretical pI: Translated: 7.01; Mature: 7.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRLVTAKKEEKVFVGIVDEEEEKVLHLREAQRQKGEKVTIPITMLECIERGTECVEKMC
CEEEEECCCCCEEEEEEECCCHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHH
EIVNWAKENEGTAYYPLTEVKILAPIPRPRKNILCVGKNYREHAMEMGGVESIPENIMIF
HHHHHHHCCCCCEEECEEEEEEEECCCCCCCCEEEECCCHHHHHHHHCCCCCCCCCEEEE
TKAPTTVIGMDEKINSHPHATNELDYEGELAIVIGKRGKQIKKEKALEHVFGYTIINDIT
EECCCEEEECCHHCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
ARDIQRKHKQFFLGKSFDTFCPMGPYLIHKSMVSAPNALHIETVVNGEVRQTSNTNKMIF
HHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEEECCCEEECCCCCCEEE
SIEEIISTISKGMTLEPGDIIATGTPAGVGKGFTPPKFLHAGDEVVITVEGIGTLRNVVK
EHHHHHHHHHCCCEECCCCEEEECCCCCCCCCCCCHHHCCCCCEEEEEEECCHHHHHHCC
>Mature Secondary Structure
MLRLVTAKKEEKVFVGIVDEEEEKVLHLREAQRQKGEKVTIPITMLECIERGTECVEKMC
CEEEEECCCCCEEEEEEECCCHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHH
EIVNWAKENEGTAYYPLTEVKILAPIPRPRKNILCVGKNYREHAMEMGGVESIPENIMIF
HHHHHHHCCCCCEEECEEEEEEEECCCCCCCCEEEECCCHHHHHHHHCCCCCCCCCEEEE
TKAPTTVIGMDEKINSHPHATNELDYEGELAIVIGKRGKQIKKEKALEHVFGYTIINDIT
EECCCEEEECCHHCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
ARDIQRKHKQFFLGKSFDTFCPMGPYLIHKSMVSAPNALHIETVVNGEVRQTSNTNKMIF
HHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEEECCCEEECCCCCCEEE
SIEEIISTISKGMTLEPGDIIATGTPAGVGKGFTPPKFLHAGDEVVITVEGIGTLRNVVK
EHHHHHHHHHCCCEECCCCEEEECCCCCCCCCCCCHHHCCCCCEEEEEEECCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9353931; 9384377 [H]