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The map label for this gene is ahcY [H]

Identifier: 221632916

GI number: 221632916

Start: 898761

End: 900029

Strand: Reverse

Name: ahcY [H]

Synonym: trd_0918

Alternate gene names: 221632916

Gene position: 900029-898761 (Counterclockwise)

Preceding gene: 221632917

Following gene: 221632915

Centisome position: 44.93

GC content: 60.68

Gene sequence:

>1269_bases
GTGAACGGTCGAGTGATACCGTACGATATCGCTGATCTCACTTTAGCTGAGCAAGGAAGGAAGCGCATTGCTTGGGCAGC
GCGGGAGATGCCCGTTTTGCGCCTCCTTCGTGAACGATTCGAACGAGAACGTCCGCTCGAGGGCCTGAGAATCGTTGCCT
GTGTCCATGTCACGACCGAGACGGCGAATCTCGCTTACGCGTTGCGTGCTGCTGGTGCAACACCGGTGATCTGCGCGAGC
AACCCGCTCTCGACGCAGGATGATGTCGCTGCCGCATTGGTTGCCGACGGCTTTCATGTCTACGCCCGGCGTGGTGAGGA
CGCCGAGACGTACTACCGACACATCAACTGGGCTCTCGATCACGAGCCCCATCTGATCATCGATGATGGAGCGGACGTGG
TCACGACCGTACACCGCGACCGACGCGATGTCCTCCAGACCGTGATCGGTTCGACCGAAGAGACGACAACTGGCGTCATC
CGACTGCGTGCGTTGGCTCGCGATGATTTGCTGGCATTTCCGGCGATCGCTGTCAACGATGCCATGACGAAGCATTTGTT
CGACAACCGATACGGCACAGGGCAAAGCACGATCGACGCCATCCTGCGCGCGACGAACCTGTTGCTAGCTGGCAAAACGG
TGGTCGTCGCGGGGTATGGCTGGTGTGGGCGCGGTATCGCGCTCCGCGCACGGGGCATGGGTGCGCACGTGATCGTGACG
GAGGTCGATCCGGTGCGAGCGCTCGAGGCCGTCATGGATGGGTATCGGGTGCTGCCGATGCGGGAAGCGGCACGGGTAGG
AGACCTTTTCGTGACGGCTACTGGTAATCTGCACGTGATCGACCGAGAACACTTTCTCGTGATGAAGAACGGGGCGATCG
TCTGCAATGCGGGGCACTTCAACGTCGAAATCAATCTCGAAGCACTGGCCGAAATGGCAGTCGAGCGCATTGTGCACCGG
CCCTTTGTCGAGGAATACGTTCTGCCCGATGGGCGCGCGATCGTCGTCCTCGCCGAGGGGCGCCTCGTGAATCTCGCGGT
TGCCGAGGGGCATCCGGCCAGTGTCATGGACATGAGCTTTGCTAACCAGGCGCTCGCCTGCGTGTACCTCGCGCAGCGGG
GACGGCAACTCCCGGCTGATGTCTATCCGGTTCCGGCGGAAATCGATCGCGAAATTGCGCAGCTCAAGCTCGAGAGTATG
GGCATTGCGATCGACCGGTTGACACCGGAACAAGAGGCCTATCTCGTCTCCTGGCAGCATGGGACATGA

Upstream 100 bases:

>100_bases
GTATCATTCCGGCGCCCGATAGGCGAAAGATCGCGAACTTTCTTGCGGCGAACGGTCGAGGAACATCGGTCGAGCCAGGG
GAAACGGGACGGGACGAACG

Downstream 100 bases:

>100_bases
CGGCGACGTGCGGTACACGAGGTGTGACGTGACGAAGCGAAGGGGTTGGGAACGGTGACACTGAGCATCATGCGTGCCTC
ACGCACGTACTTTACCTCGG

Product: adenosylhomocysteinase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MNGRVIPYDIADLTLAEQGRKRIAWAAREMPVLRLLRERFERERPLEGLRIVACVHVTTETANLAYALRAAGATPVICAS
NPLSTQDDVAAALVADGFHVYARRGEDAETYYRHINWALDHEPHLIIDDGADVVTTVHRDRRDVLQTVIGSTEETTTGVI
RLRALARDDLLAFPAIAVNDAMTKHLFDNRYGTGQSTIDAILRATNLLLAGKTVVVAGYGWCGRGIALRARGMGAHVIVT
EVDPVRALEAVMDGYRVLPMREAARVGDLFVTATGNLHVIDREHFLVMKNGAIVCNAGHFNVEINLEALAEMAVERIVHR
PFVEEYVLPDGRAIVVLAEGRLVNLAVAEGHPASVMDMSFANQALACVYLAQRGRQLPADVYPVPAEIDREIAQLKLESM
GIAIDRLTPEQEAYLVSWQHGT

Sequences:

>Translated_422_residues
MNGRVIPYDIADLTLAEQGRKRIAWAAREMPVLRLLRERFERERPLEGLRIVACVHVTTETANLAYALRAAGATPVICAS
NPLSTQDDVAAALVADGFHVYARRGEDAETYYRHINWALDHEPHLIIDDGADVVTTVHRDRRDVLQTVIGSTEETTTGVI
RLRALARDDLLAFPAIAVNDAMTKHLFDNRYGTGQSTIDAILRATNLLLAGKTVVVAGYGWCGRGIALRARGMGAHVIVT
EVDPVRALEAVMDGYRVLPMREAARVGDLFVTATGNLHVIDREHFLVMKNGAIVCNAGHFNVEINLEALAEMAVERIVHR
PFVEEYVLPDGRAIVVLAEGRLVNLAVAEGHPASVMDMSFANQALACVYLAQRGRQLPADVYPVPAEIDREIAQLKLESM
GIAIDRLTPEQEAYLVSWQHGT
>Mature_422_residues
MNGRVIPYDIADLTLAEQGRKRIAWAAREMPVLRLLRERFERERPLEGLRIVACVHVTTETANLAYALRAAGATPVICAS
NPLSTQDDVAAALVADGFHVYARRGEDAETYYRHINWALDHEPHLIIDDGADVVTTVHRDRRDVLQTVIGSTEETTTGVI
RLRALARDDLLAFPAIAVNDAMTKHLFDNRYGTGQSTIDAILRATNLLLAGKTVVVAGYGWCGRGIALRARGMGAHVIVT
EVDPVRALEAVMDGYRVLPMREAARVGDLFVTATGNLHVIDREHFLVMKNGAIVCNAGHFNVEINLEALAEMAVERIVHR
PFVEEYVLPDGRAIVVLAEGRLVNLAVAEGHPASVMDMSFANQALACVYLAQRGRQLPADVYPVPAEIDREIAQLKLESM
GIAIDRLTPEQEAYLVSWQHGT

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI9951915, Length=413, Percent_Identity=45.0363196125908, Blast_Score=341, Evalue=9e-94,
Organism=Homo sapiens, GI239937451, Length=389, Percent_Identity=44.987146529563, Blast_Score=320, Evalue=1e-87,
Organism=Homo sapiens, GI298286489, Length=419, Percent_Identity=40.0954653937947, Blast_Score=302, Evalue=3e-82,
Organism=Homo sapiens, GI195539349, Length=419, Percent_Identity=40.0954653937947, Blast_Score=302, Evalue=4e-82,
Organism=Homo sapiens, GI195539337, Length=419, Percent_Identity=40.0954653937947, Blast_Score=301, Evalue=6e-82,
Organism=Homo sapiens, GI24308043, Length=419, Percent_Identity=40.0954653937947, Blast_Score=301, Evalue=8e-82,
Organism=Homo sapiens, GI21361647, Length=419, Percent_Identity=39.618138424821, Blast_Score=278, Evalue=7e-75,
Organism=Caenorhabditis elegans, GI17506425, Length=416, Percent_Identity=43.5096153846154, Blast_Score=324, Evalue=6e-89,
Organism=Saccharomyces cerevisiae, GI6320882, Length=427, Percent_Identity=42.8571428571429, Blast_Score=323, Evalue=3e-89,
Organism=Drosophila melanogaster, GI24642172, Length=418, Percent_Identity=44.0191387559809, Blast_Score=335, Evalue=4e-92,
Organism=Drosophila melanogaster, GI24656245, Length=404, Percent_Identity=39.6039603960396, Blast_Score=281, Evalue=5e-76,
Organism=Drosophila melanogaster, GI45553387, Length=417, Percent_Identity=39.8081534772182, Blast_Score=275, Evalue=6e-74,
Organism=Drosophila melanogaster, GI45553385, Length=417, Percent_Identity=39.8081534772182, Blast_Score=274, Evalue=9e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 46401; Mature: 46401

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: PS00738 ADOHCYASE_1 ; PS00739 ADOHCYASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGRVIPYDIADLTLAEQGRKRIAWAAREMPVLRLLRERFERERPLEGLRIVACVHVTTE
CCCCEEEECHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHCCCCCCEEEEEEEEEEEC
TANLAYALRAAGATPVICASNPLSTQDDVAAALVADGFHVYARRGEDAETYYRHINWALD
CCHHEEEEECCCCCEEEECCCCCCCCHHHHHHHHHCCEEEEEECCCCHHHHHHHHCEEEC
HEPHLIIDDGADVVTTVHRDRRDVLQTVIGSTEETTTGVIRLRALARDDLLAFPAIAVND
CCCEEEEECCCCEEHHHHHHHHHHHHHHHCCCCCCHHHHEEEEEHHCCCHHCCCCHHHHH
AMTKHLFDNRYGTGQSTIDAILRATNLLLAGKTVVVAGYGWCGRGIALRARGMGAHVIVT
HHHHHHHCCCCCCCHHHHHHHHHHHHHEEECCEEEEEECCCCCCCEEEEECCCCCEEEEE
EVDPVRALEAVMDGYRVLPMREAARVGDLFVTATGNLHVIDREHFLVMKNGAIVCNAGHF
CCCHHHHHHHHHCCEEEEECHHHHCCCCEEEEECCCEEEEECCEEEEEECCEEEEECCEE
NVEINLEALAEMAVERIVHRPFVEEYVLPDGRAIVVLAEGRLVNLAVAEGHPASVMDMSF
EEEEEHHHHHHHHHHHHHHCCCHHHHCCCCCCEEEEEECCCEEEEEEECCCCCCEEEHHH
ANQALACVYLAQRGRQLPADVYPVPAEIDREIAQLKLESMGIAIDRLTPEQEAYLVSWQH
HHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCEEEECCCCCCCEEEEEEEC
GT
CC
>Mature Secondary Structure
MNGRVIPYDIADLTLAEQGRKRIAWAAREMPVLRLLRERFERERPLEGLRIVACVHVTTE
CCCCEEEECHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHCCCCCCEEEEEEEEEEEC
TANLAYALRAAGATPVICASNPLSTQDDVAAALVADGFHVYARRGEDAETYYRHINWALD
CCHHEEEEECCCCCEEEECCCCCCCCHHHHHHHHHCCEEEEEECCCCHHHHHHHHCEEEC
HEPHLIIDDGADVVTTVHRDRRDVLQTVIGSTEETTTGVIRLRALARDDLLAFPAIAVND
CCCEEEEECCCCEEHHHHHHHHHHHHHHHCCCCCCHHHHEEEEEHHCCCHHCCCCHHHHH
AMTKHLFDNRYGTGQSTIDAILRATNLLLAGKTVVVAGYGWCGRGIALRARGMGAHVIVT
HHHHHHHCCCCCCCHHHHHHHHHHHHHEEECCEEEEEECCCCCCCEEEEECCCCCEEEEE
EVDPVRALEAVMDGYRVLPMREAARVGDLFVTATGNLHVIDREHFLVMKNGAIVCNAGHF
CCCHHHHHHHHHCCEEEEECHHHHCCCCEEEEECCCEEEEECCEEEEEECCEEEEECCEE
NVEINLEALAEMAVERIVHRPFVEEYVLPDGRAIVVLAEGRLVNLAVAEGHPASVMDMSF
EEEEEHHHHHHHHHHHHHHCCCHHHHCCCCCCEEEEEECCCEEEEEEECCCCCCEEEHHH
ANQALACVYLAQRGRQLPADVYPVPAEIDREIAQLKLESMGIAIDRLTPEQEAYLVSWQH
HHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCEEEECCCCCCCEEEEEEEC
GT
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12240834 [H]