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The map label for this gene is purK [H]

Identifier: 222094048

GI number: 222094048

Start: 316414

End: 317499

Strand: Direct

Name: purK [H]

Synonym: BCQ_0341

Alternate gene names: 222094048

Gene position: 316414-317499 (Clockwise)

Preceding gene: 222094047

Following gene: 222094049

Centisome position: 6.07

GC content: 37.85

Gene sequence:

>1086_bases
ATGGCATTGGCAGCTAAGGAAATGGGATATAAAATTGCTGTTTTAGATCCTACAAAAAACTCACCATGTGCACAAGTTGC
TGATATTGAAATTGTTGCATCATATGACGATTTAAAAGCAATTCAGCATTTAGCCAACATTAGTGATGTTGTCACATATG
AATTTGAGAATATTGATTATAGATGTTTACAATGGCTTGAAAAGCATGCTTACTTACCGCAAGGCAGTCAGTTGTTAAGT
AAAACGCAAAATCGTTTTACTGAAAAGAATGCAATTGAAAAAGCGGGATTACCAGTAGCAACGTATAGATTGGTTCAAAC
TCAAGAGCAGCTTACTGAAGCAATCACTGAGTTATCATATCCTTCCGTCTTAAAAACAACGACAGGTGGATATGATGGGA
AAGGGCAAGTTGTTTTAAGAAGTGAAGCTGACGTTGATGAAGCGCGAAAGCTTGCGAATGCAGCAGAGTGTATTTTAGAG
AAATGGGTGCCTTTTGAAAAAGAAGTATCAGTTATCGTAATTCGTAGTGTAAGTGGTGAAACGAAAGTATTTCCGGTAGC
GGAAAATATTCATGTAAATAACATTTTACATGAATCCATCGTTCCAGCTCGCATTACAGAAGAACTTTCTCAAAAAGCAA
TTGCTTATGCACAAGTGCTCGCGGATGAACTAGAACTTGTGGGAACACTAGCGGTAGAGATGTTTGCTACAGCTGCTGGT
GAGATTTACATTAATGAATTGGCGCCAAGACCTCACAATTCAGGACACTATACACAGGATGCATGTGAAACGAGTCAATT
CGGTCAACATATTCGAGCAATCTGTAATTTACCTCTTGGAGAAACAAATTTGTTAAAACCAGTTGTCATGGTAAACATTT
TAGGCGAACATATAGAAGGGGTCCTAAGACAAGTGAATAGATTAACCGGGTGCTATTTACACTTGTATGGAAAAGAAGAA
GCAAAAGCGCAGCGAAAAATGGGGCATGTTAATATTTTAAATGATAATATTGAAGTCGCTCTAGAAAAAGCGAAGAGTTT
GCATATTTGGGACCATCAAGAACAACTGTTGGAGGGAAAAAGATGA

Upstream 100 bases:

>100_bases
TTGAAAAAGATGTGCGCGAAGGTAGTGAGTTAGTATGACGAGAATCATTTTACCTGGAAAAACAATCGGCATTATTGGAG
GCGGCCAGCTAGGAAGAATG

Downstream 100 bases:

>100_bases
TTAGTCGTTATACACGCCCAGAAATGGGTGCAATTTGGACGGAAGAGAACAAATTTAAAGCGTGGTTAGAAGTTGAGATT
TTAGCTTGTGAAGCATGGGC

Product: phosphoribosylaminoimidazole carboxylase ATPase subunit

Products: NA

Alternate protein names: N5-CAIR synthase; 5-(carboxyamino)imidazole ribonucleotide synthetase [H]

Number of amino acids: Translated: 361; Mature: 360

Protein sequence:

>361_residues
MALAAKEMGYKIAVLDPTKNSPCAQVADIEIVASYDDLKAIQHLANISDVVTYEFENIDYRCLQWLEKHAYLPQGSQLLS
KTQNRFTEKNAIEKAGLPVATYRLVQTQEQLTEAITELSYPSVLKTTTGGYDGKGQVVLRSEADVDEARKLANAAECILE
KWVPFEKEVSVIVIRSVSGETKVFPVAENIHVNNILHESIVPARITEELSQKAIAYAQVLADELELVGTLAVEMFATAAG
EIYINELAPRPHNSGHYTQDACETSQFGQHIRAICNLPLGETNLLKPVVMVNILGEHIEGVLRQVNRLTGCYLHLYGKEE
AKAQRKMGHVNILNDNIEVALEKAKSLHIWDHQEQLLEGKR

Sequences:

>Translated_361_residues
MALAAKEMGYKIAVLDPTKNSPCAQVADIEIVASYDDLKAIQHLANISDVVTYEFENIDYRCLQWLEKHAYLPQGSQLLS
KTQNRFTEKNAIEKAGLPVATYRLVQTQEQLTEAITELSYPSVLKTTTGGYDGKGQVVLRSEADVDEARKLANAAECILE
KWVPFEKEVSVIVIRSVSGETKVFPVAENIHVNNILHESIVPARITEELSQKAIAYAQVLADELELVGTLAVEMFATAAG
EIYINELAPRPHNSGHYTQDACETSQFGQHIRAICNLPLGETNLLKPVVMVNILGEHIEGVLRQVNRLTGCYLHLYGKEE
AKAQRKMGHVNILNDNIEVALEKAKSLHIWDHQEQLLEGKR
>Mature_360_residues
ALAAKEMGYKIAVLDPTKNSPCAQVADIEIVASYDDLKAIQHLANISDVVTYEFENIDYRCLQWLEKHAYLPQGSQLLSK
TQNRFTEKNAIEKAGLPVATYRLVQTQEQLTEAITELSYPSVLKTTTGGYDGKGQVVLRSEADVDEARKLANAAECILEK
WVPFEKEVSVIVIRSVSGETKVFPVAENIHVNNILHESIVPARITEELSQKAIAYAQVLADELELVGTLAVEMFATAAGE
IYINELAPRPHNSGHYTQDACETSQFGQHIRAICNLPLGETNLLKPVVMVNILGEHIEGVLRQVNRLTGCYLHLYGKEEA
KAQRKMGHVNILNDNIEVALEKAKSLHIWDHQEQLLEGKR

Specific function: Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) [H]

COG id: COG0026

COG function: function code F; Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Escherichia coli, GI1786733, Length=253, Percent_Identity=35.1778656126482, Blast_Score=153, Evalue=2e-38,
Organism=Escherichia coli, GI1788155, Length=365, Percent_Identity=25.4794520547945, Blast_Score=103, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6324702, Length=351, Percent_Identity=34.4729344729345, Blast_Score=194, Evalue=2e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006115
- InterPro:   IPR005875
- InterPro:   IPR011761
- InterPro:   IPR003135
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02222 ATP-grasp; PF03446 NAD_binding_2 [H]

EC number: =6.3.4.18 [H]

Molecular weight: Translated: 40210; Mature: 40079

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALAAKEMGYKIAVLDPTKNSPCAQVADIEIVASYDDLKAIQHLANISDVVTYEFENIDY
CCCCCHHCCCEEEEECCCCCCCCCEEECEEEEECHHHHHHHHHHHHHHHHEEEEECCCCH
RCLQWLEKHAYLPQGSQLLSKTQNRFTEKNAIEKAGLPVATYRLVQTQEQLTEAITELSY
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCC
PSVLKTTTGGYDGKGQVVLRSEADVDEARKLANAAECILEKWVPFEKEVSVIVIRSVSGE
CCHHHHCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCC
TKVFPVAENIHVNNILHESIVPARITEELSQKAIAYAQVLADELELVGTLAVEMFATAAG
CEEEEEECCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
EIYINELAPRPHNSGHYTQDACETSQFGQHIRAICNLPLGETNLLKPVVMVNILGEHIEG
CEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
VLRQVNRLTGCYLHLYGKEEAKAQRKMGHVNILNDNIEVALEKAKSLHIWDHQEQLLEGK
HHHHHHHHHCEEEEEECCHHHHHHHHCCCEEEECCCHHHHHHHHCCCCCCCCHHHHHCCC
R
C
>Mature Secondary Structure 
ALAAKEMGYKIAVLDPTKNSPCAQVADIEIVASYDDLKAIQHLANISDVVTYEFENIDY
CCCCHHCCCEEEEECCCCCCCCCEEECEEEEECHHHHHHHHHHHHHHHHEEEEECCCCH
RCLQWLEKHAYLPQGSQLLSKTQNRFTEKNAIEKAGLPVATYRLVQTQEQLTEAITELSY
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCC
PSVLKTTTGGYDGKGQVVLRSEADVDEARKLANAAECILEKWVPFEKEVSVIVIRSVSGE
CCHHHHCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCC
TKVFPVAENIHVNNILHESIVPARITEELSQKAIAYAQVLADELELVGTLAVEMFATAAG
CEEEEEECCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
EIYINELAPRPHNSGHYTQDACETSQFGQHIRAICNLPLGETNLLKPVVMVNILGEHIEG
CEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
VLRQVNRLTGCYLHLYGKEEAKAQRKMGHVNILNDNIEVALEKAKSLHIWDHQEQLLEGK
HHHHHHHHHCEEEEEECCHHHHHHHHCCCEEEECCCHHHHHHHHCCCCCCCCHHHHHCCC
R
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3036807; 9384377 [H]