| Definition | Yersinia pestis KIM 10 chromosome, complete genome. |
|---|---|
| Accession | NC_004088 |
| Length | 4,600,755 |
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The map label for this gene is gyrB [H]
Identifier: 22127978
GI number: 22127978
Start: 4560322
End: 4562739
Strand: Reverse
Name: gyrB [H]
Synonym: y4110
Alternate gene names: 22127978
Gene position: 4562739-4560322 (Counterclockwise)
Preceding gene: 161484720
Following gene: 229013117
Centisome position: 99.17
GC content: 49.42
Gene sequence:
>2418_bases TTGATGTCGAATACTTATGACTCCTCAAGTATCAAGGTATTAAAAGGGCTGGATGCCGTGCGTAAGCGTCCGGGCATGTA TATCGGAGATACTGATGATGGTACCGGTCTGCACCACATGGTATTCGAGGTTGTGGACAACGCTATTGACGAAGCCCTCG CGGGTCATTGTAAAGAAATTCTGGTAACCATCCACGCGGATAACTCCGTTTCTGTACAGGATGATGGCCGTGGTATCCCA ACCGGTATGCACGATGAGGAAGGGGTATCTGCAGCAGAGGTCATCATGACCGTGTTGCATGCTGGCGGTAAATTTGACGA TAACTCCTATAAAGTTTCCGGCGGTTTGCATGGCGTAGGGGTATCCGTTGTTAACGCCCTGTCTGAAAAGTTGGAACTGG TTATTCGCCGTGAAGGTAAAGTTCACGAGCAAACCTACAAAATGGGCGTGCCACAGGCACCGCTGAAAGTGGTGGGTGAA ACTGAGCAAACCGGGACTACTGTGCGTTTCTGGCCAAGTTTCCAGACCTTTACCAATAACACCGAATTCCAGTATGAGAT CCTGGCTAAACGCCTGCGCGAACTCTCTTTCCTGAACTCGGGTGTTTCAATCAAACTGAAAGACAAACGTAACGATAAAG AAGACCACTTCCATTACGAAGGTGGTATCAAGGCGTTTGTTGAATATCTGAACAAAAACAAGAACCCGATCCACCCGAAA GTGTTCTACTTCTCCACCATGAAAGACGATATCGGGGTGGAAGTGGCGCTACAGTGGAACGATGGTTTCCAGGAAAATAT TTACTGCTTCACCAATAACATTCCACAGCGTGATGGTGGTACCCATTTAGTTGGTTTCCGTACGGCGATGACCCGTACCC TGAACAGCTATATGGATAAAGAAGGCTACAGCAAAAAAGCGAAGATCAGCGCCACCGGTGATGACGCCCGTGAAGGCTTG ATTGCTGTTGTCTCAGTGAAAGTGCCCGATCCTAAATTCTCCTCACAGACCAAAGATAAATTGGTTTCTTCTGAGGTGAA AACGGCGGTCGAAACGCTGATGAACGAGAAGTTGGTTGAGTATTTGTTGGAAAACCCAACTGACGCCAAAATCGTTGTGG GTAAAATCATTGATGCGGCCCGCGCCCGTGAAGCTGCGCGTAAAGCCCGTGAAATGACACGCCGTAAAGGTGCGCTCGAT CTGGCGGGTTTACCCGGCAAACTGGCAGACTGTCAGGAACGTGACCCGGCATTGTCCGAACTCTACTTAGTGGAAGGGGA CTCTGCGGGCGGCTCGGCTAAACAAGGCCGTAACCGTAAAAATCAGGCCATTTTGCCGCTGAAAGGTAAAATCCTGAACG TTGAGAAAGCGCGTTTTGACAAAATGCTCTCTTCACAGGAAGTGGCGACACTGATCACCGCGTTAGGTTGTGGTATTGGC CGGGATGAATATAACCCGGATAAATTGCGTTATCACAATATCATTATCATGACCGATGCCGACGTGGATGGCTCGCACAT CCGTACGTTGTTGTTGACCTTCTTCTACCGTCAGATGCCGGAAATTATTGAGCGTGGTCATGTGTTTATCGCTCAGCCTC CGCTGTATAAAGTGAAGAAAGGTAAGCAAGAGCAGTACATCAAAGATGATGATGCGATGGAGCAGTACCAAATGACACTG GCTCTGGATGGCGCGGCATTGCATACCAATGCTCACGCACCAGCACTGGCTGGTGAGCCTTTGGAGAAACTGGTTGCTGA