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The map label for this gene is ggt [H]

Identifier: 221632386

GI number: 221632386

Start: 359250

End: 360881

Strand: Reverse

Name: ggt [H]

Synonym: trd_0358

Alternate gene names: 221632386

Gene position: 360881-359250 (Counterclockwise)

Preceding gene: 221632387

Following gene: 221632385

Centisome position: 18.02

GC content: 64.4

Gene sequence:

>1632_bases
ATGACAGCACGAGCGATCGCCACCTTCGCCGAGCGTGCTGGTCGACCGCTTCTGATGGGCCGTTGTTGGGCAGTCTCCAG
TGGTCATTCCCTTGCCTCTTGGGCAGGTGCCCGCGTGCTGGAGCGCGGCGGCAGTGCCGCCGACGCCGCTGTCGCTGTCG
CCGCGGCGTTGAACGTGGTCGAACCGCAGATGTCCGGTATCGGCGGTGATCTCTTCGCCCTTGTCTACGAGGCAGGGACT
TCGACCGTCTGGGCGGTGAACGGTACAGGGCCGGCACCGCTCGACGCGACCCCGGAACGCTTCCGCGATGGCATTCCGGA
ACGCGGTCCACTCGCTGCTTCTGTTCCGGCTGCTGCTCGCGCTTGGGATTTGCTGGTCCAACGCTGGGGCCGGCTGCCGC
TCTCGATAACCCTCGCGCCGGCGATCGAACTGGCCCGCGACGGCTTCCCGGTCAGCCATAATCTTGCGACCTACATCGAG
ACCTACGCTGACGTTCTCGCCAGCTATCCCGAGACGGCTCGCACCTTCCTCCCAACTGGTTCGCCACCTTGTCCGGGCGA
TGTGCTCCGCCAACCGGATCTCGCTCGCACGCTGGAAACGGTCGCTGCGGAAGGCGTCAACGCGTTGTACGAAGGCGATC
TCGCCGAGCGCTTGACGCGCGCCGTCCTGGCGGCTGGTGGGCTGTTGACACGCGAGAGTCTTCGGCTGGCGCGAGCAACG
ATCGTCGAGCCACTCCAGCTAGCGTACCGCGACTGGACCATCTGCGTCCCGCCGCCGAATTCCAGTGCTCATACCCTTCT
CGAGATGCTGGGTATCCTGCAGTACTTTCCACTCGCCCGGTGGCGCCCGCTTTCGCCCGAACTTCTGCACGTGATGATCG
AGGCCAAGAAACTCGCCTTCCTGGATCGTGAGCGCTTCACTGGAGATCCCGATTTCGTTGGTCCTTTCCCGCCCGACGTG
CTCGCCCCCGAGCGACTGCAGCGGCTCGCGGCGGCGATCGATCTCACGCGAGCAAAGCCGGTGCTCACGACTCGACCTGC
CCGCGAGGACCACACGACCTCGTTCTCGGTCATGGATCACGAGGGTAATCTCGTCGTCGTGACCGCCAGCCTCAATATGG
CATTCGGTTCCGCGTTCATCGCCGGCGATACCGGCATCTTGCTGAACAATCGGATGACCTACTGGCACTTGGAGCCGAAG
CACCCGAATCAGCTACAGCCGGGGAAGCGCGTTCGTCACACGCTCAGCCCAGTCTTGCTCACCAGACCGGGTGAACGGCT
CGGTCTCGGAACTCCGGGGAGCGATGCTCAAGTGCAGATCCTGGTGCATGTTCTCGTGCATTGGCTCGAATACGGTTTCG
ATCTCCAGACAGCGATAGAATTGCCGCGCTGGCGCCATCGCGGTCCTGGGCACGAGTCCAATTGGCCGCACGGCTCTCTC
GACCTTGTCCAGGTCGAGGGGAGGCTTCCCAACGCCACGATCGAGGGGCTCCAAGCACGCGGCCATCGTGTCGAACGACT
GGCCCGCTGGGGTCCGATCGGCTCCTGCCAGGGGATTCACTGGCGTGATGCTGAGCGTGTCGTCGAAGCTGCTGCCGATC
CGCGCAGCGACGCCTATGCACTGGCCTGGTGA

Upstream 100 bases:

>100_bases
TGTCGTTCGCCAATACCAACACTCCCGAGGCCTACCGTGCAGCCCTGGAGCGAGCGAAAGGGACCGAGCAGTGTCTCGAG
TCTCCCGTGGAGGGCAGCGC

Downstream 100 bases:

>100_bases
GAGGATCCGACGATGCTGACCACCTGGCGGCCTTCAGGGATCGTGACGTTTACCAGTGACTATGGCGTGCGTGACAGCTA
TGTGGCACAGGTCAAGGGAG

Product: gamma-glutamyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 543; Mature: 542

Protein sequence:

>543_residues
MTARAIATFAERAGRPLLMGRCWAVSSGHSLASWAGARVLERGGSAADAAVAVAAALNVVEPQMSGIGGDLFALVYEAGT
STVWAVNGTGPAPLDATPERFRDGIPERGPLAASVPAAARAWDLLVQRWGRLPLSITLAPAIELARDGFPVSHNLATYIE
TYADVLASYPETARTFLPTGSPPCPGDVLRQPDLARTLETVAAEGVNALYEGDLAERLTRAVLAAGGLLTRESLRLARAT
IVEPLQLAYRDWTICVPPPNSSAHTLLEMLGILQYFPLARWRPLSPELLHVMIEAKKLAFLDRERFTGDPDFVGPFPPDV
LAPERLQRLAAAIDLTRAKPVLTTRPAREDHTTSFSVMDHEGNLVVVTASLNMAFGSAFIAGDTGILLNNRMTYWHLEPK
HPNQLQPGKRVRHTLSPVLLTRPGERLGLGTPGSDAQVQILVHVLVHWLEYGFDLQTAIELPRWRHRGPGHESNWPHGSL
DLVQVEGRLPNATIEGLQARGHRVERLARWGPIGSCQGIHWRDAERVVEAAADPRSDAYALAW

Sequences:

>Translated_543_residues
MTARAIATFAERAGRPLLMGRCWAVSSGHSLASWAGARVLERGGSAADAAVAVAAALNVVEPQMSGIGGDLFALVYEAGT
STVWAVNGTGPAPLDATPERFRDGIPERGPLAASVPAAARAWDLLVQRWGRLPLSITLAPAIELARDGFPVSHNLATYIE
TYADVLASYPETARTFLPTGSPPCPGDVLRQPDLARTLETVAAEGVNALYEGDLAERLTRAVLAAGGLLTRESLRLARAT
IVEPLQLAYRDWTICVPPPNSSAHTLLEMLGILQYFPLARWRPLSPELLHVMIEAKKLAFLDRERFTGDPDFVGPFPPDV
LAPERLQRLAAAIDLTRAKPVLTTRPAREDHTTSFSVMDHEGNLVVVTASLNMAFGSAFIAGDTGILLNNRMTYWHLEPK
HPNQLQPGKRVRHTLSPVLLTRPGERLGLGTPGSDAQVQILVHVLVHWLEYGFDLQTAIELPRWRHRGPGHESNWPHGSL
DLVQVEGRLPNATIEGLQARGHRVERLARWGPIGSCQGIHWRDAERVVEAAADPRSDAYALAW
>Mature_542_residues
TARAIATFAERAGRPLLMGRCWAVSSGHSLASWAGARVLERGGSAADAAVAVAAALNVVEPQMSGIGGDLFALVYEAGTS
TVWAVNGTGPAPLDATPERFRDGIPERGPLAASVPAAARAWDLLVQRWGRLPLSITLAPAIELARDGFPVSHNLATYIET
YADVLASYPETARTFLPTGSPPCPGDVLRQPDLARTLETVAAEGVNALYEGDLAERLTRAVLAAGGLLTRESLRLARATI
VEPLQLAYRDWTICVPPPNSSAHTLLEMLGILQYFPLARWRPLSPELLHVMIEAKKLAFLDRERFTGDPDFVGPFPPDVL
APERLQRLAAAIDLTRAKPVLTTRPAREDHTTSFSVMDHEGNLVVVTASLNMAFGSAFIAGDTGILLNNRMTYWHLEPKH
PNQLQPGKRVRHTLSPVLLTRPGERLGLGTPGSDAQVQILVHVLVHWLEYGFDLQTAIELPRWRHRGPGHESNWPHGSLD
LVQVEGRLPNATIEGLQARGHRVERLARWGPIGSCQGIHWRDAERVVEAAADPRSDAYALAW

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=505, Percent_Identity=29.3069306930693, Blast_Score=189, Evalue=7e-48,
Organism=Homo sapiens, GI73915090, Length=505, Percent_Identity=29.3069306930693, Blast_Score=189, Evalue=7e-48,
Organism=Homo sapiens, GI73915096, Length=505, Percent_Identity=29.3069306930693, Blast_Score=189, Evalue=7e-48,
Organism=Homo sapiens, GI73915094, Length=505, Percent_Identity=29.3069306930693, Blast_Score=189, Evalue=7e-48,
Organism=Homo sapiens, GI113429324, Length=493, Percent_Identity=28.6004056795132, Blast_Score=173, Evalue=5e-43,
Organism=Homo sapiens, GI113429326, Length=506, Percent_Identity=28.6561264822134, Blast_Score=172, Evalue=9e-43,
Organism=Homo sapiens, GI109148539, Length=535, Percent_Identity=30.2803738317757, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI153266885, Length=517, Percent_Identity=26.4990328820116, Blast_Score=134, Evalue=3e-31,
Organism=Homo sapiens, GI153266901, Length=520, Percent_Identity=26.3461538461538, Blast_Score=132, Evalue=6e-31,
Organism=Homo sapiens, GI153266907, Length=512, Percent_Identity=25.5859375, Blast_Score=124, Evalue=3e-28,
Organism=Escherichia coli, GI1789856, Length=540, Percent_Identity=33.1481481481482, Blast_Score=271, Evalue=7e-74,
Organism=Caenorhabditis elegans, GI193208245, Length=481, Percent_Identity=27.2349272349272, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI193208247, Length=481, Percent_Identity=27.2349272349272, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI212646519, Length=474, Percent_Identity=27.2151898734177, Blast_Score=152, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI72000294, Length=474, Percent_Identity=27.2151898734177, Blast_Score=152, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI17506189, Length=524, Percent_Identity=26.1450381679389, Blast_Score=150, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17542894, Length=555, Percent_Identity=26.8468468468468, Blast_Score=136, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6323330, Length=469, Percent_Identity=23.2409381663113, Blast_Score=81, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24642670, Length=471, Percent_Identity=28.2377919320594, Blast_Score=160, Evalue=3e-39,
Organism=Drosophila melanogaster, GI24642666, Length=471, Percent_Identity=28.2377919320594, Blast_Score=160, Evalue=3e-39,
Organism=Drosophila melanogaster, GI161077880, Length=471, Percent_Identity=28.2377919320594, Blast_Score=160, Evalue=3e-39,
Organism=Drosophila melanogaster, GI161077878, Length=471, Percent_Identity=28.2377919320594, Blast_Score=159, Evalue=3e-39,
Organism=Drosophila melanogaster, GI45551474, Length=471, Percent_Identity=28.2377919320594, Blast_Score=159, Evalue=4e-39,
Organism=Drosophila melanogaster, GI18859741, Length=521, Percent_Identity=26.1036468330134, Blast_Score=146, Evalue=4e-35,
Organism=Drosophila melanogaster, GI18859893, Length=470, Percent_Identity=27.2340425531915, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI161077496, Length=514, Percent_Identity=26.4591439688716, Blast_Score=125, Evalue=9e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 59031; Mature: 58900

Theoretical pI: Translated: 6.84; Mature: 6.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTARAIATFAERAGRPLLMGRCWAVSSGHSLASWAGARVLERGGSAADAAVAVAAALNVV
CCHHHHHHHHHHCCCCEEEEEEEEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
EPQMSGIGGDLFALVYEAGTSTVWAVNGTGPAPLDATPERFRDGIPERGPLAASVPAAAR
CHHHHCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHCCCCCCCCCCCCCCHHHH
AWDLLVQRWGRLPLSITLAPAIELARDGFPVSHNLATYIETYADVLASYPETARTFLPTG
HHHHHHHHHCCCCEEEEEHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCHHHHHCCCCC
SPPCPGDVLRQPDLARTLETVAAEGVNALYEGDLAERLTRAVLAAGGLLTRESLRLARAT
CCCCCHHHHCCCHHHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHH
IVEPLQLAYRDWTICVPPPNSSAHTLLEMLGILQYFPLARWRPLSPELLHVMIEAKKLAF
HHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
LDRERFTGDPDFVGPFPPDVLAPERLQRLAAAIDLTRAKPVLTTRPAREDHTTSFSVMDH
HHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCEEEEEEC
EGNLVVVTASLNMAFGSAFIAGDTGILLNNRMTYWHLEPKHPNQLQPGKRVRHTLSPVLL
CCCEEEEEEECCHHHCCEEEECCCEEEECCCEEEEEECCCCCCCCCCHHHHHHHHCCCEE
TRPGERLGLGTPGSDAQVQILVHVLVHWLEYGFDLQTAIELPRWRHRGPGHESNWPHGSL
ECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHCCCCHHCCCCCCCCCCCCCCE
DLVQVEGRLPNATIEGLQARGHRVERLARWGPIGSCQGIHWRDAERVVEAAADPRSDAYA
EEEEECCCCCCHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCCCCCEE
LAW
ECC
>Mature Secondary Structure 
TARAIATFAERAGRPLLMGRCWAVSSGHSLASWAGARVLERGGSAADAAVAVAAALNVV
CHHHHHHHHHHCCCCEEEEEEEEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
EPQMSGIGGDLFALVYEAGTSTVWAVNGTGPAPLDATPERFRDGIPERGPLAASVPAAAR
CHHHHCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHCCCCCCCCCCCCCCHHHH
AWDLLVQRWGRLPLSITLAPAIELARDGFPVSHNLATYIETYADVLASYPETARTFLPTG
HHHHHHHHHCCCCEEEEEHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCHHHHHCCCCC
SPPCPGDVLRQPDLARTLETVAAEGVNALYEGDLAERLTRAVLAAGGLLTRESLRLARAT
CCCCCHHHHCCCHHHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHH
IVEPLQLAYRDWTICVPPPNSSAHTLLEMLGILQYFPLARWRPLSPELLHVMIEAKKLAF
HHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
LDRERFTGDPDFVGPFPPDVLAPERLQRLAAAIDLTRAKPVLTTRPAREDHTTSFSVMDH
HHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCEEEEEEC
EGNLVVVTASLNMAFGSAFIAGDTGILLNNRMTYWHLEPKHPNQLQPGKRVRHTLSPVLL
CCCEEEEEEECCHHHCCEEEECCCEEEECCCEEEEEECCCCCCCCCCHHHHHHHHCCCEE
TRPGERLGLGTPGSDAQVQILVHVLVHWLEYGFDLQTAIELPRWRHRGPGHESNWPHGSL
ECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHCCCCHHCCCCCCCCCCCCCCE
DLVQVEGRLPNATIEGLQARGHRVERLARWGPIGSCQGIHWRDAERVVEAAADPRSDAYA
EEEEECCCCCCHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCCCCCEE
LAW
ECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]