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The map label for this gene is mutL [H]

Identifier: 221635854

GI number: 221635854

Start: 433436

End: 435166

Strand: Reverse

Name: mutL [H]

Synonym: trd_A0448

Alternate gene names: 221635854

Gene position: 435166-433436 (Counterclockwise)

Preceding gene: 221635855

Following gene: 221635850

Centisome position: 47.42

GC content: 69.04

Gene sequence:

>1731_bases
ATGCAGGTCGCTCGTCCCCCGCGTCGCCCGATCCGCGTCCTGCCGCCGAACGTCGCTGCACGGATCGCTGCTGGTGAGGT
GATCGAGCGGCCAGCCTCGGTCGTCAAGGAACTCGTCGAGAACGCGCTCGATGCGGGTGCATCCCGGATCCGCATCAGCG
TGCGCGGCGGCGGGCTGCACGAGATCCGCGTGAGCGACGACGGCTGTGGCATCCCTGCTGATGAACTGCCGCTCGCGCTG
CAACGGCACGCCACCAGCAAGCTCGCCGAGGACGACCTGGAGCGGATCGAGACGCTCGGCTTCCGGGGCGAAGCGCTCCC
CAGTATCGCGGCCGTCGCCGAGCTGACCATCGCCAGCGCGACGAGCGACGCACCGGTCGGACGTCAGCTCACGGTCCGCG
GCGGCCGTATCCTGGCCGATGAGCCAATCGCGCACCCACCGGGAACGACGGTCACGGTCCGCCACCTTTTCGAGGACCTC
CCAGCGCGCCTCGCTCACGTGCGCAACACACGCGCTGAGATGGCGGAGATCGCTCGCGTCGTCCAGCGCCTGGCCATCGC
TGCCCCGCATGTCCGCATCGCGCTCCGTATCGAGGATCGGGTCGTCCTCCAGACCACCGGCTCGGGTGACAGGCGGGTCG
TTCTCAGCGAGCTGTACGGACCCACGCTCGCCTCTTCGCTCTTGCCGTTCGGTCCGCTCAAGATCGGCGATTGCTCGTGT
AGCGGGTTCGTCAGCAGTCCTGACCTCACGCGCTCGAGCCGCCGCCATCTGCACGTCGTCGTGAATGGCCGTTGGGCACA
GTCCCGCACCGTGCTCGCGCTCCTCGAGGCGGCCTACCAGCCCCTCCTGCCGCGCGGCCGGCACCCTGTCCTGGTGCTCG
TCATCACGGCCGACCCCGCCGCGGTCGACGTGAACATCCATCCAGCCAAACTCGAGGTCCGCCTCCGGGCCGAGCGCGAG
CTGGGACAAGCCATCGCCGAGGAAGTGCGGAGCCTTCTCGCCCGCACGCCGCGTCGCTTCACCTTCCTCGAGGCTACTCC
GGCCATCGATCCCGTGCGCGCGGCCATCGCAGAGACACCTCGCCCGTACGACCGACCGGAAACCGAGGAGCCGATCCTCA
CCCCCGCCTTTCCGCCACTGCGACTGATCGGCCAGGTGCGAGAGCGTTTACTTCTCCTGGAAGGCCCGGCCATGCTCTTG
CTCGTCGACCAGCACCGCGCTCACGAGCGGGTGCTCTACGAACGGCTCGCTGCCGCTCATCCGAGCGCCGACGACACGGT
ACCGTTACCGGAGCCGCTCGTCATCGACGTGCGGCCAGCCTATCGCGACCGCTTCGCGCGCTGGCTGGACGAACTCGCCG
CCTACGGCTTCCAGGCAGAACCGTTCGGCCCGCGCTCGTTCCTTGTGCGCACCGTCCCCGCGCTCCCTGGTGTCGTGGCT
GGACCGCCGGAACTGCAGGATCTCGGTCAACCAGCGGCGCTGGCTCCAGCTCTCCTGGCCCTGCTCGAGGAATCAGAGGA
CGCATGGGACGACACGAGCTGGCGCGATCGCCTGCTCATCCAGCTCGCTTGCCGGTTGGCCGTACGGCGTGGGCGACCAT
TAGCCCGTCCGGCGATGCGCGCGCTGGTGCAGGCATGGGGAGCCACGAAGACTCCGGCGATCTGTCCGCACGGCTCGCCG
ATCGTCCTCCGCGTCGAGGACGAGACACTCGCTCACCAGTTCGACTGGTGA