GCATTACAGTGTCCAGAAGACTATCGCCCGCATGGAACGCCGTTATCCGCGTGCTTTGCTGAATAACCTGATTTATCAGC CTACCTTGCAAGAAGAGGATTTGGGCAATAAAGAGGTTGTGACGCAATGGATTGATTCGCTGGTGGTCTTGCTGAACGAA AAAGAACACCATGGCAGCAGCTACAGTTCAGTGGTGCGTGAGAACCGTGAGCGTCAACTGTTCGAGCCTATTTTGCGTAT TCGTACCCACGGGGTTGATACCGATTATGATCTGGACTTCGATTTCATCCATGGTGGCGAGTACCGTAAAATCTGTCTAT TGGGTGACAAACTGCGTGGCTTAATCGAAGACGGTGCTTTCGTTGAACGTGGCGAGCGTCGTGTGCCGGTTTCAAGCTTC GAAGAGGCGCTGGACTGGTTAGTGAAAGAGTCTCGCCGTGGTTTGGCAATCCAGCGTTACAAAGGCTTGGGTGAAATGAA CCCCGATCAGTTGTGGGAAACCACGATGGATCCAGAGAGCCGTCGTATGCTGCGAGTCATGGTGAAAGATGCCATCGCCG CCGATCAACTCTTCACTACTCTGATGGGTGATGCTGTTGAACCTCGTCGTGCCTTTATCGAAGAGAATGCACTGCGCGCA GCCAATATTGATATCTAA
Upstream 100 bases:
>100_bases GAGCAAGTTGCCGATATGGTAGGTGAAAAGGGCAAGATGTTCCGTGTGGAACATGGCAAAATAGAGGTTCAACCACAGGA TTAAAAATGAGCGAGAAACG
Downstream 100 bases:
>100_bases TGTGTTAGCCAGATAGCCTATTGGCCAGATAAAAAAGTCCAGGGTGGGAAAACTGCCACTGGGCTTTTTTTTGCCTGAAA ATTGTTATTGTTACCTGATG
Product: DNA gyrase subunit B
Products: NA
Alternate protein names: NA
Number of amino acids: Translated: 805; Mature: 805
Protein sequence:
>805_residues MMSNTYDSSSIKVLKGLDAVRKRPGMYIGDTDDGTGLHHMVFEVVDNAIDEALAGHCKEILVTIHADNSVSVQDDGRGIP TGMHDEEGVSAAEVIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSEKLELVIRREGKVHEQTYKMGVPQAPLKVVGE TEQTGTTVRFWPSFQTFTNNTEFQYEILAKRLRELSFLNSGVSIKLKDKRNDKEDHFHYEGGIKAFVEYLNKNKNPIHPK VFYFSTMKDDIGVEVALQWNDGFQENIYCFTNNIPQRDGGTHLVGFRTAMTRTLNSYMDKEGYSKKAKISATGDDAREGL IAVVSVKVPDPKFSSQTKDKLVSSEVKTAVETLMNEKLVEYLLENPTDAKIVVGKIIDAARAREAARKAREMTRRKGALD LAGLPGKLADCQERDPALSELYLVEGDSAGGSAKQGRNRKNQAILPLKGKILNVEKARFDKMLSSQEVATLITALGCGIG RDEYNPDKLRYHNIIIMTDADVDGSHIRTLLLTFFYRQMPEIIERGHVFIAQPPLYKVKKGKQEQYIKDDDAMEQYQMTL ALDGAALHTNAHAPALAGEPLEKLVAEHYSVQKTIARMERRYPRALLNNLIYQPTLQEEDLGNKEVVTQWIDSLVVLLNE KEHHGSSYSSVVRENRERQLFEPILRIRTHGVDTDYDLDFDFIHGGEYRKICLLGDKLRGLIEDGAFVERGERRVPVSSF EEALDWLVKESRRGLAIQRYKGLGEMNPDQLWETTMDPESRRMLRVMVKDAIAADQLFTTLMGDAVEPRRAFIEENALRA ANIDI
Sequences:
>Translated_805_residues MMSNTYDSSSIKVLKGLDAVRKRPGMYIGDTDDGTGLHHMVFEVVDNAIDEALAGHCKEILVTIHADNSVSVQDDGRGIP TGMHDEEGVSAAEVIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSEKLELVIRREGKVHEQTYKMGVPQAPLKVVGE TEQTGTTVRFWPSFQTFTNNTEFQYEILAKRLRELSFLNSGVSIKLKDKRNDKEDHFHYEGGIKAFVEYLNKNKNPIHPK VFYFSTMKDDIGVEVALQWNDGFQENIYCFTNNIPQRDGGTHLVGFRTAMTRTLNSYMDKEGYSKKAKISATGDDAREGL IAVVSVKVPDPKFSSQTKDKLVSSEVKTAVETLMNEKLVEYLLENPTDAKIVVGKIIDAARAREAARKAREMTRRKGALD LAGLPGKLADCQERDPALSELYLVEGDSAGGSAKQGRNRKNQAILPLKGKILNVEKARFDKMLSSQEVATLITALGCGIG RDEYNPDKLRYHNIIIMTDADVDGSHIRTLLLTFFYRQMPEIIERGHVFIAQPPLYKVKKGKQEQYIKDDDAMEQYQMTL ALDGAALHTNAHAPALAGEPLEKLVAEHYSVQKTIARMERRYPRALLNNLIYQPTLQEEDLGNKEVVTQWIDSLVVLLNE KEHHGSSYSSVVRENRERQLFEPILRIRTHGVDTDYDLDFDFIHGGEYRKICLLGDKLRGLIEDGAFVERGERRVPVSSF EEALDWLVKESRRGLAIQRYKGLGEMNPDQLWETTMDPESRRMLRVMVKDAIAADQLFTTLMGDAVEPRRAFIEENALRA ANIDI >Mature_805_residues MMSNTYDSSSIKVLKGLDAVRKRPGMYIGDTDDGTGLHHMVFEVVDNAIDEALAGHCKEILVTIHADNSVSVQDDGRGIP TGMHDEEGVSAAEVIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSEKLELVIRREGKVHEQTYKMGVPQAPLKVVGE TEQTGTTVRFWPSFQTFTNNTEFQYEILAKRLRELSFLNSGVSIKLKDKRNDKEDHFHYEGGIKAFVEYLNKNKNPIHPK VFYFSTMKDDIGVEVALQWNDGFQENIYCFTNNIPQRDGGTHLVGFRTAMTRTLNSYMDKEGYSKKAKISATGDDAREGL IAVVSVKVPDPKFSSQTKDKLVSSEVKTAVETLMNEKLVEYLLENPTDAKIVVGKIIDAARAREAARKAREMTRRKGALD LAGLPGKLADCQERDPALSELYLVEGDSAGGSAKQGRNRKNQAILPLKGKILNVEKARFDKMLSSQEVATLITALGCGIG RDEYNPDKLRYHNIIIMTDADVDGSHIRTLLLTFFYRQMPEIIERGHVFIAQPPLYKVKKGKQEQYIKDDDAMEQYQMTL ALDGAALHTNAHAPALAGEPLEKLVAEHYSVQKTIARMERRYPRALLNNLIYQPTLQEEDLGNKEVVTQWIDSLVVLLNE KEHHGSSYSSVVRENRERQLFEPILRIRTHGVDTDYDLDFDFIHGGEYRKICLLGDKLRGLIEDGAFVERGERRVPVSSF EEALDWLVKESRRGLAIQRYKGLGEMNPDQLWETTMDPESRRMLRVMVKDAIAADQLFTTLMGDAVEPRRAFIEENALRA ANIDI
Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]
COG id: COG0187
COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the type II topoisomerase family [H]
Homologues:
Organism=Homo sapiens, GI19913406, Length=574, Percent_Identity=26.1324041811847, Blast_Score=131, Evalue=3e-30, Organism=Homo sapiens, GI19913408, Length=551, Percent_Identity=25.2268602540835, Blast_Score=122, Evalue=1e-27, Organism=Escherichia coli, GI48994957, Length=804, Percent_Identity=86.9402985074627, Blast_Score=1442, Evalue=0.0, Organism=Escherichia coli, GI1789408, Length=552, Percent_Identity=41.4855072463768, Blast_Score=395, Evalue=1e-111, Organism=Caenorhabditis elegans, GI17535065, Length=539, Percent_Identity=27.4582560296846, Blast_Score=141, Evalue=1e-33, Organism=Caenorhabditis elegans, GI212645845, Length=519, Percent_Identity=24.0847784200385, Blast_Score=118, Evalue=1e-26, Organism=Caenorhabditis elegans, GI212645657, Length=153, Percent_Identity=33.3333333333333, Blast_Score=72, Evalue=1e-12, Organism=Saccharomyces cerevisiae, GI6324241, Length=589, Percent_Identity=24.4482173174873, Blast_Score=117, Evalue=1e-26, Organism=Drosophila melanogaster, GI17136538, Length=542, Percent_Identity=24.9077490774908, Blast_Score=134, Evalue=4e-31,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR003594 - InterPro: IPR011557 - InterPro: IPR020568 - InterPro: IPR014721 - InterPro: IPR001241 - InterPro: IPR013759 - InterPro: IPR002288 - InterPro: IPR013506 - InterPro: IPR013760 - InterPro: IPR018522 [H]
Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c [H]
EC number: =5.99.1.3 [H]
Molecular weight: Translated: 90400; Mature: 90400
Theoretical pI: Translated: 6.31; Mature: 6.31
Prosite motif: PS00177 TOPOISOMERASE_II
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.6 %Cys (Translated Protein) 2.9 %Met (Translated Protein) 3.5 %Cys+Met (Translated Protein) 0.6 %Cys (Mature Protein) 2.9 %Met (Mature Protein) 3.5 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MMSNTYDSSSIKVLKGLDAVRKRPGMYIGDTDDGTGLHHMVFEVVDNAIDEALAGHCKEI CCCCCCCCCHHHHHHHHHHHHHCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEE LVTIHADNSVSVQDDGRGIPTGMHDEEGVSAAEVIMTVLHAGGKFDDNSYKVSGGLHGVG EEEEECCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCEEECCCCCHHH VSVVNALSEKLELVIRREGKVHEQTYKMGVPQAPLKVVGETEQTGTTVRFWPSFQTFTNN HHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCHHHCCCCCCCCCEEEECCCHHHHCCC TEFQYEILAKRLRELSFLNSGVSIKLKDKRNDKEDHFHYEGGIKAFVEYLNKNKNPIHPK CCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCEEECCHHHHHHHHHHCCCCCCCCE VFYFSTMKDDIGVEVALQWNDGFQENIYCFTNNIPQRDGGTHLVGFRTAMTRTLNSYMDK EEEEEECCCCCCEEEEEEECCCCCCCEEEEECCCCCCCCCCEEEEHHHHHHHHHHHHHCC EGYSKKAKISATGDDAREGLIAVVSVKVPDPKFSSQTKDKLVSSEVKTAVETLMNEKLVE CCCCCCEEEEECCCHHHCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH YLLENPTDAKIVVGKIIDAARAREAARKAREMTRRKGALDLAGLPGKLADCQERDPALSE HHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCCCCCCCCE LYLVEGDSAGGSAKQGRNRKNQAILPLKGKILNVEKARFDKMLSSQEVATLITALGCGIG EEEEECCCCCCCCCCCCCCCCCEEEECCCCEECHHHHHHHHHHHHHHHHHHHHHHHCCCC RDEYNPDKLRYHNIIIMTDADVDGSHIRTLLLTFFYRQMPEIIERGHVFIAQPPLYKVKK CCCCCCCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHC GKQEQYIKDDDAMEQYQMTLALDGAALHTNAHAPALAGEPLEKLVAEHYSVQKTIARMER CCCHHCCCCCHHHHHHEEEEEECCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH RYPRALLNNLIYQPTLQEEDLGNKEVVTQWIDSLVVLLNEKEHHGSSYSSVVRENRERQL HHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHCCCHHHHHHHHHHHHHH FEPILRIRTHGVDTDYDLDFDFIHGGEYRKICLLGDKLRGLIEDGAFVERGERRVPVSSF HHHHHHHHHCCCCCCCCCCEEEEECCCEEEEEEECHHHHHHHHCCHHHHCCCCCCCHHHH EEALDWLVKESRRGLAIQRYKGLGEMNPDQLWETTMDPESRRMLRVMVKDAIAADQLFTT HHHHHHHHHHHHCCCCHHHHCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH LMGDAVEPRRAFIEENALRAANIDI HHCCCCCHHHHHHHHCCCCCCCCCC >Mature Secondary Structure MMSNTYDSSSIKVLKGLDAVRKRPGMYIGDTDDGTGLHHMVFEVVDNAIDEALAGHCKEI CCCCCCCCCHHHHHHHHHHHHHCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEE LVTIHADNSVSVQDDGRGIPTGMHDEEGVSAAEVIMTVLHAGGKFDDNSYKVSGGLHGVG EEEEECCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCEEECCCCCHHH VSVVNALSEKLELVIRREGKVHEQTYKMGVPQAPLKVVGETEQTGTTVRFWPSFQTFTNN HHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCHHHCCCCCCCCCEEEECCCHHHHCCC TEFQYEILAKRLRELSFLNSGVSIKLKDKRNDKEDHFHYEGGIKAFVEYLNKNKNPIHPK CCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCEEECCHHHHHHHHHHCCCCCCCCE VFYFSTMKDDIGVEVALQWNDGFQENIYCFTNNIPQRDGGTHLVGFRTAMTRTLNSYMDK EEEEEECCCCCCEEEEEEECCCCCCCEEEEECCCCCCCCCCEEEEHHHHHHHHHHHHHCC EGYSKKAKISATGDDAREGLIAVVSVKVPDPKFSSQTKDKLVSSEVKTAVETLMNEKLVE CCCCCCEEEEECCCHHHCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH YLLENPTDAKIVVGKIIDAARAREAARKAREMTRRKGALDLAGLPGKLADCQERDPALSE HHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCCCCCCCCE LYLVEGDSAGGSAKQGRNRKNQAILPLKGKILNVEKARFDKMLSSQEVATLITALGCGIG EEEEECCCCCCCCCCCCCCCCCEEEECCCCEECHHHHHHHHHHHHHHHHHHHHHHHCCCC RDEYNPDKLRYHNIIIMTDADVDGSHIRTLLLTFFYRQMPEIIERGHVFIAQPPLYKVKK CCCCCCCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHC GKQEQYIKDDDAMEQYQMTLALDGAALHTNAHAPALAGEPLEKLVAEHYSVQKTIARMER CCCHHCCCCCHHHHHHEEEEEECCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH RYPRALLNNLIYQPTLQEEDLGNKEVVTQWIDSLVVLLNEKEHHGSSYSSVVRENRERQL HHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHCCCHHHHHHHHHHHHHH FEPILRIRTHGVDTDYDLDFDFIHGGEYRKICLLGDKLRGLIEDGAFVERGERRVPVSSF HHHHHHHHHCCCCCCCCCCEEEEECCCEEEEEEECHHHHHHHHCCHHHHCCCCCCCHHHH EEALDWLVKESRRGLAIQRYKGLGEMNPDQLWETTMDPESRRMLRVMVKDAIAADQLFTT HHHHHHHHHHHHCCCCHHHHCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH LMGDAVEPRRAFIEENALRAANIDI HHCCCCCHHHHHHHHCCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 11206551; 11258796 [H]