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The map label for this gene is glmS [H]

Identifier: 222093927

GI number: 222093927

Start: 157698

End: 159500

Strand: Direct

Name: glmS [H]

Synonym: BCQ_0183

Alternate gene names: 222093927

Gene position: 157698-159500 (Clockwise)

Preceding gene: 222093926

Following gene: 222093928

Centisome position: 3.02

GC content: 39.27

Gene sequence:

>1803_bases
ATGTGTGGAATCGTAGGATTTATTGGAGAGCAAGATGCAAAGGAAATTTTATTAAAAGGTTTAGAAAAGCTAGAATATCG
TGGATATGATTCAGCAGGTATTGCAGTACAAGCAGAGAACGGTGTTGTTGTATACAAAGAAAAAGGCCGTATTGCAAAAC
TTCGCGAAATCGTAGATGAGAACGTAGCAACAAGCGTGGGGATCGGTCACACACGCTGGGCTACACATGGTGTTCCGAGC
AAAGTAAACGCGCATCCGCATCAAAGTACATCAAAGCGTTTTACACTAGTTCATAACGGTGTAATTGAAAACTATGAGTT
AGTGAAGAAGGAATATTTACAAGATGTAACGTTCGTAAGTGAAACGGATACAGAGGTTATCGTACAGCTTATGGAACAAC
AAGTGAGCACAGGACTAAGTGTAGAAGAAGCGTTCCGTAATACGCTATCTCTTTTACATGGCTCTTATGCAATCGGATTA
CTTGATGCTGAAAATCCAAACATGATTTATGTTGCTAAAAACAAAAGCCCGCTATTAGTAGGTGTTGGTGACAACTTTAA
TGTTGTGGCGAGCGACGCTATGGCGATGTTACAAGTTACAGATCAATTTATTGAATTAATGGATAAAGAAATTGTAATTG
TAACGAAAGAAAGTATTACAATTAAAAACTTACAAGGTGAAACGATTGAACGTGCACCGTTTACAGCGGAATTAGACGCA
AGTGATATTGAAAAAGGAACATACCCTCATTTCATGCTTAAAGAAATCGATGAGCAACCACTTGTTATCCGTAATATAAT
TCAAAAGTACCAAGATGAAAATGGCGAGATTGAATTAGATCAAGACATCCGCAATGCGATTTTAGATAGCGATCGTATTT
ACATCATTGCATGTGGAACAAGTTATCATGCAGGTCTTGTTGGAAAACAATTTATCGAGAAGTTTGCAAAAATGCCAGTT
GAAGTGCATGTAGCAAGTGAATTCTCTTATAACATGCCATTATTAACAGAAAGACCATTCTTCATTTACATTTCACAAAG
TGGTGAAACAGCTGATAGCCGTGCAGTACTTGTACAAACAAATGAAATGGGTCATAAAGCATTAACAATTACAAACGTAC
CTGGTTCTACACTTTCTCGTGAAGCGGATTATACACTTCCGTTATACGCGGGACCAGAAATCGCCGTTGCATCAACGAAA
GCTTACACAGCACAGCTTGCAGTACTTTCAATTTTAGCTGCAGATATTGCTAAAGCAAAAGGTGAAGTTCTTGGTTTTGA
CTTAACACACGAACTAGGACTTGTAGCAAATGCAATGGTACAACTTTGTGATCAAAAAGAAGAAATGGACGCATTAGCAA
AACAATTTTTAGCAACAACTCGTAACTGTTTCTTCATCGGACGTAGCGTAGACTTCTACGTAGGATTAGAAGGAGCGTTA
AAGCTAAAAGAAATCTCTTACATCCAAGCAGAAGGATTTGCTGGAGGAGAATTAAAACACGGTACAATCGCCTTAATCGA
AAACGGTACACCAGTTATCGCACTTGCTACACAAGAACACGTAAACCTTGGAATTCGTGGTAACGTGAAAGAAGTAGTAG
CACGCGGAGCTAACCCATGTATCATCTCAATGAAAGGCTTAGAAATGGAAGGTGACAGCTTCGTATTACCAGCTGTACAC
GAAGCACTAGCACCGCTAGTAGCAGTTATTCCATTACAACTTATCTCATACTACGCAGCACTTCACCGCGAGTGTGACGT
TGATAAGCCACGTAACTTAGCTAAGTCTGTTACGGTTGAGTAG

Upstream 100 bases:

>100_bases
AGCAATATGTAATCCGTTTTTTAGTATAAATAAAAATGGTATCGGACTATGTCGTTACATGTTCGCAGAGCAGTGTAAGC
ATTTGTAACGGCGACTAAAC

Downstream 100 bases:

>100_bases
GAGATTAGTAGGTTAGTAAATATAGTGTAGTTTTGAAATAAAGTTAAGACGTTTATAAAAAAGGTGCGATGCTTTATCTC
TTTAATTAAAGAATTGTAAA

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 600; Mature: 600

Protein sequence:

>600_residues
MCGIVGFIGEQDAKEILLKGLEKLEYRGYDSAGIAVQAENGVVVYKEKGRIAKLREIVDENVATSVGIGHTRWATHGVPS
KVNAHPHQSTSKRFTLVHNGVIENYELVKKEYLQDVTFVSETDTEVIVQLMEQQVSTGLSVEEAFRNTLSLLHGSYAIGL
LDAENPNMIYVAKNKSPLLVGVGDNFNVVASDAMAMLQVTDQFIELMDKEIVIVTKESITIKNLQGETIERAPFTAELDA
SDIEKGTYPHFMLKEIDEQPLVIRNIIQKYQDENGEIELDQDIRNAILDSDRIYIIACGTSYHAGLVGKQFIEKFAKMPV
EVHVASEFSYNMPLLTERPFFIYISQSGETADSRAVLVQTNEMGHKALTITNVPGSTLSREADYTLPLYAGPEIAVASTK
AYTAQLAVLSILAADIAKAKGEVLGFDLTHELGLVANAMVQLCDQKEEMDALAKQFLATTRNCFFIGRSVDFYVGLEGAL
KLKEISYIQAEGFAGGELKHGTIALIENGTPVIALATQEHVNLGIRGNVKEVVARGANPCIISMKGLEMEGDSFVLPAVH
EALAPLVAVIPLQLISYYAALHRECDVDKPRNLAKSVTVE

Sequences:

>Translated_600_residues
MCGIVGFIGEQDAKEILLKGLEKLEYRGYDSAGIAVQAENGVVVYKEKGRIAKLREIVDENVATSVGIGHTRWATHGVPS
KVNAHPHQSTSKRFTLVHNGVIENYELVKKEYLQDVTFVSETDTEVIVQLMEQQVSTGLSVEEAFRNTLSLLHGSYAIGL
LDAENPNMIYVAKNKSPLLVGVGDNFNVVASDAMAMLQVTDQFIELMDKEIVIVTKESITIKNLQGETIERAPFTAELDA
SDIEKGTYPHFMLKEIDEQPLVIRNIIQKYQDENGEIELDQDIRNAILDSDRIYIIACGTSYHAGLVGKQFIEKFAKMPV
EVHVASEFSYNMPLLTERPFFIYISQSGETADSRAVLVQTNEMGHKALTITNVPGSTLSREADYTLPLYAGPEIAVASTK
AYTAQLAVLSILAADIAKAKGEVLGFDLTHELGLVANAMVQLCDQKEEMDALAKQFLATTRNCFFIGRSVDFYVGLEGAL
KLKEISYIQAEGFAGGELKHGTIALIENGTPVIALATQEHVNLGIRGNVKEVVARGANPCIISMKGLEMEGDSFVLPAVH
EALAPLVAVIPLQLISYYAALHRECDVDKPRNLAKSVTVE
>Mature_600_residues
MCGIVGFIGEQDAKEILLKGLEKLEYRGYDSAGIAVQAENGVVVYKEKGRIAKLREIVDENVATSVGIGHTRWATHGVPS
KVNAHPHQSTSKRFTLVHNGVIENYELVKKEYLQDVTFVSETDTEVIVQLMEQQVSTGLSVEEAFRNTLSLLHGSYAIGL
LDAENPNMIYVAKNKSPLLVGVGDNFNVVASDAMAMLQVTDQFIELMDKEIVIVTKESITIKNLQGETIERAPFTAELDA
SDIEKGTYPHFMLKEIDEQPLVIRNIIQKYQDENGEIELDQDIRNAILDSDRIYIIACGTSYHAGLVGKQFIEKFAKMPV
EVHVASEFSYNMPLLTERPFFIYISQSGETADSRAVLVQTNEMGHKALTITNVPGSTLSREADYTLPLYAGPEIAVASTK
AYTAQLAVLSILAADIAKAKGEVLGFDLTHELGLVANAMVQLCDQKEEMDALAKQFLATTRNCFFIGRSVDFYVGLEGAL
KLKEISYIQAEGFAGGELKHGTIALIENGTPVIALATQEHVNLGIRGNVKEVVARGANPCIISMKGLEMEGDSFVLPAVH
EALAPLVAVIPLQLISYYAALHRECDVDKPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI205277386, Length=684, Percent_Identity=33.3333333333333, Blast_Score=326, Evalue=3e-89,
Organism=Homo sapiens, GI4826742, Length=686, Percent_Identity=33.0903790087464, Blast_Score=325, Evalue=6e-89,
Organism=Escherichia coli, GI1790167, Length=613, Percent_Identity=41.9249592169657, Blast_Score=456, Evalue=1e-129,
Organism=Escherichia coli, GI87082251, Length=310, Percent_Identity=22.9032258064516, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI1788651, Length=242, Percent_Identity=27.2727272727273, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17532899, Length=721, Percent_Identity=29.126213592233, Blast_Score=258, Evalue=5e-69,
Organism=Caenorhabditis elegans, GI17539970, Length=436, Percent_Identity=35.7798165137615, Blast_Score=227, Evalue=1e-59,
Organism=Caenorhabditis elegans, GI17532897, Length=445, Percent_Identity=34.1573033707865, Blast_Score=215, Evalue=5e-56,
Organism=Saccharomyces cerevisiae, GI6322745, Length=428, Percent_Identity=33.8785046728972, Blast_Score=228, Evalue=2e-60,
Organism=Saccharomyces cerevisiae, GI6323731, Length=391, Percent_Identity=29.6675191815857, Blast_Score=159, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6323730, Length=205, Percent_Identity=36.5853658536585, Blast_Score=112, Evalue=2e-25,
Organism=Drosophila melanogaster, GI21357745, Length=694, Percent_Identity=32.9971181556196, Blast_Score=337, Evalue=2e-92,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 65751; Mature: 65751

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGFIGEQDAKEILLKGLEKLEYRGYDSAGIAVQAENGVVVYKEKGRIAKLREIVDE
CCCEEECCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEECCCEEEEECCCCHHHHHHHHHH
NVATSVGIGHTRWATHGVPSKVNAHPHQSTSKRFTLVHNGVIENYELVKKEYLQDVTFVS
HHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHEEC
ETDTEVIVQLMEQQVSTGLSVEEAFRNTLSLLHGSYAIGLLDAENPNMIYVAKNKSPLLV
CCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEECCCCCEEE
GVGDNFNVVASDAMAMLQVTDQFIELMDKEIVIVTKESITIKNLQGETIERAPFTAELDA
ECCCCCCEEHHHHHHHHHHHHHHHHHCCCCEEEEEECCEEEECCCCCCEECCCCEEECCH
SDIEKGTYPHFMLKEIDEQPLVIRNIIQKYQDENGEIELDQDIRNAILDSDRIYIIACGT
HHCCCCCCCHHHHHHCCCCCHHHHHHHHHHCCCCCCEEECHHHHHHHCCCCCEEEEEECC
SYHAGLVGKQFIEKFAKMPVEVHVASEFSYNMPLLTERPFFIYISQSGETADSRAVLVQT
CCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCEEECCCEEEEEECCCCCCCCCEEEEEE
NEMGHKALTITNVPGSTLSREADYTLPLYAGPEIAVASTKAYTAQLAVLSILAADIAKAK
CCCCCEEEEEECCCCCCCCCCCCCEEEEECCCCEEEECCHHHHHHHHHHHHHHHHHHHCC
GEVLGFDLTHELGLVANAMVQLCDQKEEMDALAKQFLATTRNCFFIGRSVDFYVGLEGAL
CCEEEEEHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEEEECCEEEEEECCCCE
KLKEISYIQAEGFAGGELKHGTIALIENGTPVIALATQEHVNLGIRGNVKEVVARGANPC
EEEHEEEEEECCCCCCCCCCCEEEEEECCCCEEEEEEHHHEEECCCCCHHHHHHCCCCCE
IISMKGLEMEGDSFVLPAVHEALAPLVAVIPLQLISYYAALHRECDVDKPRNLAKSVTVE
EEEEECCEECCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCC
>Mature Secondary Structure
MCGIVGFIGEQDAKEILLKGLEKLEYRGYDSAGIAVQAENGVVVYKEKGRIAKLREIVDE
CCCEEECCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEECCCEEEEECCCCHHHHHHHHHH
NVATSVGIGHTRWATHGVPSKVNAHPHQSTSKRFTLVHNGVIENYELVKKEYLQDVTFVS
HHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHEEC
ETDTEVIVQLMEQQVSTGLSVEEAFRNTLSLLHGSYAIGLLDAENPNMIYVAKNKSPLLV
CCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEECCCCCEEE
GVGDNFNVVASDAMAMLQVTDQFIELMDKEIVIVTKESITIKNLQGETIERAPFTAELDA
ECCCCCCEEHHHHHHHHHHHHHHHHHCCCCEEEEEECCEEEECCCCCCEECCCCEEECCH
SDIEKGTYPHFMLKEIDEQPLVIRNIIQKYQDENGEIELDQDIRNAILDSDRIYIIACGT
HHCCCCCCCHHHHHHCCCCCHHHHHHHHHHCCCCCCEEECHHHHHHHCCCCCEEEEEECC
SYHAGLVGKQFIEKFAKMPVEVHVASEFSYNMPLLTERPFFIYISQSGETADSRAVLVQT
CCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCEEECCCEEEEEECCCCCCCCCEEEEEE
NEMGHKALTITNVPGSTLSREADYTLPLYAGPEIAVASTKAYTAQLAVLSILAADIAKAK
CCCCCEEEEEECCCCCCCCCCCCCEEEEECCCCEEEECCHHHHHHHHHHHHHHHHHHHCC
GEVLGFDLTHELGLVANAMVQLCDQKEEMDALAKQFLATTRNCFFIGRSVDFYVGLEGAL
CCEEEEEHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEEEECCEEEEEECCCCE
KLKEISYIQAEGFAGGELKHGTIALIENGTPVIALATQEHVNLGIRGNVKEVVARGANPC
EEEHEEEEEECCCCCCCCCCCEEEEEECCCCEEEEEEHHHEEECCCCCHHHHHHCCCCCE
IISMKGLEMEGDSFVLPAVHEALAPLVAVIPLQLISYYAALHRECDVDKPRNLAKSVTVE
EEEEECCEECCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12721629 [H]