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The map label for this gene is moaA [H]

Identifier: 221633026

GI number: 221633026

Start: 1011360

End: 1012409

Strand: Reverse

Name: moaA [H]

Synonym: trd_1041

Alternate gene names: 221633026

Gene position: 1012409-1011360 (Counterclockwise)

Preceding gene: 221633027

Following gene: 221633023

Centisome position: 50.54

GC content: 62.76

Gene sequence:

>1050_bases
ATGATCAGCCCCGTCGTACAGCAACCCCGGCGAACCGACGAGCGAGCCGTGCCTCGCCCCGGCGAGCGAATCACGCGCGA
TGCCTACGGTCGGCCGATCACCTATCTCCGAATTTCTTTAACGGACCGCTGTAATCTCCGCTGCGTCTATTGCATGCCAG
CTCACGGCATGAAGTTCGCCCCGCGTGAGGAACTCCTGACTGACGAGGAACTGTTGACGATCGTGCGTGCCGCAGCGCGT
ATCGGGTTCAGTCGCTTGCGGCTTACGGGAGGGGAGCCGACGGTTCGTCCGGGTCTGGTGGAACTCGTGCGTGCCATGGC
GGCGATTCCCGGCGTCGAAGATATTTCGATGACGACGAACGGGCTTCTCCTCGAGCGCTTGGCACACGACCTCGCGGCCG
CCGGTTTGCGACGCATCAACATCAGCCTGGACACGCTCGATCCCGAGCGCTACCGAATCATGACCCGTGGAGGGCGGATC
GAGAAAGTCTTCGCGGGTATCGCGGCGGCTGAGGACGCTGGTTTGCGACCGATCAAGCTGAATGCCGTGGTCGTTCGCGG
CCTCAACGATCACGAGGTGCCAGCACTCGCTGGTCTAACGCTCGAGCGACCATGGCAGGTGCGCTTCATCGAGGTTATGC
CCTTGGAGGGTGTCGCTGACGTCCACGATGCGGGACTCGTCACCAGCGCCGAGACGCGGGCGCGTATCGAGGAAGTCTTT
GGTCCTCTCGAAGAAGTCGAGGCGCCGCTGAGCGATCCGGCCCGAGTCTTTCGCATTCGCGGAGCGCAGGGCACGCTCGG
ATTCATCAGTCCGGTGAGCGAGCCATTTTGCGCTTTTTGCAACCGGATTCGTCTGACCGCTGACGGGAAGCTTCGTCTCT
GCTTGCTGCGGAGCGACGAAGTCGATATCCGCGAGCTCGTGCGTCGAGGGGCGAGCGAGGAGGAGCTGATCGAGCGTATT
CGTGCAGCAGTCTGGCGGAAGCCGTGGGGACACGGACTCCGCGAAGGCGATCGTCGAACTGGGCGAGGTATGAGTCAGAT
CGGTGGTTGA

Upstream 100 bases:

>100_bases
TTGTCTTTCTCTTCGTCGCCTGCTATCCTGGTGATAGCTGTTCCGCGATGCCGTATGATACGAGAGGCGCGGCTTGCAGG
CTGACGAAGGGAGTTTCGAG

Downstream 100 bases:

>100_bases
ATCAGTCGTGAAGAGGAGCGGAGAAGGGACGGTCGATCGACCGTCCCTTCTCCGCTCGTGCGGTGCTCAATCGCAGTGAT
AACCGTTGGAAAGGGTAGCG

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 349; Mature: 349

Protein sequence:

>349_residues
MISPVVQQPRRTDERAVPRPGERITRDAYGRPITYLRISLTDRCNLRCVYCMPAHGMKFAPREELLTDEELLTIVRAAAR
IGFSRLRLTGGEPTVRPGLVELVRAMAAIPGVEDISMTTNGLLLERLAHDLAAAGLRRINISLDTLDPERYRIMTRGGRI
EKVFAGIAAAEDAGLRPIKLNAVVVRGLNDHEVPALAGLTLERPWQVRFIEVMPLEGVADVHDAGLVTSAETRARIEEVF
GPLEEVEAPLSDPARVFRIRGAQGTLGFISPVSEPFCAFCNRIRLTADGKLRLCLLRSDEVDIRELVRRGASEEELIERI
RAAVWRKPWGHGLREGDRRTGRGMSQIGG

Sequences:

>Translated_349_residues
MISPVVQQPRRTDERAVPRPGERITRDAYGRPITYLRISLTDRCNLRCVYCMPAHGMKFAPREELLTDEELLTIVRAAAR
IGFSRLRLTGGEPTVRPGLVELVRAMAAIPGVEDISMTTNGLLLERLAHDLAAAGLRRINISLDTLDPERYRIMTRGGRI
EKVFAGIAAAEDAGLRPIKLNAVVVRGLNDHEVPALAGLTLERPWQVRFIEVMPLEGVADVHDAGLVTSAETRARIEEVF
GPLEEVEAPLSDPARVFRIRGAQGTLGFISPVSEPFCAFCNRIRLTADGKLRLCLLRSDEVDIRELVRRGASEEELIERI
RAAVWRKPWGHGLREGDRRTGRGMSQIGG
>Mature_349_residues
MISPVVQQPRRTDERAVPRPGERITRDAYGRPITYLRISLTDRCNLRCVYCMPAHGMKFAPREELLTDEELLTIVRAAAR
IGFSRLRLTGGEPTVRPGLVELVRAMAAIPGVEDISMTTNGLLLERLAHDLAAAGLRRINISLDTLDPERYRIMTRGGRI
EKVFAGIAAAEDAGLRPIKLNAVVVRGLNDHEVPALAGLTLERPWQVRFIEVMPLEGVADVHDAGLVTSAETRARIEEVF
GPLEEVEAPLSDPARVFRIRGAQGTLGFISPVSEPFCAFCNRIRLTADGKLRLCLLRSDEVDIRELVRRGASEEELIERI
RAAVWRKPWGHGLREGDRRTGRGMSQIGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI116734668, Length=341, Percent_Identity=43.4017595307918, Blast_Score=269, Evalue=4e-72,
Organism=Homo sapiens, GI22027536, Length=341, Percent_Identity=43.4017595307918, Blast_Score=268, Evalue=6e-72,
Organism=Escherichia coli, GI1786999, Length=328, Percent_Identity=35.3658536585366, Blast_Score=204, Evalue=9e-54,
Organism=Caenorhabditis elegans, GI32566331, Length=310, Percent_Identity=40.9677419354839, Blast_Score=248, Evalue=5e-66,
Organism=Caenorhabditis elegans, GI32566329, Length=327, Percent_Identity=40.6727828746177, Blast_Score=247, Evalue=8e-66,
Organism=Caenorhabditis elegans, GI17561210, Length=327, Percent_Identity=40.3669724770642, Blast_Score=240, Evalue=7e-64,
Organism=Drosophila melanogaster, GI28574488, Length=338, Percent_Identity=43.1952662721894, Blast_Score=246, Evalue=2e-65,
Organism=Drosophila melanogaster, GI28574490, Length=320, Percent_Identity=43.75, Blast_Score=244, Evalue=8e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 38744; Mature: 38744

Theoretical pI: Translated: 8.61; Mature: 8.61

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISPVVQQPRRTDERAVPRPGERITRDAYGRPITYLRISLTDRCNLRCVYCMPAHGMKFA
CCCCHHCCCCCCCCCCCCCCCHHHHHHHCCCCEEEEEEEECCCCCEEEEEEECCCCCCCC
PREELLTDEELLTIVRAAARIGFSRLRLTGGEPTVRPGLVELVRAMAAIPGVEDISMTTN
CHHHHCCHHHHHHHHHHHHHHCHHHEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCC
GLLLERLAHDLAAAGLRRINISLDTLDPERYRIMTRGGRIEKVFAGIAAAEDAGLRPIKL
HHHHHHHHHHHHHCCCEEEEEEEECCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCEEEE
NAVVVRGLNDHEVPALAGLTLERPWQVRFIEVMPLEGVADVHDAGLVTSAETRARIEEVF
EEEEEECCCCCCCCEEECCEECCCCEEEEEEEECCCCCCCCCCCCCEECHHHHHHHHHHH
GPLEEVEAPLSDPARVFRIRGAQGTLGFISPVSEPFCAFCNRIRLTADGKLRLCLLRSDE
CCHHHHCCCCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHCCEEEEECCCEEEEEEECCC
VDIRELVRRGASEEELIERIRAAVWRKPWGHGLREGDRRTGRGMSQIGG
CCHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHCCCHHHHCC
>Mature Secondary Structure
MISPVVQQPRRTDERAVPRPGERITRDAYGRPITYLRISLTDRCNLRCVYCMPAHGMKFA
CCCCHHCCCCCCCCCCCCCCCHHHHHHHCCCCEEEEEEEECCCCCEEEEEEECCCCCCCC
PREELLTDEELLTIVRAAARIGFSRLRLTGGEPTVRPGLVELVRAMAAIPGVEDISMTTN
CHHHHCCHHHHHHHHHHHHHHCHHHEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCC
GLLLERLAHDLAAAGLRRINISLDTLDPERYRIMTRGGRIEKVFAGIAAAEDAGLRPIKL
HHHHHHHHHHHHHCCCEEEEEEEECCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCEEEE
NAVVVRGLNDHEVPALAGLTLERPWQVRFIEVMPLEGVADVHDAGLVTSAETRARIEEVF
EEEEEECCCCCCCCEEECCEECCCCEEEEEEEECCCCCCCCCCCCCEECHHHHHHHHHHH
GPLEEVEAPLSDPARVFRIRGAQGTLGFISPVSEPFCAFCNRIRLTADGKLRLCLLRSDE
CCHHHHCCCCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHCCEEEEECCCEEEEEEECCC
VDIRELVRRGASEEELIERIRAAVWRKPWGHGLREGDRRTGRGMSQIGG
CCHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA