Click here to switch to the map view.

The map label for this gene is kdgR [H]

Identifier: 221636000

GI number: 221636000

Start: 585101

End: 585937

Strand: Reverse

Name: kdgR [H]

Synonym: trd_A0594

Alternate gene names: 221636000

Gene position: 585937-585101 (Counterclockwise)

Preceding gene: 221636001

Following gene: 221635999

Centisome position: 63.85

GC content: 66.07

Gene sequence:

>837_bases
ATGGCACGTCGCGTACCGGCAGTCGAGCGAGCCCTGGATATCCTCGAGCTCTTTCTGCGCACCCCGCAGCCAGAGTCGCT
GTCGGTGCCGGAAATCGCGCGCGCTCTGGGTCTGCCCCGCAGCACGGCGCACGAGCTCGTGGCGACGCTGGTCGCGCGCC
GGTATCTTCGGCCGATCGAGGGAAATCCGCACCGGTTCGCGCTGGATGCTCGTGTCTTCGAGTTGGGGAACGCCTATGCC
TCCGGTCTCGATCTGGCGCGCGAAGGCCAGCAGGTGGCGCGGGAGATCGCGGCCCGATGCGACGAGACGGTGCACATCGC
GGTGCTGGAGGGGCGAGACGTCTTCTACATCGCCAAGGTGGACAGCACGAACGCCTTGCGGCTGGTGTCGGCGATCGGTC
GACGATTGCCAGCTCATTGCACCGCAGTGGGGAAGATGTTGCTGTCCAGCTTGACCGATGAGGAACTGGAAGAACGGTTC
GCCGGTGTGGACCTGCTGCCGACGATGACGCGGAACAGTATCCGCACGCTCGCTGAGCTGCGGAGCGAACTCGAGCGAAC
ACGTGCCCGTGGGCTCGCCTGGGACAACTGCGAGTCCAATCCCGATGTTCGTTGCGTAGCGGCACCGATCTACGACCACC
GTGGGCGGATGGTCGCAGCGATGAGCATCTCGTTTCCGGTCGTGCGGGATACGCCGGAGCGGTTCCTCGAGTTATCGCGA
CTGGTGCGCCGAGGAGCACGAGACGTCTCGCTGCGCCTGGGTGCTCGCCAGCTGGCGCGCGACACCGAGGAGCCGGAACT
CCCGCCCTGGCATTTGCCTGCTGTGGCGGACGGGTAA

Upstream 100 bases:

>100_bases
CCGCTCACAGGGGGATTGACAGCTGGACACGCGAGGACTAGACTGTGACCAGATGAGAGTCGACAGATCGGATAATGTCT
GATATATCGGACAGAGAACG

Downstream 100 bases:

>100_bases
CGGATCACCGGAGGGAGGTGCATGCGCGGACACGTTATATTGTCGTTCCATCGGGTGATCGGGCGATCAAGACACAGGAC
GGCATGAGTGAAGGAGGAGA

Product: IclR-family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 278; Mature: 277

Protein sequence:

>278_residues
MARRVPAVERALDILELFLRTPQPESLSVPEIARALGLPRSTAHELVATLVARRYLRPIEGNPHRFALDARVFELGNAYA
SGLDLAREGQQVAREIAARCDETVHIAVLEGRDVFYIAKVDSTNALRLVSAIGRRLPAHCTAVGKMLLSSLTDEELEERF
AGVDLLPTMTRNSIRTLAELRSELERTRARGLAWDNCESNPDVRCVAAPIYDHRGRMVAAMSISFPVVRDTPERFLELSR
LVRRGARDVSLRLGARQLARDTEEPELPPWHLPAVADG

Sequences:

>Translated_278_residues
MARRVPAVERALDILELFLRTPQPESLSVPEIARALGLPRSTAHELVATLVARRYLRPIEGNPHRFALDARVFELGNAYA
SGLDLAREGQQVAREIAARCDETVHIAVLEGRDVFYIAKVDSTNALRLVSAIGRRLPAHCTAVGKMLLSSLTDEELEERF
AGVDLLPTMTRNSIRTLAELRSELERTRARGLAWDNCESNPDVRCVAAPIYDHRGRMVAAMSISFPVVRDTPERFLELSR
LVRRGARDVSLRLGARQLARDTEEPELPPWHLPAVADG
>Mature_277_residues
ARRVPAVERALDILELFLRTPQPESLSVPEIARALGLPRSTAHELVATLVARRYLRPIEGNPHRFALDARVFELGNAYAS
GLDLAREGQQVAREIAARCDETVHIAVLEGRDVFYIAKVDSTNALRLVSAIGRRLPAHCTAVGKMLLSSLTDEELEERFA
GVDLLPTMTRNSIRTLAELRSELERTRARGLAWDNCESNPDVRCVAAPIYDHRGRMVAAMSISFPVVRDTPERFLELSRL
VRRGARDVSLRLGARQLARDTEEPELPPWHLPAVADG

Specific function: Transcriptional repressor of genes involved in pectinolysis and in pectinase secretion. Controls all the genes involved in pectin catabolism, including the pel genes encoding pectate lyases, kdgT which encodes the 2-keto-3-deoxygluconate transport system

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI1786468, Length=222, Percent_Identity=35.5855855855856, Blast_Score=138, Evalue=3e-34,
Organism=Escherichia coli, GI1788131, Length=248, Percent_Identity=29.8387096774194, Blast_Score=133, Evalue=1e-32,
Organism=Escherichia coli, GI87082359, Length=254, Percent_Identity=29.9212598425197, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1786715, Length=250, Percent_Identity=31.6, Blast_Score=110, Evalue=7e-26,
Organism=Escherichia coli, GI1788581, Length=258, Percent_Identity=29.0697674418605, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1790752, Length=234, Percent_Identity=28.6324786324786, Blast_Score=88, Evalue=7e-19,
Organism=Escherichia coli, GI1789999, Length=249, Percent_Identity=25.3012048192771, Blast_Score=75, Evalue=7e-15,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 30967; Mature: 30836

Theoretical pI: Translated: 7.55; Mature: 7.55

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARRVPAVERALDILELFLRTPQPESLSVPEIARALGLPRSTAHELVATLVARRYLRPIE
CCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCC
GNPHRFALDARVFELGNAYASGLDLAREGQQVAREIAARCDETVHIAVLEGRDVFYIAKV
CCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCEEEEEEE
DSTNALRLVSAIGRRLPAHCTAVGKMLLSSLTDEELEERFAGVDLLPTMTRNSIRTLAEL
CCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHH
RSELERTRARGLAWDNCESNPDVRCVAAPIYDHRGRMVAAMSISFPVVRDTPERFLELSR
HHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCEEEEEECCCCCCCCCHHHHHHHHH
LVRRGARDVSLRLGARQLARDTEEPELPPWHLPAVADG
HHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
ARRVPAVERALDILELFLRTPQPESLSVPEIARALGLPRSTAHELVATLVARRYLRPIE
CCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCC
GNPHRFALDARVFELGNAYASGLDLAREGQQVAREIAARCDETVHIAVLEGRDVFYIAKV
CCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCEEEEEEE
DSTNALRLVSAIGRRLPAHCTAVGKMLLSSLTDEELEERFAGVDLLPTMTRNSIRTLAEL
CCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHH
RSELERTRARGLAWDNCESNPDVRCVAAPIYDHRGRMVAAMSISFPVVRDTPERFLELSR
HHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCEEEEEECCCCCCCCCHHHHHHHHH
LVRRGARDVSLRLGARQLARDTEEPELPPWHLPAVADG
HHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1840643; 1545709 [H]