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The map label for this gene is ciaH [H]

Identifier: 222094324

GI number: 222094324

Start: 626982

End: 628217

Strand: Direct

Name: ciaH [H]

Synonym: BCQ_0638

Alternate gene names: 222094324

Gene position: 626982-628217 (Clockwise)

Preceding gene: 222094323

Following gene: 222094325

Centisome position: 12.02

GC content: 35.36

Gene sequence:

>1236_bases
ATGTTTCAGAAGACGCGCATTCGATTGACTATATTGAATTCATTAGTATTTATCATTTTGATAGGCGTATTAGGTAGTAT
CATTTATTCTTACACATATAAGCGTATTTATAGTGGAGTAAATGAATCGATAGAAAAAGCCGTTCAACATAGAAAGAATG
CAGATGATAAAAAACTACCTAAAAAAATTAGGGGATATCCTCCAATTGGGGATCCAAGGATAATGGAGTTAACTTGGATA
GGAAACACAGTGGAGATAGGTGTTGAAAACGGTAAACGTCGTATTATCTTTGAAGACAATTTGGAAAAGTTTTCGCCAAA
GAAATTAGGGATTTTGCAAGATATAGAAGTGCAAGGACTATATTTTAGGACGTTTGTATTTCAACAAGATGGAAAAATAG
TTCAAATCGTACGCGATATAACAGCTGAAGAAGAAATGTTAAATACTTTATTTCTAATTCTTACTATAGGTTGTAGCATA
GGAAGCCTCTGTGCAATCGGTATCGGCTTTTTCCTAGCTGGTAGGGCACTCGTACCTATTCAAAATTCATGGGAAAAACA
GCAGCAATTCGTTTCTGATGCGTCACATGAACTAAGGACACCGCTTGCAGTTATTCAATCAAAAACGGATGTTTTATTCC
AGTCACCATCCGCTACGATAGAAGAAAAAGCGATGGATATTTCTACAATTTCAAAAGAATGTAGGCGGTTATCAAAACTC
GTTAGTAATTTATTATTGCTAGCACGCTCTGATTCTAATCAAATTGAGATGGATAAGAAAACATTTGAACTCGATAAATT
GTTAGAAGAAATAGTAGCTCCATATAAGGAGATTGCTTCTTATCAAGAAAAAGAAATGATATTAAAAGTAGAACGTGGCG
TATCTTTTATGGGTGATAGAGAGCGGATTCATCAAATGATGGTCATACTGTTAGATAATGCGATGAAGTATACGAACGAA
GGCGGTCATATTCAAATCAATTGCACGCAAACGAGTAGTTCAATTCGTATACAGGTGAAAGATGACGGGATAGGAGTGAA
AGAAGAAGATATTCCGAAATTATTTGATCGTTTTTATCAAGGGGATAAAGCAAGAAGTACGTCAGAAGGAGCTGGATTAG
GTCTTTCAATCGCAAATTGGATTGTAGAGAAACATTACGGAAAAATATCAGTAGAGAGCAAATGGGAAGAGGGCACTTGT
TTTGAAGTGATTTTCCCTAAACACCAAAGAATATAA

Upstream 100 bases:

>100_bases
ATCATTTACGTAAAAAATTAGAGCCATTCGGTTATCAGAAAGATATTCAAACCGTTCGAGGTATTGGATATATATTAAAA
GAACAATGAAAAAGGGAAGT

Downstream 100 bases:

>100_bases
GTGAGAAGACGATCTTGTTTTTACAAGGTCGTCTTTTTTTAAGGGAAAGTTAAGAAACTATTTTTAACATGTATTCTATA
CGGAAAGTTCGCCGCATGAA

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 411; Mature: 411

Protein sequence:

>411_residues
MFQKTRIRLTILNSLVFIILIGVLGSIIYSYTYKRIYSGVNESIEKAVQHRKNADDKKLPKKIRGYPPIGDPRIMELTWI
GNTVEIGVENGKRRIIFEDNLEKFSPKKLGILQDIEVQGLYFRTFVFQQDGKIVQIVRDITAEEEMLNTLFLILTIGCSI
GSLCAIGIGFFLAGRALVPIQNSWEKQQQFVSDASHELRTPLAVIQSKTDVLFQSPSATIEEKAMDISTISKECRRLSKL
VSNLLLLARSDSNQIEMDKKTFELDKLLEEIVAPYKEIASYQEKEMILKVERGVSFMGDRERIHQMMVILLDNAMKYTNE
GGHIQINCTQTSSSIRIQVKDDGIGVKEEDIPKLFDRFYQGDKARSTSEGAGLGLSIANWIVEKHYGKISVESKWEEGTC
FEVIFPKHQRI

Sequences:

>Translated_411_residues
MFQKTRIRLTILNSLVFIILIGVLGSIIYSYTYKRIYSGVNESIEKAVQHRKNADDKKLPKKIRGYPPIGDPRIMELTWI
GNTVEIGVENGKRRIIFEDNLEKFSPKKLGILQDIEVQGLYFRTFVFQQDGKIVQIVRDITAEEEMLNTLFLILTIGCSI
GSLCAIGIGFFLAGRALVPIQNSWEKQQQFVSDASHELRTPLAVIQSKTDVLFQSPSATIEEKAMDISTISKECRRLSKL
VSNLLLLARSDSNQIEMDKKTFELDKLLEEIVAPYKEIASYQEKEMILKVERGVSFMGDRERIHQMMVILLDNAMKYTNE
GGHIQINCTQTSSSIRIQVKDDGIGVKEEDIPKLFDRFYQGDKARSTSEGAGLGLSIANWIVEKHYGKISVESKWEEGTC
FEVIFPKHQRI
>Mature_411_residues
MFQKTRIRLTILNSLVFIILIGVLGSIIYSYTYKRIYSGVNESIEKAVQHRKNADDKKLPKKIRGYPPIGDPRIMELTWI
GNTVEIGVENGKRRIIFEDNLEKFSPKKLGILQDIEVQGLYFRTFVFQQDGKIVQIVRDITAEEEMLNTLFLILTIGCSI
GSLCAIGIGFFLAGRALVPIQNSWEKQQQFVSDASHELRTPLAVIQSKTDVLFQSPSATIEEKAMDISTISKECRRLSKL
VSNLLLLARSDSNQIEMDKKTFELDKLLEEIVAPYKEIASYQEKEMILKVERGVSFMGDRERIHQMMVILLDNAMKYTNE
GGHIQINCTQTSSSIRIQVKDDGIGVKEEDIPKLFDRFYQGDKARSTSEGAGLGLSIANWIVEKHYGKISVESKWEEGTC
FEVIFPKHQRI

Specific function: Member of the two-component regulatory system CiaH/CiaR. Involved in early steps of competence regulation and in penicillin susceptibility. Probably phosphorylates CiaR [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=232, Percent_Identity=31.8965517241379, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1786600, Length=223, Percent_Identity=29.1479820627803, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1786783, Length=228, Percent_Identity=29.8245614035088, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI1788279, Length=239, Percent_Identity=31.3807531380753, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI145693157, Length=228, Percent_Identity=28.9473684210526, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1789149, Length=229, Percent_Identity=27.9475982532751, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1786912, Length=221, Percent_Identity=29.8642533936652, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1790346, Length=247, Percent_Identity=27.1255060728745, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1790551, Length=238, Percent_Identity=26.4705882352941, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1790436, Length=276, Percent_Identity=23.5507246376812, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1788549, Length=220, Percent_Identity=27.2727272727273, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI87082128, Length=229, Percent_Identity=26.6375545851528, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI87081816, Length=225, Percent_Identity=25.7777777777778, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1787374, Length=226, Percent_Identity=26.5486725663717, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1790861, Length=224, Percent_Identity=25.4464285714286, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI1788713, Length=230, Percent_Identity=25.6521739130435, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI1789403, Length=201, Percent_Identity=28.3582089552239, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1789808, Length=220, Percent_Identity=26.8181818181818, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI48994928, Length=220, Percent_Identity=22.7272727272727, Blast_Score=68, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 46796; Mature: 46796

Theoretical pI: Translated: 7.88; Mature: 7.88

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFQKTRIRLTILNSLVFIILIGVLGSIIYSYTYKRIYSGVNESIEKAVQHRKNADDKKLP
CCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
KKIRGYPPIGDPRIMELTWIGNTVEIGVENGKRRIIFEDNLEKFSPKKLGILQDIEVQGL
HHHCCCCCCCCCEEEEEEEECCEEEEEECCCCEEEEECCCCCCCCCCCCCCEECCCCCCE
YFRTFVFQQDGKIVQIVRDITAEEEMLNTLFLILTIGCSIGSLCAIGIGFFLAGRALVPI
EEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCEEECC
QNSWEKQQQFVSDASHELRTPLAVIQSKTDVLFQSPSATIEEKAMDISTISKECRRLSKL
CCCHHHHHHHHHHHHHHHHCHHHHHHCCCHHEEECCCCHHHHHHHHHHHHHHHHHHHHHH
VSNLLLLARSDSNQIEMDKKTFELDKLLEEIVAPYKEIASYQEKEMILKVERGVSFMGDR
HHHHHHHCCCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCH
ERIHQMMVILLDNAMKYTNEGGHIQINCTQTSSSIRIQVKDDGIGVKEEDIPKLFDRFYQ
HHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCEEEEEEECCCCCCCHHHHHHHHHHHHC
GDKARSTSEGAGLGLSIANWIVEKHYGKISVESKWEEGTCFEVIFPKHQRI
CCCCCCCCCCCCCCHHHHHHHHHHHCCCEEECCCCCCCCEEEEECCCCCCC
>Mature Secondary Structure
MFQKTRIRLTILNSLVFIILIGVLGSIIYSYTYKRIYSGVNESIEKAVQHRKNADDKKLP
CCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
KKIRGYPPIGDPRIMELTWIGNTVEIGVENGKRRIIFEDNLEKFSPKKLGILQDIEVQGL
HHHCCCCCCCCCEEEEEEEECCEEEEEECCCCEEEEECCCCCCCCCCCCCCEECCCCCCE
YFRTFVFQQDGKIVQIVRDITAEEEMLNTLFLILTIGCSIGSLCAIGIGFFLAGRALVPI
EEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCEEECC
QNSWEKQQQFVSDASHELRTPLAVIQSKTDVLFQSPSATIEEKAMDISTISKECRRLSKL
CCCHHHHHHHHHHHHHHHHCHHHHHHCCCHHEEECCCCHHHHHHHHHHHHHHHHHHHHHH
VSNLLLLARSDSNQIEMDKKTFELDKLLEEIVAPYKEIASYQEKEMILKVERGVSFMGDR
HHHHHHHCCCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCH
ERIHQMMVILLDNAMKYTNEGGHIQINCTQTSSSIRIQVKDDGIGVKEEDIPKLFDRFYQ
HHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCEEEEEEECCCCCCCHHHHHHHHHHHHC
GDKARSTSEGAGLGLSIANWIVEKHYGKISVESKWEEGTCFEVIFPKHQRI
CCCCCCCCCCCCCCHHHHHHHHHHHCCCEEECCCCCCCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11463916 [H]