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The map label for this gene is rnz

Identifier: 221632624

GI number: 221632624

Start: 595403

End: 596314

Strand: Reverse

Name: rnz

Synonym: trd_0603

Alternate gene names: 221632624

Gene position: 596314-595403 (Counterclockwise)

Preceding gene: 221632626

Following gene: 221632623

Centisome position: 29.77

GC content: 64.8

Gene sequence:

>912_bases
ATGGTCGACGTCTGTCTTCTCGGCACCGGTGGGATGATGCCGCTTCCGGATCGTTGGCTGTCCGCTCTCCTTGTCCGGTG
CGAAGGGCATGTTGTCCTCCTCGATTGCGGCGAGGGCACGCAGATTTCCTGGCGATACACCGGATGGAGCTTCCGCGATC
TCGATGCGATCGTCTTCACGCACCTCCACGCCGATCATGTCGCTGGTCTCCCTGGTATCCTCTACGCTCTTGCCTTCGCC
GACCGTCAGGAGCCGGTTCGCATCATCGGCCCTGTCGGTACCGCGCAGGTGGTCGCTGCACTGCGGAGCATCGTACCGAC
TCTCCCGTTTCCTGTCGAAACACTGGAGCTCTCCGGGACCAGCGAACTCGAACTTCCTGGCGGACTCCTCCTGCGCGCCC
TGCCGGTCACACACCGGATCCCTTGCTTCGCATACACGCTGCACCGTCCACGGGGACGCCGGTTCGACCCACAGCGAGCG
CAGGCGCTCGGCATCCCGATGACGCTCTGGCACCGCCTGCAGCGTGGAGAAACGGTCGAGTTCGCGGGACAGCTCCTGAC
CCCTGATCTCGTGCTCGGCCCGCCGCGACGCGGTATCACCGTCGCCTTCGTGACCGATACCCGACCCACCCCAGAGCTTC
CCGGGTTCGTCGCTGGAGCGGACCTCCTGGTCTGTGAGGGGATGTACGGCGACACCGCTCTGCTGCCGCGAGCGATCGAA
CGCGGCCATATGCTGATGCAAGAGGCAGCCGAATTGGCCCGTGCCGCCAGCGTCGAGCGCCTCTGGCTCACTCATTTTAG
TCCTTCGCTGACCGATCCCGAAGCCTGGTTACCTGCCATTCGCGCGATTTTCCCCGCGAGCGAGATCGGCCCCGTGCACC
AGACTGTGACGCTGCGTTACCGGGACGCGTGA

Upstream 100 bases:

>100_bases
CCTGGAGCTTGTCTTCCGCCGCGCATCCTAGCATGTCGGGAACAGACGCCCAACGTGATACGATTCGCCACCGGCGTGGA
GTTCGGTGAGGTGCACAGCC

Downstream 100 bases:

>100_bases
GACGAACCGGAAGCATCGCGCAAGGAGCGAGCCTGCTCGCTCGCATCGCATCTGCGTTGGTGAATCACCACTTCACCGTA
CAGCATGGTTCCGCTACATT

Product: ribonuclease Z

Products: NA

Alternate protein names: RNase Z; tRNA 3 endonuclease; tRNase Z

Number of amino acids: Translated: 303; Mature: 303

Protein sequence:

>303_residues
MVDVCLLGTGGMMPLPDRWLSALLVRCEGHVVLLDCGEGTQISWRYTGWSFRDLDAIVFTHLHADHVAGLPGILYALAFA
DRQEPVRIIGPVGTAQVVAALRSIVPTLPFPVETLELSGTSELELPGGLLLRALPVTHRIPCFAYTLHRPRGRRFDPQRA
QALGIPMTLWHRLQRGETVEFAGQLLTPDLVLGPPRRGITVAFVTDTRPTPELPGFVAGADLLVCEGMYGDTALLPRAIE
RGHMLMQEAAELARAASVERLWLTHFSPSLTDPEAWLPAIRAIFPASEIGPVHQTVTLRYRDA

Sequences:

>Translated_303_residues
MVDVCLLGTGGMMPLPDRWLSALLVRCEGHVVLLDCGEGTQISWRYTGWSFRDLDAIVFTHLHADHVAGLPGILYALAFA
DRQEPVRIIGPVGTAQVVAALRSIVPTLPFPVETLELSGTSELELPGGLLLRALPVTHRIPCFAYTLHRPRGRRFDPQRA
QALGIPMTLWHRLQRGETVEFAGQLLTPDLVLGPPRRGITVAFVTDTRPTPELPGFVAGADLLVCEGMYGDTALLPRAIE
RGHMLMQEAAELARAASVERLWLTHFSPSLTDPEAWLPAIRAIFPASEIGPVHQTVTLRYRDA
>Mature_303_residues
MVDVCLLGTGGMMPLPDRWLSALLVRCEGHVVLLDCGEGTQISWRYTGWSFRDLDAIVFTHLHADHVAGLPGILYALAFA
DRQEPVRIIGPVGTAQVVAALRSIVPTLPFPVETLELSGTSELELPGGLLLRALPVTHRIPCFAYTLHRPRGRRFDPQRA
QALGIPMTLWHRLQRGETVEFAGQLLTPDLVLGPPRRGITVAFVTDTRPTPELPGFVAGADLLVCEGMYGDTALLPRAIE
RGHMLMQEAAELARAASVERLWLTHFSPSLTDPEAWLPAIRAIFPASEIGPVHQTVTLRYRDA

Specific function: Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA

COG id: COG1234

COG function: function code R; Metal-dependent hydrolases of the beta-lactamase superfamily III

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RNase Z family

Homologues:

Organism=Homo sapiens, GI8922122, Length=314, Percent_Identity=29.6178343949045, Blast_Score=113, Evalue=2e-25,
Organism=Escherichia coli, GI87082078, Length=298, Percent_Identity=31.2080536912752, Blast_Score=124, Evalue=7e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNZ_THERP (B9KYQ3)

Other databases:

- EMBL:   CP001275
- RefSeq:   YP_002521845.1
- ProteinModelPortal:   B9KYQ3
- GeneID:   7355286
- GenomeReviews:   CP001275_GR
- KEGG:   tro:trd_0603
- OMA:   WLTHFSP
- ProtClustDB:   PRK00055
- HAMAP:   MF_01818
- InterPro:   IPR001279
- InterPro:   IPR013471
- SMART:   SM00849

Pfam domain/function: PF00753 Lactamase_B

EC number: =3.1.26.11

Molecular weight: Translated: 33249; Mature: 33249

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDVCLLGTGGMMPLPDRWLSALLVRCEGHVVLLDCGEGTQISWRYTGWSFRDLDAIVFT
CEEEEEECCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCEEEEEECCCCHHHHHHHHHH
HLHADHVAGLPGILYALAFADRQEPVRIIGPVGTAQVVAALRSIVPTLPFPVETLELSGT
HHHHHHHCCCHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHCCCCCCCEEEEECCC
SELELPGGLLLRALPVTHRIPCFAYTLHRPRGRRFDPQRAQALGIPMTLWHRLQRGETVE
CCEECCCCCEEEECCCHHCCCEEEEEEECCCCCCCCHHHHHHCCCCHHHHHHHHCCCCHH
FAGQLLTPDLVLGPPRRGITVAFVTDTRPTPELPGFVAGADLLVCEGMYGDTALLPRAIE
HHHHHCCCCEEECCCCCCEEEEEEECCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHH
RGHMLMQEAAELARAASVERLWLTHFSPSLTDPEAWLPAIRAIFPASEIGPVHQTVTLRY
HHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHHHCCCHHCCCCEEEEEEEE
RDA
ECC
>Mature Secondary Structure
MVDVCLLGTGGMMPLPDRWLSALLVRCEGHVVLLDCGEGTQISWRYTGWSFRDLDAIVFT
CEEEEEECCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCEEEEEECCCCHHHHHHHHHH
HLHADHVAGLPGILYALAFADRQEPVRIIGPVGTAQVVAALRSIVPTLPFPVETLELSGT
HHHHHHHCCCHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHCCCCCCCEEEEECCC
SELELPGGLLLRALPVTHRIPCFAYTLHRPRGRRFDPQRAQALGIPMTLWHRLQRGETVE
CCEECCCCCEEEECCCHHCCCEEEEEEECCCCCCCCHHHHHHCCCCHHHHHHHHCCCCHH
FAGQLLTPDLVLGPPRRGITVAFVTDTRPTPELPGFVAGADLLVCEGMYGDTALLPRAIE
HHHHHCCCCEEECCCCCCEEEEEEECCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHH
RGHMLMQEAAELARAASVERLWLTHFSPSLTDPEAWLPAIRAIFPASEIGPVHQTVTLRY
HHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHHHCCCHHCCCCEEEEEEEE
RDA
ECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA