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The map label for this gene is rdgB [H]

Identifier: 221632750

GI number: 221632750

Start: 730613

End: 731245

Strand: Reverse

Name: rdgB [H]

Synonym: trd_0741

Alternate gene names: 221632750

Gene position: 731245-730613 (Counterclockwise)

Preceding gene: 221632751

Following gene: 221632749

Centisome position: 36.51

GC content: 63.03

Gene sequence:

>633_bases
ATGCCGACACATCGGATCGTTCTCGCAACGGCCAACCCAGGAAAGATCCGCGAACTCCGCTCCCTGCTCCCGCCGAACGT
CGAAGTCGTGAGCGCGCCCGCACTCGGCATCCGACTTCCGCCCGAAACCGGCGAAACCTTCGTCGAGAACGCACTGCTCA
AAGCCAGGGTCGCTGCCCAGGAAAGCGGCCTTATCGCGCTCGCCGATGATTCCGGACTCGAAGTCGACGCGCTGGGGGGA
CGACCCGGCGTCCACTCTGCCCGATACGCTGGTGAGCACGCGGACGATGCTCAAAATATCGCCCGGTTACTGCGTGAGCT
GCGTGATGTCCCCCTTTCCCAACGTACCGCGCGTTTCCGTGCGGTCGTCGCGATCGTCGCACCGGATGGTCGGGAAGCCG
TCGTCGAAGGCACGGTCGAAGGGTGTATTGCCGAAAAGCCACGCGGTCGCGGCGGTTTCGGATACGATCCCGTCTTCATT
CCCTGCGGGTATGACCGGACATTCGCAGAGATGACGCTGGAAGAGAAGAATCGCTTGAGCCACCGTGCTCAGGCTCTCCA
GCGCGCCGTACCGATCTTGCTCGACTGGCTCGGCTGTACCGGCCAGGCTGCCGATAATGATGACAGCAGCTGA

Upstream 100 bases:

>100_bases
CCGCAGGCAGACCGAGGACGAGGTCGCTCGGGCTACCACCCGAAACGCAGTCGCACTGTTCAGGATTCCTCTCTCGATCG
AATGAGCGAGGTGCAGACGT

Downstream 100 bases:

>100_bases
TCACCACGCCGGGAGTATCTTATGACGAGCCTCGATCAGAGCGGGTTGCGAAGTCAGACGAGATTTCCGCTCTCGCTCGT
TGCTATCACCGGGACACGCG

Product: non-canonical purine NTP pyrophosphatase

Products: NA

Alternate protein names: Nucleoside triphosphate phosphohydrolase; NTPase [H]

Number of amino acids: Translated: 210; Mature: 209

Protein sequence:

>210_residues
MPTHRIVLATANPGKIRELRSLLPPNVEVVSAPALGIRLPPETGETFVENALLKARVAAQESGLIALADDSGLEVDALGG
RPGVHSARYAGEHADDAQNIARLLRELRDVPLSQRTARFRAVVAIVAPDGREAVVEGTVEGCIAEKPRGRGGFGYDPVFI
PCGYDRTFAEMTLEEKNRLSHRAQALQRAVPILLDWLGCTGQAADNDDSS

Sequences:

>Translated_210_residues
MPTHRIVLATANPGKIRELRSLLPPNVEVVSAPALGIRLPPETGETFVENALLKARVAAQESGLIALADDSGLEVDALGG
RPGVHSARYAGEHADDAQNIARLLRELRDVPLSQRTARFRAVVAIVAPDGREAVVEGTVEGCIAEKPRGRGGFGYDPVFI
PCGYDRTFAEMTLEEKNRLSHRAQALQRAVPILLDWLGCTGQAADNDDSS
>Mature_209_residues
PTHRIVLATANPGKIRELRSLLPPNVEVVSAPALGIRLPPETGETFVENALLKARVAAQESGLIALADDSGLEVDALGGR
PGVHSARYAGEHADDAQNIARLLRELRDVPLSQRTARFRAVVAIVAPDGREAVVEGTVEGCIAEKPRGRGGFGYDPVFIP
CGYDRTFAEMTLEEKNRLSHRAQALQRAVPILLDWLGCTGQAADNDDSS

Specific function: Hydrolyzes non-standard nucleotides such as XTP and dITP/ITP. Might exclude non-standard purines from DNA precursor pool, preventing thus incorporation into DNA and avoiding chromosomal lesions [H]

COG id: COG0127

COG function: function code F; Xanthosine triphosphate pyrophosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HAM1 NTPase family [H]

Homologues:

Organism=Escherichia coli, GI1789324, Length=197, Percent_Identity=49.746192893401, Blast_Score=176, Evalue=1e-45,
Organism=Drosophila melanogaster, GI19920712, Length=186, Percent_Identity=34.4086021505376, Blast_Score=80, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002637
- InterPro:   IPR020922 [H]

Pfam domain/function: PF01725 Ham1p_like [H]

EC number: =3.6.1.15 [H]

Molecular weight: Translated: 22523; Mature: 22392

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTHRIVLATANPGKIRELRSLLPPNVEVVSAPALGIRLPPETGETFVENALLKARVAAQ
CCCCEEEEEECCCHHHHHHHHHCCCCCEEEECCCCEEECCCCCCHHHHHHHHHHHHHHHC
ESGLIALADDSGLEVDALGGRPGVHSARYAGEHADDAQNIARLLRELRDVPLSQRTARFR
CCCEEEEECCCCCEEEECCCCCCCCCHHHCCCCCCCHHHHHHHHHHHHCCCCCHHHHHEE
AVVAIVAPDGREAVVEGTVEGCIAEKPRGRGGFGYDPVFIPCGYDRTFAEMTLEEKNRLS
EEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHH
HRAQALQRAVPILLDWLGCTGQAADNDDSS
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
PTHRIVLATANPGKIRELRSLLPPNVEVVSAPALGIRLPPETGETFVENALLKARVAAQ
CCCEEEEEECCCHHHHHHHHHCCCCCEEEECCCCEEECCCCCCHHHHHHHHHHHHHHHC
ESGLIALADDSGLEVDALGGRPGVHSARYAGEHADDAQNIARLLRELRDVPLSQRTARFR
CCCEEEEECCCCCEEEECCCCCCCCCHHHCCCCCCCHHHHHHHHHHHHCCCCCHHHHHEE
AVVAIVAPDGREAVVEGTVEGCIAEKPRGRGGFGYDPVFIPCGYDRTFAEMTLEEKNRLS
EEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHH
HRAQALQRAVPILLDWLGCTGQAADNDDSS
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377; 1624460 [H]