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The map label for this gene is tcyA [H]

Identifier: 222094599

GI number: 222094599

Start: 919578

End: 920375

Strand: Direct

Name: tcyA [H]

Synonym: BCQ_0937

Alternate gene names: 222094599

Gene position: 919578-920375 (Clockwise)

Preceding gene: 222094598

Following gene: 222094600

Centisome position: 17.64

GC content: 35.34

Gene sequence:

>798_bases
ATGAAGAAATTATTTTCAGTACTTGCAGTAACTACATTAGCGATCGGGATTGTAGCCGGCTGCGGTAAAGAAGAGAAAAA
AGATACAGCTAGTCAAGACGCGTTACAAAAGATTAAACAAAGCGGTGAACTTGTAATTGGTACAGAAGGTACATACCCAC
CATTTACGTTCCACGATTCAAGCAATAAATTAACTGGATTTGACGTTGAACTATCAGAAGAAGTTGCAAAACGTTTAGGT
GTAAAACCTGTATTTAAAGAAACGCAATGGGATAGCTTACTTGCTGGTTTAGATGCAAAACGTTTCGATATGGTTGCAAA
CGAAGTTGGTATTCGTGAAGATCGTCAAAAGAAATACGACTTCTCTAAACCATACATTTCATCTTCAGCGGCATTAGTTA
TCGCAAAAGATAAAGATAAACCTGCTACATTTGCTGATGTAAAAGGATTAAAAGGAGCACAATCTTTAACAAGTAACTAT
GCAGATATCGCTAAGAAAAATGGTGCGGAAATCGTTGGTGTAGAAGGATTTAGCCAAGCAGCAGAACTATTAGCTTCAGG
ACGCGTTGATTTCACAATCAATGATAAATTATCAGTGTTAAATTATTTAGAAACGAAAAAAGATGCGAAAATTAAAATTG
TAGATACAGAAAAAGAAGCTTCAGAAAGTGGATTCTTATTCCGTAAAGGTAGCACTAAGCTTGTACAAGAAGTAGATAAA
GCGTTAGAAGATATGAAAAAAGACGGTACGTATGACAAAATAACGAAAAAATGGTTTGGTGAAAATGTATCTAAGTAG

Upstream 100 bases:

>100_bases
ATAAACTAAATAAGAACATTTTCATTGAAAAATTGTTCAAGATTGCATACAATCAATATAGTTTTTAAATTCCTATCAGA
ATACTTGGAGGATTACCATC

Downstream 100 bases:

>100_bases
TGCATTGATTTCAGATCGATTGTCTACTTGGCTAGATATTATGCAGACTTCCTTCATGCCTATGCTGAAGGAAGCTGTTT
TTACGACAATTCCATTAACG

Product: amino acid ABC transporter substrate-binding protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 265; Mature: 265

Protein sequence:

>265_residues
MKKLFSVLAVTTLAIGIVAGCGKEEKKDTASQDALQKIKQSGELVIGTEGTYPPFTFHDSSNKLTGFDVELSEEVAKRLG
VKPVFKETQWDSLLAGLDAKRFDMVANEVGIREDRQKKYDFSKPYISSSAALVIAKDKDKPATFADVKGLKGAQSLTSNY
ADIAKKNGAEIVGVEGFSQAAELLASGRVDFTINDKLSVLNYLETKKDAKIKIVDTEKEASESGFLFRKGSTKLVQEVDK
ALEDMKKDGTYDKITKKWFGENVSK

Sequences:

>Translated_265_residues
MKKLFSVLAVTTLAIGIVAGCGKEEKKDTASQDALQKIKQSGELVIGTEGTYPPFTFHDSSNKLTGFDVELSEEVAKRLG
VKPVFKETQWDSLLAGLDAKRFDMVANEVGIREDRQKKYDFSKPYISSSAALVIAKDKDKPATFADVKGLKGAQSLTSNY
ADIAKKNGAEIVGVEGFSQAAELLASGRVDFTINDKLSVLNYLETKKDAKIKIVDTEKEASESGFLFRKGSTKLVQEVDK
ALEDMKKDGTYDKITKKWFGENVSK
>Mature_265_residues
MKKLFSVLAVTTLAIGIVAGCGKEEKKDTASQDALQKIKQSGELVIGTEGTYPPFTFHDSSNKLTGFDVELSEEVAKRLG
VKPVFKETQWDSLLAGLDAKRFDMVANEVGIREDRQKKYDFSKPYISSSAALVIAKDKDKPATFADVKGLKGAQSLTSNY
ADIAKKNGAEIVGVEGFSQAAELLASGRVDFTINDKLSVLNYLETKKDAKIKIVDTEKEASESGFLFRKGSTKLVQEVDK
ALEDMKKDGTYDKITKKWFGENVSK

Specific function: Part of the ABC transporter complex tcyABC involved in L-cystine import [H]

COG id: COG0834

COG function: function code ET; ABC-type amino acid transport/signal transduction systems, periplasmic component/domain

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial solute-binding protein 3 family [H]

Homologues:

Organism=Escherichia coli, GI1788228, Length=256, Percent_Identity=38.671875, Blast_Score=175, Evalue=3e-45,
Organism=Escherichia coli, GI1787085, Length=221, Percent_Identity=30.7692307692308, Blast_Score=108, Evalue=5e-25,
Organism=Escherichia coli, GI1787088, Length=220, Percent_Identity=33.1818181818182, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1788648, Length=225, Percent_Identity=32, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1787031, Length=220, Percent_Identity=28.6363636363636, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1788649, Length=230, Percent_Identity=30.4347826086957, Blast_Score=96, Evalue=2e-21,

Paralogues:

None

Copy number: 1920 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1060 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 80 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001638
- InterPro:   IPR018313 [H]

Pfam domain/function: PF00497 SBP_bac_3 [H]

EC number: NA

Molecular weight: Translated: 29054; Mature: 29054

Theoretical pI: Translated: 8.83; Mature: 8.83

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS01039 SBP_BACTERIAL_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKLFSVLAVTTLAIGIVAGCGKEEKKDTASQDALQKIKQSGELVIGTEGTYPPFTFHDS
CHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCEEEECCCCCCCEEEECC
SNKLTGFDVELSEEVAKRLGVKPVFKETQWDSLLAGLDAKRFDMVANEVGIREDRQKKYD
CCCEEECCCHHHHHHHHHCCCCCHHHCCHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHCC
FSKPYISSSAALVIAKDKDKPATFADVKGLKGAQSLTSNYADIAKKNGAEIVGVEGFSQA
CCCCCCCCCCEEEEEECCCCCCCHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEECCHHHH
AELLASGRVDFTINDKLSVLNYLETKKDAKIKIVDTEKEASESGFLFRKGSTKLVQEVDK
HHHHHCCCCEEEECCHHHHHHHHHCCCCCEEEEEECCCCCCCCCEEEECCCHHHHHHHHH
ALEDMKKDGTYDKITKKWFGENVSK
HHHHHHHCCCHHHHHHHHHCCCCCC
>Mature Secondary Structure
MKKLFSVLAVTTLAIGIVAGCGKEEKKDTASQDALQKIKQSGELVIGTEGTYPPFTFHDS
CHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCEEEECCCCCCCEEEECC
SNKLTGFDVELSEEVAKRLGVKPVFKETQWDSLLAGLDAKRFDMVANEVGIREDRQKKYD
CCCEEECCCHHHHHHHHHCCCCCHHHCCHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHCC
FSKPYISSSAALVIAKDKDKPATFADVKGLKGAQSLTSNYADIAKKNGAEIVGVEGFSQA
CCCCCCCCCCEEEEEECCCCCCCHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEECCHHHH
AELLASGRVDFTINDKLSVLNYLETKKDAKIKIVDTEKEASESGFLFRKGSTKLVQEVDK
HHHHHCCCCEEEECCHHHHHHHHHCCCCCEEEEEECCCCCCCCCEEEECCCHHHHHHHHH
ALEDMKKDGTYDKITKKWFGENVSK
HHHHHHHCCCHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7551042; 8969502; 9384377 [H]