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The map label for this gene is bphB [H]

Identifier: 221635744

GI number: 221635744

Start: 326531

End: 327397

Strand: Reverse

Name: bphB [H]

Synonym: trd_A0338

Alternate gene names: 221635744

Gene position: 327397-326531 (Counterclockwise)

Preceding gene: 221635745

Following gene: 221635743

Centisome position: 35.67

GC content: 58.48

Gene sequence:

>867_bases
GTGACTGTCCCGACCGATCCGAACTGTTTCCTCAAGGCACTCGACGGCCAGGTCGCACTCATCGTTGGCGCGACATCAGG
GATCGGCCGTGCTGTTGTCGACGCCTTTCTTCGGTGTGGGGCACACGTAGTCGCCTTCGGCCGGAGCGAGGAGAAACTAC
GCGAACTGGTGGCCAGTAGTCAGTCCTTTGCTCGCGCTCTGGCGACCTACGCCGGCGATGCGACCGATCATCACGATCTG
GACCGGGCAGCCACCCTCGCAGTAGACCGTTTCGGCAAACTCGATACGCTCGTTTGCACGGTCGGAGCATTCGATTATTA
TCGCACCATTCTCGACTACGACACGGAAACGTTATCGAGTGCCTTTGAGGAGCTTTTCCGGATCAATGTTCTTTCCTATA
TCCTTGCGGTAAGGGCGAGTCTACCATATCTTCTTCGTCAACCCAGCAGCATCGTTCTGACACTGTCGACTGCTTCATTC
TATCCTGAGGGCGGCGGTGTCTTGTATGGAGCGTCCAAGTTCGCGACCAGGGGACTCGTCACCCACCTCGCCTACGAGCT
GGCACCACGGGTCCGCGTCAATGGTGTTGCCCCAGGTGGCACGATCGGGACGAATCTTCGAGGACTGGCCTCGCTGCGCG
AGCAAGACAAACGCGTCGACGATGCGACGGGGGATCGGGCACAGCGAATCCAGCGGAGTGTTCCTTTGCAGGTTGCAGCG
ACACCAGATGACCATACAGCTGCTTTTGTCTATCTTGCCTCGCATCGTCTCAGTCGCGTCGTGACCGGAACCATCATCAA
CAGTGACGGTGGGAGAGGCGTTGCGGGGACTGTGCGAGTGGCACATCTCGTGGAGGAGATCTCATGA

Upstream 100 bases:

>100_bases
TCGGGTACACCATTCGCCTGGATCCTCTGGAACTCGAAGCGATCAGTTGGCAACCAGTCGACACGTTTTCGCGGATGCTC
GAAAACCCCTGGGGGCCAGC

Downstream 100 bases:

>100_bases
TCGGCCAGTCGGTCAAACGTGTCGAGGATTTTCGCTTTCTTACAGGCCAGGCCTGTTATACGAGAGACGTGCAGATTCCC
GGGACTGCTCCGCTTCAGGC

Product: 2,3-dihydroxy-2,3-dihydro-phenylpropionate dehydrogenase

Products: NA

Alternate protein names: 2,3-dihydro-2,3-dihydroxybiphenyl dehydrogenase; 2,3-dihydroxy-4-phenylhexa-4,6-diene dehydrogenase; B2,3D; Biphenyl-2,3-dihydro-2,3-diol dehydrogenase; Biphenyl-cis-diol dehydrogenase [H]

Number of amino acids: Translated: 288; Mature: 287

Protein sequence:

>288_residues
MTVPTDPNCFLKALDGQVALIVGATSGIGRAVVDAFLRCGAHVVAFGRSEEKLRELVASSQSFARALATYAGDATDHHDL
DRAATLAVDRFGKLDTLVCTVGAFDYYRTILDYDTETLSSAFEELFRINVLSYILAVRASLPYLLRQPSSIVLTLSTASF
YPEGGGVLYGASKFATRGLVTHLAYELAPRVRVNGVAPGGTIGTNLRGLASLREQDKRVDDATGDRAQRIQRSVPLQVAA
TPDDHTAAFVYLASHRLSRVVTGTIINSDGGRGVAGTVRVAHLVEEIS

Sequences:

>Translated_288_residues
MTVPTDPNCFLKALDGQVALIVGATSGIGRAVVDAFLRCGAHVVAFGRSEEKLRELVASSQSFARALATYAGDATDHHDL
DRAATLAVDRFGKLDTLVCTVGAFDYYRTILDYDTETLSSAFEELFRINVLSYILAVRASLPYLLRQPSSIVLTLSTASF
YPEGGGVLYGASKFATRGLVTHLAYELAPRVRVNGVAPGGTIGTNLRGLASLREQDKRVDDATGDRAQRIQRSVPLQVAA
TPDDHTAAFVYLASHRLSRVVTGTIINSDGGRGVAGTVRVAHLVEEIS
>Mature_287_residues
TVPTDPNCFLKALDGQVALIVGATSGIGRAVVDAFLRCGAHVVAFGRSEEKLRELVASSQSFARALATYAGDATDHHDLD
RAATLAVDRFGKLDTLVCTVGAFDYYRTILDYDTETLSSAFEELFRINVLSYILAVRASLPYLLRQPSSIVLTLSTASFY
PEGGGVLYGASKFATRGLVTHLAYELAPRVRVNGVAPGGTIGTNLRGLASLREQDKRVDDATGDRAQRIQRSVPLQVAAT
PDDHTAAFVYLASHRLSRVVTGTIINSDGGRGVAGTVRVAHLVEEIS

Specific function: Converts Cis-3-(3-Carboxyethyl)-3,5-Cyclohexadiene-1,2- Diol (Pp-Dihydrodiol) Into 3-(2,3-Dihydroxylphenyl)Propionate (Dhpp). [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI32483357, Length=259, Percent_Identity=28.957528957529, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI33667109, Length=250, Percent_Identity=29.6, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI5031737, Length=187, Percent_Identity=31.5508021390374, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI126723191, Length=183, Percent_Identity=31.1475409836066, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI126723750, Length=263, Percent_Identity=28.1368821292776, Blast_Score=73, Evalue=3e-13,
Organism=Escherichia coli, GI1788891, Length=249, Percent_Identity=37.7510040160643, Blast_Score=166, Evalue=2e-42,
Organism=Escherichia coli, GI1787526, Length=193, Percent_Identity=30.5699481865285, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1789378, Length=263, Percent_Identity=28.5171102661597, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1787905, Length=265, Percent_Identity=26.0377358490566, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17563726, Length=263, Percent_Identity=28.1368821292776, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI72000259, Length=271, Percent_Identity=26.9372693726937, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71994604, Length=263, Percent_Identity=30.0380228136882, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17562910, Length=265, Percent_Identity=27.9245283018868, Blast_Score=81, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI71994600, Length=262, Percent_Identity=29.7709923664122, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17562908, Length=275, Percent_Identity=29.0909090909091, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17561402, Length=271, Percent_Identity=27.3062730627306, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17531453, Length=281, Percent_Identity=28.4697508896797, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17544670, Length=282, Percent_Identity=24.822695035461, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17551412, Length=279, Percent_Identity=28.3154121863799, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17562990, Length=263, Percent_Identity=26.2357414448669, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17560150, Length=271, Percent_Identity=26.1992619926199, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17560676, Length=265, Percent_Identity=27.5471698113208, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI193204405, Length=273, Percent_Identity=28.5714285714286, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17560220, Length=277, Percent_Identity=28.158844765343, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17560332, Length=269, Percent_Identity=28.6245353159851, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17538480, Length=280, Percent_Identity=26.7857142857143, Blast_Score=71, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17562906, Length=265, Percent_Identity=25.6603773584906, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17559104, Length=264, Percent_Identity=26.1363636363636, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17567345, Length=260, Percent_Identity=24.2307692307692, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17562904, Length=268, Percent_Identity=25.7462686567164, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6322226, Length=234, Percent_Identity=28.2051282051282, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6324126, Length=273, Percent_Identity=27.1062271062271, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6322227, Length=189, Percent_Identity=29.6296296296296, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI23397609, Length=262, Percent_Identity=30.5343511450382, Blast_Score=88, Evalue=8e-18,
Organism=Drosophila melanogaster, GI24644339, Length=265, Percent_Identity=27.5471698113208, Blast_Score=71, Evalue=7e-13,
Organism=Drosophila melanogaster, GI21355319, Length=192, Percent_Identity=28.6458333333333, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI28571526, Length=272, Percent_Identity=27.2058823529412, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017711
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.3.1.56 [H]

Molecular weight: Translated: 30800; Mature: 30669

Theoretical pI: Translated: 7.20; Mature: 7.20

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
0.3 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVPTDPNCFLKALDGQVALIVGATSGIGRAVVDAFLRCGAHVVAFGRSEEKLRELVASS
CCCCCCCCHHHHCCCCCEEEEEECCCCCHHHHHHHHHHCCCEEEEECCCHHHHHHHHHCH
QSFARALATYAGDATDHHDLDRAATLAVDRFGKLDTLVCTVGAFDYYRTILDYDTETLSS
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHH
AFEELFRINVLSYILAVRASLPYLLRQPSSIVLTLSTASFYPEGGGVLYGASKFATRGLV
HHHHHHHHHHHHHHHHHHHCCCHHHCCCCCEEEEEEECCCCCCCCCEEEECHHHHHHHHH
THLAYELAPRVRVNGVAPGGTIGTNLRGLASLREQDKRVDDATGDRAQRIQRSVPLQVAA
HHHHHHHCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCEEEEE
TPDDHTAAFVYLASHRLSRVVTGTIINSDGGRGVAGTVRVAHLVEEIS
CCCCCCEEHHHHHHHHHHHHHEEEEEECCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
TVPTDPNCFLKALDGQVALIVGATSGIGRAVVDAFLRCGAHVVAFGRSEEKLRELVASS
CCCCCCCHHHHCCCCCEEEEEECCCCCHHHHHHHHHHCCCEEEEECCCHHHHHHHHHCH
QSFARALATYAGDATDHHDLDRAATLAVDRFGKLDTLVCTVGAFDYYRTILDYDTETLSS
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHH
AFEELFRINVLSYILAVRASLPYLLRQPSSIVLTLSTASFYPEGGGVLYGASKFATRGLV
HHHHHHHHHHHHHHHHHHHCCCHHHCCCCCEEEEEEECCCCCCCCCEEEECHHHHHHHHH
THLAYELAPRVRVNGVAPGGTIGTNLRGLASLREQDKRVDDATGDRAQRIQRSVPLQVAA
HHHHHHHCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCEEEEE
TPDDHTAAFVYLASHRLSRVVTGTIINSDGGRGVAGTVRVAHLVEEIS
CCCCCCEEHHHHHHHHHHHHHEEEEEECCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8702262; 8890734 [H]