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The map label for this gene is guaB [H]

Identifier: 222093782

GI number: 222093782

Start: 15476

End: 16939

Strand: Direct

Name: guaB [H]

Synonym: BCQ_0014

Alternate gene names: 222093782

Gene position: 15476-16939 (Clockwise)

Preceding gene: 222093780

Following gene: 222093783

Centisome position: 0.3

GC content: 38.59

Gene sequence:

>1464_bases
ATGTGGGAATCTAAATTTGTTAAAGAAGGTTTGACTTTTGATGACGTATTACTTGTACCAGCAAAGTCAGATGTACTACC
AAGAGAAGTAAGTGTTAAAACAGTTTTATCTGAAAGCTTACAGTTAAACATCCCGTTAATTAGTGCAGGAATGGATACAG
TAACAGAAGCGGATATGGCTATTGCAATGGCTCGTCAAGGCGGTTTAGGAATTATTCATAAAAATATGTCTATTGAACAA
CAAGCCGAGCAGGTTGATAAAGTAAAACGTTCTGAAAGTGGTGTTATTTCAGATCCTTTCTTTTTAACTCCAGAACATCA
AGTGTATGATGCAGAGCACCTTATGGGGAAATATCGTATCTCAGGTGTACCGGTTGTAAATAATTTAGACGAGCGAAAAT
TAGTTGGTATTATTACAAACCGTGATATGCGTTTTATCCAAGACTACTCAATCAAAATTTCCGACGTAATGACAAAAGAA
CAGCTAATTACAGCTCCAGTTGGTACAACGCTAGATGAGGCTGAAAAGATCCTACAAAAGTATAAAATTGAAAAACTCCC
TCTTGTTGATAACAACGGTGTATTACAAGGGCTTATTACAATAAAAGATATTGAAAAAGTAATTGAATTCCCAAATTCTG
CGAAGGATAAGCAAGGGCGCTTATTAGTTGGAGCAGCAGTTGGTGTAACGGCTGATGCTATGACTCGCATTGACGCATTA
GTAAAAGCTAGCGTAGATGCAATCGTACTTGATACAGCCCATGGACATTCTCAAGGCGTTATTGATAAAGTAAAAGAAGT
TCGTGCAAAGTATCCATCATTAAATATTATCGCTGGAAATGTTGCTACTGCTGAAGCAACAGGAGCATTAATTGAAGCAG
GGGCAAACGTAGTTAAAGTTGGTATTGGACCAGGCTCTATCTGTACAACACGTGTTGTAGCTGGGGTTGGTGTACCACAA
TTAACAGCGGTTTATGATTGTGCAACAGAAGCTCGTAAACACGGTATCCCAGTTATCGCTGACGGTGGTATTAAGTACTC
TGGTGATATGGTTAAAGCTTTAGCAGCAGGAGCACATGTTGTTATGCTAGGTAGTATGTTTGCTGGTGTTGCTGAAAGTC
CTGGTGAAACTGAAATTTATCAAGGTCGCCAATTTAAAGTATATCGTGGTATGGGTTCTGTCGGAGCGATGGAAAAAGGA
AGTAAAGATCGTTATTTCCAAGAAGGAAATAAAAAACTTGTTCCAGAAGGTATTGAAGGACGAGTACCATATAAAGGACC
TTTAGCAGATACAGTTCATCAATTAGTTGGTGGATTACGTGCAGGTATGGGATATTGCGGAGCACAAGATTTAGAATTCT
TACGTGAGAATGCACAATTTGTTCGTATGTCAGGTGCTGGTTTACTTGAAAGTCATCCTCATCACGTACAAATTACAAAA
GAGGCTCCAAACTACTCATTATAA

Upstream 100 bases:

>100_bases
TATTGTCTAAAAATTCTAACATATATATACGTCCTTGACAGTATTTTAACCAATTGATAAGCTACTAATAATAATTTCTG
GTATCATGGGGGGAACAATT

Downstream 100 bases:

>100_bases
TGTCTTATATATAAATAGACGGAGATTTTATATCTCTGTCTATTTTTTTTTGATTATGTTAGAATAACGGTTATGTGAGT
ACATAGATATTGGGGGTAGC

Product: inosine 5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH; Superoxide-inducible protein 12; SOI12 [H]

Number of amino acids: Translated: 487; Mature: 487

Protein sequence:

>487_residues
MWESKFVKEGLTFDDVLLVPAKSDVLPREVSVKTVLSESLQLNIPLISAGMDTVTEADMAIAMARQGGLGIIHKNMSIEQ
QAEQVDKVKRSESGVISDPFFLTPEHQVYDAEHLMGKYRISGVPVVNNLDERKLVGIITNRDMRFIQDYSIKISDVMTKE
QLITAPVGTTLDEAEKILQKYKIEKLPLVDNNGVLQGLITIKDIEKVIEFPNSAKDKQGRLLVGAAVGVTADAMTRIDAL
VKASVDAIVLDTAHGHSQGVIDKVKEVRAKYPSLNIIAGNVATAEATGALIEAGANVVKVGIGPGSICTTRVVAGVGVPQ
LTAVYDCATEARKHGIPVIADGGIKYSGDMVKALAAGAHVVMLGSMFAGVAESPGETEIYQGRQFKVYRGMGSVGAMEKG
SKDRYFQEGNKKLVPEGIEGRVPYKGPLADTVHQLVGGLRAGMGYCGAQDLEFLRENAQFVRMSGAGLLESHPHHVQITK
EAPNYSL

Sequences:

>Translated_487_residues
MWESKFVKEGLTFDDVLLVPAKSDVLPREVSVKTVLSESLQLNIPLISAGMDTVTEADMAIAMARQGGLGIIHKNMSIEQ
QAEQVDKVKRSESGVISDPFFLTPEHQVYDAEHLMGKYRISGVPVVNNLDERKLVGIITNRDMRFIQDYSIKISDVMTKE
QLITAPVGTTLDEAEKILQKYKIEKLPLVDNNGVLQGLITIKDIEKVIEFPNSAKDKQGRLLVGAAVGVTADAMTRIDAL
VKASVDAIVLDTAHGHSQGVIDKVKEVRAKYPSLNIIAGNVATAEATGALIEAGANVVKVGIGPGSICTTRVVAGVGVPQ
LTAVYDCATEARKHGIPVIADGGIKYSGDMVKALAAGAHVVMLGSMFAGVAESPGETEIYQGRQFKVYRGMGSVGAMEKG
SKDRYFQEGNKKLVPEGIEGRVPYKGPLADTVHQLVGGLRAGMGYCGAQDLEFLRENAQFVRMSGAGLLESHPHHVQITK
EAPNYSL
>Mature_487_residues
MWESKFVKEGLTFDDVLLVPAKSDVLPREVSVKTVLSESLQLNIPLISAGMDTVTEADMAIAMARQGGLGIIHKNMSIEQ
QAEQVDKVKRSESGVISDPFFLTPEHQVYDAEHLMGKYRISGVPVVNNLDERKLVGIITNRDMRFIQDYSIKISDVMTKE
QLITAPVGTTLDEAEKILQKYKIEKLPLVDNNGVLQGLITIKDIEKVIEFPNSAKDKQGRLLVGAAVGVTADAMTRIDAL
VKASVDAIVLDTAHGHSQGVIDKVKEVRAKYPSLNIIAGNVATAEATGALIEAGANVVKVGIGPGSICTTRVVAGVGVPQ
LTAVYDCATEARKHGIPVIADGGIKYSGDMVKALAAGAHVVMLGSMFAGVAESPGETEIYQGRQFKVYRGMGSVGAMEKG
SKDRYFQEGNKKLVPEGIEGRVPYKGPLADTVHQLVGGLRAGMGYCGAQDLEFLRENAQFVRMSGAGLLESHPHHVQITK
EAPNYSL

