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The map label for this gene is mtlD [H]

Identifier: 22127955

GI number: 22127955

Start: 4532934

End: 4534202

Strand: Reverse

Name: mtlD [H]

Synonym: y4086

Alternate gene names: 22127955

Gene position: 4534202-4532934 (Counterclockwise)

Preceding gene: 22127956

Following gene: 22127954

Centisome position: 98.55

GC content: 50.51

Gene sequence:

>1269_bases
TTGGCTGCTTTGCCTACCTGCAACGCGAATTATTTAGCGTATAAACAAGTCATAACTGCTAGGGCTGTTGGAAGAAAATG
GCCCTTTTACAGCAAGGTAACGAATATGAAAGCATTACATTTTGGCGCAGGGAATATTGGCCGTGGCTTCATCGGCAAAC
TGCTCGCGGATGCCGGTGCGCAACTGACCTTCGCCGATGTGAATCAACCGTTGTTGGATGAACTGAATAAACGTAAACGT
TATCAGGTCAATGTGGTCGGTGAACAGGCTCGGGTTGAAGAGGTAAAGAATGTCAGTGCGGTAAACAGCGGTAGCCCGGA
AGTGGTTGCGCTGATTGCTGAGGCCGATATTGTCACCACCGCTGTTGGCCCACAAATTTTGGCCAGAATTGCGGCGACAG
TGGCACAGGGTCTGATCACTCGACATCAGCAAGGGAATACCCGCCCACTGAATATTATTGCCTGCGAAAATATGGTGCGT
GGCACTAGCCAATTAAAACAACATGTGTTTGCTGCCTTATCAGAAGACGAACAAATATGGGTAGAGCAGCATGTGGGTTT
TGTGGATTCGGCAGTCGATCGTATTGTCCCACCATCAGAAGCGGGCAGTACTGATATCCTGGCTGTCACGGTAGAAACCT
TTAGCGAATGGATAGTCGACGGTACCCAATTTAAAGGCCAGCCACCCGAAATCGTGGGTATGGAATTGACCGATAATCTC
ATGGCTTTTGTCGAGCGTAAGCTCTTCACGTTGAACACCGGGCATGCTATTACCGCGTATCTGGGCCAACTGGCAGGCCA
TCAAACGATCCGCGATGCGATTCTCGACCCGGCGGTACGTCAAACAGTAAAAGGTGCGATGGAAGAGAGCGGTGCGGTAC
TGATTAAGCGTTATGCTTTCGACCCACAGAAACATGCGGCTTATATCAACAAAATTCTCTCTCGTTTTGAAAACCCTTAT
TTGCACGATGATGTCGAGCGGGTTGGCCGTCAACCACTGCGTAAGCTGAGCGCCGGTGATCGTTTGATCAAACCGCTGCT
AGGCACGCTGGAGTATCAATTGCCGCACGATTCTCTGGTAACGGGTATTGCCGCCGCCATGAGCTATCGCAGTGAGCAAG
ATCCACAGGCCCAAGAGTTGGTGACGTTATTGGCACAATTAGGGCCGAAAGCTGCGTTAGCGCAAATTTCAGGCTTGCCT
GCTGATAGTGAGGTTGTCGAACAGGCGGTGAGTGTGTATAACGCCATGCAGCAGAAGCTGGCGCACTGA

Upstream 100 bases:

>100_bases
GCGCGTTTAAGTAAGACGACCAGCGTGCAGGAAGTATTGGACTTACTGGGCGGTAAAACGTCTGCTTGATATACCCGTCA
TACTTCACGCTGCATGAACA

Downstream 100 bases:

>100_bases
TTTTAGTGACTAAGCCAGCTATGTCCCATTGGCCTGATAACGGAAACGATAGCGGGCCAATGATTTAAGACACTAAAGTA
TTTGCCAACGGATGATTTGT

Product: mannitol-1-phosphate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 422; Mature: 421

Protein sequence:

>422_residues
MAALPTCNANYLAYKQVITARAVGRKWPFYSKVTNMKALHFGAGNIGRGFIGKLLADAGAQLTFADVNQPLLDELNKRKR
YQVNVVGEQARVEEVKNVSAVNSGSPEVVALIAEADIVTTAVGPQILARIAATVAQGLITRHQQGNTRPLNIIACENMVR
GTSQLKQHVFAALSEDEQIWVEQHVGFVDSAVDRIVPPSEAGSTDILAVTVETFSEWIVDGTQFKGQPPEIVGMELTDNL
MAFVERKLFTLNTGHAITAYLGQLAGHQTIRDAILDPAVRQTVKGAMEESGAVLIKRYAFDPQKHAAYINKILSRFENPY
LHDDVERVGRQPLRKLSAGDRLIKPLLGTLEYQLPHDSLVTGIAAAMSYRSEQDPQAQELVTLLAQLGPKAALAQISGLP
ADSEVVEQAVSVYNAMQQKLAH

Sequences:

>Translated_422_residues
MAALPTCNANYLAYKQVITARAVGRKWPFYSKVTNMKALHFGAGNIGRGFIGKLLADAGAQLTFADVNQPLLDELNKRKR
YQVNVVGEQARVEEVKNVSAVNSGSPEVVALIAEADIVTTAVGPQILARIAATVAQGLITRHQQGNTRPLNIIACENMVR
GTSQLKQHVFAALSEDEQIWVEQHVGFVDSAVDRIVPPSEAGSTDILAVTVETFSEWIVDGTQFKGQPPEIVGMELTDNL
MAFVERKLFTLNTGHAITAYLGQLAGHQTIRDAILDPAVRQTVKGAMEESGAVLIKRYAFDPQKHAAYINKILSRFENPY
LHDDVERVGRQPLRKLSAGDRLIKPLLGTLEYQLPHDSLVTGIAAAMSYRSEQDPQAQELVTLLAQLGPKAALAQISGLP
ADSEVVEQAVSVYNAMQQKLAH
>Mature_421_residues
AALPTCNANYLAYKQVITARAVGRKWPFYSKVTNMKALHFGAGNIGRGFIGKLLADAGAQLTFADVNQPLLDELNKRKRY
QVNVVGEQARVEEVKNVSAVNSGSPEVVALIAEADIVTTAVGPQILARIAATVAQGLITRHQQGNTRPLNIIACENMVRG
TSQLKQHVFAALSEDEQIWVEQHVGFVDSAVDRIVPPSEAGSTDILAVTVETFSEWIVDGTQFKGQPPEIVGMELTDNLM
AFVERKLFTLNTGHAITAYLGQLAGHQTIRDAILDPAVRQTVKGAMEESGAVLIKRYAFDPQKHAAYINKILSRFENPYL
HDDVERVGRQPLRKLSAGDRLIKPLLGTLEYQLPHDSLVTGIAAAMSYRSEQDPQAQELVTLLAQLGPKAALAQISGLPA
DSEVVEQAVSVYNAMQQKLAH

Specific function: Unknown

COG id: COG0246

COG function: function code G; Mannitol-1-phosphate/altronate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannitol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1790028, Length=382, Percent_Identity=75.6544502617801, Blast_Score=585, Evalue=1e-168,
Organism=Escherichia coli, GI1787823, Length=260, Percent_Identity=27.6923076923077, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1788497, Length=259, Percent_Identity=27.7992277992278, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1790779, Length=262, Percent_Identity=27.4809160305344, Blast_Score=93, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6324401, Length=259, Percent_Identity=29.3436293436293, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6320765, Length=259, Percent_Identity=29.3436293436293, Blast_Score=101, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR023028
- InterPro:   IPR000669
- InterPro:   IPR013118
- InterPro:   IPR023027
- InterPro:   IPR013131
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01232 Mannitol_dh; PF08125 Mannitol_dh_C [H]

EC number: =1.1.1.17 [H]

Molecular weight: Translated: 45948; Mature: 45817

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: PS00974 MANNITOL_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAALPTCNANYLAYKQVITARAVGRKWPFYSKVTNMKALHFGAGNIGRGFIGKLLADAGA
CCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHCCCEEEECCCCCCHHHHHHHHHHCCC
QLTFADVNQPLLDELNKRKRYQVNVVGEQARVEEVKNVSAVNSGSPEVVALIAEADIVTT
EEEEHHCCCHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHH
AVGPQILARIAATVAQGLITRHQQGNTRPLNIIACENMVRGTSQLKQHVFAALSEDEQIW
HCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCHHHH
VEQHVGFVDSAVDRIVPPSEAGSTDILAVTVETFSEWIVDGTQFKGQPPEIVGMELTDNL
HHHHCCHHHHHHHHCCCCCCCCCCCEEEEEHHHHHHHHCCCCCCCCCCCCEECHHHHHHH
MAFVERKLFTLNTGHAITAYLGQLAGHQTIRDAILDPAVRQTVKGAMEESGAVLIKRYAF
HHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCEEEEECCC
DPQKHAAYINKILSRFENPYLHDDVERVGRQPLRKLSAGDRLIKPLLGTLEYQLPHDSLV
CHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHH
TGIAAAMSYRSEQDPQAQELVTLLAQLGPKAALAQISGLPADSEVVEQAVSVYNAMQQKL
HHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
AH
CC
>Mature Secondary Structure 
AALPTCNANYLAYKQVITARAVGRKWPFYSKVTNMKALHFGAGNIGRGFIGKLLADAGA
CCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHCCCEEEECCCCCCHHHHHHHHHHCCC
QLTFADVNQPLLDELNKRKRYQVNVVGEQARVEEVKNVSAVNSGSPEVVALIAEADIVTT
EEEEHHCCCHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHH
AVGPQILARIAATVAQGLITRHQQGNTRPLNIIACENMVRGTSQLKQHVFAALSEDEQIW
HCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCHHHH
VEQHVGFVDSAVDRIVPPSEAGSTDILAVTVETFSEWIVDGTQFKGQPPEIVGMELTDNL
HHHHCCHHHHHHHHCCCCCCCCCCCEEEEEHHHHHHHHCCCCCCCCCCCCEECHHHHHHH
MAFVERKLFTLNTGHAITAYLGQLAGHQTIRDAILDPAVRQTVKGAMEESGAVLIKRYAF
HHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCEEEEECCC
DPQKHAAYINKILSRFENPYLHDDVERVGRQPLRKLSAGDRLIKPLLGTLEYQLPHDSLV
CHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHH
TGIAAAMSYRSEQDPQAQELVTLLAQLGPKAALAQISGLPADSEVVEQAVSVYNAMQQKL
HHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
AH
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA