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The map label for this gene is uvrC [H]

Identifier: 221632241

GI number: 221632241

Start: 213313

End: 215394

Strand: Reverse

Name: uvrC [H]

Synonym: trd_0207

Alternate gene names: 221632241

Gene position: 215394-213313 (Counterclockwise)

Preceding gene: 221632242

Following gene: 221632240

Centisome position: 10.75

GC content: 65.47

Gene sequence:

>2082_bases
ATGAGCGACCAGCCCGTGGAGCCAGCCTACGATCGTCTCCGCAGTCGAGCTCGGCAGCTCTTGTTGGCGCGAGGAGGGAT
CGCCAGCGAAGAGCAGCTGATCGAGGGGCTCTTTGGCTCGCTCGGCAACCGCCGGCTGTGGGCACCATTCCTGGCTCAAT
TGCTGGAGACCGACGCGGAGATCGTCCGTCGACCGGATGGGACCTGGGCACTCCGACGTCGCCCGCTGGTACCCAGCAGG
GGGTGGCCTCGCTCGTTCGTCGCGCTCGATGTCGAAACCACCGGTCTCCGCCCAGCACGGCACCGCATCATCGAGATCGG
CGCAGTGCGTTACGAGGACGGCTGCTGCGTCGAGCGCTTCTCGGTCCTCGTCAACCCCCATCGGCGCTTGCCGGTCTACA
TCGTCCGTCTGACCGGGATCCGGGACGAGGATCTGCTGACGGCACCGTCGTTCGTCGATGTGGCCGCCGCATTTCGTGTC
TTTTTGGGCGAGAGCACGGTCATCGGCTACAACGTGGGGTTCGACCTCGATTTTCTGAACGCCGAACTCCGGCGCATCGG
TCAGGGACCGCTCCCCAATCCCGCACTCGACGTCTTGCCGCTCGCCCGGGCACTTCTCACCGCAAACGGCCGCTACGACC
TCGACGCGATCTGTCGATCCATCGGTCTCGCTCGGGGCACCCGTCACCGTGCGCTACCGGATGCCGAAGCGACTGCCGTC
CTCTATCTCCACCTCGTCGAGCGAGCCGAGCAGGTCGGATACCGCTCGCCGAGCGACCTCCAGCCAGCTGCCACGCGGCG
AACGATCGTCGTCGAGCCGGTCGCCCGGGGGCGCGCAGTCCTGGACCAGCGCCTGCTGGCCGACACACCCGAACTTCCGG
GGGTGTATCTCATGCGCGATGCGCTGGGACGTGTCCTGTATGTCGGCAAGGCGCGCAATCTCAGACAGCGAGTTCGCTCC
TACTTCAGTCAACCACTGGGATACACCCGCAAGATGGACGGCTTGCTCGAATCGGTGGCCGAGATCGAGACGGTCGTTAC
CGGCTCGGAGTTAGAAGCACTGCTTTTGGAGAGTCAATTCGTCCAGCGGTACAAGCCGCCGTACAATACGCAACTCCGCA
ATCACGAGGCATACCCCTACGTGAAGGTCGAGCTCGGTCGCCCCTGGCCGCGCCTGATGCTGGCTCGTCAGCGTGACGAT
GACGACGCCGTGTACGTCGGGCCTTTTCGGAGCACGGCTGCTGCCCGCTCGGTCGTCGAGTTGCTCCACCAACTCCTCCC
TTTGCGCACCTGCCACCGATCGTTCCGGGATGCCCGTTCCTATGGGCGCCCGTGCTTGCAACTGACGCTGGGACGCTGTA
TCGGCCCATGCACCGGATGCGTGACGCCTGACGAGTACCGAGCGCTCGTCGACTGCGCGCTGCGTTATCTCAGCGGCGAG
ACGAGCGTCGTCGTCGAACGTGCTCAACAGCTTCTCGCTGACGCGGTGGAGCGACTCGACTTCGAACGAGCAGCGCGCTT
GCGCGATCTCCTGCGGCGCAGCGAGGAACTCGTGTTCAGTCATCGATTGGTCCGCCAGACGATCAGCGGACGACCGTGCG
TCATCGTCACTCCCTGTCCTGAGACCGGCGATCGCGCCTTTCTCCTCATCGTTGCCGGACGACTCTGGGCGCGTGTCGTG
GCCGATCCGCGCGAGCACGATGCAGCCGTGGCCGCCCGATTGGGAGCGGCCTGGGAACGCGCCCAACAGGCCGCTCCCTG
GACGCTCGACCAGGACTCGCTCGATGCCGCAGTGATCATCGCGCGCTGGCTGTCCGAGCACGCGGAGGACCCGACCGTCT
TCTTCCTCGAGCATCCGGTGGACTGGCTCGCACTGGTGCGGAACGGTCGATCGCTGCCCGCGTCGGCTTTCGCTGTCCAT
GCCCCGGTGGATGACGAGAACGGGACGACGAAACGAACGAGAGGAGCAGACAGTGAGCGAGGAACGCAGTGCGAGGGAAC
TCCTGGAAAGCATCGCCGAGCGCGTCCGTCACTGCACGCGCTGCGATCTATGGCGGACCCGCACTCAGGCGGTGCCAGGT
GA

Upstream 100 bases:

>100_bases
GTATACGCCAGCGCCCTCTCCGTGCAGCAGCTGGTCGGCAGGATGAGCCGTCGACCGTGGGTCGGGTACCATACCAGGGG
TGCGGGACGAGGAGTGCGGG

Downstream 100 bases:

>100_bases
GGGGGATCCGCATGCTGAGGTGATGTTCATCGGGGAGGCACCGGGGTACCACGAAGATCGACAGGGTCGCCCGTTCGTCG
GAGCAGCAGGACAATTCTTG

Product: DNA polymerase III subunit epsilon

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C [H]

Number of amino acids: Translated: 693; Mature: 692

Protein sequence:

>693_residues
MSDQPVEPAYDRLRSRARQLLLARGGIASEEQLIEGLFGSLGNRRLWAPFLAQLLETDAEIVRRPDGTWALRRRPLVPSR
GWPRSFVALDVETTGLRPARHRIIEIGAVRYEDGCCVERFSVLVNPHRRLPVYIVRLTGIRDEDLLTAPSFVDVAAAFRV
FLGESTVIGYNVGFDLDFLNAELRRIGQGPLPNPALDVLPLARALLTANGRYDLDAICRSIGLARGTRHRALPDAEATAV
LYLHLVERAEQVGYRSPSDLQPAATRRTIVVEPVARGRAVLDQRLLADTPELPGVYLMRDALGRVLYVGKARNLRQRVRS
YFSQPLGYTRKMDGLLESVAEIETVVTGSELEALLLESQFVQRYKPPYNTQLRNHEAYPYVKVELGRPWPRLMLARQRDD
DDAVYVGPFRSTAAARSVVELLHQLLPLRTCHRSFRDARSYGRPCLQLTLGRCIGPCTGCVTPDEYRALVDCALRYLSGE
TSVVVERAQQLLADAVERLDFERAARLRDLLRRSEELVFSHRLVRQTISGRPCVIVTPCPETGDRAFLLIVAGRLWARVV
ADPREHDAAVAARLGAAWERAQQAAPWTLDQDSLDAAVIIARWLSEHAEDPTVFFLEHPVDWLALVRNGRSLPASAFAVH
APVDDENGTTKRTRGADSERGTQCEGTPGKHRRARPSLHALRSMADPHSGGAR

Sequences:

>Translated_693_residues
MSDQPVEPAYDRLRSRARQLLLARGGIASEEQLIEGLFGSLGNRRLWAPFLAQLLETDAEIVRRPDGTWALRRRPLVPSR
GWPRSFVALDVETTGLRPARHRIIEIGAVRYEDGCCVERFSVLVNPHRRLPVYIVRLTGIRDEDLLTAPSFVDVAAAFRV
FLGESTVIGYNVGFDLDFLNAELRRIGQGPLPNPALDVLPLARALLTANGRYDLDAICRSIGLARGTRHRALPDAEATAV
LYLHLVERAEQVGYRSPSDLQPAATRRTIVVEPVARGRAVLDQRLLADTPELPGVYLMRDALGRVLYVGKARNLRQRVRS
YFSQPLGYTRKMDGLLESVAEIETVVTGSELEALLLESQFVQRYKPPYNTQLRNHEAYPYVKVELGRPWPRLMLARQRDD
DDAVYVGPFRSTAAARSVVELLHQLLPLRTCHRSFRDARSYGRPCLQLTLGRCIGPCTGCVTPDEYRALVDCALRYLSGE
TSVVVERAQQLLADAVERLDFERAARLRDLLRRSEELVFSHRLVRQTISGRPCVIVTPCPETGDRAFLLIVAGRLWARVV
ADPREHDAAVAARLGAAWERAQQAAPWTLDQDSLDAAVIIARWLSEHAEDPTVFFLEHPVDWLALVRNGRSLPASAFAVH
APVDDENGTTKRTRGADSERGTQCEGTPGKHRRARPSLHALRSMADPHSGGAR
>Mature_692_residues
SDQPVEPAYDRLRSRARQLLLARGGIASEEQLIEGLFGSLGNRRLWAPFLAQLLETDAEIVRRPDGTWALRRRPLVPSRG
WPRSFVALDVETTGLRPARHRIIEIGAVRYEDGCCVERFSVLVNPHRRLPVYIVRLTGIRDEDLLTAPSFVDVAAAFRVF
LGESTVIGYNVGFDLDFLNAELRRIGQGPLPNPALDVLPLARALLTANGRYDLDAICRSIGLARGTRHRALPDAEATAVL
YLHLVERAEQVGYRSPSDLQPAATRRTIVVEPVARGRAVLDQRLLADTPELPGVYLMRDALGRVLYVGKARNLRQRVRSY
FSQPLGYTRKMDGLLESVAEIETVVTGSELEALLLESQFVQRYKPPYNTQLRNHEAYPYVKVELGRPWPRLMLARQRDDD
DAVYVGPFRSTAAARSVVELLHQLLPLRTCHRSFRDARSYGRPCLQLTLGRCIGPCTGCVTPDEYRALVDCALRYLSGET
SVVVERAQQLLADAVERLDFERAARLRDLLRRSEELVFSHRLVRQTISGRPCVIVTPCPETGDRAFLLIVAGRLWARVVA
DPREHDAAVAARLGAAWERAQQAAPWTLDQDSLDAAVIIARWLSEHAEDPTVFFLEHPVDWLALVRNGRSLPASAFAVHA
PVDDENGTTKRTRGADSERGTQCEGTPGKHRRARPSLHALRSMADPHSGGAR

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision [H]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI87081999, Length=229, Percent_Identity=39.3013100436681, Blast_Score=168, Evalue=1e-42,
Organism=Escherichia coli, GI1786409, Length=209, Percent_Identity=29.1866028708134, Blast_Score=71, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305 [H]

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N [H]