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=453, Percent_Identity=45.2538631346578, Blast_Score=369, Evalue=1e-102,
Organism=Homo sapiens, GI34328930, Length=453, Percent_Identity=45.2538631346578, Blast_Score=368, Evalue=1e-102,
Organism=Homo sapiens, GI156616279, Length=453, Percent_Identity=45.2538631346578, Blast_Score=368, Evalue=1e-102,
Organism=Homo sapiens, GI34328928, Length=453, Percent_Identity=45.2538631346578, Blast_Score=367, Evalue=1e-101,
Organism=Homo sapiens, GI217035152, Length=447, Percent_Identity=45.1901565995526, Blast_Score=359, Evalue=3e-99,
Organism=Homo sapiens, GI217035148, Length=453, Percent_Identity=44.3708609271523, Blast_Score=357, Evalue=2e-98,
Organism=Homo sapiens, GI66933016, Length=453, Percent_Identity=42.3841059602649, Blast_Score=352, Evalue=6e-97,
Organism=Homo sapiens, GI217035150, Length=453, Percent_Identity=42.3841059602649, Blast_Score=332, Evalue=6e-91,
Organism=Homo sapiens, GI156104880, Length=248, Percent_Identity=41.9354838709677, Blast_Score=176, Evalue=4e-44,
Organism=Homo sapiens, GI50541956, Length=246, Percent_Identity=40.2439024390244, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI50541954, Length=246, Percent_Identity=40.2439024390244, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI50541952, Length=246, Percent_Identity=40.2439024390244, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI50541948, Length=246, Percent_Identity=40.2439024390244, Blast_Score=170, Evalue=2e-42,
Organism=Escherichia coli, GI1788855, Length=486, Percent_Identity=56.1728395061728, Blast_Score=495, Evalue=1e-141,
Organism=Escherichia coli, GI1786293, Length=220, Percent_Identity=40, Blast_Score=161, Evalue=7e-41,
Organism=Caenorhabditis elegans, GI71994385, Length=501, Percent_Identity=35.5289421157685, Blast_Score=280, Evalue=8e-76,
Organism=Caenorhabditis elegans, GI71994389, Length=424, Percent_Identity=37.7358490566038, Blast_Score=267, Evalue=1e-71,
Organism=Caenorhabditis elegans, GI17560440, Length=241, Percent_Identity=40.2489626556017, Blast_Score=174, Evalue=8e-44,
Organism=Saccharomyces cerevisiae, GI6322012, Length=467, Percent_Identity=40.4710920770878, Blast_Score=342, Evalue=1e-94,
Organism=Saccharomyces cerevisiae, GI6323585, Length=458, Percent_Identity=40.8296943231441, Blast_Score=334, Evalue=2e-92,
Organism=Saccharomyces cerevisiae, GI6323464, Length=469, Percent_Identity=41.36460554371, Blast_Score=332, Evalue=1e-91,
Organism=Saccharomyces cerevisiae, GI6319352, Length=341, Percent_Identity=40.1759530791789, Blast_Score=254, Evalue=2e-68,
Organism=Saccharomyces cerevisiae, GI6319353, Length=116, Percent_Identity=41.3793103448276, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24641071, Length=479, Percent_Identity=41.3361169102296, Blast_Score=339, Evalue=3e-93,
Organism=Drosophila melanogaster, GI24641073, Length=479, Percent_Identity=41.3361169102296, Blast_Score=339, Evalue=3e-93,
Organism=Drosophila melanogaster, GI28571163, Length=437, Percent_Identity=41.4187643020595, Blast_Score=305, Evalue=7e-83,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 52318; Mature: 52318

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWESKFVKEGLTFDDVLLVPAKSDVLPREVSVKTVLSESLQLNIPLISAGMDTVTEADMA
CCCHHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHCCCEEECEEEECCCHHHHHHHHH
IAMARQGGLGIIHKNMSIEQQAEQVDKVKRSESGVISDPFFLTPEHQVYDAEHLMGKYRI
HHHHCCCCCEEEECCCCHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCHHHHHHHHEE
SGVPVVNNLDERKLVGIITNRDMRFIQDYSIKISDVMTKEQLITAPVGTTLDEAEKILQK
CCCCEECCCCCCEEEEEEECCCEEEHHHCCEEHHHHHHHHHHEECCCCCCHHHHHHHHHH
YKIEKLPLVDNNGVLQGLITIKDIEKVIEFPNSAKDKQGRLLVGAAVGVTADAMTRIDAL
HCCCCCCEECCCCCEEEEEEHHHHHHHHHCCCCCCCCCCCEEEEEECCCCHHHHHHHHHH
VKASVDAIVLDTAHGHSQGVIDKVKEVRAKYPSLNIIAGNVATAEATGALIEAGANVVKV
HHCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHCCCCEEEE
GIGPGSICTTRVVAGVGVPQLTAVYDCATEARKHGIPVIADGGIKYSGDMVKALAAGAHV
ECCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEECCCEEECCHHHHHHHCCCHH
VMLGSMFAGVAESPGETEIYQGRQFKVYRGMGSVGAMEKGSKDRYFQEGNKKLVPEGIEG
HHHHHHHHHHCCCCCCCHHCCCCEEEEEECCCCCCCCCCCCCCCHHHCCCCEECCCCCCC
RVPYKGPLADTVHQLVGGLRAGMGYCGAQDLEFLRENAQFVRMSGAGLLESHPHHVQITK
CCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCEEEEECCCCCCCCCCCEEEEEE
EAPNYSL
CCCCCCC
>Mature Secondary Structure
MWESKFVKEGLTFDDVLLVPAKSDVLPREVSVKTVLSESLQLNIPLISAGMDTVTEADMA
CCCHHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHCCCEEECEEEECCCHHHHHHHHH
IAMARQGGLGIIHKNMSIEQQAEQVDKVKRSESGVISDPFFLTPEHQVYDAEHLMGKYRI
HHHHCCCCCEEEECCCCHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCHHHHHHHHEE
SGVPVVNNLDERKLVGIITNRDMRFIQDYSIKISDVMTKEQLITAPVGTTLDEAEKILQK
CCCCEECCCCCCEEEEEEECCCEEEHHHCCEEHHHHHHHHHHEECCCCCCHHHHHHHHHH
YKIEKLPLVDNNGVLQGLITIKDIEKVIEFPNSAKDKQGRLLVGAAVGVTADAMTRIDAL
HCCCCCCEECCCCCEEEEEEHHHHHHHHHCCCCCCCCCCCEEEEEECCCCHHHHHHHHHH
VKASVDAIVLDTAHGHSQGVIDKVKEVRAKYPSLNIIAGNVATAEATGALIEAGANVVKV
HHCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHCCCCEEEE
GIGPGSICTTRVVAGVGVPQLTAVYDCATEARKHGIPVIADGGIKYSGDMVKALAAGAHV
ECCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEECCCEEECCHHHHHHHCCCHH
VMLGSMFAGVAESPGETEIYQGRQFKVYRGMGSVGAMEKGSKDRYFQEGNKKLVPEGIEG
HHHHHHHHHHCCCCCCCHHCCCCEEEEEECCCCCCCCCCCCCCCHHHCCCCEECCCCCCC
RVPYKGPLADTVHQLVGGLRAGMGYCGAQDLEFLRENAQFVRMSGAGLLESHPHHVQITK
CCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCEEEEECCCCCCCCCCCEEEEEE
EAPNYSL
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1979163; 7584024; 9384377; 9298659 [H]