Upstream 100 bases:

>100_bases
GCTCGATCTCGCCAATCTCACGCCGCGCCAAGCGCTGGACTGGCTCTTCGAGCAGCGCGCCAAGCTGGGCAGAGCGTAGT
CGACAGGGTGGAGCCGTACG

Downstream 100 bases:

>100_bases
GCGAGTCACGCACGAACCGCTCGCAGCCACACGCATCCGGTTAGCGAGCCGCCCCGTCGTACGCCCGGAACACTGCAACC
GCGTTCTGTCCACCGAACCC

Product: DNA mismatch repair protein MutL

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 576; Mature: 576

Protein sequence:

>576_residues
MQVARPPRRPIRVLPPNVAARIAAGEVIERPASVVKELVENALDAGASRIRISVRGGGLHEIRVSDDGCGIPADELPLAL
QRHATSKLAEDDLERIETLGFRGEALPSIAAVAELTIASATSDAPVGRQLTVRGGRILADEPIAHPPGTTVTVRHLFEDL
PARLAHVRNTRAEMAEIARVVQRLAIAAPHVRIALRIEDRVVLQTTGSGDRRVVLSELYGPTLASSLLPFGPLKIGDCSC
SGFVSSPDLTRSSRRHLHVVVNGRWAQSRTVLALLEAAYQPLLPRGRHPVLVLVITADPAAVDVNIHPAKLEVRLRAERE
LGQAIAEEVRSLLARTPRRFTFLEATPAIDPVRAAIAETPRPYDRPETEEPILTPAFPPLRLIGQVRERLLLLEGPAMLL
LVDQHRAHERVLYERLAAAHPSADDTVPLPEPLVIDVRPAYRDRFARWLDELAAYGFQAEPFGPRSFLVRTVPALPGVVA
GPPELQDLGQPAALAPALLALLEESEDAWDDTSWRDRLLIQLACRLAVRRGRPLARPAMRALVQAWGATKTPAICPHGSP
IVLRVEDETLAHQFDW

Sequences:

>Translated_576_residues
MQVARPPRRPIRVLPPNVAARIAAGEVIERPASVVKELVENALDAGASRIRISVRGGGLHEIRVSDDGCGIPADELPLAL
QRHATSKLAEDDLERIETLGFRGEALPSIAAVAELTIASATSDAPVGRQLTVRGGRILADEPIAHPPGTTVTVRHLFEDL
PARLAHVRNTRAEMAEIARVVQRLAIAAPHVRIALRIEDRVVLQTTGSGDRRVVLSELYGPTLASSLLPFGPLKIGDCSC
SGFVSSPDLTRSSRRHLHVVVNGRWAQSRTVLALLEAAYQPLLPRGRHPVLVLVITADPAAVDVNIHPAKLEVRLRAERE
LGQAIAEEVRSLLARTPRRFTFLEATPAIDPVRAAIAETPRPYDRPETEEPILTPAFPPLRLIGQVRERLLLLEGPAMLL
LVDQHRAHERVLYERLAAAHPSADDTVPLPEPLVIDVRPAYRDRFARWLDELAAYGFQAEPFGPRSFLVRTVPALPGVVA
GPPELQDLGQPAALAPALLALLEESEDAWDDTSWRDRLLIQLACRLAVRRGRPLARPAMRALVQAWGATKTPAICPHGSP
IVLRVEDETLAHQFDW
>Mature_576_residues
MQVARPPRRPIRVLPPNVAARIAAGEVIERPASVVKELVENALDAGASRIRISVRGGGLHEIRVSDDGCGIPADELPLAL
QRHATSKLAEDDLERIETLGFRGEALPSIAAVAELTIASATSDAPVGRQLTVRGGRILADEPIAHPPGTTVTVRHLFEDL
PARLAHVRNTRAEMAEIARVVQRLAIAAPHVRIALRIEDRVVLQTTGSGDRRVVLSELYGPTLASSLLPFGPLKIGDCSC
SGFVSSPDLTRSSRRHLHVVVNGRWAQSRTVLALLEAAYQPLLPRGRHPVLVLVITADPAAVDVNIHPAKLEVRLRAERE
LGQAIAEEVRSLLARTPRRFTFLEATPAIDPVRAAIAETPRPYDRPETEEPILTPAFPPLRLIGQVRERLLLLEGPAMLL
LVDQHRAHERVLYERLAAAHPSADDTVPLPEPLVIDVRPAYRDRFARWLDELAAYGFQAEPFGPRSFLVRTVPALPGVVA
GPPELQDLGQPAALAPALLALLEESEDAWDDTSWRDRLLIQLACRLAVRRGRPLARPAMRALVQAWGATKTPAICPHGSP
IVLRVEDETLAHQFDW

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=341, Percent_Identity=32.258064516129, Blast_Score=182, Evalue=8e-46,
Organism=Homo sapiens, GI4505913, Length=342, Percent_Identity=31.8713450292398, Blast_Score=166, Evalue=5e-41,
Organism=Homo sapiens, GI310128478, Length=342, Percent_Identity=31.8713450292398, Blast_Score=166, Evalue=7e-41,
Organism=Homo sapiens, GI4505911, Length=375, Percent_Identity=28.5333333333333, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI189458898, Length=375, Percent_Identity=28.5333333333333, Blast_Score=143, Evalue=4e-34,
Organism=Homo sapiens, GI310128480, Length=302, Percent_Identity=30.794701986755, Blast_Score=133, Evalue=5e-31,
Organism=Homo sapiens, GI189458896, Length=369, Percent_Identity=28.1842818428184, Blast_Score=132, Evalue=1e-30,
Organism=Homo sapiens, GI263191589, Length=247, Percent_Identity=25.9109311740891, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI310128484, Length=239, Percent_Identity=27.1966527196653, Blast_Score=83, Evalue=6e-16,
Organism=Homo sapiens, GI310128482, Length=236, Percent_Identity=27.5423728813559, Blast_Score=83, Evalue=8e-16,
Organism=Homo sapiens, GI91992160, Length=257, Percent_Identity=28.4046692607004, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI91992162, Length=244, Percent_Identity=29.0983606557377, Blast_Score=80, Evalue=6e-15,
Organism=Homo sapiens, GI310128486, Length=213, Percent_Identity=27.6995305164319, Blast_Score=76, Evalue=7e-14,
Organism=Escherichia coli, GI1790612, Length=334, Percent_Identity=42.5149700598802, Blast_Score=224, Evalue=8e-60,
Organism=Caenorhabditis elegans, GI71991825, Length=323, Percent_Identity=36.2229102167183, Blast_Score=172, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17562796, Length=354, Percent_Identity=28.5310734463277, Blast_Score=149, Evalue=5e-36,
Organism=Saccharomyces cerevisiae, GI6323819, Length=339, Percent_Identity=32.7433628318584, Blast_Score=184, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6324247, Length=331, Percent_Identity=28.7009063444109, Blast_Score=125, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6323063, Length=363, Percent_Identity=26.1707988980716, Blast_Score=92, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6325093, Length=371, Percent_Identity=23.1805929919137, Blast_Score=77, Evalue=6e-15,
Organism=Drosophila melanogaster, GI17136968, Length=383, Percent_Identity=30.8093994778068, Blast_Score=186, Evalue=3e-47,
Organism=Drosophila melanogaster, GI17136970, Length=383, Percent_Identity=28.4595300261097, Blast_Score=135, Evalue=6e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 62962; Mature: 62962

Theoretical pI: Translated: 7.46; Mature: 7.46

Prosite motif: PS00018 EF_HAND_1 ; PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQVARPPRRPIRVLPPNVAARIAAGEVIERPASVVKELVENALDAGASRIRISVRGGGLH
CCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCEE
EIRVSDDGCGIPADELPLALQRHATSKLAEDDLERIETLGFRGEALPSIAAVAELTIASA
EEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCC
TSDAPVGRQLTVRGGRILADEPIAHPPGTTVTVRHLFEDLPARLAHVRNTRAEMAEIARV
CCCCCCCCEEEECCCEEEECCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VQRLAIAAPHVRIALRIEDRVVLQTTGSGDRRVVLSELYGPTLASSLLPFGPLKIGDCSC
HHHHHHCCCCEEEEEEEECEEEEEECCCCCCEEEHHHHCCHHHHHHCCCCCCCEECCCCC
SGFVSSPDLTRSSRRHLHVVVNGRWAQSRTVLALLEAAYQPLLPRGRHPVLVLVITADPA
CCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCC
AVDVNIHPAKLEVRLRAERELGQAIAEEVRSLLARTPRRFTFLEATPAIDPVRAAIAETP
EEEEEECCCEEEEEEHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHCCC
RPYDRPETEEPILTPAFPPLRLIGQVRERLLLLEGPAMLLLVDQHRAHERVLYERLAAAH
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHEEEECCCEEEEEECCHHHHHHHHHHHHHHCC
PSADDTVPLPEPLVIDVRPAYRDRFARWLDELAAYGFQAEPFGPRSFLVRTVPALPGVVA
CCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCC
GPPELQDLGQPAALAPALLALLEESEDAWDDTSWRDRLLIQLACRLAVRRGRPLARPAMR
CCCCHHHCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHH
ALVQAWGATKTPAICPHGSPIVLRVEDETLAHQFDW
HHHHHHCCCCCCCCCCCCCEEEEEECCHHHHHCCCC
>Mature Secondary Structure
MQVARPPRRPIRVLPPNVAARIAAGEVIERPASVVKELVENALDAGASRIRISVRGGGLH
CCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCEE
EIRVSDDGCGIPADELPLALQRHATSKLAEDDLERIETLGFRGEALPSIAAVAELTIASA
EEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCC
TSDAPVGRQLTVRGGRILADEPIAHPPGTTVTVRHLFEDLPARLAHVRNTRAEMAEIARV
CCCCCCCCEEEECCCEEEECCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VQRLAIAAPHVRIALRIEDRVVLQTTGSGDRRVVLSELYGPTLASSLLPFGPLKIGDCSC
HHHHHHCCCCEEEEEEEECEEEEEECCCCCCEEEHHHHCCHHHHHHCCCCCCCEECCCCC
SGFVSSPDLTRSSRRHLHVVVNGRWAQSRTVLALLEAAYQPLLPRGRHPVLVLVITADPA
CCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCC
AVDVNIHPAKLEVRLRAERELGQAIAEEVRSLLARTPRRFTFLEATPAIDPVRAAIAETP
EEEEEECCCEEEEEEHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHCCC
RPYDRPETEEPILTPAFPPLRLIGQVRERLLLLEGPAMLLLVDQHRAHERVLYERLAAAH
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHEEEECCCEEEEEECCHHHHHHHHHHHHHHCC
PSADDTVPLPEPLVIDVRPAYRDRFARWLDELAAYGFQAEPFGPRSFLVRTVPALPGVVA
CCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCC
GPPELQDLGQPAALAPALLALLEESEDAWDDTSWRDRLLIQLACRLAVRRGRPLARPAMR
CCCCHHHCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHH
ALVQAWGATKTPAICPHGSPIVLRVEDETLAHQFDW
HHHHHHCCCCCCCCCCCCCEEEEEECCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA