| Definition | Thermomicrobium roseum DSM 5159 chromosome, complete genome. |
|---|---|
| Accession | NC_011959 |
| Length | 2,003,006 |
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The map label for this gene is bhbA [H]
Identifier: 221633536
GI number: 221633536
Start: 1543124
End: 1544698
Strand: Reverse
Name: bhbA [H]
Synonym: trd_1560
Alternate gene names: 221633536
Gene position: 1544698-1543124 (Counterclockwise)
Preceding gene: 221633537
Following gene: 221633534
Centisome position: 77.12
GC content: 64.51
Gene sequence:
>1575_bases ATGGCGACGACCGAGATCCGCCGCGTGGTGACCGATTCAGGAATCGAGATCGCGCCGGTCTATCGCGAAACCGGTCGTCG GCCCGAGCCGGATCCCGGTGCATACCCCTACACGCGGGGGATCCACCCCACGATGTACCGCGGCAAGAAGTGGACGATCC GGCAATATGCTGGATACGGCTCGGCAGAAGAGACGAATCGTCGTTTCCGGCTTCTTCTCGAGCGGGGACAAACCGGACTG AGCGTCGCCTTCGACCTCCCTACTCAGCTCGGTTACGACTCCGATCATCCGCTGGCGCGACCGGAGGTGGGGCGAGTCGG GGTGGCTATCTCGACGCTCGATGACATGCGTCGGCTGTTCGCTGGAATCGATCTCGGTGCTGTCACGACCTCGATGACGA TCAATGCCCCAGCGGCGATTCTCCTGCTCATGTACCAGATCGTCGCCGAGGAGCAGGGGGTGGATCCGAAGCAGCTGCGC GGCACCATCCAGAACGACATTCTCAAAGAGTATGCTGCGCGCGGTACCTACATCTTTCCACCGCGCCCGTCGATGCGTTT GGTCGTCGATACGTTCGCGTACTGTAAGGAGCACCTCCCCAACTGGAACACCATCTCGATCAGCGGCTACCACATCCGCG AAGCTGGGGCGACCGCTGTGCAGGAAGTCGCGTTCACGCTGGCCAACGCCATCGCCTATGTCCGGGCGGCGATCGATGCG GGGCTCGCGGTGGACGAGTTCGCGCCGCGCCTCAGCTTCTTTTTCGGCGCCCACAACAACTTCTTCGAGGAGGTCGCCAA GTTCCGGGCCGCGCGCCGGATGTGGGCCATCATCATGCGAGAGCGGTTCGGCGCCCAGAACCCACGATCCTGGATGTTGC GGTTCCACACGCAGACCTGTGGCTGCACCCTCACTGCGCAACAGCCCTTGAACAACATCGTACGCGTCGCCTACCAGGCT CTGGCTGCTGTCCTGGGGGGAACCCAGAGCTTGCACACCAACTCCTATGACGAGGCGCTGGGCTTGCCCACCGAGGAATC GGCGACGATCGCCTTGCGCACGCAGCAGATCCTGGCCGAAGAGACCGGTGTGGCTGATACGGCTGATCCGCTGGGCGGCT CCTATTTCGTCGAGGCTTTGACCGACGAGGTGGAGCGGCGCGCGTGGGAGCTCATCGATGCCATCGAGGAGCTCGGCGGG GCAGTCGCCGCGATCGAGCGAGGCTGGATCCAAGCGCAGATCGCCGAAAGCGCCTACGCGTGGGAGCAAGCCGTCGAGCG TGGAGAGCGTATCGTCGTCGGCGTCAACCGCTATCAAGACGCGATACCGGTGCACGTACCGGTGCACCGGTTGGATGATG CAGCGGTCGAGCGACAGATCGCGCGTGTGCAGGAGTACCGGGCGCGGCAGGACAGCGAGCGGGTCGCCCGAGCGCTCGAC CGCCTGGAAGAGGCTGCCCGAGGAACGGAGAACATGCTCCCTGTCCTGCGCGAGGCGCTCCTGGCAGGGGCGACGCTCGG TCAGATCTGTGGGCGCCTGCGCCAGGTGTGGGGAGAGTACCGACCCCGCTTCTGA
Upstream 100 bases:
>100_bases TGGAAAGTCGCCGATTCGGGGCGGCAGGCCAGAATCACCCGCCCCCATCGGTGTGCTGAGGAATCGAACACGCCCGCGAG CAAGAGCGAGGAGGTCGAAA
Downstream 100 bases:
>100_bases GTACCCGCACGACCGGTTCGAGCGCTCACTCGTCCAGATAGGGGTGGTCGGTGGAGCCACGGCGCAAGAGATGGTGGATC GCATTCGGCGGAGCAGGCCG
Product: methylmalonyl Coenzyme A mutase
Products: NA
Alternate protein names: MCM [H]
Number of amino acids: Translated: 524; Mature: 523
Protein sequence:
>524_residues MATTEIRRVVTDSGIEIAPVYRETGRRPEPDPGAYPYTRGIHPTMYRGKKWTIRQYAGYGSAEETNRRFRLLLERGQTGL SVAFDLPTQLGYDSDHPLARPEVGRVGVAISTLDDMRRLFAGIDLGAVTTSMTINAPAAILLLMYQIVAEEQGVDPKQLR GTIQNDILKEYAARGTYIFPPRPSMRLVVDTFAYCKEHLPNWNTISISGYHIREAGATAVQEVAFTLANAIAYVRAAIDA GLAVDEFAPRLSFFFGAHNNFFEEVAKFRAARRMWAIIMRERFGAQNPRSWMLRFHTQTCGCTLTAQQPLNNIVRVAYQA LAAVLGGTQSLHTNSYDEALGLPTEESATIALRTQQILAEETGVADTADPLGGSYFVEALTDEVERRAWELIDAIEELGG AVAAIERGWIQAQIAESAYAWEQAVERGERIVVGVNRYQDAIPVHVPVHRLDDAAVERQIARVQEYRARQDSERVARALD RLEEAARGTENMLPVLREALLAGATLGQICGRLRQVWGEYRPRF
Sequences:
>Translated_524_residues MATTEIRRVVTDSGIEIAPVYRETGRRPEPDPGAYPYTRGIHPTMYRGKKWTIRQYAGYGSAEETNRRFRLLLERGQTGL SVAFDLPTQLGYDSDHPLARPEVGRVGVAISTLDDMRRLFAGIDLGAVTTSMTINAPAAILLLMYQIVAEEQGVDPKQLR GTIQNDILKEYAARGTYIFPPRPSMRLVVDTFAYCKEHLPNWNTISISGYHIREAGATAVQEVAFTLANAIAYVRAAIDA GLAVDEFAPRLSFFFGAHNNFFEEVAKFRAARRMWAIIMRERFGAQNPRSWMLRFHTQTCGCTLTAQQPLNNIVRVAYQA LAAVLGGTQSLHTNSYDEALGLPTEESATIALRTQQILAEETGVADTADPLGGSYFVEALTDEVERRAWELIDAIEELGG AVAAIERGWIQAQIAESAYAWEQAVERGERIVVGVNRYQDAIPVHVPVHRLDDAAVERQIARVQEYRARQDSERVARALD RLEEAARGTENMLPVLREALLAGATLGQICGRLRQVWGEYRPRF >Mature_523_residues ATTEIRRVVTDSGIEIAPVYRETGRRPEPDPGAYPYTRGIHPTMYRGKKWTIRQYAGYGSAEETNRRFRLLLERGQTGLS VAFDLPTQLGYDSDHPLARPEVGRVGVAISTLDDMRRLFAGIDLGAVTTSMTINAPAAILLLMYQIVAEEQGVDPKQLRG TIQNDILKEYAARGTYIFPPRPSMRLVVDTFAYCKEHLPNWNTISISGYHIREAGATAVQEVAFTLANAIAYVRAAIDAG LAVDEFAPRLSFFFGAHNNFFEEVAKFRAARRMWAIIMRERFGAQNPRSWMLRFHTQTCGCTLTAQQPLNNIVRVAYQAL AAVLGGTQSLHTNSYDEALGLPTEESATIALRTQQILAEETGVADTADPLGGSYFVEALTDEVERRAWELIDAIEELGGA VAAIERGWIQAQIAESAYAWEQAVERGERIVVGVNRYQDAIPVHVPVHRLDDAAVERQIARVQEYRARQDSERVARALDR LEEAARGTENMLPVLREALLAGATLGQICGRLRQVWGEYRPRF
Specific function: Catalyzes the interconversion of succinyl-CoA and methylmalonyl-CoA during the polyhydroxyalkanoate degradation pathway [H]
COG id: COG1884
COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 B12-binding domain [H]
Homologues:
Organism=Homo sapiens, GI156105689, Length=515, Percent_Identity=48.7378640776699, Blast_Score=495, Evalue=1e-140, Organism=Escherichia coli, GI1789284, Length=519, Percent_Identity=48.9402697495183, Blast_Score=472, Evalue=1e-134, Organism=Caenorhabditis elegans, GI25144500, Length=516, Percent_Identity=48.6434108527132, Blast_Score=511, Evalue=1e-145,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR006159 - InterPro: IPR016176 - InterPro: IPR014348 - InterPro: IPR006158 - InterPro: IPR006099 - InterPro: IPR006098 [H]
Pfam domain/function: PF02310 B12-binding; PF01642 MM_CoA_mutase [H]
EC number: =5.4.99.2 [H]
Molecular weight: Translated: 58428; Mature: 58297
Theoretical pI: Translated: 6.10; Mature: 6.10
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.8 %Cys (Translated Protein) 1.9 %Met (Translated Protein) 2.7 %Cys+Met (Translated Protein) 0.8 %Cys (Mature Protein) 1.7 %Met (Mature Protein) 2.5 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MATTEIRRVVTDSGIEIAPVYRETGRRPEPDPGAYPYTRGIHPTMYRGKKWTIRQYAGYG CCCHHHHHHHHCCCCEEEECHHHCCCCCCCCCCCCCCCCCCCCHHCCCCCEEHHHHCCCC SAEETNRRFRLLLERGQTGLSVAFDLPTQLGYDSDHPLARPEVGRVGVAISTLDDMRRLF CCHHHHHHHHHHHHCCCCCCEEEEECCHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH AGIDLGAVTTSMTINAPAAILLLMYQIVAEEQGVDPKQLRGTIQNDILKEYAARGTYIFP HCCCHHHHHEEEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCEEEC PRPSMRLVVDTFAYCKEHLPNWNTISISGYHIREAGATAVQEVAFTLANAIAYVRAAIDA CCCCHHHHHHHHHHHHHHCCCCCEEEEECEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHC GLAVDEFAPRLSFFFGAHNNFFEEVAKFRAARRMWAIIMRERFGAQNPRSWMLRFHTQTC CCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHEEEECCCC GCTLTAQQPLNNIVRVAYQALAAVLGGTQSLHTNSYDEALGLPTEESATIALRTQQILAE CEEEECHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCCCCCEEEEHHHHHHHH ETGVADTADPLGGSYFVEALTDEVERRAWELIDAIEELGGAVAAIERGWIQAQIAESAYA HCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHH WEQAVERGERIVVGVNRYQDAIPVHVPVHRLDDAAVERQIARVQEYRARQDSERVARALD HHHHHHCCCEEEEEECHHCCCCCCEECHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH RLEEAARGTENMLPVLREALLAGATLGQICGRLRQVWGEYRPRF HHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCC >Mature Secondary Structure ATTEIRRVVTDSGIEIAPVYRETGRRPEPDPGAYPYTRGIHPTMYRGKKWTIRQYAGYG CCHHHHHHHHCCCCEEEECHHHCCCCCCCCCCCCCCCCCCCCHHCCCCCEEHHHHCCCC SAEETNRRFRLLLERGQTGLSVAFDLPTQLGYDSDHPLARPEVGRVGVAISTLDDMRRLF CCHHHHHHHHHHHHCCCCCCEEEEECCHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH AGIDLGAVTTSMTINAPAAILLLMYQIVAEEQGVDPKQLRGTIQNDILKEYAARGTYIFP HCCCHHHHHEEEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCEEEC PRPSMRLVVDTFAYCKEHLPNWNTISISGYHIREAGATAVQEVAFTLANAIAYVRAAIDA CCCCHHHHHHHHHHHHHHCCCCCEEEEECEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHC GLAVDEFAPRLSFFFGAHNNFFEEVAKFRAARRMWAIIMRERFGAQNPRSWMLRFHTQTC CCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHEEEECCCC GCTLTAQQPLNNIVRVAYQALAAVLGGTQSLHTNSYDEALGLPTEESATIALRTQQILAE CEEEECHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCCCCCEEEEHHHHHHHH ETGVADTADPLGGSYFVEALTDEVERRAWELIDAIEELGGAVAAIERGWIQAQIAESAYA HCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHH WEQAVERGERIVVGVNRYQDAIPVHVPVHRLDDAAVERQIARVQEYRARQDSERVARALD HHHHHHCCCEEEEEECHHCCCCCCEECHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH RLEEAARGTENMLPVLREALLAGATLGQICGRLRQVWGEYRPRF HHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 9889346; 11481431 [H]