Click here to switch to the map view.

The map label for this gene is lcoS [H]

Identifier: 222094404

GI number: 222094404

Start: 715731

End: 717122

Strand: Reverse

Name: lcoS [H]

Synonym: BCQ_0718

Alternate gene names: 222094404

Gene position: 717122-715731 (Counterclockwise)

Preceding gene: 222094405

Following gene: 222094402

Centisome position: 13.75

GC content: 34.99

Gene sequence:

>1392_bases
ATGAAGCGAATTTCTATTCAGCTCGGATTTTATTTTTTGATTGTTACACTTTTAATCGAAAGTGTTCTATTTGTCTCGCT
TTATTATAGTCTTGTCAACAATAGAGTAAATGAAGAAATGACAGCTTTATTAAAACGCGGAAATAGTCACAGAGATGTCC
TTGAAAAGTATTTTGATAAGCAAACAATCTCTCATGTTGCACTAATGGAATCCGAAGCCGAAACCACTGTTGTTATTACA
AATGCAAATAAGGAAGTACTAGCTAAATCCAATGAAATAAATACTACTATAAAAAAGCATATTGAAAAGATGCAAACACG
GACAGATCATGATGGAGCGATTATAGAGAATCACTGGAAAACATCTAATTATATATGTACGGTTAGTCCCATCATAGTAG
CTGGAAAACATGAGGGGTATGTGTATATGTTTCTTGGGACAGAATCTATTGAAAAGTTGGTGAATGGATTAACAAAACAA
TTCATTATCGCAGGTGCCATCACGTTTCTACTCACAGTCATTACCATTTTTCTTTTATCTCGGTTATTAACAAAACCATT
GTTACACATGAAACATGCCACTGAAAAAATGAGTAAAGGAGATTTATCAGTTTCATTAACGACTACTCGAAATGATGAAA
TTGGTGAACTAGCATCATCTATTCAAACACTCGCAAATGATTTACATTATATGAAAACAGAGCGAAGTGAATTTCTAGCA
AGTGTTGCTCATGAATTACGAACACCTTTGACATACGTAAGAGGTTACGCTGACATTGCTTTAAAAGAAACCACATCTCC
CAAGCAACGTTTACGATATTTATCTATTATAAAAGATGAGTCTGATTACATCACAAACTTAGTTCAAGATTTGTTCTCCC
TTGCACAAATGGAACAACATAACTTTTCTATTCAAGTAAAGGAAGTGCATTTACACACCTTCCTTACGCGTATATGTGAA
AAAGTAAACGCCATGTATAAAGAAAGGTACATTACAGTTTCTTTCTCTTGTCCTCCTACACTGCTAGTAAACTTAGATGA
ACAACGATTCGAACAAGTTGTGGTGAATATTTTAAATAACGCTTATAGACATTCAAAAGAGCATTCTCATATAAACATTT
CTGTTACAGAAGAAAATAAACGTATCTCCATTACAATGGAAGATGAAGGCGAAGGTATTCCGCTTGAAGACCTCCCTCAC
ATTTTCGACCGCTTTTATCGAGTTGATAAAGCGAGATCACGAGCTACAGGCGGAACTGGTTTAGGATTATCTATCGTGAA
AGAAATTGTAGAGCTGCACGGTGGGAATATTACTGTAACGAGCGAAGTTGATCACGGATCTTGCTTTATTATTTCATTGC
CATCTATACAAAAACACGACTACCATCAGTAG

Upstream 100 bases:

>100_bases
ATAAATTACGAAAAGTGAATTTCCCTATTGATGATCATTTAAAAACTGTGTACGGAGTTGGCTATCGATGGGTTGATACT
CTAGATTAAGGAGCAAAGCA

Downstream 100 bases:

>100_bases
TCGTGTTTCTTTATCATTTTACTTTATAATATAAGTTTACAAATTGCCCAAAACGTTTCGTATCCGTTAAAGTTAAATGA
ATTTCTGGGTTCTTGTCTTG

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MKRISIQLGFYFLIVTLLIESVLFVSLYYSLVNNRVNEEMTALLKRGNSHRDVLEKYFDKQTISHVALMESEAETTVVIT
NANKEVLAKSNEINTTIKKHIEKMQTRTDHDGAIIENHWKTSNYICTVSPIIVAGKHEGYVYMFLGTESIEKLVNGLTKQ
FIIAGAITFLLTVITIFLLSRLLTKPLLHMKHATEKMSKGDLSVSLTTTRNDEIGELASSIQTLANDLHYMKTERSEFLA
SVAHELRTPLTYVRGYADIALKETTSPKQRLRYLSIIKDESDYITNLVQDLFSLAQMEQHNFSIQVKEVHLHTFLTRICE
KVNAMYKERYITVSFSCPPTLLVNLDEQRFEQVVVNILNNAYRHSKEHSHINISVTEENKRISITMEDEGEGIPLEDLPH
IFDRFYRVDKARSRATGGTGLGLSIVKEIVELHGGNITVTSEVDHGSCFIISLPSIQKHDYHQ

Sequences:

>Translated_463_residues
MKRISIQLGFYFLIVTLLIESVLFVSLYYSLVNNRVNEEMTALLKRGNSHRDVLEKYFDKQTISHVALMESEAETTVVIT
NANKEVLAKSNEINTTIKKHIEKMQTRTDHDGAIIENHWKTSNYICTVSPIIVAGKHEGYVYMFLGTESIEKLVNGLTKQ
FIIAGAITFLLTVITIFLLSRLLTKPLLHMKHATEKMSKGDLSVSLTTTRNDEIGELASSIQTLANDLHYMKTERSEFLA
SVAHELRTPLTYVRGYADIALKETTSPKQRLRYLSIIKDESDYITNLVQDLFSLAQMEQHNFSIQVKEVHLHTFLTRICE
KVNAMYKERYITVSFSCPPTLLVNLDEQRFEQVVVNILNNAYRHSKEHSHINISVTEENKRISITMEDEGEGIPLEDLPH
IFDRFYRVDKARSRATGGTGLGLSIVKEIVELHGGNITVTSEVDHGSCFIISLPSIQKHDYHQ
>Mature_463_residues
MKRISIQLGFYFLIVTLLIESVLFVSLYYSLVNNRVNEEMTALLKRGNSHRDVLEKYFDKQTISHVALMESEAETTVVIT
NANKEVLAKSNEINTTIKKHIEKMQTRTDHDGAIIENHWKTSNYICTVSPIIVAGKHEGYVYMFLGTESIEKLVNGLTKQ
FIIAGAITFLLTVITIFLLSRLLTKPLLHMKHATEKMSKGDLSVSLTTTRNDEIGELASSIQTLANDLHYMKTERSEFLA
SVAHELRTPLTYVRGYADIALKETTSPKQRLRYLSIIKDESDYITNLVQDLFSLAQMEQHNFSIQVKEVHLHTFLTRICE
KVNAMYKERYITVSFSCPPTLLVNLDEQRFEQVVVNILNNAYRHSKEHSHINISVTEENKRISITMEDEGEGIPLEDLPH
IFDRFYRVDKARSRATGGTGLGLSIVKEIVELHGGNITVTSEVDHGSCFIISLPSIQKHDYHQ

