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The map label for this gene is mntH [H]

Identifier: 221635645

GI number: 221635645

Start: 227355

End: 228644

Strand: Reverse

Name: mntH [H]

Synonym: trd_A0239

Alternate gene names: 221635645

Gene position: 228644-227355 (Counterclockwise)

Preceding gene: 221635649

Following gene: 221635644

Centisome position: 24.91

GC content: 64.42

Gene sequence:

>1290_bases
GTGAACGAGCCGCCCAGCGAACCATCGTCCACTGCCCCGATCGCCCGCCGATCCAGGCAGCTCCGCGTGCGTGGACTCGC
GAGCGTTCTCCCTTACCTCGGTCCAGCTTTCGTTGCCAGCGTGGCGTACATCGATCCTGGCAACTACGCGACCAATATCG
AAAGCGGCGCTCAATTCGGCTACACCCTTCTCTGGGTCATCCTGGCCGCCAACCTCGCTGCGATGCTGATCCAGTCGCTT
TCCGCCAAGCTGGGTATCGCCACTGGCCGCAACCTCGCTGAGCTCTGCCGGGAGCGCTTCCCCCGTCCCGTGGTCTGGCT
CATGTGGATCGTCGCCGAACTGGTCGCCATGGCGACCGACCTCGCCGAGTTCCTCGGTGCCGCGCTCGGGTTCGCTCTCC
TCTTCCACTTTCCGCTGCTGATCGGTGGCATCTTGACGGGAATCACGACGTTCGCCATCCTCGCGCTGGAGCGCTACGGA
CACCGGCCGATCGAAGCGGTGATCACGAGTCTCGTCGGTGTCATCGCCGGCTGCTATGTCGTGGAAACGGTCCTCGAGCG
ACCGGACTGGAACGCCATCGCTCGCCATGCGCTCATCCCGGAGTTCGCCGGCCCGGAAAGCGTGCTGCTGGCCACCGGAA
TTCTCGGAGCGACCGTCATGCCGCATGTCATCTACTTGCACTCGGCACTCACCCAGCATCGTATCGTGCCGCGCACGCCG
GCCGAAGCACAGCGCATCTTCCGCTTCGAGGTGCTCGACGTCGTGATCGCCATGGGCATCGCTGGGCTCGTCAATGCTGC
CATGCTCATCATGGCAGCTTCGACCTTTCATGCCCGCGGACTCTCCGACGTCGGGACGATCGAGGAGGCCCACCGCACGT
TGCAGCCATTGCTCGGACCATTGGCCAGCACCGCGTTCGCGCTCTCACTGCTCGCGTCGGGCCTTTCCTCCTCCACGGTC
GGCACGATGGCCGGTCAAGTGGTGATGCAAGGCTTCCTTCATCGGACGATCCCCGTCTGGCTCCGCCGGGGAATCACCAT
GCTCCCGGCCCTCATCGCCATCGCGCTCGGGCTCGATCCCACACGCACGCTCGTGATCAGCCAGGTCGTCTTGAGCTTCG
GCATCCCGTTCGCGCTCCTCCCACTGATTCTCTTCACCGCCGATCGGGCACTGATGGGTGCACTGGTGAACCGGCGACCG
ACGACACTGGTGGCGAGCATCCTCGCTCTCCTCATCATCGGGCTCAACCTCTGGCTGCTCTGGACGACATTCACGGGAAG
TGGCGCATGA

Upstream 100 bases:

>100_bases
CCCGACCACCGAGCGGAACCGGAAAGCGACGGAGCATTCTCGGCACGTCGAAAACGAGCGCCGTATCATTAGCATTGGCT
AAAATCGGGAGGGGTATGAT

Downstream 100 bases:

>100_bases
GCGAGATCCCGTTGGCGCACATCCTCGTTCCCCTCGATGGCTCATCGCTGGCCGAGCAGATCCTCCCCGTCGCCGCTGGA
CTCGTCCGTGCGTGCGGCCG

Product: mn2+/fe2+ transporter, nramp family

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 429; Mature: 429

Protein sequence:

>429_residues
MNEPPSEPSSTAPIARRSRQLRVRGLASVLPYLGPAFVASVAYIDPGNYATNIESGAQFGYTLLWVILAANLAAMLIQSL
SAKLGIATGRNLAELCRERFPRPVVWLMWIVAELVAMATDLAEFLGAALGFALLFHFPLLIGGILTGITTFAILALERYG
HRPIEAVITSLVGVIAGCYVVETVLERPDWNAIARHALIPEFAGPESVLLATGILGATVMPHVIYLHSALTQHRIVPRTP
AEAQRIFRFEVLDVVIAMGIAGLVNAAMLIMAASTFHARGLSDVGTIEEAHRTLQPLLGPLASTAFALSLLASGLSSSTV
GTMAGQVVMQGFLHRTIPVWLRRGITMLPALIAIALGLDPTRTLVISQVVLSFGIPFALLPLILFTADRALMGALVNRRP
TTLVASILALLIIGLNLWLLWTTFTGSGA

Sequences:

>Translated_429_residues
MNEPPSEPSSTAPIARRSRQLRVRGLASVLPYLGPAFVASVAYIDPGNYATNIESGAQFGYTLLWVILAANLAAMLIQSL
SAKLGIATGRNLAELCRERFPRPVVWLMWIVAELVAMATDLAEFLGAALGFALLFHFPLLIGGILTGITTFAILALERYG
HRPIEAVITSLVGVIAGCYVVETVLERPDWNAIARHALIPEFAGPESVLLATGILGATVMPHVIYLHSALTQHRIVPRTP
AEAQRIFRFEVLDVVIAMGIAGLVNAAMLIMAASTFHARGLSDVGTIEEAHRTLQPLLGPLASTAFALSLLASGLSSSTV
GTMAGQVVMQGFLHRTIPVWLRRGITMLPALIAIALGLDPTRTLVISQVVLSFGIPFALLPLILFTADRALMGALVNRRP
TTLVASILALLIIGLNLWLLWTTFTGSGA
>Mature_429_residues
MNEPPSEPSSTAPIARRSRQLRVRGLASVLPYLGPAFVASVAYIDPGNYATNIESGAQFGYTLLWVILAANLAAMLIQSL
SAKLGIATGRNLAELCRERFPRPVVWLMWIVAELVAMATDLAEFLGAALGFALLFHFPLLIGGILTGITTFAILALERYG
HRPIEAVITSLVGVIAGCYVVETVLERPDWNAIARHALIPEFAGPESVLLATGILGATVMPHVIYLHSALTQHRIVPRTP
AEAQRIFRFEVLDVVIAMGIAGLVNAAMLIMAASTFHARGLSDVGTIEEAHRTLQPLLGPLASTAFALSLLASGLSSSTV
GTMAGQVVMQGFLHRTIPVWLRRGITMLPALIAIALGLDPTRTLVISQVVLSFGIPFALLPLILFTADRALMGALVNRRP
TTLVASILALLIIGLNLWLLWTTFTGSGA

Specific function: H(+)-stimulated, highly selective, manganese uptake system [H]

COG id: COG1914

COG function: function code P; Mn2+ and Fe2+ transporters of the NRAMP family

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NRAMP family [H]

Homologues:

Organism=Homo sapiens, GI109255241, Length=453, Percent_Identity=32.6710816777042, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI295293167, Length=426, Percent_Identity=31.2206572769953, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI295293175, Length=426, Percent_Identity=31.2206572769953, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI295293173, Length=426, Percent_Identity=31.2206572769953, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI10835169, Length=426, Percent_Identity=31.2206572769953, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI295293178, Length=426, Percent_Identity=31.2206572769953, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI295293171, Length=426, Percent_Identity=31.2206572769953, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI295293169, Length=426, Percent_Identity=31.2206572769953, Blast_Score=176, Evalue=3e-44,
Organism=Escherichia coli, GI1788736, Length=426, Percent_Identity=52.8169014084507, Blast_Score=424, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI17569473, Length=408, Percent_Identity=31.1274509803922, Blast_Score=197, Evalue=6e-51,
Organism=Caenorhabditis elegans, GI193210616, Length=465, Percent_Identity=27.741935483871, Blast_Score=184, Evalue=9e-47,
Organism=Caenorhabditis elegans, GI71999499, Length=432, Percent_Identity=30.0925925925926, Blast_Score=181, Evalue=5e-46,
Organism=Caenorhabditis elegans, GI71993856, Length=235, Percent_Identity=31.9148936170213, Blast_Score=142, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6324450, Length=427, Percent_Identity=31.8501170960187, Blast_Score=195, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6323062, Length=390, Percent_Identity=34.1025641025641, Blast_Score=193, Evalue=4e-50,
Organism=Saccharomyces cerevisiae, GI6321841, Length=450, Percent_Identity=31.7777777777778, Blast_Score=173, Evalue=4e-44,
Organism=Drosophila melanogaster, GI24648607, Length=429, Percent_Identity=31.002331002331, Blast_Score=210, Evalue=1e-54,
Organism=Drosophila melanogaster, GI281362176, Length=429, Percent_Identity=31.002331002331, Blast_Score=210, Evalue=1e-54,
Organism=Drosophila melanogaster, GI24648609, Length=429, Percent_Identity=31.002331002331, Blast_Score=210, Evalue=1e-54,
Organism=Drosophila melanogaster, GI45553443, Length=406, Percent_Identity=31.2807881773399, Blast_Score=198, Evalue=5e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023056
- InterPro:   IPR001046 [H]

Pfam domain/function: PF01566 Nramp [H]

EC number: NA

Molecular weight: Translated: 45812; Mature: 45812

Theoretical pI: Translated: 9.10; Mature: 9.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEPPSEPSSTAPIARRSRQLRVRGLASVLPYLGPAFVASVAYIDPGNYATNIESGAQFG
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCHHHH
YTLLWVILAANLAAMLIQSLSAKLGIATGRNLAELCRERFPRPVVWLMWIVAELVAMATD
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
LAEFLGAALGFALLFHFPLLIGGILTGITTFAILALERYGHRPIEAVITSLVGVIAGCYV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
VETVLERPDWNAIARHALIPEFAGPESVLLATGILGATVMPHVIYLHSALTQHRIVPRTP
HHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
AEAQRIFRFEVLDVVIAMGIAGLVNAAMLIMAASTFHARGLSDVGTIEEAHRTLQPLLGP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
LASTAFALSLLASGLSSSTVGTMAGQVVMQGFLHRTIPVWLRRGITMLPALIAIALGLDP
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCH
TRTLVISQVVLSFGIPFALLPLILFTADRALMGALVNRRPTTLVASILALLIIGLNLWLL
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
WTTFTGSGA
HHHCCCCCC
>Mature Secondary Structure
MNEPPSEPSSTAPIARRSRQLRVRGLASVLPYLGPAFVASVAYIDPGNYATNIESGAQFG
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCHHHH
YTLLWVILAANLAAMLIQSLSAKLGIATGRNLAELCRERFPRPVVWLMWIVAELVAMATD
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
LAEFLGAALGFALLFHFPLLIGGILTGITTFAILALERYGHRPIEAVITSLVGVIAGCYV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
VETVLERPDWNAIARHALIPEFAGPESVLLATGILGATVMPHVIYLHSALTQHRIVPRTP
HHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
AEAQRIFRFEVLDVVIAMGIAGLVNAAMLIMAASTFHARGLSDVGTIEEAHRTLQPLLGP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
LASTAFALSLLASGLSSSTVGTMAGQVVMQGFLHRTIPVWLRRGITMLPALIAIALGLDP
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCH
TRTLVISQVVLSFGIPFALLPLILFTADRALMGALVNRRPTTLVASILALLIIGLNLWLL
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
WTTFTGSGA
HHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10567266 [H]