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The map label for this gene is folE [H]

Identifier: 221633111

GI number: 221633111

Start: 1112634

End: 1113257

Strand: Reverse

Name: folE [H]

Synonym: trd_1127

Alternate gene names: 221633111

Gene position: 1113257-1112634 (Counterclockwise)

Preceding gene: 221633112

Following gene: 221633109

Centisome position: 55.58

GC content: 59.62

Gene sequence:

>624_bases
ATGCACCATCATGAAGAACTCGTCCACCTCGAGGATACGGGCCTCGAGTTCACGACGACCTGCGATCTGGAGCGTCTGCG
CTCGTTGGTTGCCCAGTGGTTGGAAATCATCGGCGAGGATCCGCACCGGGAGGGATTGGTGCGGACACCGCAGCGCGTCG
CGGAGGCATGGGCATTCCTGACCCGGGGCTACCGCCAGAATCTCCACGAGATCGTCAATGGCGCGATCTTTCATGTGGAG
CAGGATACCATGGTCGTCGTCAAGGGGATCGAGTTTTACTCGATGTGCGAGCACCATCTCCTCCCGTTCTTCGGTCATGT
TCACATCGGGTATCTGCCACGCGGCCGCATTCTCGGGTTGAGTAAGTTCGCCCGCATCGTCGATCTCTATGCGCGTCGCT
TACAAGTCCAGGAACGTTTGACAAACCAAATCGCGGAAGCGATTGCCGAGCTGCTCGATCCCCAAGGTGTCGCGGTCGTG
GCCGATGGCATTCATCTCTGCATGATGATGCGCGGTGTCGAGAAGCAGCACGCGCGCACCACGACCAGCGCCATGCTCGG
AGTCTTCCGAGAATCGGCAGCGGCCCGCGAGGAGTTTTACCGTCTCCTCTCCACGAGTTCCTGA

Upstream 100 bases:

>100_bases
CGTGCGGTATCCTCTATCGCGCGCTGCTCCGGGCAGAAGATGTATTCGAGCATGAACGGAACGGCGTTGGATGAGCAATG
ATTTGGTAAGCGAGGCGGCA

Downstream 100 bases:

>100_bases
GTCCAACCACGATTCAATGGCGCCGTGCCGGATCTTGGGCGAGCCAGGCGGCGAGTTCCTGTTGCATCAGGGCAAAGCCA
TCGGTACTCGGTGACTGGAA

Product: GTP cyclohydrolase I

Products: NA

Alternate protein names: GTP cyclohydrolase I; GTP-CH-I [H]

Number of amino acids: Translated: 207; Mature: 207

Protein sequence:

>207_residues
MHHHEELVHLEDTGLEFTTTCDLERLRSLVAQWLEIIGEDPHREGLVRTPQRVAEAWAFLTRGYRQNLHEIVNGAIFHVE
QDTMVVVKGIEFYSMCEHHLLPFFGHVHIGYLPRGRILGLSKFARIVDLYARRLQVQERLTNQIAEAIAELLDPQGVAVV
ADGIHLCMMMRGVEKQHARTTTSAMLGVFRESAAAREEFYRLLSTSS

Sequences:

>Translated_207_residues
MHHHEELVHLEDTGLEFTTTCDLERLRSLVAQWLEIIGEDPHREGLVRTPQRVAEAWAFLTRGYRQNLHEIVNGAIFHVE
QDTMVVVKGIEFYSMCEHHLLPFFGHVHIGYLPRGRILGLSKFARIVDLYARRLQVQERLTNQIAEAIAELLDPQGVAVV
ADGIHLCMMMRGVEKQHARTTTSAMLGVFRESAAAREEFYRLLSTSS
>Mature_207_residues
MHHHEELVHLEDTGLEFTTTCDLERLRSLVAQWLEIIGEDPHREGLVRTPQRVAEAWAFLTRGYRQNLHEIVNGAIFHVE
QDTMVVVKGIEFYSMCEHHLLPFFGHVHIGYLPRGRILGLSKFARIVDLYARRLQVQERLTNQIAEAIAELLDPQGVAVV
ADGIHLCMMMRGVEKQHARTTTSAMLGVFRESAAAREEFYRLLSTSS

Specific function: Tetrahydrofolate biosynthesis; first step. [C]

COG id: COG0302

COG function: function code H; GTP cyclohydrolase I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase I family [H]

Homologues:

Organism=Homo sapiens, GI66932968, Length=184, Percent_Identity=54.3478260869565, Blast_Score=220, Evalue=8e-58,
Organism=Homo sapiens, GI4503949, Length=184, Percent_Identity=54.3478260869565, Blast_Score=220, Evalue=8e-58,
Organism=Homo sapiens, GI66932970, Length=152, Percent_Identity=51.3157894736842, Blast_Score=169, Evalue=2e-42,
Organism=Homo sapiens, GI66932972, Length=142, Percent_Identity=54.2253521126761, Blast_Score=167, Evalue=4e-42,
Organism=Escherichia coli, GI1788476, Length=195, Percent_Identity=33.8461538461538, Blast_Score=107, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI17560486, Length=184, Percent_Identity=53.2608695652174, Blast_Score=215, Evalue=1e-56,
Organism=Saccharomyces cerevisiae, GI6321706, Length=186, Percent_Identity=50.5376344086022, Blast_Score=199, Evalue=2e-52,
Organism=Drosophila melanogaster, GI24656782, Length=169, Percent_Identity=57.396449704142, Blast_Score=209, Evalue=9e-55,
Organism=Drosophila melanogaster, GI24656791, Length=169, Percent_Identity=57.396449704142, Blast_Score=209, Evalue=1e-54,
Organism=Drosophila melanogaster, GI24656796, Length=169, Percent_Identity=57.396449704142, Blast_Score=209, Evalue=1e-54,

Paralogues:

None

Copy number: 420 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001474
- InterPro:   IPR020602
- InterPro:   IPR018234 [H]

Pfam domain/function: PF01227 GTP_cyclohydroI [H]

EC number: =3.5.4.16 [H]

Molecular weight: Translated: 23670; Mature: 23670

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: PS00860 GTP_CYCLOHYDROL_1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHHHEELVHLEDTGLEFTTTCDLERLRSLVAQWLEIIGEDPHREGLVRTPQRVAEAWAFL
CCCHHHHHEECCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHH
TRGYRQNLHEIVNGAIFHVEQDTMVVVKGIEFYSMCEHHLLPFFGHVHIGYLPRGRILGL
HHHHHHHHHHHHCCHHEEECCCCEEEEECHHHHHHHHHHHHHHHCCEEECCCCCCCCHHH
SKFARIVDLYARRLQVQERLTNQIAEAIAELLDPQGVAVVADGIHLCMMMRGVEKQHART
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHH
TTSAMLGVFRESAAAREEFYRLLSTSS
HHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MHHHEELVHLEDTGLEFTTTCDLERLRSLVAQWLEIIGEDPHREGLVRTPQRVAEAWAFL
CCCHHHHHEECCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHH
TRGYRQNLHEIVNGAIFHVEQDTMVVVKGIEFYSMCEHHLLPFFGHVHIGYLPRGRILGL
HHHHHHHHHHHHCCHHEEECCCCEEEEECHHHHHHHHHHHHHHHCCEEECCCCCCCCHHH
SKFARIVDLYARRLQVQERLTNQIAEAIAELLDPQGVAVVADGIHLCMMMRGVEKQHART
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHH
TTSAMLGVFRESAAAREEFYRLLSTSS
HHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10567266 [H]