EC number: NA

Molecular weight: Translated: 77439; Mature: 77307

Theoretical pI: Translated: 8.85; Mature: 8.85

Prosite motif: PS50151 UVR ; PS50164 UVRC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDQPVEPAYDRLRSRARQLLLARGGIASEEQLIEGLFGSLGNRRLWAPFLAQLLETDAE
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCEEHHHHHHHHHHCCHH
IVRRPDGTWALRRRPLVPSRGWPRSFVALDVETTGLRPARHRIIEIGAVRYEDGCCVERF
HHHCCCCCCHHCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHEEEEEEEEECCCCHHHHH
SVLVNPHRRLPVYIVRLTGIRDEDLLTAPSFVDVAAAFRVFLGESTVIGYNVGFDLDFLN
HHHHCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCHHHHH
AELRRIGQGPLPNPALDVLPLARALLTANGRYDLDAICRSIGLARGTRHRALPDAEATAV
HHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHH
LYLHLVERAEQVGYRSPSDLQPAATRRTIVVEPVARGRAVLDQRLLADTPELPGVYLMRD
HHHHHHHHHHHCCCCCCCCCCCHHHCCEEEECCHHCCHHHHHHHHHHCCCCCCCHHHHHH
ALGRVLYVGKARNLRQRVRSYFSQPLGYTRKMDGLLESVAEIETVVTGSELEALLLESQF
HHHHEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
VQRYKPPYNTQLRNHEAYPYVKVELGRPWPRLMLARQRDDDDAVYVGPFRSTAAARSVVE
HHHCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHCCCCCCCEEECCCHHHHHHHHHHH
LLHQLLPLRTCHRSFRDARSYGRPCLQLTLGRCIGPCTGCVTPDEYRALVDCALRYLSGE
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCC
TSVVVERAQQLLADAVERLDFERAARLRDLLRRSEELVFSHRLVRQTISGRPCVIVTPCP
HHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCC
ETGDRAFLLIVAGRLWARVVADPREHDAAVAARLGAAWERAQQAAPWTLDQDSLDAAVII
CCCCCEEEEEEHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
ARWLSEHAEDPTVFFLEHPVDWLALVRNGRSLPASAFAVHAPVDDENGTTKRTRGADSER
HHHHHHHCCCCEEEEECCCHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCC
GTQCEGTPGKHRRARPSLHALRSMADPHSGGAR
CCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
SDQPVEPAYDRLRSRARQLLLARGGIASEEQLIEGLFGSLGNRRLWAPFLAQLLETDAE
CCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCEEHHHHHHHHHHCCHH
IVRRPDGTWALRRRPLVPSRGWPRSFVALDVETTGLRPARHRIIEIGAVRYEDGCCVERF
HHHCCCCCCHHCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHEEEEEEEEECCCCHHHHH
SVLVNPHRRLPVYIVRLTGIRDEDLLTAPSFVDVAAAFRVFLGESTVIGYNVGFDLDFLN
HHHHCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCHHHHH
AELRRIGQGPLPNPALDVLPLARALLTANGRYDLDAICRSIGLARGTRHRALPDAEATAV
HHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHH
LYLHLVERAEQVGYRSPSDLQPAATRRTIVVEPVARGRAVLDQRLLADTPELPGVYLMRD
HHHHHHHHHHHCCCCCCCCCCCHHHCCEEEECCHHCCHHHHHHHHHHCCCCCCCHHHHHH
ALGRVLYVGKARNLRQRVRSYFSQPLGYTRKMDGLLESVAEIETVVTGSELEALLLESQF
HHHHEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
VQRYKPPYNTQLRNHEAYPYVKVELGRPWPRLMLARQRDDDDAVYVGPFRSTAAARSVVE
HHHCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHCCCCCCCEEECCCHHHHHHHHHHH
LLHQLLPLRTCHRSFRDARSYGRPCLQLTLGRCIGPCTGCVTPDEYRALVDCALRYLSGE
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCC
TSVVVERAQQLLADAVERLDFERAARLRDLLRRSEELVFSHRLVRQTISGRPCVIVTPCP
HHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCC
ETGDRAFLLIVAGRLWARVVADPREHDAAVAARLGAAWERAQQAAPWTLDQDSLDAAVII
CCCCCEEEEEEHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
ARWLSEHAEDPTVFFLEHPVDWLALVRNGRSLPASAFAVHAPVDDENGTTKRTRGADSER
HHHHHHHCCCCEEEEECCCHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCC
GTQCEGTPGKHRRARPSLHALRSMADPHSGGAR
CCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA