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The map label for this gene is polC [H]

Identifier: 221633099

GI number: 221633099

Start: 1094467

End: 1095153

Strand: Reverse

Name: polC [H]

Synonym: trd_1114

Alternate gene names: 221633099

Gene position: 1095153-1094467 (Counterclockwise)

Preceding gene: 221633100

Following gene: 221633094

Centisome position: 54.68

GC content: 64.48

Gene sequence:

>687_bases
ATGAGCGGGCAGGGGAACTGGTTCACGCGCCTGGCGGGCGCCTTGGTGGAGCGGGTTGGTCGGGATCGCCGCGGCGCGAC
GCTTTCCAATCTCGCGTACACCGTTCTCGATGCCGAAATGACCGGACTCGATCCTGAGCGGGACGAGTTGCTGGCGCTGG
GTGCTGTGCGCATGGTCGGGACGCGACTTCTTCTCGGCGCATCGTTCTACCAGCTGATTCGACCGCAACGGCAGGGCTGG
GGACAGAGCGTGACCGTGCACGGAATCCGGCCGGTCGATGTGGTAGGGGCTCCGCCACTGGAGCAGGTCTTGCCTGAGTT
TGTGCGCTTTTGCGCGAGCAGTATTCTCGTGGGACACGGCGTCGAGATCGATCGGAAGTTCTTGCAGCGAGCGGCGGCGC
GCTGTGGGCTTTCCTGGCCGAGGACGTATTGGGTGGACACCGGTCGCGTGGCACGCTGGCTCACCTCCCATCATGGAGCG
CTGCCGGAGGCAGCGGCAGACCGGGGGCGGTTCAGTTTGGAGGACTTGCTGGCAGCATACGAGATCGAGCCACCAGCTCG
CCATCATGCCTTGGCCGATGCGTTCGTGACGGCCTTGGTTTGGCAGCGGCAGTTGACGGAACTAGCGACTGAAGGCGTGC
GGACCTTGCGCGATCTTCGCTTGGCGGGGTTGATTACCTCGGCATAG

Upstream 100 bases:

>100_bases
TCTCCTCGCTCGATCGGACGCTGCTCAAGGAGGCGTTCCGCGTCGTCGGGCGAGCGCAAGCAGTGGTGCGCGAGCGCTTC
CATCTCGAACAGGCTGGCGA

Downstream 100 bases:

>100_bases
CCACCACGAAGAGGATGAGACGTACGGCGAGCAAGGCGAGGACCCAGAGGACCGATTGCGCGATCGTCGACAACCGCGGG
AAGAGTTGCGACGAAAATCG

Product: DNA polymerase III subunit epsilon

Products: NA

Alternate protein names: PolIII [H]

Number of amino acids: Translated: 228; Mature: 227

Protein sequence:

>228_residues
MSGQGNWFTRLAGALVERVGRDRRGATLSNLAYTVLDAEMTGLDPERDELLALGAVRMVGTRLLLGASFYQLIRPQRQGW
GQSVTVHGIRPVDVVGAPPLEQVLPEFVRFCASSILVGHGVEIDRKFLQRAAARCGLSWPRTYWVDTGRVARWLTSHHGA
LPEAAADRGRFSLEDLLAAYEIEPPARHHALADAFVTALVWQRQLTELATEGVRTLRDLRLAGLITSA

Sequences:

>Translated_228_residues
MSGQGNWFTRLAGALVERVGRDRRGATLSNLAYTVLDAEMTGLDPERDELLALGAVRMVGTRLLLGASFYQLIRPQRQGW
GQSVTVHGIRPVDVVGAPPLEQVLPEFVRFCASSILVGHGVEIDRKFLQRAAARCGLSWPRTYWVDTGRVARWLTSHHGA
LPEAAADRGRFSLEDLLAAYEIEPPARHHALADAFVTALVWQRQLTELATEGVRTLRDLRLAGLITSA
>Mature_227_residues
SGQGNWFTRLAGALVERVGRDRRGATLSNLAYTVLDAEMTGLDPERDELLALGAVRMVGTRLLLGASFYQLIRPQRQGWG
QSVTVHGIRPVDVVGAPPLEQVLPEFVRFCASSILVGHGVEIDRKFLQRAAARCGLSWPRTYWVDTGRVARWLTSHHGAL
PEAAADRGRFSLEDLLAAYEIEPPARHHALADAFVTALVWQRQLTELATEGVRTLRDLRLAGLITSA

Specific function: Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity [H]

COG id: COG0847

COG function: function code L; DNA polymerase III, epsilon subunit and related 3'-5' exonucleases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 exonuclease domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011708
- InterPro:   IPR006054
- InterPro:   IPR006055
- InterPro:   IPR013520
- InterPro:   IPR023223
- InterPro:   IPR004013
- InterPro:   IPR003141
- InterPro:   IPR006308
- InterPro:   IPR012337 [H]

Pfam domain/function: PF07733 DNA_pol3_alpha; PF00929 Exonuc_X-T; PF02811 PHP [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 25116; Mature: 24985

Theoretical pI: Translated: 8.74; Mature: 8.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGQGNWFTRLAGALVERVGRDRRGATLSNLAYTVLDAEMTGLDPERDELLALGAVRMVG
CCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
TRLLLGASFYQLIRPQRQGWGQSVTVHGIRPVDVVGAPPLEQVLPEFVRFCASSILVGHG
HHHHHHHHHHHHHCHHHHCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
VEIDRKFLQRAAARCGLSWPRTYWVDTGRVARWLTSHHGALPEAAADRGRFSLEDLLAAY
CHHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHCCCCCHHHHHCCCCCHHHHHHHH
EIEPPARHHALADAFVTALVWQRQLTELATEGVRTLRDLRLAGLITSA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SGQGNWFTRLAGALVERVGRDRRGATLSNLAYTVLDAEMTGLDPERDELLALGAVRMVG
CCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
TRLLLGASFYQLIRPQRQGWGQSVTVHGIRPVDVVGAPPLEQVLPEFVRFCASSILVGHG
HHHHHHHHHHHHHCHHHHCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
VEIDRKFLQRAAARCGLSWPRTYWVDTGRVARWLTSHHGALPEAAADRGRFSLEDLLAAY
CHHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHCCCCCHHHHHCCCCCHHHHHHHH
EIEPPARHHALADAFVTALVWQRQLTELATEGVRTLRDLRLAGLITSA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9826752; 10360571 [H]