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The map label for this gene is drrB [H]

Identifier: 221633058

GI number: 221633058

Start: 1048652

End: 1049509

Strand: Reverse

Name: drrB [H]

Synonym: trd_1074

Alternate gene names: 221633058

Gene position: 1049509-1048652 (Counterclockwise)

Preceding gene: 221633059

Following gene: 221633057

Centisome position: 52.4

GC content: 60.02

Gene sequence:

>858_bases
GTGACACGAGACGGCTCCGCCGACGTCTCCAGCGTTTCAACTGATTTCAGCGAACGCCTCGCCGAAGCGACCCGGCCTTT
ACCGCGTTGGGAATCTCTCGTGTCCTTCGCCAGTGCCGCGCTCGTCGTGGCCGAGGTGGAAGCACGGAAGCTCCGCCATG
ATCCTTGGGAGGTCGTGACCCGTGCTTTACAACCGCTTCTCTGGTTGACGGTCTTTGGGCAGGCGGTGGCGCGAGCTCGA
CTGCTCAGTGAGCAAGAGGATTATCTCACCTTCATGGCTCCAGGAATTCTCGCCCAATCAGTCATGTTCACGTCGATCTT
TTATGGACTCGCGATTATCTGGGAACGCGATGCGGGGATTCTCCAAAAGATTCTCGTCTTGCCTGTTCCGCGCGCCAGTT
TCGTCGCGGGCAAAGCGTTGGGGGCAGGTCTGCGAGCTCTGCTGCAGGCGGCCGTCGTCGTCACGGTGGCGCTGTTGCTC
CAGGTGCGATTTCACCTCGACCTTTTCTCGCTGGTCACGTGCGCTCTGGCTGTTCTTCTCGGTGCCGGTGTCTTCGCCAG
CCTGTCCATGCTGCTCGCGACACTGCTCAAGACACGGGAGCGCTTCATGGGCATCGGTCAAGTCTTGACGATACCGCTGT
TTTTCGCGAGCAACGCGATCTATCCGATCCACCTCATGCCTGCCTGGCTACAGGTTCTCGCTCAGGTCAATCCGCTGACC
TACCTGGTGGAACTTCTTCGCGACACCCTCGTCGACGGGCAACGCTTCGGCGTGATCCAGGATTGGCTCGTGCTTCTGGC
GTGGCTCGTACTGTTGCAAGCGATCGTGAGTCGCCGTTACGACCGCGTGCTGCTGTGA

Upstream 100 bases:

>100_bases
ACGCCTGCCGAGCTCGAGCGGGCTGTTCCCGGGGCGACGACACTGGACGATGTCTTTACGGCATTGACCGGTGACGTTCT
CGAGTCGGGAGGATCGTTCA

Downstream 100 bases:

>100_bases
CGGGTGCGCGCATCGTTCGACGTGGGTCCGCTGGTCTATACGGTCATCGGCTCCTGTTCACTTTCGCGGGTACGCCAGCT
CATTGCGCGGGGAAGCATGC

Product: ABC-2 type transporter superfamily

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 285; Mature: 284

Protein sequence:

>285_residues
MTRDGSADVSSVSTDFSERLAEATRPLPRWESLVSFASAALVVAEVEARKLRHDPWEVVTRALQPLLWLTVFGQAVARAR
LLSEQEDYLTFMAPGILAQSVMFTSIFYGLAIIWERDAGILQKILVLPVPRASFVAGKALGAGLRALLQAAVVVTVALLL
QVRFHLDLFSLVTCALAVLLGAGVFASLSMLLATLLKTRERFMGIGQVLTIPLFFASNAIYPIHLMPAWLQVLAQVNPLT
YLVELLRDTLVDGQRFGVIQDWLVLLAWLVLLQAIVSRRYDRVLL

Sequences:

>Translated_285_residues
MTRDGSADVSSVSTDFSERLAEATRPLPRWESLVSFASAALVVAEVEARKLRHDPWEVVTRALQPLLWLTVFGQAVARAR
LLSEQEDYLTFMAPGILAQSVMFTSIFYGLAIIWERDAGILQKILVLPVPRASFVAGKALGAGLRALLQAAVVVTVALLL
QVRFHLDLFSLVTCALAVLLGAGVFASLSMLLATLLKTRERFMGIGQVLTIPLFFASNAIYPIHLMPAWLQVLAQVNPLT
YLVELLRDTLVDGQRFGVIQDWLVLLAWLVLLQAIVSRRYDRVLL
>Mature_284_residues
TRDGSADVSSVSTDFSERLAEATRPLPRWESLVSFASAALVVAEVEARKLRHDPWEVVTRALQPLLWLTVFGQAVARARL
LSEQEDYLTFMAPGILAQSVMFTSIFYGLAIIWERDAGILQKILVLPVPRASFVAGKALGAGLRALLQAAVVVTVALLLQ
VRFHLDLFSLVTCALAVLLGAGVFASLSMLLATLLKTRERFMGIGQVLTIPLFFASNAIYPIHLMPAWLQVLAQVNPLTY
LVELLRDTLVDGQRFGVIQDWLVLLAWLVLLQAIVSRRYDRVLL

Specific function: Part of the ABC transporter complex drrAB involved in daunorubicin and doxorubicin resistance. Probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0842

COG function: function code V; ABC-type multidrug transport system, permease component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-2 domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000412
- InterPro:   IPR013525 [H]

Pfam domain/function: PF01061 ABC2_membrane [H]

EC number: NA

Molecular weight: Translated: 31495; Mature: 31364

Theoretical pI: Translated: 9.05; Mature: 9.05

Prosite motif: PS51012 ABC_TM2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRDGSADVSSVSTDFSERLAEATRPLPRWESLVSFASAALVVAEVEARKLRHDPWEVVT
CCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
RALQPLLWLTVFGQAVARARLLSEQEDYLTFMAPGILAQSVMFTSIFYGLAIIWERDAGI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
LQKILVLPVPRASFVAGKALGAGLRALLQAAVVVTVALLLQVRFHLDLFSLVTCALAVLL
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GAGVFASLSMLLATLLKTRERFMGIGQVLTIPLFFASNAIYPIHLMPAWLQVLAQVNPLT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHH
YLVELLRDTLVDGQRFGVIQDWLVLLAWLVLLQAIVSRRYDRVLL
HHHHHHHHHHHCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TRDGSADVSSVSTDFSERLAEATRPLPRWESLVSFASAALVVAEVEARKLRHDPWEVVT
CCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
RALQPLLWLTVFGQAVARARLLSEQEDYLTFMAPGILAQSVMFTSIFYGLAIIWERDAGI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
LQKILVLPVPRASFVAGKALGAGLRALLQAAVVVTVALLLQVRFHLDLFSLVTCALAVLL
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GAGVFASLSMLLATLLKTRERFMGIGQVLTIPLFFASNAIYPIHLMPAWLQVLAQVNPLT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHH
YLVELLRDTLVDGQRFGVIQDWLVLLAWLVLLQAIVSRRYDRVLL
HHHHHHHHHHHCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1924314 [H]