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The map label for this gene is nrdZ [H]

Identifier: 221632943

GI number: 221632943

Start: 924123

End: 925892

Strand: Reverse

Name: nrdZ [H]

Synonym: trd_0949

Alternate gene names: 221632943

Gene position: 925892-924123 (Counterclockwise)

Preceding gene: 221632947

Following gene: 221632941

Centisome position: 46.23

GC content: 58.7

Gene sequence:

>1770_bases
ATGCCGCTGGAGTTGAGCGATTCTGCTCGATCGTTGCTTCGCCTCCGCTATCTCCGTCGGGACGAAGAGGGCCGGATCAT
CGAGACCGAGGAAGAGCTTTTTTGGCGCGTCGCACGAGCGGTCGCTGCTGCAGAGGATGCCTTTCCGCGAGGCCCACGCA
GTGCGGAGATTGCCGAAAAGTTCTACGAACTGATGACGACCCTACGCTTTCTTCCTAATACTCCAGCACTGATCAACGCG
GGAACGCAGCTCGGGCAACTCTTCGCCTGTTTCGTCATACCGGTTCCTGATTCCTTGGATGGAATCTTCGGGGCGGTGCG
GGATGCTGCAAAGATTCAGCAGACCGGTGGCGGGACAGGATTTTCCTTTTCTCATCTTCGACCGCGCGGCGACCTTGTCC
GTTCGACTCGCCGTCCGTCGTCGGGAGCGGTTTCCTTCATTCGCATTTTCGATGTCGCGAGTGACGTGATCGCGACCGAA
AGTGTTCGTGGCGGGGCGAACATGGCCGTCTTGCGCTGTGATCACCCTGACGTGCGCGAGTTCATCGATGCCAAACGGAA
TCCCGCTCTCTTCTCGCGCTTCAATTTTTCCGTTCTGGTAACCGATGACTTTCTGCGGGCAGCCATTGAGCGACGCGAGA
TCGCTTTGATCAATCCTCGAACGGGACTTCCCTTCGCGCAAGCGAATGCTGGTGAGTTGTTCGATGCCATGGTCGACGCA
GCATGGGAGGTCGGTGATCCTGGCCTACTCTTTTACGACCGAATCCAGCGCGATAACGCGGTGCCGGCGCTCGGACCGTT
GGAAGCGACCAACCCTTGCGGAGAAGTACCCCTGCACCCATGGGAAGCGTGCGTTCTCGGGTCCTTGAATTTGCGTGCGT
TCATTGTCGAACGCGGTGATCGAGCTTTTCTCGACGAAGCAGGTCTGCAGGAGTCAGCTCGGCTGGCTCTTCGCTTCCTG
GACAATATGGTGGAGGTATCCCGTTACCCGAAGGTGGAAATCGAGACGATCTGTCGGGCGAATCGAAAAGTGGGACTCGG
CATCATGGGATTCGCTGACCTGCTGTTGGCACTCCGCATTCCGTATGGGTCAGACGAATCCGTTGCGGTGGCTGATCGAG
TGATGGGTTTGGTGCAGGCTGCTGCGGTCGAGGCGAGTCGTCGATTGGCTGAGGAGCGCGGACCGTTTCCGAATTTTCCG
ATCAGCCGTTATGCTGCTCGTGGGGAACCACCACGACGCAATGCCACCGTTACGACTGTCGCGCCGACGGGAAGCATCAG
CATCATCGCTGGATGCAGTAGTGGGATCGAGCCACTGTATGCGCTGGCGTACCGTCATGTCGGCGAGTTCGTGGGCATAG
TCGAGCCGCATCCGCTCCTCTTGCGCGAACTGAGTCGGATCGGGAAGTACGATCCAGCACTGCTCCACGAGATCGAAGTC
ACTGGACGGATCGGTCATCGCACCGATTTGCCGGAGGAGCTCCGGCGACTCTTCCGTGTTGCGACAGAAATCAGCCCGGA
AGAGCATATCAGAGTGCAGGCCGCGGTGCAGCGCCACGTCGAGAACGCCGTCAGCAAGACGATCAATCTCCCGTACGAGG
CAACACGCGATGACGTCCGCCGAGCATTCCTGCTCGCGCATGAGCTGGGTTGCAAGGGTGTGACAGTCTATCGCGAAGGT
GCACCGCGAGGTCAGGTCCTCCAGGTTCTCGGGCACTGTTTGAGCTGCGTCGGTGAAGATGTGATTCCAGAAGACCGAAC
TCGCTATTGA

Upstream 100 bases:

>100_bases
CTGGCAGACAACATGGAGCACACAGAGACGCGAAACGGGCTTGGGGTCCATGAACCCCTGGTGGCATGATACGTGCGACA
TGCAGCGAGGAGGTGAACGG

Downstream 100 bases:

>100_bases
ACCGAACGGAGAAACAGGCGACCCCGCCTGGATCGCAGGAGCGGGGTCGCCCTGGTACGGAAGCGTCTGGGGGCTTCAGG
AACGAACCTGGACAGGAATA

Product: ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 589; Mature: 588

Protein sequence:

>589_residues
MPLELSDSARSLLRLRYLRRDEEGRIIETEEELFWRVARAVAAAEDAFPRGPRSAEIAEKFYELMTTLRFLPNTPALINA
GTQLGQLFACFVIPVPDSLDGIFGAVRDAAKIQQTGGGTGFSFSHLRPRGDLVRSTRRPSSGAVSFIRIFDVASDVIATE
SVRGGANMAVLRCDHPDVREFIDAKRNPALFSRFNFSVLVTDDFLRAAIERREIALINPRTGLPFAQANAGELFDAMVDA
AWEVGDPGLLFYDRIQRDNAVPALGPLEATNPCGEVPLHPWEACVLGSLNLRAFIVERGDRAFLDEAGLQESARLALRFL
DNMVEVSRYPKVEIETICRANRKVGLGIMGFADLLLALRIPYGSDESVAVADRVMGLVQAAAVEASRRLAEERGPFPNFP
ISRYAARGEPPRRNATVTTVAPTGSISIIAGCSSGIEPLYALAYRHVGEFVGIVEPHPLLLRELSRIGKYDPALLHEIEV
TGRIGHRTDLPEELRRLFRVATEISPEEHIRVQAAVQRHVENAVSKTINLPYEATRDDVRRAFLLAHELGCKGVTVYREG
APRGQVLQVLGHCLSCVGEDVIPEDRTRY

Sequences:

>Translated_589_residues
MPLELSDSARSLLRLRYLRRDEEGRIIETEEELFWRVARAVAAAEDAFPRGPRSAEIAEKFYELMTTLRFLPNTPALINA
GTQLGQLFACFVIPVPDSLDGIFGAVRDAAKIQQTGGGTGFSFSHLRPRGDLVRSTRRPSSGAVSFIRIFDVASDVIATE
SVRGGANMAVLRCDHPDVREFIDAKRNPALFSRFNFSVLVTDDFLRAAIERREIALINPRTGLPFAQANAGELFDAMVDA
AWEVGDPGLLFYDRIQRDNAVPALGPLEATNPCGEVPLHPWEACVLGSLNLRAFIVERGDRAFLDEAGLQESARLALRFL
DNMVEVSRYPKVEIETICRANRKVGLGIMGFADLLLALRIPYGSDESVAVADRVMGLVQAAAVEASRRLAEERGPFPNFP
ISRYAARGEPPRRNATVTTVAPTGSISIIAGCSSGIEPLYALAYRHVGEFVGIVEPHPLLLRELSRIGKYDPALLHEIEV
TGRIGHRTDLPEELRRLFRVATEISPEEHIRVQAAVQRHVENAVSKTINLPYEATRDDVRRAFLLAHELGCKGVTVYREG
APRGQVLQVLGHCLSCVGEDVIPEDRTRY
>Mature_588_residues
PLELSDSARSLLRLRYLRRDEEGRIIETEEELFWRVARAVAAAEDAFPRGPRSAEIAEKFYELMTTLRFLPNTPALINAG
TQLGQLFACFVIPVPDSLDGIFGAVRDAAKIQQTGGGTGFSFSHLRPRGDLVRSTRRPSSGAVSFIRIFDVASDVIATES
VRGGANMAVLRCDHPDVREFIDAKRNPALFSRFNFSVLVTDDFLRAAIERREIALINPRTGLPFAQANAGELFDAMVDAA
WEVGDPGLLFYDRIQRDNAVPALGPLEATNPCGEVPLHPWEACVLGSLNLRAFIVERGDRAFLDEAGLQESARLALRFLD
NMVEVSRYPKVEIETICRANRKVGLGIMGFADLLLALRIPYGSDESVAVADRVMGLVQAAAVEASRRLAEERGPFPNFPI
SRYAARGEPPRRNATVTTVAPTGSISIIAGCSSGIEPLYALAYRHVGEFVGIVEPHPLLLRELSRIGKYDPALLHEIEVT
GRIGHRTDLPEELRRLFRVATEISPEEHIRVQAAVQRHVENAVSKTINLPYEATRDDVRRAFLLAHELGCKGVTVYREGA
PRGQVLQVLGHCLSCVGEDVIPEDRTRY

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0209

COG function: function code F; Ribonucleotide reductase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-cone domain [H]

Homologues:

Organism=Homo sapiens, GI4506749, Length=571, Percent_Identity=25.0437828371278, Blast_Score=172, Evalue=8e-43,
Organism=Escherichia coli, GI1789030, Length=615, Percent_Identity=26.1788617886179, Blast_Score=144, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17555242, Length=533, Percent_Identity=25.328330206379, Blast_Score=150, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6320914, Length=582, Percent_Identity=27.1477663230241, Blast_Score=173, Evalue=6e-44,
Organism=Saccharomyces cerevisiae, GI6322123, Length=586, Percent_Identity=27.3037542662116, Blast_Score=166, Evalue=8e-42,
Organism=Drosophila melanogaster, GI17352481, Length=623, Percent_Identity=25.6821829855538, Blast_Score=170, Evalue=3e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005144
- InterPro:   IPR013344
- InterPro:   IPR013509
- InterPro:   IPR000788
- InterPro:   IPR008926 [H]

Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 65038; Mature: 64907

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLELSDSARSLLRLRYLRRDEEGRIIETEEELFWRVARAVAAAEDAFPRGPRSAEIAEK
CCCCCCHHHHHHHHHHHHHCCCCCCEECCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
FYELMTTLRFLPNTPALINAGTQLGQLFACFVIPVPDSLDGIFGAVRDAAKIQQTGGGTG
HHHHHHHHHHCCCCCHHEECCHHHHHHHEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCC
FSFSHLRPRGDLVRSTRRPSSGAVSFIRIFDVASDVIATESVRGGANMAVLRCDHPDVRE
CCCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHH
FIDAKRNPALFSRFNFSVLVTDDFLRAAIERREIALINPRTGLPFAQANAGELFDAMVDA
HHHCCCCCCCEEECCCEEEEEHHHHHHHHHCCCEEEECCCCCCCCCCCCHHHHHHHHHHH
AWEVGDPGLLFYDRIQRDNAVPALGPLEATNPCGEVPLHPWEACVLGSLNLRAFIVERGD
HHCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCEEEEEEECCC
RAFLDEAGLQESARLALRFLDNMVEVSRYPKVEIETICRANRKVGLGIMGFADLLLALRI
HHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHCC
PYGSDESVAVADRVMGLVQAAAVEASRRLAEERGPFPNFPISRYAARGEPPRRNATVTTV
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCCCEEEEE
APTGSISIIAGCSSGIEPLYALAYRHVGEFVGIVEPHPLLLRELSRIGKYDPALLHEIEV
ECCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCHHHHEEEE
TGRIGHRTDLPEELRRLFRVATEISPEEHIRVQAAVQRHVENAVSKTINLPYEATRDDVR
CCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
RAFLLAHELGCKGVTVYREGAPRGQVLQVLGHCLSCVGEDVIPEDRTRY
HHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
PLELSDSARSLLRLRYLRRDEEGRIIETEEELFWRVARAVAAAEDAFPRGPRSAEIAEK
CCCCCHHHHHHHHHHHHHCCCCCCEECCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
FYELMTTLRFLPNTPALINAGTQLGQLFACFVIPVPDSLDGIFGAVRDAAKIQQTGGGTG
HHHHHHHHHHCCCCCHHEECCHHHHHHHEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCC
FSFSHLRPRGDLVRSTRRPSSGAVSFIRIFDVASDVIATESVRGGANMAVLRCDHPDVRE
CCCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHH
FIDAKRNPALFSRFNFSVLVTDDFLRAAIERREIALINPRTGLPFAQANAGELFDAMVDA
HHHCCCCCCCEEECCCEEEEEHHHHHHHHHCCCEEEECCCCCCCCCCCCHHHHHHHHHHH
AWEVGDPGLLFYDRIQRDNAVPALGPLEATNPCGEVPLHPWEACVLGSLNLRAFIVERGD
HHCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCEEEEEEECCC
RAFLDEAGLQESARLALRFLDNMVEVSRYPKVEIETICRANRKVGLGIMGFADLLLALRI
HHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHCC
PYGSDESVAVADRVMGLVQAAAVEASRRLAEERGPFPNFPISRYAARGEPPRRNATVTTV
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCCCEEEEE
APTGSISIIAGCSSGIEPLYALAYRHVGEFVGIVEPHPLLLRELSRIGKYDPALLHEIEV
ECCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCHHHHEEEE
TGRIGHRTDLPEELRRLFRVATEISPEEHIRVQAAVQRHVENAVSKTINLPYEATRDDVR
CCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
RAFLLAHELGCKGVTVYREGAPRGQVLQVLGHCLSCVGEDVIPEDRTRY
HHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]