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The map label for this gene is serS [H]

Identifier: 222094107

GI number: 222094107

Start: 385314

End: 386597

Strand: Reverse

Name: serS [H]

Synonym: BCQ_0400

Alternate gene names: 222094107

Gene position: 386597-385314 (Counterclockwise)

Preceding gene: 222094111

Following gene: 222094094

Centisome position: 7.41

GC content: 30.53

Gene sequence:

>1284_bases
ATGTTAGACATTAATTTTATTAGAAATCACCAACAAGATCTAAGTTTAATTGCTAACCAAAAGGGGATTAATATTTCAAT
CGAGAGAATTATTCAACTAGATTTTGAAAGGAGAAAGCTAATTCATGATATCGAATTAGCTAGATTCACAAAAAAGAAAT
TATCTAATGATATGAAAGATTTTGTGTTAAAAGGCGATAATCAGCACCTAATAAAAAGTATAAAATTACAGATAGATGAA
ATTAATAAGTCATTAAAAGCTAATCAACAAAATTTAGAGTCTATATTAAATGAATACAATACACTAATGCTTTTAGTACC
TAATATTATTTCAAGCGATACACCTATCGGTCTTTCTGACAAAGATAATGTTGTTGTCAAAGAATGCGGAAGAAAACCTA
CGTTTACTTTCAGTATCAAAGATCACATTGAACTTGGACATTCATTAGACATCATTGATATAAAAAGAGGCGTGAAAGTA
GCTGGTACAAGGAATTATTACTTAAAAAATATGGGAGCTTCTCTACATAGAGCAGTTCAGCAACTAGCCATTGATCATTT
AATTCAAAAAGGCTTCACTCTTTTAGAAGTTCCTGCAATGGTTAATGAAGAAATGTTTATTAATACTGGATTTTTTCCAA
TTGGACAAGACCAAACCTATAAACTAGCAAACAGTAATAAATATTTAATAGGAACTTCTGAGGTACCTATCGTCTCCTAT
TATTCAAATGAATTCGTTAATATAGAAAAACCTATCAAATTAGCTGGAATATCAAATTGCTTTAGAAGTGAAGTAGGTGC
CGCTGGAAGGGATGTAAAAGGATTATATAGAGTTCATCAATTTAGTAAAGTTGAACAAGTTATTCTATGTGAAAATAATG
TTGAAAAGTCTAACCTTATTTTAGAAGAAATCACTCAAAATGCGGAAGAAATTCTACAGCTGCTCGAGCTTCCTTATCGT
GTTGTTTCTGTTTGTACAGGGGATATTGGACAGGGTGTTTTTAAAAAATATGATATTGAAACTTGGATGCCTAGCAGAAA
CAGTTATGGCGAAACACAATCTGCATCCAATTTATTGGACTTTCAATCTCGAAGATCTAAAATTAGATATAAAGATAATA
ATGGCGAAATAAAATACTGTCATACTTTAAATAATACAGCTATCGCGACACCAAGAATATTAATCCCCTTACTTGAAGTT
CATCAACAAGAAGATGGATCCATCTATATACCTAGAGCATTAAGAAAATACTTAAATAATCAAGAATACATCGAATCACG
TTAA

Upstream 100 bases:

>100_bases
TTTCATCTATAGTTTTGATTAAATATTACTTATTAATTTTAAATGCCTAAATCATAAATGATTCGATCAATTCAATGTAA
AAAAAGTGAGGTTTTTAATT

Downstream 100 bases:

>100_bases
TCATAATAATTAATGCTACTAAATCTAAATTTAGTAGCATTAATTATTATGATTCTTTTAATATACAACTTTTTTCAAAA
TATTCACTAGCAAGTTTGTA

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase [H]

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MLDINFIRNHQQDLSLIANQKGINISIERIIQLDFERRKLIHDIELARFTKKKLSNDMKDFVLKGDNQHLIKSIKLQIDE
INKSLKANQQNLESILNEYNTLMLLVPNIISSDTPIGLSDKDNVVVKECGRKPTFTFSIKDHIELGHSLDIIDIKRGVKV
AGTRNYYLKNMGASLHRAVQQLAIDHLIQKGFTLLEVPAMVNEEMFINTGFFPIGQDQTYKLANSNKYLIGTSEVPIVSY
YSNEFVNIEKPIKLAGISNCFRSEVGAAGRDVKGLYRVHQFSKVEQVILCENNVEKSNLILEEITQNAEEILQLLELPYR
VVSVCTGDIGQGVFKKYDIETWMPSRNSYGETQSASNLLDFQSRRSKIRYKDNNGEIKYCHTLNNTAIATPRILIPLLEV
HQQEDGSIYIPRALRKYLNNQEYIESR

Sequences:

>Translated_427_residues
MLDINFIRNHQQDLSLIANQKGINISIERIIQLDFERRKLIHDIELARFTKKKLSNDMKDFVLKGDNQHLIKSIKLQIDE
INKSLKANQQNLESILNEYNTLMLLVPNIISSDTPIGLSDKDNVVVKECGRKPTFTFSIKDHIELGHSLDIIDIKRGVKV
AGTRNYYLKNMGASLHRAVQQLAIDHLIQKGFTLLEVPAMVNEEMFINTGFFPIGQDQTYKLANSNKYLIGTSEVPIVSY
YSNEFVNIEKPIKLAGISNCFRSEVGAAGRDVKGLYRVHQFSKVEQVILCENNVEKSNLILEEITQNAEEILQLLELPYR
VVSVCTGDIGQGVFKKYDIETWMPSRNSYGETQSASNLLDFQSRRSKIRYKDNNGEIKYCHTLNNTAIATPRILIPLLEV
HQQEDGSIYIPRALRKYLNNQEYIESR
>Mature_427_residues
MLDINFIRNHQQDLSLIANQKGINISIERIIQLDFERRKLIHDIELARFTKKKLSNDMKDFVLKGDNQHLIKSIKLQIDE
INKSLKANQQNLESILNEYNTLMLLVPNIISSDTPIGLSDKDNVVVKECGRKPTFTFSIKDHIELGHSLDIIDIKRGVKV
AGTRNYYLKNMGASLHRAVQQLAIDHLIQKGFTLLEVPAMVNEEMFINTGFFPIGQDQTYKLANSNKYLIGTSEVPIVSY
YSNEFVNIEKPIKLAGISNCFRSEVGAAGRDVKGLYRVHQFSKVEQVILCENNVEKSNLILEEITQNAEEILQLLELPYR
VVSVCTGDIGQGVFKKYDIETWMPSRNSYGETQSASNLLDFQSRRSKIRYKDNNGEIKYCHTLNNTAIATPRILIPLLEV
HQQEDGSIYIPRALRKYLNNQEYIESR

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) [H]

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily [H]

Homologues:

Organism=Homo sapiens, GI8923421, Length=322, Percent_Identity=38.5093167701863, Blast_Score=234, Evalue=1e-61,
Organism=Homo sapiens, GI225579074, Length=322, Percent_Identity=38.5093167701863, Blast_Score=234, Evalue=1e-61,
Organism=Homo sapiens, GI16306548, Length=367, Percent_Identity=32.6975476839237, Blast_Score=193, Evalue=3e-49,
Organism=Escherichia coli, GI1787120, Length=438, Percent_Identity=34.703196347032, Blast_Score=275, Evalue=3e-75,
Organism=Caenorhabditis elegans, GI17539260, Length=368, Percent_Identity=35.8695652173913, Blast_Score=226, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI17542084, Length=343, Percent_Identity=31.4868804664723, Blast_Score=165, Evalue=4e-41,
Organism=Saccharomyces cerevisiae, GI6321799, Length=418, Percent_Identity=34.4497607655502, Blast_Score=226, Evalue=7e-60,
Organism=Saccharomyces cerevisiae, GI6320226, Length=442, Percent_Identity=32.579185520362, Blast_Score=209, Evalue=8e-55,
Organism=Drosophila melanogaster, GI24581334, Length=366, Percent_Identity=33.3333333333333, Blast_Score=208, Evalue=6e-54,
Organism=Drosophila melanogaster, GI17737985, Length=298, Percent_Identity=36.241610738255, Blast_Score=187, Evalue=1e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.11 [H]

Molecular weight: Translated: 48879; Mature: 48879

Theoretical pI: Translated: 7.92; Mature: 7.92

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDINFIRNHQQDLSLIANQKGINISIERIIQLDFERRKLIHDIELARFTKKKLSNDMKD
CCCCHHHHCCHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
FVLKGDNQHLIKSIKLQIDEINKSLKANQQNLESILNEYNTLMLLVPNIISSDTPIGLSD
HHCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCEEEEEECHHHCCCCCCCCCC
KDNVVVKECGRKPTFTFSIKDHIELGHSLDIIDIKRGVKVAGTRNYYLKNMGASLHRAVQ
CCCCHHHHCCCCCCEEEEEHHHHCCCCCEEEEEECCCEEEECCCCHHHHHCCHHHHHHHH
QLAIDHLIQKGFTLLEVPAMVNEEMFINTGFFPIGQDQTYKLANSNKYLIGTSEVPIVSY
HHHHHHHHHCCCEEEECHHHHCCCEEEECCCEECCCCCEEEEECCCEEEEECCCCCEEEE
YSNEFVNIEKPIKLAGISNCFRSEVGAAGRDVKGLYRVHQFSKVEQVILCENNVEKSNLI
CCCCEEECCCCEEHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHEEEEECCCCCHHHHH
LEEITQNAEEILQLLELPYRVVSVCTGDIGQGVFKKYDIETWMPSRNSYGETQSASNLLD
HHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHCCCCCCCCCCCHHHHHHHH
FQSRRSKIRYKDNNGEIKYCHTLNNTAIATPRILIPLLEVHQQEDGSIYIPRALRKYLNN
HHHHHCCEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCCCEEECHHHHHHCCC
QEYIESR
CHHHCCC
>Mature Secondary Structure
MLDINFIRNHQQDLSLIANQKGINISIERIIQLDFERRKLIHDIELARFTKKKLSNDMKD
CCCCHHHHCCHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
FVLKGDNQHLIKSIKLQIDEINKSLKANQQNLESILNEYNTLMLLVPNIISSDTPIGLSD
HHCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCEEEEEECHHHCCCCCCCCCC
KDNVVVKECGRKPTFTFSIKDHIELGHSLDIIDIKRGVKVAGTRNYYLKNMGASLHRAVQ
CCCCHHHHCCCCCCEEEEEHHHHCCCCCEEEEEECCCEEEECCCCHHHHHCCHHHHHHHH
QLAIDHLIQKGFTLLEVPAMVNEEMFINTGFFPIGQDQTYKLANSNKYLIGTSEVPIVSY
HHHHHHHHHCCCEEEECHHHHCCCEEEECCCEECCCCCEEEEECCCEEEEECCCCCEEEE
YSNEFVNIEKPIKLAGISNCFRSEVGAAGRDVKGLYRVHQFSKVEQVILCENNVEKSNLI
CCCCEEECCCCEEHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHEEEEECCCCCHHHHH
LEEITQNAEEILQLLELPYRVVSVCTGDIGQGVFKKYDIETWMPSRNSYGETQSASNLLD
HHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHCCCCCCCCCCCHHHHHHHH
FQSRRSKIRYKDNNGEIKYCHTLNNTAIATPRILIPLLEVHQQEDGSIYIPRALRKYLNN
HHHHHCCEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCCCEEECHHHHHHCCC
QEYIESR
CHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA