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The map label for this gene is glmU [H]

Identifier: 221632373

GI number: 221632373

Start: 348058

End: 349050

Strand: Reverse

Name: glmU [H]

Synonym: trd_0344

Alternate gene names: 221632373

Gene position: 349050-348058 (Counterclockwise)

Preceding gene: 221632380

Following gene: 221632372

Centisome position: 17.43

GC content: 62.64

Gene sequence:

>993_bases
ATGCACGTGGTGATTCCCGTTGCCGGCCTGGGGACCCGACTTCGCCCCCACACCTGGAGCAAACCCAAGCCGCTCGTGAC
CGTCGCCGGGAAACCGATCCTCGGCCATGTCCTGGACCGACTGAACCGGTTGCCACTCCAACGCGTCGTCTTCGTGACCG
GATATCTCGGCGAGCAGATCGAAGAGTATGTGCGCACCCACTACCGATTCGACGCTGTGTTCGTCGAGCAACCTGAGCCG
CTCGGGCAATCGCATGCCTTGCTCCAGGCTAAAGGTCTCGTCCATGGTCCGACGCTCGTCGTGTTTCCCGACCTCGTTTT
CGATGCCAACCTCGAAGCGGTTCTCACTTGTCCGTGGGATGGAATCGTTTTCGTGAAAGAGGTCGACGATCCCCGCCGCT
TCGGTGTCGTCATCGTCGAAGACGGACGGATCGCCCAACTGGTCGAAAAGCCAGCGCAACCGGTCTCTCGGCTCGCCGTG
GTCGGGGTGTATTACTTCCGTGACTTCGGAGACCTCATCGCTGCGATCGAGCAGCAGATCGCCGAGGGCCGCAAGCGCGG
GAACGAGTACTACTTGGCAGAAGCGATCCAGATCCTCATCGACCGCGGCCGCACGATCGTGGCGCAACCTGTCTCGGTTT
GGGAGGATTGCGGCACGGTCGAAGCGCTCCTCGAAACCAATCGTTTCCTCCTGGACCGTCAAGCCGGCCCACAGCCGTCC
TTCCCGACCGCCGTCGTCGTTCCACCGGTCGTGATCGATCCCACTGCCCGCATCGAGCACGCCGTGATCGGTCCTTACGT
GAGCATCGGTCCGGGCGCGGTCGTCTCCCACGCGATCGTCACCGACTCGATCATCGACGAGGAGGCGACCATCAACGGCG
TTATGCTGCACCGCTCAATCGTCGGTCGCCGCGCCCGGGTACTCGGTGACTTCGTGCGCGTGAACGTCGGCGATTCCTCG
GAGATCACCTTCTCCGGACGAGACGGAGCATGA

Upstream 100 bases:

>100_bases
CGCCCAGACTCGAGCACGAGCGCGGGTACACTCGGCGCTCGTTGGAATCGGACCTGCTCGGGAAGGACACACCCTCGATT
CCGACGAGGGAGGTGAGCCG

Downstream 100 bases:

>100_bases
GCTGATGCCTGCGCGTTGGCTCGAAGTCGCTGTCGAGACTGATGCTGAGGTCGCCGATGCAGTCGCCGAACTGTTCGCCC
GCTTCGGCTACCAGCAGGGA

Product: putative glucose-1-phosphate thymidylyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 330; Mature: 330

Protein sequence:

>330_residues
MHVVIPVAGLGTRLRPHTWSKPKPLVTVAGKPILGHVLDRLNRLPLQRVVFVTGYLGEQIEEYVRTHYRFDAVFVEQPEP
LGQSHALLQAKGLVHGPTLVVFPDLVFDANLEAVLTCPWDGIVFVKEVDDPRRFGVVIVEDGRIAQLVEKPAQPVSRLAV
VGVYYFRDFGDLIAAIEQQIAEGRKRGNEYYLAEAIQILIDRGRTIVAQPVSVWEDCGTVEALLETNRFLLDRQAGPQPS
FPTAVVVPPVVIDPTARIEHAVIGPYVSIGPGAVVSHAIVTDSIIDEEATINGVMLHRSIVGRRARVLGDFVRVNVGDSS
EITFSGRDGA

Sequences:

>Translated_330_residues
MHVVIPVAGLGTRLRPHTWSKPKPLVTVAGKPILGHVLDRLNRLPLQRVVFVTGYLGEQIEEYVRTHYRFDAVFVEQPEP
LGQSHALLQAKGLVHGPTLVVFPDLVFDANLEAVLTCPWDGIVFVKEVDDPRRFGVVIVEDGRIAQLVEKPAQPVSRLAV
VGVYYFRDFGDLIAAIEQQIAEGRKRGNEYYLAEAIQILIDRGRTIVAQPVSVWEDCGTVEALLETNRFLLDRQAGPQPS
FPTAVVVPPVVIDPTARIEHAVIGPYVSIGPGAVVSHAIVTDSIIDEEATINGVMLHRSIVGRRARVLGDFVRVNVGDSS
EITFSGRDGA
>Mature_330_residues
MHVVIPVAGLGTRLRPHTWSKPKPLVTVAGKPILGHVLDRLNRLPLQRVVFVTGYLGEQIEEYVRTHYRFDAVFVEQPEP
LGQSHALLQAKGLVHGPTLVVFPDLVFDANLEAVLTCPWDGIVFVKEVDDPRRFGVVIVEDGRIAQLVEKPAQPVSRLAV
VGVYYFRDFGDLIAAIEQQIAEGRKRGNEYYLAEAIQILIDRGRTIVAQPVSVWEDCGTVEALLETNRFLLDRQAGPQPS
FPTAVVVPPVVIDPTARIEHAVIGPYVSIGPGAVVSHAIVTDSIIDEEATINGVMLHRSIVGRRARVLGDFVRVNVGDSS
EITFSGRDGA

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetyl-glucosamine (UDP- GlcNAc). Responsible for the acetylation of GlcN-1-P to GlcNAc-1- P, and for the uridyl transfer from UTP to GlcNAc-1-P, to produce UDP-GlcN

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=332, Percent_Identity=29.5180722891566, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI11761619, Length=338, Percent_Identity=29.2899408284024, Blast_Score=112, Evalue=4e-25,
Organism=Escherichia coli, GI1788351, Length=273, Percent_Identity=26.3736263736264, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1790224, Length=248, Percent_Identity=28.2258064516129, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1790168, Length=312, Percent_Identity=26.2820512820513, Blast_Score=68, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI133931050, Length=340, Percent_Identity=29.4117647058824, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17509979, Length=331, Percent_Identity=27.190332326284, Blast_Score=91, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI17509981, Length=330, Percent_Identity=26.969696969697, Blast_Score=89, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6320148, Length=344, Percent_Identity=27.3255813953488, Blast_Score=93, Evalue=5e-20,
Organism=Drosophila melanogaster, GI21355443, Length=333, Percent_Identity=29.7297297297297, Blast_Score=111, Evalue=8e-25,
Organism=Drosophila melanogaster, GI24644084, Length=333, Percent_Identity=29.7297297297297, Blast_Score=111, Evalue=8e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 36190; Mature: 36190

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHVVIPVAGLGTRLRPHTWSKPKPLVTVAGKPILGHVLDRLNRLPLQRVVFVTGYLGEQI
CEEEEEECCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHH
EEYVRTHYRFDAVFVEQPEPLGQSHALLQAKGLVHGPTLVVFPDLVFDANLEAVLTCPWD
HHHHHHHHEEEEEEEECCCCCCCCHHHHHCCCCCCCCEEEEECCEEECCCCCEEEECCCC
GIVFVKEVDDPRRFGVVIVEDGRIAQLVEKPAQPVSRLAVVGVYYFRDFGDLIAAIEQQI
CEEEEEECCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AEGRKRGNEYYLAEAIQILIDRGRTIVAQPVSVWEDCGTVEALLETNRFLLDRQAGPQPS
HHHHHCCCEEHHHHHHHHHHHCCCEEEECHHHHHHHCCHHHHHHHCCHHEEECCCCCCCC
FPTAVVVPPVVIDPTARIEHAVIGPYVSIGPGAVVSHAIVTDSIIDEEATINGVMLHRSI
CCEEEEECCEEECCCHHHCHHEECCCEECCCCHHHHHHHHHHHHHCCCHHCCHHHHHHHH
VGRRARVLGDFVRVNVGDSSEITFSGRDGA
HHHHHHHHHHEEEEECCCCCEEEECCCCCC
>Mature Secondary Structure
MHVVIPVAGLGTRLRPHTWSKPKPLVTVAGKPILGHVLDRLNRLPLQRVVFVTGYLGEQI
CEEEEEECCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHH
EEYVRTHYRFDAVFVEQPEPLGQSHALLQAKGLVHGPTLVVFPDLVFDANLEAVLTCPWD
HHHHHHHHEEEEEEEECCCCCCCCHHHHHCCCCCCCCEEEEECCEEECCCCCEEEECCCC
GIVFVKEVDDPRRFGVVIVEDGRIAQLVEKPAQPVSRLAVVGVYYFRDFGDLIAAIEQQI
CEEEEEECCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AEGRKRGNEYYLAEAIQILIDRGRTIVAQPVSVWEDCGTVEALLETNRFLLDRQAGPQPS
HHHHHCCCEEHHHHHHHHHHHCCCEEEECHHHHHHHCCHHHHHHHCCHHEEECCCCCCCC
FPTAVVVPPVVIDPTARIEHAVIGPYVSIGPGAVVSHAIVTDSIIDEEATINGVMLHRSI
CCEEEEECCEEECCCHHHCHHEECCCEECCCCHHHHHHHHHHHHHCCCHHCCHHHHHHHH
VGRRARVLGDFVRVNVGDSSEITFSGRDGA
HHHHHHHHHHEEEEECCCCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]