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The map label for this gene is pth [H]

Identifier: 221632813

GI number: 221632813

Start: 787369

End: 788088

Strand: Reverse

Name: pth [H]

Synonym: trd_0807

Alternate gene names: 221632813

Gene position: 788088-787369 (Counterclockwise)

Preceding gene: 221632814

Following gene: 221632812

Centisome position: 39.35

GC content: 59.03

Gene sequence:

>720_bases
ATGCTGATCTCCGGGCTGAACTGGCTTACCGGGCTCGTCTTCGAGCACAGCGCTTTACCTGGGAGGAGTCGGGTCGACAA
ACGCTCGCAGTCTATCAGGAGGTGCTCGATCGTGGCTTCTGATGCATGGCTCGTGGTTGGATTGGGTAATCCAGGCTCAG
AATACATGGAAACCCGACACAATATAGGGTTTTGGGTGATCGATCGCGTAGCACAACTCACCAATGTCGTCGGTTTTCAG
CGGCGATTCGAAGGCGAGTTCGCAACGGTGCGTACCGACCGTGGGCTACTTTTACTCCTGAAGCCTCTGACATTCATGAA
TCGCAGTGGTGTGGCTGTCGCAGCAGCCGTTCGCTGGTACAAACTTTCCTTGGATCGAACGCTGGTGGTTCACGACGACA
TGGACTTGCCACTCGGCACGTTGCGGTTTCGGCAGGGAGGGAGCGCTGCCGGTCATCACGGTGTCGAATCAGTGACTCGC
GAACTGGGAAGCAACGGTTTCGGACGTCTTCGGATCGGCATTGGGCGACCGACCCGCCGCGAGGAAGGACGCGACTTTGT
CCTGAGCCCGTTCCATCCCGAAGAGCGACCGCTCGCAGAGCGCATCGCAGCCCTCGCAGCCGAAGCGGTCCTGGTGTGGC
ACCGGGAAGGCATGACGGTCGCGATGAATCGGTTCAACGGACTCCGTCTGTCTCTCGATGAGAGTGCGCTGCCTCGCTGA

Upstream 100 bases:

>100_bases
GCTGTCGGTGCACTTCCCGAGATCGTGGGTGATGCCGGACTGTTGGTTCGAGAAGAAACAGTGGCTAGCCTCGCGGGAGC
ACTGGTCCGCTTACTGAGCG

Downstream 100 bases:

>100_bases
TCGAGCGTCGCAGGCGAGACTCCGGATCGGCCGCAGAGCATGGACCGATCGGTGTATGCCCGCGCGAGTGCATCGTGGCA
GTGCTTCGCCATCGCGCGCG

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH [H]

Number of amino acids: Translated: 239; Mature: 239

Protein sequence:

>239_residues
MLISGLNWLTGLVFEHSALPGRSRVDKRSQSIRRCSIVASDAWLVVGLGNPGSEYMETRHNIGFWVIDRVAQLTNVVGFQ
RRFEGEFATVRTDRGLLLLLKPLTFMNRSGVAVAAAVRWYKLSLDRTLVVHDDMDLPLGTLRFRQGGSAAGHHGVESVTR
ELGSNGFGRLRIGIGRPTRREEGRDFVLSPFHPEERPLAERIAALAAEAVLVWHREGMTVAMNRFNGLRLSLDESALPR

Sequences:

>Translated_239_residues
MLISGLNWLTGLVFEHSALPGRSRVDKRSQSIRRCSIVASDAWLVVGLGNPGSEYMETRHNIGFWVIDRVAQLTNVVGFQ
RRFEGEFATVRTDRGLLLLLKPLTFMNRSGVAVAAAVRWYKLSLDRTLVVHDDMDLPLGTLRFRQGGSAAGHHGVESVTR
ELGSNGFGRLRIGIGRPTRREEGRDFVLSPFHPEERPLAERIAALAAEAVLVWHREGMTVAMNRFNGLRLSLDESALPR
>Mature_239_residues
MLISGLNWLTGLVFEHSALPGRSRVDKRSQSIRRCSIVASDAWLVVGLGNPGSEYMETRHNIGFWVIDRVAQLTNVVGFQ
RRFEGEFATVRTDRGLLLLLKPLTFMNRSGVAVAAAVRWYKLSLDRTLVVHDDMDLPLGTLRFRQGGSAAGHHGVESVTR
ELGSNGFGRLRIGIGRPTRREEGRDFVLSPFHPEERPLAERIAALAAEAVLVWHREGMTVAMNRFNGLRLSLDESALPR

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis [H]

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family [H]

Homologues:

Organism=Homo sapiens, GI50897284, Length=194, Percent_Identity=36.0824742268041, Blast_Score=108, Evalue=5e-24,
Organism=Escherichia coli, GI1787455, Length=188, Percent_Identity=39.3617021276596, Blast_Score=116, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001328
- InterPro:   IPR018171 [H]

Pfam domain/function: PF01195 Pept_tRNA_hydro [H]

EC number: =3.1.1.29 [H]

Molecular weight: Translated: 26653; Mature: 26653

Theoretical pI: Translated: 11.12; Mature: 11.12

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLISGLNWLTGLVFEHSALPGRSRVDKRSQSIRRCSIVASDAWLVVGLGNPGSEYMETRH
CEECCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHEEEECCCEEEEECCCCCHHHHHHHH
NIGFWVIDRVAQLTNVVGFQRRFEGEFATVRTDRGLLLLLKPLTFMNRSGVAVAAAVRWY
CCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCEEEEECCHHHCCCCCCEEEHHHEEE
KLSLDRTLVVHDDMDLPLGTLRFRQGGSAAGHHGVESVTRELGSNGFGRLRIGIGRPTRR
EEECCCEEEEECCCCCCHHHEEECCCCCCCCCCCHHHHHHHHCCCCCEEEEEECCCCCCC
EEGRDFVLSPFHPEERPLAERIAALAAEAVLVWHREGMTVAMNRFNGLRLSLDESALPR
CCCCCEEECCCCCCCCCHHHHHHHHHHHHHEEEECCCCEEEEECCCCEEEEECCCCCCC
>Mature Secondary Structure
MLISGLNWLTGLVFEHSALPGRSRVDKRSQSIRRCSIVASDAWLVVGLGNPGSEYMETRH
CEECCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHEEEECCCEEEEECCCCCHHHHHHHH
NIGFWVIDRVAQLTNVVGFQRRFEGEFATVRTDRGLLLLLKPLTFMNRSGVAVAAAVRWY
CCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCEEEEECCHHHCCCCCCEEEHHHEEE
KLSLDRTLVVHDDMDLPLGTLRFRQGGSAAGHHGVESVTRELGSNGFGRLRIGIGRPTRR
EEECCCEEEEECCCCCCHHHEEECCCCCCCCCCCHHHHHHHHCCCCCEEEEEECCCCCCC
EEGRDFVLSPFHPEERPLAERIAALAAEAVLVWHREGMTVAMNRFNGLRLSLDESALPR
CCCCCEEECCCCCCCCCHHHHHHHHHHHHHEEEECCCCEEEEECCCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA