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The map label for this gene is proC [H]

Identifier: 222093964

GI number: 222093964

Start: 200000

End: 200803

Strand: Reverse

Name: proC [H]

Synonym: BCQ_0220

Alternate gene names: 222093964

Gene position: 200803-200000 (Counterclockwise)

Preceding gene: 222093966

Following gene: 222093963

Centisome position: 3.85

GC content: 39.93

Gene sequence:

>804_bases
ATGCTAACTAAACATCGAATTCTATTTATTGGTGCTGGTCGTATGGCAGAAGCTATATTTTCCGGATTACTTAAAACAAG
CAAAGAATACATCGAAGAGATTATCGTTTCTAACCGAAGTAACGTAGAAAAGCTAGATCAATTACGAGCGCGATATAATG
TGTCTACTACAACAGATTGGAAGCAACATGTTACGTCTGTTGATACGATTGTTTTAGCAATGCCGCCTTCTGCACATGAA
GAATTATTAGCAGAGTTATCTCCGTTACTATCGAATCAACTTGTCGTAACGGTAGCTGCCGGCATCGGCCCATCTTATTT
AGAAGAAAGACTTCCTAAAGGAACGCCTGTTGCTTGGATTATGCCAAATACAGCTGCTGAAATTGGTAAGTCTATCTCCT
TATACACGATGGGACAATTCGTAAACGAGACTGATCAAGAAACCCTGCAATTGCTTTTAGGGGGCATTGGTACTTCGCAA
CTTTGTACCGAGGAAGAAGTTCATCAACTTACTGCAGTTACTGGAAGTGCACCAGCCTTCCTTTATTACTTTGCTGAAAG
TTTAATTGAAGCAACAAAAAGTTATGGAGTCGATGAAGCAACCGCAAAACACCTTGTCATTCAAATGATTTCTGGCTCTG
CTTCTATGCTTGAACAAACACAAGATCCAGCTAACCTCCGTGAACAAGTAACAACGCCAGGTGGTTCCACAGCTGAAGGT
CTCAAAGCTTTATATGAATATAATTTTTCAGAGGCAATTCAAAAAGCAGTAGAAGCAACAAACAAAAAAGCTAGGGGGAA
ATAA

Upstream 100 bases:

>100_bases
TTATCTATTCCATCTACAATAAGCCTTTTCTTTTTACAAAATTCTCTTAAAAATGGTATCGTTTTTTATAACATATCTCC
ACTAGAAAGGAATAGAGGAT

Downstream 100 bases:

>100_bases
TATGAATTTAACAAGTTTAAAAGACTATACAACATTACATAACGGTGTAAAAATGCCTTGGTTCGGTTTAGGTGTTTTTA
AAGTAGAAGATGGTTCAGAA

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase 2; P5CR 2 [H]

Number of amino acids: Translated: 267; Mature: 267

Protein sequence:

>267_residues
MLTKHRILFIGAGRMAEAIFSGLLKTSKEYIEEIIVSNRSNVEKLDQLRARYNVSTTTDWKQHVTSVDTIVLAMPPSAHE
ELLAELSPLLSNQLVVTVAAGIGPSYLEERLPKGTPVAWIMPNTAAEIGKSISLYTMGQFVNETDQETLQLLLGGIGTSQ
LCTEEEVHQLTAVTGSAPAFLYYFAESLIEATKSYGVDEATAKHLVIQMISGSASMLEQTQDPANLREQVTTPGGSTAEG
LKALYEYNFSEAIQKAVEATNKKARGK

Sequences:

>Translated_267_residues
MLTKHRILFIGAGRMAEAIFSGLLKTSKEYIEEIIVSNRSNVEKLDQLRARYNVSTTTDWKQHVTSVDTIVLAMPPSAHE
ELLAELSPLLSNQLVVTVAAGIGPSYLEERLPKGTPVAWIMPNTAAEIGKSISLYTMGQFVNETDQETLQLLLGGIGTSQ
LCTEEEVHQLTAVTGSAPAFLYYFAESLIEATKSYGVDEATAKHLVIQMISGSASMLEQTQDPANLREQVTTPGGSTAEG
LKALYEYNFSEAIQKAVEATNKKARGK
>Mature_267_residues
MLTKHRILFIGAGRMAEAIFSGLLKTSKEYIEEIIVSNRSNVEKLDQLRARYNVSTTTDWKQHVTSVDTIVLAMPPSAHE
ELLAELSPLLSNQLVVTVAAGIGPSYLEERLPKGTPVAWIMPNTAAEIGKSISLYTMGQFVNETDQETLQLLLGGIGTSQ
LCTEEEVHQLTAVTGSAPAFLYYFAESLIEATKSYGVDEATAKHLVIQMISGSASMLEQTQDPANLREQVTTPGGSTAEG
LKALYEYNFSEAIQKAVEATNKKARGK

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI198041662, Length=262, Percent_Identity=33.206106870229, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI21361454, Length=266, Percent_Identity=28.9473684210526, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI24797095, Length=266, Percent_Identity=28.1954887218045, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI24797097, Length=266, Percent_Identity=28.1954887218045, Blast_Score=92, Evalue=6e-19,
Organism=Escherichia coli, GI1786585, Length=268, Percent_Identity=28.3582089552239, Blast_Score=110, Evalue=9e-26,
Organism=Caenorhabditis elegans, GI17569021, Length=263, Percent_Identity=31.5589353612167, Blast_Score=125, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17540664, Length=276, Percent_Identity=30.4347826086957, Blast_Score=99, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6320861, Length=275, Percent_Identity=24.7272727272727, Blast_Score=81, Evalue=1e-16,
Organism=Drosophila melanogaster, GI21358587, Length=265, Percent_Identity=29.0566037735849, Blast_Score=112, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24648116, Length=270, Percent_Identity=30.3703703703704, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24647700, Length=166, Percent_Identity=30.1204819277108, Blast_Score=84, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 29054; Mature: 29054

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTKHRILFIGAGRMAEAIFSGLLKTSKEYIEEIIVSNRSNVEKLDQLRARYNVSTTTDW
CCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHH
KQHVTSVDTIVLAMPPSAHEELLAELSPLLSNQLVVTVAAGIGPSYLEERLPKGTPVAWI
HHHHHHHHEEEEECCCCHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHCCCCCCEEEE
MPNTAAEIGKSISLYTMGQFVNETDQETLQLLLGGIGTSQLCTEEEVHQLTAVTGSAPAF
CCCCHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHCCCCHHH
LYYFAESLIEATKSYGVDEATAKHLVIQMISGSASMLEQTQDPANLREQVTTPGGSTAEG
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHCCCCCCHHHH
LKALYEYNFSEAIQKAVEATNKKARGK
HHHHHHCCHHHHHHHHHHHHCHHCCCC
>Mature Secondary Structure
MLTKHRILFIGAGRMAEAIFSGLLKTSKEYIEEIIVSNRSNVEKLDQLRARYNVSTTTDW
CCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHH
KQHVTSVDTIVLAMPPSAHEELLAELSPLLSNQLVVTVAAGIGPSYLEERLPKGTPVAWI
HHHHHHHHEEEEECCCCHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHCCCCCCEEEE
MPNTAAEIGKSISLYTMGQFVNETDQETLQLLLGGIGTSQLCTEEEVHQLTAVTGSAPAF
CCCCHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHCCCCHHH
LYYFAESLIEATKSYGVDEATAKHLVIQMISGSASMLEQTQDPANLREQVTTPGGSTAEG
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHCCCCCCHHHH
LKALYEYNFSEAIQKAVEATNKKARGK
HHHHHHCCHHHHHHHHHHHHCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377; 11418582 [H]