Click here to switch to the map view.

The map label for this gene is holB [H]

Identifier: 222093801

GI number: 222093801

Start: 36449

End: 37381

Strand: Direct

Name: holB [H]

Synonym: BCQ_0038

Alternate gene names: 222093801

Gene position: 36449-37381 (Clockwise)

Preceding gene: 222093800

Following gene: 222093802

Centisome position: 0.7

GC content: 36.66

Gene sequence:

>933_bases
ATGTTGATGAATAGCATCGCAAAAGAGCGTATATCCCACGCTTACTTGTTAGAGGGAGGGAAAGGGACGGGAAAGTTTGC
GACAGCAATTCAAATGGCAAAGAGTTTCCTCTGTTCTCAGCGGAATGGGGTAGAACCTTGTCATGTATGTACAAATTGTA
AGCGAATTGATTCAGGTAACCACCCAAACTTACATATTGTAAAACCAGACGGATTATCTATTAAGAAGCAGCAAATTCAT
GATTTACAAGAAGAGTTTTCCAAAACAGGATTAGAAGCAAATAAAAAAGTATATGTTATTGAGCACGCAGACCGTATGAC
GGCAAACGCAGCGAATACACTGTTGAAATTTTTAGAAGAACCAAGTAGTGATACAACAGCTATTCTACTTACTGAACAAA
GTCATCAAATTTTAAATACGATTTTATCTCGCTGTCAAGTTGTTACATTTAGACCGTTACCTACGGAATCTTTAATTAGA
AGATTACAGGATGAAGGTATTACGGCATCTTTATCAACACTTGCTGCACAACTTACGAATAGTTTTGATGAAGCTTTAGC
TTTATGTAGTGATGAATGGTTTGCACAAGCACGAGCTTTAGTGATAAAATTATGTGAAGCGCTCGAAAAAGATAAAGCCT
CTATTTTTTTTGTACAAGAAAAATGGGGAAAACACTTTAGAGAGAAAGAGCAATTACAGCAAGGTTTAGATATGTTACTC
CTTATTTATAAGGATTTATTATATGTTCAACTTGGAGAAGAAGATCGTCTTGTTTTTCATGAGCAGAAAGAGATGTTTGA
ATCTTTCTCCTACGCTCAGAAGCGCATTGTATCAGCTCTCTTTAATATATTAGAGGCAAAAAATAGAATCAACGCTAATG
TAAATGCGCAGCTTGTGTTCGAACAGTTAGTGTTGCGGTTGCAGGAGGGATGA

Upstream 100 bases:

>100_bases
ATAAATTGTTATAATAGAAGGAAAGAATGAAATAAGTGAGGTATGCATTATGATGAAGACGTGGGAGCAGCTTTCTGCTA
TACAACCCATCGGTGTAAAA

Downstream 100 bases:

>100_bases
CCGTTTTGTATGATGTAGTAGGTGTTCGCTTTAAGAAGGCCGGAAAGGTGTATTACTTTGATCCGAATCAGTTCGATATC
TCTGAAAATGAGTTTGTAAT

Product: DNA polymerase iii subunit delta'

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 310; Mature: 310

Protein sequence:

>310_residues
MLMNSIAKERISHAYLLEGGKGTGKFATAIQMAKSFLCSQRNGVEPCHVCTNCKRIDSGNHPNLHIVKPDGLSIKKQQIH
DLQEEFSKTGLEANKKVYVIEHADRMTANAANTLLKFLEEPSSDTTAILLTEQSHQILNTILSRCQVVTFRPLPTESLIR
RLQDEGITASLSTLAAQLTNSFDEALALCSDEWFAQARALVIKLCEALEKDKASIFFVQEKWGKHFREKEQLQQGLDMLL
LIYKDLLYVQLGEEDRLVFHEQKEMFESFSYAQKRIVSALFNILEAKNRINANVNAQLVFEQLVLRLQEG

Sequences:

>Translated_310_residues
MLMNSIAKERISHAYLLEGGKGTGKFATAIQMAKSFLCSQRNGVEPCHVCTNCKRIDSGNHPNLHIVKPDGLSIKKQQIH
DLQEEFSKTGLEANKKVYVIEHADRMTANAANTLLKFLEEPSSDTTAILLTEQSHQILNTILSRCQVVTFRPLPTESLIR
RLQDEGITASLSTLAAQLTNSFDEALALCSDEWFAQARALVIKLCEALEKDKASIFFVQEKWGKHFREKEQLQQGLDMLL
LIYKDLLYVQLGEEDRLVFHEQKEMFESFSYAQKRIVSALFNILEAKNRINANVNAQLVFEQLVLRLQEG
>Mature_310_residues
MLMNSIAKERISHAYLLEGGKGTGKFATAIQMAKSFLCSQRNGVEPCHVCTNCKRIDSGNHPNLHIVKPDGLSIKKQQIH
DLQEEFSKTGLEANKKVYVIEHADRMTANAANTLLKFLEEPSSDTTAILLTEQSHQILNTILSRCQVVTFRPLPTESLIR
RLQDEGITASLSTLAAQLTNSFDEALALCSDEWFAQARALVIKLCEALEKDKASIFFVQEKWGKHFREKEQLQQGLDMLL
LIYKDLLYVQLGEEDRLVFHEQKEMFESFSYAQKRIVSALFNILEAKNRINANVNAQLVFEQLVLRLQEG

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria [H]

COG id: COG0470

COG function: function code L; ATPase involved in DNA replication

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786676, Length=145, Percent_Identity=34.4827586206897, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1787341, Length=213, Percent_Identity=30.0469483568075, Blast_Score=69, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004622 [H]

Pfam domain/function: NA

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 35141; Mature: 35141

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLMNSIAKERISHAYLLEGGKGTGKFATAIQMAKSFLCSQRNGVEPCHVCTNCKRIDSGN
CCHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHCCCHHCCCCC
HPNLHIVKPDGLSIKKQQIHDLQEEFSKTGLEANKKVYVIEHADRMTANAANTLLKFLEE
CCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHC
PSSDTTAILLTEQSHQILNTILSRCQVVTFRPLPTESLIRRLQDEGITASLSTLAAQLTN
CCCCCEEEEEECCHHHHHHHHHHHCEEEEECCCCHHHHHHHHHHCCCHHHHHHHHHHHHH
SFDEALALCSDEWFAQARALVIKLCEALEKDKASIFFVQEKWGKHFREKEQLQQGLDMLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHH
LIYKDLLYVQLGEEDRLVFHEQKEMFESFSYAQKRIVSALFNILEAKNRINANVNAQLVF
HHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
EQLVLRLQEG
HHHHHHHCCC
>Mature Secondary Structure
MLMNSIAKERISHAYLLEGGKGTGKFATAIQMAKSFLCSQRNGVEPCHVCTNCKRIDSGN
CCHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHCCCHHCCCCC
HPNLHIVKPDGLSIKKQQIHDLQEEFSKTGLEANKKVYVIEHADRMTANAANTLLKFLEE
CCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHC
PSSDTTAILLTEQSHQILNTILSRCQVVTFRPLPTESLIRRLQDEGITASLSTLAAQLTN
CCCCCEEEEEECCHHHHHHHHHHHCEEEEECCCCHHHHHHHHHHCCCHHHHHHHHHHHHH
SFDEALALCSDEWFAQARALVIKLCEALEKDKASIFFVQEKWGKHFREKEQLQQGLDMLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHH
LIYKDLLYVQLGEEDRLVFHEQKEMFESFSYAQKRIVSALFNILEAKNRINANVNAQLVF
HHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
EQLVLRLQEG
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377 [H]