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The map label for this gene is hemN [H]

Identifier: 222094624

GI number: 222094624

Start: 945696

End: 947186

Strand: Direct

Name: hemN [H]

Synonym: BCQ_0962

Alternate gene names: 222094624

Gene position: 945696-947186 (Clockwise)

Preceding gene: 222094622

Following gene: 222094625

Centisome position: 18.14

GC content: 36.35

Gene sequence:

>1491_bases
ATGTTGTTAATTTCAATTAAAACGTTACAAGATGATCGTTTTTTACGTCCGCTACAAAATATTGGCGGCTTATTTTTTGA
AGATAGTACGATTGGATTTGAACAAGAGGAAGCAAATCTTATCGTTGATATACACATTGAAGAGAATGTGAAAGCATCAG
CTCGTTTAACAGATGTTGCGACTGGAAATGTGTATGAAGAAACATTCGCAAAAGATTTATCTGCTTTTACAGATGAAAAA
GAGCGTATGAAGCAAGTGAAGCACGTTGTTTCTTATGTATATCTTTCTGTTCTTCAGCAGTTAACTGGTATTGAACAAAG
CTGGGGTATTTTAACTGGAGTTCGTCCAACGAAACTTCTTCATAAAATGCTTCAAAACGGTATGTCAAAAGAAGAAGCAC
ACCAAGAACTTCGTGAAAGTTATTTAATTCATGAAGAGAAAATTGAACTCCTTCAACGTATCGTTGATTGCCAATTAGCG
GTAGTTCCGGATTTATATCGTTTGAAAGAGGAAGTAAGTATTTATATCGGTATCCCATTCTGCCCAACAAAATGTGCATA
TTGTACATTCCCGGCGTATGCAATTAACGGACGTCAAGGCTCTGTTGATTCATTCTTAGGTGGTTTACATTATGAAGTTC
GTGAAATTGGTAAGTTTTTAAAAGAAAAAGGTGTAAAAGTTACGACGATTTATTACGGCGGCGGTACACCGACAAGTATT
ACAGCAGAAGAGATGGATATGCTGTATGAAGAAATGTATGAAGCGTTCCCAGATGTGAAAAATGTGCGTGAAGTAACAGT
TGAGGCAGGTCGCCCAGATACAATTACGCCAGCGAAGCTAGAAGTGTTAAATAAATGGAACATTGACCGTATTAGTATTA
ATCCGCAGTCATACCATCAAGAAACATTAAAAGCAATTGGACGTCATCATACTGTAGAAGAAACAATTGAGAAGTATCAT
TTAGCTCGTGAAATGGGAATGAATAATATTAATATGGATTTAATTATTGGTCTTCCTGGTGAAGGGTTAGATATTTTCAA
GCATACGCTAGATGAAACAGAAAAGTTAATGCCAGAATCATTAACAGTTCATACGTTATCATTTAAACGTGCTTCCGAAA
TGACGCAAAACAAACGTAAATATAAAGTAGCAGGTCGCGAAGAAATTACAGCGATGATGCACGAAGCAGAAGAGTGGACG
CAAAAGCATAATTACGTACCATATTACCTATACCGTCAAAAGAATATTTTAGGTAACTTAGAGAACGTTGGTTATGCAAT
GCCGACGCAAGAAAGTATTTACAACATTGTCATTATGGAAGAAGTACAATCAATTATCGGACTTGGCTGCGGGGCATCAA
GTAAATTTGTTCATCCGAAGACAGGTGCAATTACGCACTTTGCGAATCCGAAAGATCCAAAATCATATAATGATGGCTTC
GTAAAATATACAGAAGACAAACTGAAAATTTTAGAAGAGCTATTTGCATAA

Upstream 100 bases:

>100_bases
TTGTTTTAAATAGGATATGAAAATAAGGTAAAACCTTCTGTATTGACCTGCAAACGCCCTTCAAGTAAACTAAAGAGAGT
TTGCAAATGAAAAGGTGATA

Downstream 100 bases:

>100_bases
GAAGAAAGGAGCTGTTCCGAGTCTGAAGTGCACCCCAATTGTTAGACACAGTCTAACAATTGGAGGTGCATTTTTTATGG
CTAAATTTTCTTCAAAAGAA

Product: coproporphyrinogen iii oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 496; Mature: 496

Protein sequence:

>496_residues
MLLISIKTLQDDRFLRPLQNIGGLFFEDSTIGFEQEEANLIVDIHIEENVKASARLTDVATGNVYEETFAKDLSAFTDEK
ERMKQVKHVVSYVYLSVLQQLTGIEQSWGILTGVRPTKLLHKMLQNGMSKEEAHQELRESYLIHEEKIELLQRIVDCQLA
VVPDLYRLKEEVSIYIGIPFCPTKCAYCTFPAYAINGRQGSVDSFLGGLHYEVREIGKFLKEKGVKVTTIYYGGGTPTSI
TAEEMDMLYEEMYEAFPDVKNVREVTVEAGRPDTITPAKLEVLNKWNIDRISINPQSYHQETLKAIGRHHTVEETIEKYH
LAREMGMNNINMDLIIGLPGEGLDIFKHTLDETEKLMPESLTVHTLSFKRASEMTQNKRKYKVAGREEITAMMHEAEEWT
QKHNYVPYYLYRQKNILGNLENVGYAMPTQESIYNIVIMEEVQSIIGLGCGASSKFVHPKTGAITHFANPKDPKSYNDGF
VKYTEDKLKILEELFA

Sequences:

>Translated_496_residues
MLLISIKTLQDDRFLRPLQNIGGLFFEDSTIGFEQEEANLIVDIHIEENVKASARLTDVATGNVYEETFAKDLSAFTDEK
ERMKQVKHVVSYVYLSVLQQLTGIEQSWGILTGVRPTKLLHKMLQNGMSKEEAHQELRESYLIHEEKIELLQRIVDCQLA
VVPDLYRLKEEVSIYIGIPFCPTKCAYCTFPAYAINGRQGSVDSFLGGLHYEVREIGKFLKEKGVKVTTIYYGGGTPTSI
TAEEMDMLYEEMYEAFPDVKNVREVTVEAGRPDTITPAKLEVLNKWNIDRISINPQSYHQETLKAIGRHHTVEETIEKYH
LAREMGMNNINMDLIIGLPGEGLDIFKHTLDETEKLMPESLTVHTLSFKRASEMTQNKRKYKVAGREEITAMMHEAEEWT
QKHNYVPYYLYRQKNILGNLENVGYAMPTQESIYNIVIMEEVQSIIGLGCGASSKFVHPKTGAITHFANPKDPKSYNDGF
VKYTEDKLKILEELFA
>Mature_496_residues
MLLISIKTLQDDRFLRPLQNIGGLFFEDSTIGFEQEEANLIVDIHIEENVKASARLTDVATGNVYEETFAKDLSAFTDEK
ERMKQVKHVVSYVYLSVLQQLTGIEQSWGILTGVRPTKLLHKMLQNGMSKEEAHQELRESYLIHEEKIELLQRIVDCQLA
VVPDLYRLKEEVSIYIGIPFCPTKCAYCTFPAYAINGRQGSVDSFLGGLHYEVREIGKFLKEKGVKVTTIYYGGGTPTSI
TAEEMDMLYEEMYEAFPDVKNVREVTVEAGRPDTITPAKLEVLNKWNIDRISINPQSYHQETLKAIGRHHTVEETIEKYH
LAREMGMNNINMDLIIGLPGEGLDIFKHTLDETEKLMPESLTVHTLSFKRASEMTQNKRKYKVAGREEITAMMHEAEEWT
QKHNYVPYYLYRQKNILGNLENVGYAMPTQESIYNIVIMEEVQSIIGLGCGASSKFVHPKTGAITHFANPKDPKSYNDGF
VKYTEDKLKILEELFA

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=302, Percent_Identity=24.1721854304636, Blast_Score=82, Evalue=8e-16,
Organism=Escherichia coli, GI1789325, Length=322, Percent_Identity=26.3975155279503, Blast_Score=109, Evalue=4e-25,
Organism=Escherichia coli, GI87082341, Length=192, Percent_Identity=28.125, Blast_Score=85, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR007197 [H]

Pfam domain/function: PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 56688; Mature: 56688

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLISIKTLQDDRFLRPLQNIGGLFFEDSTIGFEQEEANLIVDIHIEENVKASARLTDVA
CEEEEEEECCCCHHHHHHHHCCCEEEECCCCCCCCCCCCEEEEEEECCCCCCCCEEEECC
TGNVYEETFAKDLSAFTDEKERMKQVKHVVSYVYLSVLQQLTGIEQSWGILTGVRPTKLL
CCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCHHCCCCHHHHH
HKMLQNGMSKEEAHQELRESYLIHEEKIELLQRIVDCQLAVVPDLYRLKEEVSIYIGIPF
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCC
CPTKCAYCTFPAYAINGRQGSVDSFLGGLHYEVREIGKFLKEKGVKVTTIYYGGGTPTSI
CCCCCCEECCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCC
TAEEMDMLYEEMYEAFPDVKNVREVTVEAGRPDTITPAKLEVLNKWNIDRISINPQSYHQ
CHHHHHHHHHHHHHHCCCHHHHHHHHEECCCCCCCCHHHHHHHHCCCCEEEEECHHHHHH
ETLKAIGRHHTVEETIEKYHLAREMGMNNINMDLIIGLPGEGLDIFKHTLDETEKLMPES
HHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCC
LTVHTLSFKRASEMTQNKRKYKVAGREEITAMMHEAEEWTQKHNYVPYYLYRQKNILGNL
EEEEEEHHHHHHHHHHCCHHEECCCHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHCCH
ENVGYAMPTQESIYNIVIMEEVQSIIGLGCGASSKFVHPKTGAITHFANPKDPKSYNDGF
HHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCC
VKYTEDKLKILEELFA
EEECHHHHHHHHHHHC
>Mature Secondary Structure
MLLISIKTLQDDRFLRPLQNIGGLFFEDSTIGFEQEEANLIVDIHIEENVKASARLTDVA
CEEEEEEECCCCHHHHHHHHCCCEEEECCCCCCCCCCCCEEEEEEECCCCCCCCEEEECC
TGNVYEETFAKDLSAFTDEKERMKQVKHVVSYVYLSVLQQLTGIEQSWGILTGVRPTKLL
CCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCHHCCCCHHHHH
HKMLQNGMSKEEAHQELRESYLIHEEKIELLQRIVDCQLAVVPDLYRLKEEVSIYIGIPF
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCC
CPTKCAYCTFPAYAINGRQGSVDSFLGGLHYEVREIGKFLKEKGVKVTTIYYGGGTPTSI
CCCCCCEECCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCC
TAEEMDMLYEEMYEAFPDVKNVREVTVEAGRPDTITPAKLEVLNKWNIDRISINPQSYHQ
CHHHHHHHHHHHHHHCCCHHHHHHHHEECCCCCCCCHHHHHHHHCCCCEEEEECHHHHHH
ETLKAIGRHHTVEETIEKYHLAREMGMNNINMDLIIGLPGEGLDIFKHTLDETEKLMPES
HHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCC
LTVHTLSFKRASEMTQNKRKYKVAGREEITAMMHEAEEWTQKHNYVPYYLYRQKNILGNL
EEEEEEHHHHHHHHHHCCHHEECCCHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHCCH
ENVGYAMPTQESIYNIVIMEEVQSIIGLGCGASSKFVHPKTGAITHFANPKDPKSYNDGF
HHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCC
VKYTEDKLKILEELFA
EEECHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 10568751 [H]