Specific function: Member of the two-component regulatory system resD/resE involved in the global regulation of aerobic and anaerobic respiration. Probably phosphorylates resD [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=274, Percent_Identity=31.021897810219, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI1786600, Length=259, Percent_Identity=31.6602316602317, Blast_Score=132, Evalue=5e-32,
Organism=Escherichia coli, GI1786783, Length=348, Percent_Identity=27.8735632183908, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1786912, Length=253, Percent_Identity=30.4347826086957, Blast_Score=115, Evalue=5e-27,
Organism=Escherichia coli, GI1790346, Length=294, Percent_Identity=27.891156462585, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI145693157, Length=241, Percent_Identity=28.2157676348548, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1787894, Length=286, Percent_Identity=25.8741258741259, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1788713, Length=227, Percent_Identity=27.3127753303965, Blast_Score=109, Evalue=4e-25,
Organism=Escherichia coli, GI1790436, Length=216, Percent_Identity=30.0925925925926, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI48994928, Length=237, Percent_Identity=28.6919831223629, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI1789149, Length=222, Percent_Identity=28.3783783783784, Blast_Score=102, Evalue=6e-23,
Organism=Escherichia coli, GI87081816, Length=336, Percent_Identity=24.702380952381, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1788549, Length=221, Percent_Identity=31.6742081447964, Blast_Score=99, Evalue=7e-22,
Organism=Escherichia coli, GI87082128, Length=299, Percent_Identity=23.4113712374582, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1790861, Length=386, Percent_Identity=21.7616580310881, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1788279, Length=320, Percent_Identity=26.875, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1789403, Length=336, Percent_Identity=26.4880952380952, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1790551, Length=282, Percent_Identity=27.6595744680851, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1790300, Length=250, Percent_Identity=29.6, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1787374, Length=299, Percent_Identity=24.4147157190635, Blast_Score=75, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 52764; Mature: 52764

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRISIQLGFYFLIVTLLIESVLFVSLYYSLVNNRVNEEMTALLKRGNSHRDVLEKYFDK
CCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCHHHHHHHHHHH
QTISHVALMESEAETTVVITNANKEVLAKSNEINTTIKKHIEKMQTRTDHDGAIIENHWK
HHHHHHHHHCCCCCEEEEEECCCHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCEEECCCC
TSNYICTVSPIIVAGKHEGYVYMFLGTESIEKLVNGLTKQFIIAGAITFLLTVITIFLLS
CCCEEEEECEEEEEECCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLLTKPLLHMKHATEKMSKGDLSVSLTTTRNDEIGELASSIQTLANDLHYMKTERSEFLA
HHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SVAHELRTPLTYVRGYADIALKETTSPKQRLRYLSIIKDESDYITNLVQDLFSLAQMEQH
HHHHHHHCCHHHHCCHHHEEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHC
NFSIQVKEVHLHTFLTRICEKVNAMYKERYITVSFSCPPTLLVNLDEQRFEQVVVNILNN
CCEEEEEHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCEEEEECCHHHHHHHHHHHHHH
AYRHSKEHSHINISVTEENKRISITMEDEGEGIPLEDLPHIFDRFYRVDKARSRATGGTG
HHHCCCCCCEEEEEEEECCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
LGLSIVKEIVELHGGNITVTSEVDHGSCFIISLPSIQKHDYHQ
CCHHHHHHHHHHCCCCEEEEEECCCCCEEEEECCCCCCCCCCC
>Mature Secondary Structure
MKRISIQLGFYFLIVTLLIESVLFVSLYYSLVNNRVNEEMTALLKRGNSHRDVLEKYFDK
CCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCHHHHHHHHHHH
QTISHVALMESEAETTVVITNANKEVLAKSNEINTTIKKHIEKMQTRTDHDGAIIENHWK
HHHHHHHHHCCCCCEEEEEECCCHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCEEECCCC
TSNYICTVSPIIVAGKHEGYVYMFLGTESIEKLVNGLTKQFIIAGAITFLLTVITIFLLS
CCCEEEEECEEEEEECCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLLTKPLLHMKHATEKMSKGDLSVSLTTTRNDEIGELASSIQTLANDLHYMKTERSEFLA
HHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SVAHELRTPLTYVRGYADIALKETTSPKQRLRYLSIIKDESDYITNLVQDLFSLAQMEQH
HHHHHHHCCHHHHCCHHHEEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHC
NFSIQVKEVHLHTFLTRICEKVNAMYKERYITVSFSCPPTLLVNLDEQRFEQVVVNILNN
CCEEEEEHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCEEEEECCHHHHHHHHHHHHHH
AYRHSKEHSHINISVTEENKRISITMEDEGEGIPLEDLPHIFDRFYRVDKARSRATGGTG
HHHCCCCCCEEEEEEEECCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
LGLSIVKEIVELHGGNITVTSEVDHGSCFIISLPSIQKHDYHQ
CCHHHHHHHHHHCCCCEEEEEECCCCCEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7934829; 9384377; 8631715 [H]