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The map label for this gene is nrdA [H]

Identifier: 221633389

GI number: 221633389

Start: 1401092

End: 1403404

Strand: Reverse

Name: nrdA [H]

Synonym: trd_1409

Alternate gene names: 221633389

Gene position: 1403404-1401092 (Counterclockwise)

Preceding gene: 221633390

Following gene: 221633388

Centisome position: 70.06

GC content: 65.89

Gene sequence:

>2313_bases
ATGGTATCCCTGGTGTCGAGTTCTCTCCACCTCCGACCGATCGCACGGGACGAAGCAGCCGAGCTGGACAGTCGGATCTT
GAGCTGTCTCCAGCAGTTACCCGATCGGCCCGAGGCCGAGCGGGAAGCAGCGGCGCTGCTCCTGGAAAAGATCGCACGCG
AGGCGGATGACGGGACGCCCCTCCCCTATCCCGAGCATTTCCGGCGATTCGTCGAGCGTGGCATCGCTCGCGGCGCGCTC
GACCCGCGACTCCGTACCTTCCAGCTCGATGTGCTGGCGCGAGCGCTGGACCCGGCGCGTGACGCGCTCCTCGGTTATGC
GGCGCTGGCGACGCTGGCCGATCGGTACCTGGTCCGGGATCCGGAGACGCGCCAGCTGCTCGAGCGACCACAGGCGCTCT
TCATGCGCGTGGCGATGGGGCTGGCGCTGGTCGAACCGCCTGAGACGCGGACCAGCTGGGCCCTGCGCTGGTACGACCTG
ATGAGTTCGCTCCGGTATCTGCCGAGTACCCCGACACTCTTCAATGCGGGCACGCCGCACCACCAGTTGGCCTCGTGCTA
CCTGGCGGAGGTCGAGGACAGTCTGGAAAGCATTTTGGGCTCGGCGTACGAGTTCGGGATGCTGGCCAAGTACGCCGGCG
GGATCGGCACGGCCGTGACGCGCATCCGGGCCACGGGTGCTCCCGTGCGTGGGATCAACGGGACGAGCGGTGGGCTGATC
CCGTTTCTTCACCTGTACGATGCCCTGATCGCCTCGATCAGTCAGGGTGGTCGTCGGCGCGGCACGATGTGCGTGTACCT
GGAGCCGTGGCACCTGGAGGTGGAAGCGTTCCTCGATCTGCGCCGCAATGCCGGTGATCCCTACCGTCGTACGCATCAGC
TCAACACCGCGCTCTGGATCCCCGATGAGTTCTTGCGGCGTGTCGAGACGGACGACCTCTGGTACCTTTTCGATCCGATC
GTTGCGCCCGAGCTCCCGGATCTGGTGGGTGCCGCGTTCTCGGAGCGTTACCGAGAACTCTGCCGACAGGCAGAGGCGGG
GATGCTCCCCCGACGAGCCTGGCGCCGCCTGCCTGCCCGCGAGCTGTGGTTGGCCATCTTGGCGAGCCTGATGGAAACCG
GGCACCCCTGGCTCACCTTCAAAGATGCCGGGAACCTCCGTTCTCAGTTGCGCGGGATCGGTGTCATTCACTCGAGCAAC
CTCTGTACGGAGATCTTCCTCCCGACCAGTCGCGACGAGGTGGCGGTGTGCAATCTCGGCAGTGTAAACCTCGCTCGCCA
CTGCACGCCGACCGGCGAACTGGACTGGGAGCAGCTGGCGGCGACGGTGCGGCTGGCGATGCGGGCACTCGACAACGTCA
TCGATGCGAACCTGTATCCCTCGGAACGCGCGGCGCGAGCCAACCAGCTCAATCGCCCCGTGGGACTCGGCCTCATGGGC
TTCGCCGAGCTCTTGGCCCGCCGCGCTGTCTCGTACGCTGAGCCAGCAGCAGCGGATCTGGCGGATCAGATCGCCGAGTT
CCTCAGCTATCACGCCATCAGCGCCAGTTGCGCACTGGCGGAGGAGCGAGGCGCGTTTCCCAACTTTGCCTTTTCCCGCT
GGGCAGCCGGTGTTCTTCCGATCGATACCCTCGATGAACTTGCAGCCGATCGTGGGTTGCCGGTGGAGGTCGACCGCACG
CGGCGACTGGACTGGGAACCGCTGCGCCAGCGGGTGCGGCGGGGCATGCGCAATGGTGCCGTGATGGCGGTGGCACCGAC
CGCAACCATCGCTTTACTGGCGGGAACCACCCCGAGTCTCGATCCGTACTATGCGAACGTCTTCAGCCGGCAAACGCTCT
CCGGGAAGTTCCTGGAAGTCAACCCCATCCTCGTCGAGGAACTCCGGCGTCGGGGGCTTTGGGAGCAGTTGTTGCCCGGT
CTCGTGGCAGCGCGTGGGGACTTGCGAGCGGTGCCGGGGTGTCCACCCGACCTCGTCGCGCGCTTCCCGACCGCCTATCA
AGTGCCGGCGGAGTCGTACATCGAAGTGGCGGCGCGGGTTCAGAAGTGGGTGGACATGGGGGTCAGTCGCAATCTCTACC
ATGCGGCTGATCGACCAGGGCAGATGAGTGCGGTGTATCTGGCGGCCTGGCGCAAGGGGCTCAAGAGCACCTACTACTGC
TTCGTGCGTCCACGCATGGAGATCGAGCAATCCACGGTTGCCGTCAACAAGGCGCGGCGTCGCCCGCAATGGGTGCAGCT
CGCCGAGCGCGAGGTGCTGGCGAGCGATGCGGCGAGCTGCCGTCTCGATGGGTCGTGCGAAAGTTGCCAGTGA

Upstream 100 bases:

>100_bases
GTGGTCGGTTCGGGATGCTCGATCCCGGGGGAGCATCCGTTCGCTGCCGCTCTGGCCGCTCGGTCGCGCGAGGCGGCCGG
AAAAACAGGAGGGCGGTGCG

Downstream 100 bases:

>100_bases
AGGACGAGGAGGGACCAGAATGGCCCGCCGATTGCTCGGAGGCGATCCCCTAGCTGCTGTGGAGCTCTTCCCGCTGAGTC
ACCCGTGGGCCTATGCGCAT

Product: ribonucleoside-diphosphate reductase subunit alpha

Products: NA

Alternate protein names: Ribonucleotide reductase [H]

Number of amino acids: Translated: 770; Mature: 770

Protein sequence:

>770_residues
MVSLVSSSLHLRPIARDEAAELDSRILSCLQQLPDRPEAEREAAALLLEKIAREADDGTPLPYPEHFRRFVERGIARGAL
DPRLRTFQLDVLARALDPARDALLGYAALATLADRYLVRDPETRQLLERPQALFMRVAMGLALVEPPETRTSWALRWYDL
MSSLRYLPSTPTLFNAGTPHHQLASCYLAEVEDSLESILGSAYEFGMLAKYAGGIGTAVTRIRATGAPVRGINGTSGGLI
PFLHLYDALIASISQGGRRRGTMCVYLEPWHLEVEAFLDLRRNAGDPYRRTHQLNTALWIPDEFLRRVETDDLWYLFDPI
VAPELPDLVGAAFSERYRELCRQAEAGMLPRRAWRRLPARELWLAILASLMETGHPWLTFKDAGNLRSQLRGIGVIHSSN
LCTEIFLPTSRDEVAVCNLGSVNLARHCTPTGELDWEQLAATVRLAMRALDNVIDANLYPSERAARANQLNRPVGLGLMG
FAELLARRAVSYAEPAAADLADQIAEFLSYHAISASCALAEERGAFPNFAFSRWAAGVLPIDTLDELAADRGLPVEVDRT
RRLDWEPLRQRVRRGMRNGAVMAVAPTATIALLAGTTPSLDPYYANVFSRQTLSGKFLEVNPILVEELRRRGLWEQLLPG
LVAARGDLRAVPGCPPDLVARFPTAYQVPAESYIEVAARVQKWVDMGVSRNLYHAADRPGQMSAVYLAAWRKGLKSTYYC
FVRPRMEIEQSTVAVNKARRRPQWVQLAEREVLASDAASCRLDGSCESCQ

Sequences:

>Translated_770_residues
MVSLVSSSLHLRPIARDEAAELDSRILSCLQQLPDRPEAEREAAALLLEKIAREADDGTPLPYPEHFRRFVERGIARGAL
DPRLRTFQLDVLARALDPARDALLGYAALATLADRYLVRDPETRQLLERPQALFMRVAMGLALVEPPETRTSWALRWYDL
MSSLRYLPSTPTLFNAGTPHHQLASCYLAEVEDSLESILGSAYEFGMLAKYAGGIGTAVTRIRATGAPVRGINGTSGGLI
PFLHLYDALIASISQGGRRRGTMCVYLEPWHLEVEAFLDLRRNAGDPYRRTHQLNTALWIPDEFLRRVETDDLWYLFDPI
VAPELPDLVGAAFSERYRELCRQAEAGMLPRRAWRRLPARELWLAILASLMETGHPWLTFKDAGNLRSQLRGIGVIHSSN
LCTEIFLPTSRDEVAVCNLGSVNLARHCTPTGELDWEQLAATVRLAMRALDNVIDANLYPSERAARANQLNRPVGLGLMG
FAELLARRAVSYAEPAAADLADQIAEFLSYHAISASCALAEERGAFPNFAFSRWAAGVLPIDTLDELAADRGLPVEVDRT
RRLDWEPLRQRVRRGMRNGAVMAVAPTATIALLAGTTPSLDPYYANVFSRQTLSGKFLEVNPILVEELRRRGLWEQLLPG
LVAARGDLRAVPGCPPDLVARFPTAYQVPAESYIEVAARVQKWVDMGVSRNLYHAADRPGQMSAVYLAAWRKGLKSTYYC
FVRPRMEIEQSTVAVNKARRRPQWVQLAEREVLASDAASCRLDGSCESCQ
>Mature_770_residues
MVSLVSSSLHLRPIARDEAAELDSRILSCLQQLPDRPEAEREAAALLLEKIAREADDGTPLPYPEHFRRFVERGIARGAL
DPRLRTFQLDVLARALDPARDALLGYAALATLADRYLVRDPETRQLLERPQALFMRVAMGLALVEPPETRTSWALRWYDL
MSSLRYLPSTPTLFNAGTPHHQLASCYLAEVEDSLESILGSAYEFGMLAKYAGGIGTAVTRIRATGAPVRGINGTSGGLI
PFLHLYDALIASISQGGRRRGTMCVYLEPWHLEVEAFLDLRRNAGDPYRRTHQLNTALWIPDEFLRRVETDDLWYLFDPI
VAPELPDLVGAAFSERYRELCRQAEAGMLPRRAWRRLPARELWLAILASLMETGHPWLTFKDAGNLRSQLRGIGVIHSSN
LCTEIFLPTSRDEVAVCNLGSVNLARHCTPTGELDWEQLAATVRLAMRALDNVIDANLYPSERAARANQLNRPVGLGLMG
FAELLARRAVSYAEPAAADLADQIAEFLSYHAISASCALAEERGAFPNFAFSRWAAGVLPIDTLDELAADRGLPVEVDRT
RRLDWEPLRQRVRRGMRNGAVMAVAPTATIALLAGTTPSLDPYYANVFSRQTLSGKFLEVNPILVEELRRRGLWEQLLPG
LVAARGDLRAVPGCPPDLVARFPTAYQVPAESYIEVAARVQKWVDMGVSRNLYHAADRPGQMSAVYLAAWRKGLKSTYYC
FVRPRMEIEQSTVAVNKARRRPQWVQLAEREVLASDAASCRLDGSCESCQ

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0209

COG function: function code F; Ribonucleotide reductase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 3 ATP-cone domains [H]

Homologues:

Organism=Homo sapiens, GI4506749, Length=655, Percent_Identity=35.5725190839695, Blast_Score=423, Evalue=1e-118,
Organism=Escherichia coli, GI2367133, Length=719, Percent_Identity=29.0681502086231, Blast_Score=253, Evalue=3e-68,
Organism=Escherichia coli, GI1789030, Length=631, Percent_Identity=29.0015847860539, Blast_Score=206, Evalue=7e-54,
Organism=Caenorhabditis elegans, GI17555242, Length=659, Percent_Identity=36.4188163884674, Blast_Score=426, Evalue=1e-119,
Organism=Saccharomyces cerevisiae, GI6320914, Length=639, Percent_Identity=35.3677621283255, Blast_Score=394, Evalue=1e-110,
Organism=Saccharomyces cerevisiae, GI6322123, Length=639, Percent_Identity=35.0547730829421, Blast_Score=394, Evalue=1e-110,
Organism=Drosophila melanogaster, GI17352481, Length=739, Percent_Identity=32.4763193504736, Blast_Score=404, Evalue=1e-113,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005144
- InterPro:   IPR013346
- InterPro:   IPR013509
- InterPro:   IPR000788
- InterPro:   IPR008926 [H]

Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 85747; Mature: 85747

Theoretical pI: Translated: 7.09; Mature: 7.09

Prosite motif: PS00089 RIBORED_LARGE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSLVSSSLHLRPIARDEAAELDSRILSCLQQLPDRPEAEREAAALLLEKIAREADDGTP
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCC
LPYPEHFRRFVERGIARGALDPRLRTFQLDVLARALDPARDALLGYAALATLADRYLVRD
CCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCC
PETRQLLERPQALFMRVAMGLALVEPPETRTSWALRWYDLMSSLRYLPSTPTLFNAGTPH
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEECCCCCH
HQLASCYLAEVEDSLESILGSAYEFGMLAKYAGGIGTAVTRIRATGAPVRGINGTSGGLI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCHH
PFLHLYDALIASISQGGRRRGTMCVYLEPWHLEVEAFLDLRRNAGDPYRRTHQLNTALWI
HHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHCCCCHHHHHHHCCCEEEC
PDEFLRRVETDDLWYLFDPIVAPELPDLVGAAFSERYRELCRQAEAGMLPRRAWRRLPAR
CHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCHH
ELWLAILASLMETGHPWLTFKDAGNLRSQLRGIGVIHSSNLCTEIFLPTSRDEVAVCNLG
HHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHCCEEECCCCCEEEECCCCCCCEEEECCC
SVNLARHCTPTGELDWEQLAATVRLAMRALDNVIDANLYPSERAARANQLNRPVGLGLMG
CCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCHHHH
FAELLARRAVSYAEPAAADLADQIAEFLSYHAISASCALAEERGAFPNFAFSRWAAGVLP
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCC
IDTLDELAADRGLPVEVDRTRRLDWEPLRQRVRRGMRNGAVMAVAPTATIALLAGTTPSL
HHHHHHHHHCCCCCEEECCCCCCCHHHHHHHHHHHHCCCCEEEEECCCEEEEEECCCCCC
DPYYANVFSRQTLSGKFLEVNPILVEELRRRGLWEQLLPGLVAARGDLRAVPGCPPDLVA
CHHHHHHHHHHCCCCCEEEECHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCHHHHH
RFPTAYQVPAESYIEVAARVQKWVDMGVSRNLYHAADRPGQMSAVYLAAWRKGLKSTYYC
HCCCCEECCHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCHHHHHHHHHHHCCCCCEEE
FVRPRMEIEQSTVAVNKARRRPQWVQLAEREVLASDAASCRLDGSCESCQ
EECCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEECCCCCCCC
>Mature Secondary Structure
MVSLVSSSLHLRPIARDEAAELDSRILSCLQQLPDRPEAEREAAALLLEKIAREADDGTP
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCC
LPYPEHFRRFVERGIARGALDPRLRTFQLDVLARALDPARDALLGYAALATLADRYLVRD
CCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCC
PETRQLLERPQALFMRVAMGLALVEPPETRTSWALRWYDLMSSLRYLPSTPTLFNAGTPH
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEECCCCCH
HQLASCYLAEVEDSLESILGSAYEFGMLAKYAGGIGTAVTRIRATGAPVRGINGTSGGLI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCHH
PFLHLYDALIASISQGGRRRGTMCVYLEPWHLEVEAFLDLRRNAGDPYRRTHQLNTALWI
HHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHCCCCHHHHHHHCCCEEEC
PDEFLRRVETDDLWYLFDPIVAPELPDLVGAAFSERYRELCRQAEAGMLPRRAWRRLPAR
CHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCHH
ELWLAILASLMETGHPWLTFKDAGNLRSQLRGIGVIHSSNLCTEIFLPTSRDEVAVCNLG
HHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHCCEEECCCCCEEEECCCCCCCEEEECCC
SVNLARHCTPTGELDWEQLAATVRLAMRALDNVIDANLYPSERAARANQLNRPVGLGLMG
CCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCHHHH
FAELLARRAVSYAEPAAADLADQIAEFLSYHAISASCALAEERGAFPNFAFSRWAAGVLP
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCC
IDTLDELAADRGLPVEVDRTRRLDWEPLRQRVRRGMRNGAVMAVAPTATIALLAGTTPSL
HHHHHHHHHCCCCCEEECCCCCCCHHHHHHHHHHHHCCCCEEEEECCCEEEEEECCCCCC
DPYYANVFSRQTLSGKFLEVNPILVEELRRRGLWEQLLPGLVAARGDLRAVPGCPPDLVA
CHHHHHHHHHHCCCCCEEEECHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCHHHHH
RFPTAYQVPAESYIEVAARVQKWVDMGVSRNLYHAADRPGQMSAVYLAAWRKGLKSTYYC
HCCCCEECCHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCHHHHHHHHHHHCCCCCEEE
FVRPRMEIEQSTVAVNKARRRPQWVQLAEREVLASDAASCRLDGSCESCQ
EECCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10684935 [H]