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The map label for this gene is purP [H]

Identifier: 22127989

GI number: 22127989

Start: 4574467

End: 4575852

Strand: Reverse

Name: purP [H]

Synonym: y4121

Alternate gene names: 22127989

Gene position: 4575852-4574467 (Counterclockwise)

Preceding gene: 22127991

Following gene: 22127988

Centisome position: 99.46

GC content: 50.14

Gene sequence:

>1386_bases
ATGATTTTTGTTATAGGATATGCCCCGACTATCACTCCCTTCAGCGGAACTCTTCGAATGAGTAAATCAAACCTTGATAC
CGAGCAGGGCCTGCTCGAACGTGTATTTAAACTGAAACAGCATGGCACCACAGCTCGTACTGAGCTGATTGCGGGTATCA
CGACTTTCTTGACCATGGTCTATATCGTATTCGTAAACCCGCAGATTCTCGGGGTTGCGGGTATGGATGTGCAGGCGGTG
TTCGTGACAACCTGCCTGATCGCCGCATTTGGCAGCATTTTTATGGGCTTATTGGCTAACTTACCTGTGGCACTGGCACC
GGCGATGGGGCTCAACGCTTTCTTCGCTTTTGTGGTGGTGGGGGCGATGGGTATTTCTTGGCAGGTCGGTATGGGCGCTA
TTTTCTGGGGGGCAATCGGTTTCCTTTTGCTAACCATTTTCCGCATTCGTTACTGGATGATAGCGAACATCCCACTGAGC
CTGCGTGTGGGGATCACAAGTGGTATTGGCCTGTTTATTGCCATGATGGGGTTGAAGAATGCCGGTATCGTGGTCGCAAA
CCCAGATACACTGGTGGCGGTGGGTAATCTGACCTCTCACAGTGTACTGTTGGGTGCACTGGGTTTCTTTATTATCGCAG
TCTTGGCTTCTCGTAATATTCACGCGGCAGTGCTGGTTTCTATTGTGGTTACCACACTGATTGGCTGGGCGCTGGGTGAT
GTGCATTATTCGGGCGTTTTCTCCATGCCACCAAGTGTGACTTCTGTGGTTGGGCAGGTTGATTTAGCTGGCGCGTTGAA
TATTGGTATGGCGGGTATTATTTTCTCCTTCATGCTGGTTAACCTGTTTGATTCATCCGGCACATTGATTGGTGTCACGG
ATAAAGCCGGTTTAGCGGATCATAAAGGCAAGTTTCCGCGCATGAAACAAGCGCTGTATGTGGACAGTATCAGCTCCGTT
GCCGGTGCTTTTATTGGTACTTCATCAGTGACCGCGTATATCGAAAGTTCTTCCGGGGTATCTGTTGGCGGCCGTACCGG
GTTAACCGCTGTTGTTGTCGGGATACTCTTCCTGCTGGTGATATTTATTTCTCCGTTGGCGGGTATGGTTCCTGCGTATG
CGGCCGCGGGCGCGCTGATTTATGTTGGCGTGTTGATGACATCTAGCCTGGCACGGGTGAAGTGGGATGATTTGACTGAA
GCCGTTCCAGCCTTTGTCACGGCTGTCATGATGCCGTTCAGTTTCTCTATCACTGAAGGGATCGCACTGGGCTTTATCTC
TTATTGTTTGATGAAATTAGGTACTGGCCGCTGGCGTGAAATCAGCCCTTGCGTAGTGGTAGTGGCGCTACTGTTTATGC
TGAAAATTGCGTTTGTTGATCACTGA

Upstream 100 bases:

>100_bases
TAATCCGGTCATCGGGCTGGCGCGTTTGGCGCGAAAAGAGACGTTTATAAAAGCCATAATAAAAAAGAGGTAAAAAAGAG
TGTGATCACGCTCTAAACAA

Downstream 100 bases:

>100_bases
TAATGGCGATTAACTCGTTTGAATATTAAGTAAAAAACTCCCCCTCTCGGTGTATTAGGATTGGGGGAACTCGATTAATA
AAAGCATTCGTTTAGGATAA

Product: xanthine/uracil permease family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 461; Mature: 461

Protein sequence:

>461_residues
MIFVIGYAPTITPFSGTLRMSKSNLDTEQGLLERVFKLKQHGTTARTELIAGITTFLTMVYIVFVNPQILGVAGMDVQAV
FVTTCLIAAFGSIFMGLLANLPVALAPAMGLNAFFAFVVVGAMGISWQVGMGAIFWGAIGFLLLTIFRIRYWMIANIPLS
LRVGITSGIGLFIAMMGLKNAGIVVANPDTLVAVGNLTSHSVLLGALGFFIIAVLASRNIHAAVLVSIVVTTLIGWALGD
VHYSGVFSMPPSVTSVVGQVDLAGALNIGMAGIIFSFMLVNLFDSSGTLIGVTDKAGLADHKGKFPRMKQALYVDSISSV
AGAFIGTSSVTAYIESSSGVSVGGRTGLTAVVVGILFLLVIFISPLAGMVPAYAAAGALIYVGVLMTSSLARVKWDDLTE
AVPAFVTAVMMPFSFSITEGIALGFISYCLMKLGTGRWREISPCVVVVALLFMLKIAFVDH

Sequences:

>Translated_461_residues
MIFVIGYAPTITPFSGTLRMSKSNLDTEQGLLERVFKLKQHGTTARTELIAGITTFLTMVYIVFVNPQILGVAGMDVQAV
FVTTCLIAAFGSIFMGLLANLPVALAPAMGLNAFFAFVVVGAMGISWQVGMGAIFWGAIGFLLLTIFRIRYWMIANIPLS
LRVGITSGIGLFIAMMGLKNAGIVVANPDTLVAVGNLTSHSVLLGALGFFIIAVLASRNIHAAVLVSIVVTTLIGWALGD
VHYSGVFSMPPSVTSVVGQVDLAGALNIGMAGIIFSFMLVNLFDSSGTLIGVTDKAGLADHKGKFPRMKQALYVDSISSV
AGAFIGTSSVTAYIESSSGVSVGGRTGLTAVVVGILFLLVIFISPLAGMVPAYAAAGALIYVGVLMTSSLARVKWDDLTE
AVPAFVTAVMMPFSFSITEGIALGFISYCLMKLGTGRWREISPCVVVVALLFMLKIAFVDH
>Mature_461_residues
MIFVIGYAPTITPFSGTLRMSKSNLDTEQGLLERVFKLKQHGTTARTELIAGITTFLTMVYIVFVNPQILGVAGMDVQAV
FVTTCLIAAFGSIFMGLLANLPVALAPAMGLNAFFAFVVVGAMGISWQVGMGAIFWGAIGFLLLTIFRIRYWMIANIPLS
LRVGITSGIGLFIAMMGLKNAGIVVANPDTLVAVGNLTSHSVLLGALGFFIIAVLASRNIHAAVLVSIVVTTLIGWALGD
VHYSGVFSMPPSVTSVVGQVDLAGALNIGMAGIIFSFMLVNLFDSSGTLIGVTDKAGLADHKGKFPRMKQALYVDSISSV
AGAFIGTSSVTAYIESSSGVSVGGRTGLTAVVVGILFLLVIFISPLAGMVPAYAAAGALIYVGVLMTSSLARVKWDDLTE
AVPAFVTAVMMPFSFSITEGIALGFISYCLMKLGTGRWREISPCVVVVALLFMLKIAFVDH

Specific function: High-affinity uptake of adenine [H]

COG id: COG2252

COG function: function code R; Permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. AzgA purine transporter (TC 2.A.1.40) subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790150, Length=432, Percent_Identity=86.8055555555556, Blast_Score=740, Evalue=0.0,
Organism=Escherichia coli, GI87082309, Length=444, Percent_Identity=76.3513513513514, Blast_Score=681, Evalue=0.0,
Organism=Escherichia coli, GI1790499, Length=428, Percent_Identity=39.9532710280374, Blast_Score=290, Evalue=2e-79,
Organism=Escherichia coli, GI48994909, Length=437, Percent_Identity=36.8421052631579, Blast_Score=261, Evalue=7e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 48453; Mature: 48453

Theoretical pI: Translated: 9.05; Mature: 9.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIFVIGYAPTITPFSGTLRMSKSNLDTEQGLLERVFKLKQHGTTARTELIAGITTFLTMV
CEEEEEECCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
YIVFVNPQILGVAGMDVQAVFVTTCLIAAFGSIFMGLLANLPVALAPAMGLNAFFAFVVV
HHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
GAMGISWQVGMGAIFWGAIGFLLLTIFRIRYWMIANIPLSLRVGITSGIGLFIAMMGLKN
HHCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCC
AGIVVANPDTLVAVGNLTSHSVLLGALGFFIIAVLASRNIHAAVLVSIVVTTLIGWALGD
CCEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
VHYSGVFSMPPSVTSVVGQVDLAGALNIGMAGIIFSFMLVNLFDSSGTLIGVTDKAGLAD
HHCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCC
HKGKFPRMKQALYVDSISSVAGAFIGTSSVTAYIESSSGVSVGGRTGLTAVVVGILFLLV
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHH
IFISPLAGMVPAYAAAGALIYVGVLMTSSLARVKWDDLTEAVPAFVTAVMMPFSFSITEG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHH
IALGFISYCLMKLGTGRWREISPCVVVVALLFMLKIAFVDH
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIFVIGYAPTITPFSGTLRMSKSNLDTEQGLLERVFKLKQHGTTARTELIAGITTFLTMV
CEEEEEECCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
YIVFVNPQILGVAGMDVQAVFVTTCLIAAFGSIFMGLLANLPVALAPAMGLNAFFAFVVV
HHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
GAMGISWQVGMGAIFWGAIGFLLLTIFRIRYWMIANIPLSLRVGITSGIGLFIAMMGLKN
HHCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCC
AGIVVANPDTLVAVGNLTSHSVLLGALGFFIIAVLASRNIHAAVLVSIVVTTLIGWALGD
CCEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
VHYSGVFSMPPSVTSVVGQVDLAGALNIGMAGIIFSFMLVNLFDSSGTLIGVTDKAGLAD
HHCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCC
HKGKFPRMKQALYVDSISSVAGAFIGTSSVTAYIESSSGVSVGGRTGLTAVVVGILFLLV
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHH
IFISPLAGMVPAYAAAGALIYVGVLMTSSLARVKWDDLTEAVPAFVTAVMMPFSFSITEG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHH
IALGFISYCLMKLGTGRWREISPCVVVVALLFMLKIAFVDH
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7686882; 9278503 [H]