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The map label for this gene is proY [H]

Identifier: 222094448

GI number: 222094448

Start: 764761

End: 766152

Strand: Reverse

Name: proY [H]

Synonym: BCQ_0762

Alternate gene names: 222094448

Gene position: 766152-764761 (Counterclockwise)

Preceding gene: 222094453

Following gene: 222094447

Centisome position: 14.69

GC content: 37.93

Gene sequence:

>1392_bases
ATGCAGCACACAAACAAATCTGGAACTTTAAACCGAGGTTTAAAAGAACGACATATTACTTTAATGTCACTCGGTTCAGC
TATTGGCGTTGGACTATTTTTAGGATCTGCTTCTGCTATTAAACTAGCTGGTCCTTCTATTTTACTAGGCTATATGATTG
CTGGACTCGTTATTTTTTTCATTATGCGAGCACTCGGAGAAATGGCAATTGAACAACCTGTTGCTGGCTCTTTTAGTAAA
TATGCATATGATTATCTTGGACCACTAGCTGGCTATATTACCGGTTGGAACTACTGGTTCTTATGGGTTGTTACTTGCAT
GGCTGAAATTACGGCTGCTGGCATTTACATGCAGTACTGGTTCCCAGATATTCCGCGCTGGACTTGGGCTTTACTCGCTC
TATTATTAATGAGTGCTTTCAACTTTTTATCTGTAAAAGTATTTGGAGAACTTGAATTTTGGTTTGCTCTCATTAAAATT
GTCACAATTATCTGTATGATAGTAGTTGGGGCTGGTATTATTTTATTTGGCTTCGGAAACGGTGGTATCGCTACTGGCAT
TTCAAACCTTTGGTCACATGGTGGCTGGTTCCCAAATGGTTTTTCTGGGTTATTACTCTCCATGCAAATGGTATTATTCG
CTTATTTAGGCGTTGAATTAATCGGCGTTACAGCGGGTGAAGCGCAAAACCCGAAAAAAACACTCGCAAAAGCAATTGAT
AACGTATTTTGGAGAATATTACTGTTCTACGTTGGGGCTCTATTCGTTATGATGGCAATTTATCCATGGAACGAACTTGG
TGAGAAAGGAAGTCCATTTGTATTAACATTCCAGCAAATCGGTATCGCAAAAGCAGCAGGAATTATTAACTTCGTCGTAT
TAACAGCAGCTCTTTCTTCTTGTAATGGTGGTTTATTTAGTACAGGCCGCATGCTGTATACATTAGCTCAACAGAAAAAA
GCTCCGGAAAGATTCGGTCGTTTAAATAAAAATGGCATTCCAAGTCAAGGAATTGTAGCAACAGCAATCGTTTTACTCGT
TGGTGTTATATTAAACTATCTTGTGCCCGCAAAAGTATTTACATGGCTCACTAGTATTTCAACTTTCGGGGCAATTTGGA
CTTGGGGTATTATATTAGTCGCTCAAATTAAGTTCCGTAAAAGTTTGCCGACGCAAAACAAACAAAAGTTATCGTATAAA
ATGCCTTTATACCCATTAAGTTCATATTTCTCACTTGCTTTCCTTGCACTCGTATTATGTATAATGGCGTATTCAGAAGA
TACAAGGATTGCATTAATTGTTGGACCAATTTGGCTTATCGGTTTAGCTGTCGTGTATTACATGAAAGGTTTTCATAAAA
TTGATGAAACACCTAATTCAAAAATTGGTTAA

Upstream 100 bases:

>100_bases
TTTTGTAGCATAACAGATGGAAATGTTTTATAATTTGAAATAGTTAAATATTTAGTAAACGCATTCAAATATCGTTCACT
CTACAAGGGGGATTCTTCTT

Downstream 100 bases:

>100_bases
GCAAAACATCCCTTCCTTATTACTTGGAAGGGATATTTTTATGCCTATATAAATATTTCTCAACAAATTTCACGGTATTT
TTACAAATTTTTAATATTTT

Product: amino acid permease; proline-specific permease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MQHTNKSGTLNRGLKERHITLMSLGSAIGVGLFLGSASAIKLAGPSILLGYMIAGLVIFFIMRALGEMAIEQPVAGSFSK
YAYDYLGPLAGYITGWNYWFLWVVTCMAEITAAGIYMQYWFPDIPRWTWALLALLLMSAFNFLSVKVFGELEFWFALIKI
VTIICMIVVGAGIILFGFGNGGIATGISNLWSHGGWFPNGFSGLLLSMQMVLFAYLGVELIGVTAGEAQNPKKTLAKAID
NVFWRILLFYVGALFVMMAIYPWNELGEKGSPFVLTFQQIGIAKAAGIINFVVLTAALSSCNGGLFSTGRMLYTLAQQKK
APERFGRLNKNGIPSQGIVATAIVLLVGVILNYLVPAKVFTWLTSISTFGAIWTWGIILVAQIKFRKSLPTQNKQKLSYK
MPLYPLSSYFSLAFLALVLCIMAYSEDTRIALIVGPIWLIGLAVVYYMKGFHKIDETPNSKIG

Sequences:

>Translated_463_residues
MQHTNKSGTLNRGLKERHITLMSLGSAIGVGLFLGSASAIKLAGPSILLGYMIAGLVIFFIMRALGEMAIEQPVAGSFSK
YAYDYLGPLAGYITGWNYWFLWVVTCMAEITAAGIYMQYWFPDIPRWTWALLALLLMSAFNFLSVKVFGELEFWFALIKI
VTIICMIVVGAGIILFGFGNGGIATGISNLWSHGGWFPNGFSGLLLSMQMVLFAYLGVELIGVTAGEAQNPKKTLAKAID
NVFWRILLFYVGALFVMMAIYPWNELGEKGSPFVLTFQQIGIAKAAGIINFVVLTAALSSCNGGLFSTGRMLYTLAQQKK
APERFGRLNKNGIPSQGIVATAIVLLVGVILNYLVPAKVFTWLTSISTFGAIWTWGIILVAQIKFRKSLPTQNKQKLSYK
MPLYPLSSYFSLAFLALVLCIMAYSEDTRIALIVGPIWLIGLAVVYYMKGFHKIDETPNSKIG
>Mature_463_residues
MQHTNKSGTLNRGLKERHITLMSLGSAIGVGLFLGSASAIKLAGPSILLGYMIAGLVIFFIMRALGEMAIEQPVAGSFSK
YAYDYLGPLAGYITGWNYWFLWVVTCMAEITAAGIYMQYWFPDIPRWTWALLALLLMSAFNFLSVKVFGELEFWFALIKI
VTIICMIVVGAGIILFGFGNGGIATGISNLWSHGGWFPNGFSGLLLSMQMVLFAYLGVELIGVTAGEAQNPKKTLAKAID
NVFWRILLFYVGALFVMMAIYPWNELGEKGSPFVLTFQQIGIAKAAGIINFVVLTAALSSCNGGLFSTGRMLYTLAQQKK
APERFGRLNKNGIPSQGIVATAIVLLVGVILNYLVPAKVFTWLTSISTFGAIWTWGIILVAQIKFRKSLPTQNKQKLSYK
MPLYPLSSYFSLAFLALVLCIMAYSEDTRIALIVGPIWLIGLAVVYYMKGFHKIDETPNSKIG

Specific function: Probable Amino-Acid Or Metabolite Transport Protein. [C]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Homo sapiens, GI110347453, Length=363, Percent_Identity=25.068870523416, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI258645169, Length=405, Percent_Identity=22.7160493827161, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI258614003, Length=406, Percent_Identity=23.1527093596059, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI258614005, Length=406, Percent_Identity=23.1527093596059, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI4507047, Length=444, Percent_Identity=22.7477477477477, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI114326544, Length=430, Percent_Identity=21.6279069767442, Blast_Score=73, Evalue=6e-13,
Organism=Homo sapiens, GI114326550, Length=430, Percent_Identity=21.6279069767442, Blast_Score=73, Evalue=6e-13,
Organism=Homo sapiens, GI181337167, Length=319, Percent_Identity=23.1974921630094, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI48994972, Length=461, Percent_Identity=48.8069414316703, Blast_Score=459, Evalue=1e-130,
Organism=Escherichia coli, GI1786602, Length=460, Percent_Identity=51.5217391304348, Blast_Score=442, Evalue=1e-125,
Organism=Escherichia coli, GI1786789, Length=437, Percent_Identity=45.0800915331808, Blast_Score=421, Evalue=1e-119,
Organism=Escherichia coli, GI1786302, Length=451, Percent_Identity=45.4545454545455, Blast_Score=412, Evalue=1e-116,
Organism=Escherichia coli, GI1790653, Length=451, Percent_Identity=44.3458980044346, Blast_Score=403, Evalue=1e-113,
Organism=Escherichia coli, GI87081708, Length=471, Percent_Identity=39.4904458598726, Blast_Score=333, Evalue=1e-92,
Organism=Escherichia coli, GI87081915, Length=433, Percent_Identity=40.4157043879908, Blast_Score=333, Evalue=1e-92,
Organism=Escherichia coli, GI1789017, Length=443, Percent_Identity=35.8916478555305, Blast_Score=301, Evalue=7e-83,
Organism=Escherichia coli, GI1788480, Length=432, Percent_Identity=37.962962962963, Blast_Score=297, Evalue=1e-81,
Organism=Escherichia coli, GI87081869, Length=472, Percent_Identity=22.0338983050847, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI2367353, Length=341, Percent_Identity=23.1671554252199, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17532491, Length=366, Percent_Identity=23.224043715847, Blast_Score=79, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17540018, Length=496, Percent_Identity=25.8064516129032, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6324061, Length=480, Percent_Identity=31.6666666666667, Blast_Score=249, Evalue=6e-67,
Organism=Saccharomyces cerevisiae, GI6324924, Length=447, Percent_Identity=33.7807606263982, Blast_Score=222, Evalue=8e-59,
Organism=Saccharomyces cerevisiae, GI6320772, Length=446, Percent_Identity=30.9417040358744, Blast_Score=221, Evalue=2e-58,
Organism=Saccharomyces cerevisiae, GI6322892, Length=433, Percent_Identity=32.5635103926097, Blast_Score=220, Evalue=4e-58,
Organism=Saccharomyces cerevisiae, GI6324990, Length=450, Percent_Identity=32, Blast_Score=204, Evalue=3e-53,
Organism=Saccharomyces cerevisiae, GI6324059, Length=440, Percent_Identity=30.6818181818182, Blast_Score=202, Evalue=1e-52,
Organism=Saccharomyces cerevisiae, GI6319824, Length=405, Percent_Identity=27.4074074074074, Blast_Score=189, Evalue=9e-49,
Organism=Saccharomyces cerevisiae, GI6321629, Length=409, Percent_Identity=28.361858190709, Blast_Score=188, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6324553, Length=397, Percent_Identity=31.2342569269521, Blast_Score=187, Evalue=4e-48,
Organism=Saccharomyces cerevisiae, GI6320717, Length=436, Percent_Identity=27.0642201834862, Blast_Score=186, Evalue=7e-48,
Organism=Saccharomyces cerevisiae, GI6320251, Length=430, Percent_Identity=28.3720930232558, Blast_Score=183, Evalue=4e-47,
Organism=Saccharomyces cerevisiae, GI6319542, Length=417, Percent_Identity=26.6187050359712, Blast_Score=173, Evalue=4e-44,
Organism=Saccharomyces cerevisiae, GI6321053, Length=429, Percent_Identity=27.7389277389277, Blast_Score=172, Evalue=7e-44,
Organism=Saccharomyces cerevisiae, GI6322967, Length=397, Percent_Identity=25.6926952141058, Blast_Score=170, Evalue=5e-43,
Organism=Saccharomyces cerevisiae, GI6319543, Length=412, Percent_Identity=25.9708737864078, Blast_Score=163, Evalue=6e-41,
Organism=Saccharomyces cerevisiae, GI6324981, Length=403, Percent_Identity=25.5583126550869, Blast_Score=148, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6319608, Length=450, Percent_Identity=26, Blast_Score=147, Evalue=3e-36,
Organism=Saccharomyces cerevisiae, GI6320364, Length=505, Percent_Identity=25.5445544554455, Blast_Score=129, Evalue=7e-31,
Organism=Drosophila melanogaster, GI221512776, Length=424, Percent_Identity=20.5188679245283, Blast_Score=83, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24666159, Length=424, Percent_Identity=20.5188679245283, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24668806, Length=342, Percent_Identity=24.2690058479532, Blast_Score=79, Evalue=7e-15,
Organism=Drosophila melanogaster, GI21356285, Length=342, Percent_Identity=24.2690058479532, Blast_Score=79, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24668802, Length=342, Percent_Identity=24.2690058479532, Blast_Score=79, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24667468, Length=349, Percent_Identity=22.9226361031519, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI161077963, Length=368, Percent_Identity=23.6413043478261, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI281366235, Length=360, Percent_Identity=25.5555555555556, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI116007820, Length=360, Percent_Identity=25.5555555555556, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI116007818, Length=332, Percent_Identity=26.2048192771084, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI85725152, Length=332, Percent_Identity=26.2048192771084, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 50840; Mature: 50840

Theoretical pI: Translated: 9.92; Mature: 9.92

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQHTNKSGTLNRGLKERHITLMSLGSAIGVGLFLGSASAIKLAGPSILLGYMIAGLVIFF
CCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHH
IMRALGEMAIEQPVAGSFSKYAYDYLGPLAGYITGWNYWFLWVVTCMAEITAAGIYMQYW
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
FPDIPRWTWALLALLLMSAFNFLSVKVFGELEFWFALIKIVTIICMIVVGAGIILFGFGN
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCC
GGIATGISNLWSHGGWFPNGFSGLLLSMQMVLFAYLGVELIGVTAGEAQNPKKTLAKAID
CCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHH
NVFWRILLFYVGALFVMMAIYPWNELGEKGSPFVLTFQQIGIAKAAGIINFVVLTAALSS
HHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHH
CNGGLFSTGRMLYTLAQQKKAPERFGRLNKNGIPSQGIVATAIVLLVGVILNYLVPAKVF
CCCCCCHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
TWLTSISTFGAIWTWGIILVAQIKFRKSLPTQNKQKLSYKMPLYPLSSYFSLAFLALVLC
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCEECCCCCCHHHHHHHHHHHHHHH
IMAYSEDTRIALIVGPIWLIGLAVVYYMKGFHKIDETPNSKIG
HHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MQHTNKSGTLNRGLKERHITLMSLGSAIGVGLFLGSASAIKLAGPSILLGYMIAGLVIFF
CCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHH
IMRALGEMAIEQPVAGSFSKYAYDYLGPLAGYITGWNYWFLWVVTCMAEITAAGIYMQYW
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
FPDIPRWTWALLALLLMSAFNFLSVKVFGELEFWFALIKIVTIICMIVVGAGIILFGFGN
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCC
GGIATGISNLWSHGGWFPNGFSGLLLSMQMVLFAYLGVELIGVTAGEAQNPKKTLAKAID
CCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHH
NVFWRILLFYVGALFVMMAIYPWNELGEKGSPFVLTFQQIGIAKAAGIINFVVLTAALSS
HHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHH
CNGGLFSTGRMLYTLAQQKKAPERFGRLNKNGIPSQGIVATAIVLLVGVILNYLVPAKVF
CCCCCCHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
TWLTSISTFGAIWTWGIILVAQIKFRKSLPTQNKQKLSYKMPLYPLSSYFSLAFLALVLC
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCEECCCCCCHHHHHHHHHHHHHHH
IMAYSEDTRIALIVGPIWLIGLAVVYYMKGFHKIDETPNSKIG
HHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377 [H]