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The map label for this gene is ndk

Identifier: 221633743

GI number: 221633743

Start: 1773222

End: 1773671

Strand: Reverse

Name: ndk

Synonym: trd_1770

Alternate gene names: 221633743

Gene position: 1773671-1773222 (Counterclockwise)

Preceding gene: 221633744

Following gene: 221633740

Centisome position: 88.55

GC content: 62.89

Gene sequence:

>450_bases
GTGGAGCGGACGCTGATCATCGTGAAGCCGGATGCGGTCCAGCGGGGACTGGTTGGGGAGGTGCTGCGGCGATTGGAGCA
GCGTGGCCTGCGCTTCGTCGGTTTGAAGTTGATGAAGGTCGATCGTGAGGTAGCTGAACGGCACTACGCAGAGCACCGGG
GCAAACCGTTTTATGAGGACCTGCTGGCGTTCATCACGTCGGGTCCGGTGGTGGTCGGGGTGGTCGAGGGGCCGCGGGCG
ATCGAGATCACGCGGAAGACGATGGGAAAGACCGATCCGGCGCAGGCGGAGCCCGGCACCATTCGGGGTGATCTGGCGCT
GACGATCGGGCAGAACGTGATCCACGGGTCGGACAGCCCGGAGAAGGCGTCGTACGAAATCGGTCTGTTTTTCCGCGAAG
ATGAACTCGTAAGCTACGAGCGGGCGATCGATCGCTGGATCATGGGCTGA

Upstream 100 bases:

>100_bases
TGGCGCTGCGGTTGCGGAACGAGTAGGCTGAACAGTGGAGAAAGGACGTGGCGGTGGCGGGCGAGGGGATCGCCCGCGTT
CGTTGTCGGAGGGTAGTGGC

Downstream 100 bases:

>100_bases
GGAGTGTTTCACGTGAAACAACCGGAGAGAGGCAGGGGAGTGCCTCCTGCCTCTCTCCCTTTTCAGCTATCGCTCTGGCG
GATGATCAGCGGGTGCTTGT

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 149; Mature: 149

Protein sequence:

>149_residues
MERTLIIVKPDAVQRGLVGEVLRRLEQRGLRFVGLKLMKVDREVAERHYAEHRGKPFYEDLLAFITSGPVVVGVVEGPRA
IEITRKTMGKTDPAQAEPGTIRGDLALTIGQNVIHGSDSPEKASYEIGLFFREDELVSYERAIDRWIMG

Sequences:

>Translated_149_residues
MERTLIIVKPDAVQRGLVGEVLRRLEQRGLRFVGLKLMKVDREVAERHYAEHRGKPFYEDLLAFITSGPVVVGVVEGPRA
IEITRKTMGKTDPAQAEPGTIRGDLALTIGQNVIHGSDSPEKASYEIGLFFREDELVSYERAIDRWIMG
>Mature_149_residues
MERTLIIVKPDAVQRGLVGEVLRRLEQRGLRFVGLKLMKVDREVAERHYAEHRGKPFYEDLLAFITSGPVVVGVVEGPRA
IEITRKTMGKTDPAQAEPGTIRGDLALTIGQNVIHGSDSPEKASYEIGLFFREDELVSYERAIDRWIMG

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI4557797, Length=147, Percent_Identity=48.2993197278912, Blast_Score=160, Evalue=3e-40,
Organism=Homo sapiens, GI38045913, Length=147, Percent_Identity=48.2993197278912, Blast_Score=160, Evalue=3e-40,
Organism=Homo sapiens, GI37693993, Length=146, Percent_Identity=49.3150684931507, Blast_Score=155, Evalue=2e-38,
Organism=Homo sapiens, GI66392227, Length=147, Percent_Identity=44.8979591836735, Blast_Score=153, Evalue=4e-38,
Organism=Homo sapiens, GI66392205, Length=147, Percent_Identity=44.8979591836735, Blast_Score=153, Evalue=4e-38,
Organism=Homo sapiens, GI4505409, Length=147, Percent_Identity=44.8979591836735, Blast_Score=153, Evalue=4e-38,
Organism=Homo sapiens, GI66392192, Length=147, Percent_Identity=44.8979591836735, Blast_Score=153, Evalue=4e-38,
Organism=Homo sapiens, GI66392203, Length=147, Percent_Identity=44.8979591836735, Blast_Score=153, Evalue=5e-38,
Organism=Homo sapiens, GI4826862, Length=138, Percent_Identity=50.7246376811594, Blast_Score=143, Evalue=6e-35,
Organism=Homo sapiens, GI5031951, Length=135, Percent_Identity=36.2962962962963, Blast_Score=81, Evalue=3e-16,
Organism=Homo sapiens, GI7019465, Length=133, Percent_Identity=32.3308270676692, Blast_Score=75, Evalue=1e-14,
Organism=Homo sapiens, GI37574614, Length=133, Percent_Identity=32.3308270676692, Blast_Score=75, Evalue=2e-14,
Organism=Homo sapiens, GI148839372, Length=140, Percent_Identity=29.2857142857143, Blast_Score=67, Evalue=6e-12,
Organism=Escherichia coli, GI1788866, Length=141, Percent_Identity=44.6808510638298, Blast_Score=132, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17506807, Length=147, Percent_Identity=40.8163265306122, Blast_Score=133, Evalue=4e-32,
Organism=Saccharomyces cerevisiae, GI6322783, Length=146, Percent_Identity=47.945205479452, Blast_Score=156, Evalue=1e-39,
Organism=Drosophila melanogaster, GI45549037, Length=146, Percent_Identity=47.945205479452, Blast_Score=157, Evalue=3e-39,
Organism=Drosophila melanogaster, GI18860097, Length=136, Percent_Identity=32.3529411764706, Blast_Score=82, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_THERP (B9L159)

Other databases:

- EMBL:   CP001275
- RefSeq:   YP_002522969.1
- GeneID:   7356224
- GenomeReviews:   CP001275_GR
- KEGG:   tro:trd_1770
- OMA:   ERPFFGA
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- InterPro:   IPR023005
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 16747; Mature: 16747

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 115-115 BINDING 9-9 BINDING 57-57 BINDING 85-85 BINDING 91-91 BINDING 102-102 BINDING 112-112

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERTLIIVKPDAVQRGLVGEVLRRLEQRGLRFVGLKLMKVDREVAERHYAEHRGKPFYED
CCCEEEEECCCHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
LLAFITSGPVVVGVVEGPRAIEITRKTMGKTDPAQAEPGTIRGDLALTIGQNVIHGSDSP
HHHHHHCCCEEEEEECCCCEEEEEHHHCCCCCCCCCCCCCEECCEEEEECCEEECCCCCC
EKASYEIGLFFREDELVSYERAIDRWIMG
CCCCEEEEEEEECCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MERTLIIVKPDAVQRGLVGEVLRRLEQRGLRFVGLKLMKVDREVAERHYAEHRGKPFYED
CCCEEEEECCCHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
LLAFITSGPVVVGVVEGPRAIEITRKTMGKTDPAQAEPGTIRGDLALTIGQNVIHGSDSP
HHHHHHCCCEEEEEECCCCEEEEEHHHCCCCCCCCCCCCCEECCEEEEECCEEECCCCCC
EKASYEIGLFFREDELVSYERAIDRWIMG
CCCCEEEEEEEECCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA