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The map label for this gene is upp [H]

Identifier: 221636099

GI number: 221636099

Start: 682467

End: 683171

Strand: Reverse

Name: upp [H]

Synonym: trd_A0693

Alternate gene names: 221636099

Gene position: 683171-682467 (Counterclockwise)

Preceding gene: 221636104

Following gene: 221636098

Centisome position: 74.44

GC content: 66.81

Gene sequence:

>705_bases
ATGGCTGAGCAACTCGTCCATCCAACTCCGATGCGGGGCGTCCCGCAGCCGCGGCGCGAGGACGTCCTGGGGCAAGCACG
GTTGCGCGTGCTCGACCATCCGTTAGTGACGGCGCTGCTCACGGTCGCGCGCGACGAGCGCACGCCGCCAGCCGAGTTCG
AGCGAGTGTTGCACGAGCTGACGCGGTTTCTTCTCTACGAAGCGCTGCGCGAGGAACCGTTGCAAACGTTCCGGGTCCCC
TCGCCGACGGGCGAGGAAGCAGACGGGGGAGCGCTGCGGGCTGGACTGGCCGTGCTGGCGATCTTGCGGGCCGGACTCGG
CATGCTCGCACCGGTGCGCCAGCTGGTCCCCGCTGCACCGATCTACCTGGTGGGAGCGCGACGCGACGAGGAAACGCTGC
GCTCGACCATCTATTACAAGAAGCTTCCGGGGCGATTCGATGTCCTCCGCCATGTCGTCATCGTCGATCCGATGCTGGCG
ACCGGAGGTTCGGCCGTGGCGACGGTGGAGCTCCTCCGGCAGACCTACAGCGGGCCGATCTCATTTCTCGGGATCATCGG
TGCGCCCTATGGTGTCCAGCACCTGCTTTCGGCCGATCCCGACGTGCGGATCTACCTGGCGGCACTCGACGAGCGCCTCG
ACGACCGGGGATTCATCGTACCTGGTTTGGGCGATGCTGGAGACCGGCTGTTCGGGACGCAGTGA

Upstream 100 bases:

>100_bases
GAGCTGGATGAGGTGGCGCAGCCGGCCGCTGGCGGCTGGCGATGGATGGGGAGCGGACGGCACGCGGATCGGTCGTGCCG
GCGACAGAGGGGAGACACGC

Downstream 100 bases:

>100_bases
GCGGCCGAGCGCGTCGAGGCAACAGCGGTTGAGCGGTGGTGCTGATGCGGTGGACGCCGATCCGGTCCCGGCTGCTCGCC
TGGCTCCTGATCCCGGTTCT

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase [H]

Number of amino acids: Translated: 234; Mature: 233

Protein sequence:

>234_residues
MAEQLVHPTPMRGVPQPRREDVLGQARLRVLDHPLVTALLTVARDERTPPAEFERVLHELTRFLLYEALREEPLQTFRVP
SPTGEEADGGALRAGLAVLAILRAGLGMLAPVRQLVPAAPIYLVGARRDEETLRSTIYYKKLPGRFDVLRHVVIVDPMLA
TGGSAVATVELLRQTYSGPISFLGIIGAPYGVQHLLSADPDVRIYLAALDERLDDRGFIVPGLGDAGDRLFGTQ

Sequences:

>Translated_234_residues
MAEQLVHPTPMRGVPQPRREDVLGQARLRVLDHPLVTALLTVARDERTPPAEFERVLHELTRFLLYEALREEPLQTFRVP
SPTGEEADGGALRAGLAVLAILRAGLGMLAPVRQLVPAAPIYLVGARRDEETLRSTIYYKKLPGRFDVLRHVVIVDPMLA
TGGSAVATVELLRQTYSGPISFLGIIGAPYGVQHLLSADPDVRIYLAALDERLDDRGFIVPGLGDAGDRLFGTQ
>Mature_233_residues
AEQLVHPTPMRGVPQPRREDVLGQARLRVLDHPLVTALLTVARDERTPPAEFERVLHELTRFLLYEALREEPLQTFRVPS
PTGEEADGGALRAGLAVLAILRAGLGMLAPVRQLVPAAPIYLVGARRDEETLRSTIYYKKLPGRFDVLRHVVIVDPMLAT
GGSAVATVELLRQTYSGPISFLGIIGAPYGVQHLLSADPDVRIYLAALDERLDDRGFIVPGLGDAGDRLFGTQ

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate [H]

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family [H]

Homologues:

Organism=Homo sapiens, GI57863312, Length=204, Percent_Identity=31.8627450980392, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI301129207, Length=204, Percent_Identity=31.8627450980392, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI21450816, Length=172, Percent_Identity=27.3255813953488, Blast_Score=72, Evalue=4e-13,
Organism=Escherichia coli, GI87082118, Length=204, Percent_Identity=39.7058823529412, Blast_Score=147, Evalue=6e-37,
Organism=Caenorhabditis elegans, GI17539892, Length=215, Percent_Identity=25.1162790697674, Blast_Score=77, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17539894, Length=215, Percent_Identity=25.1162790697674, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6321920, Length=196, Percent_Identity=35.7142857142857, Blast_Score=113, Evalue=2e-26,
Organism=Drosophila melanogaster, GI45550449, Length=204, Percent_Identity=27.4509803921569, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI28573516, Length=204, Percent_Identity=27.4509803921569, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI28573514, Length=204, Percent_Identity=27.4509803921569, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI28573512, Length=204, Percent_Identity=27.4509803921569, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI21358379, Length=203, Percent_Identity=25.1231527093596, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000836
- InterPro:   IPR005765 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.9 [H]

Molecular weight: Translated: 25626; Mature: 25495

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEQLVHPTPMRGVPQPRREDVLGQARLRVLDHPLVTALLTVARDERTPPAEFERVLHEL
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
TRFLLYEALREEPLQTFRVPSPTGEEADGGALRAGLAVLAILRAGLGMLAPVRQLVPAAP
HHHHHHHHHHHCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCC
IYLVGARRDEETLRSTIYYKKLPGRFDVLRHVVIVDPMLATGGSAVATVELLRQTYSGPI
EEEEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHCCHH
SFLGIIGAPYGVQHLLSADPDVRIYLAALDERLDDRGFIVPGLGDAGDRLFGTQ
HHHHHHCCCHHHHHHHCCCCCCEEEHHHHHHHHCCCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
AEQLVHPTPMRGVPQPRREDVLGQARLRVLDHPLVTALLTVARDERTPPAEFERVLHEL
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
TRFLLYEALREEPLQTFRVPSPTGEEADGGALRAGLAVLAILRAGLGMLAPVRQLVPAAP
HHHHHHHHHHHCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCC
IYLVGARRDEETLRSTIYYKKLPGRFDVLRHVVIVDPMLATGGSAVATVELLRQTYSGPI
EEEEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHCCHH
SFLGIIGAPYGVQHLLSADPDVRIYLAALDERLDDRGFIVPGLGDAGDRLFGTQ
HHHHHHCCCHHHHHHHCCCCCCEEEHHHHHHHHCCCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA