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The map label for this gene is cysK [H]

Identifier: 22127909

GI number: 22127909

Start: 4480139

End: 4481146

Strand: Direct

Name: cysK [H]

Synonym: y4039

Alternate gene names: 22127909

Gene position: 4480139-4481146 (Clockwise)

Preceding gene: 22127898

Following gene: 22127910

Centisome position: 97.38

GC content: 37.5

Gene sequence:

>1008_bases
TTGATATTTACCCTCCGGGAAATTTATGTTTTATTGTGCACCTCCATAAAAAAGGAGTGTGTCATGGAACTTAAGGATAT
TGGTAACACCGAGCTTATTGAGCTAAAAAACTTATCAATAAATAATAATTCTCTTTTTTCTAAGTGCGAATTCAACAATC
CTACAGGTAGCCATAAAGACCGAACATTTCTGCATATCCTCAATATCTTGGAAGAAGAAAATAAAATAATTCCCGGAATG
ACATTGATAGACTGCTCAACAGGGAATGGAGGTGCAGCACTGGCTTGGATTGGTCAAAAAAAAGGCTATAAAATTAAAAT
ATTTATGCCTGAAGGCATGACTGAAGAACGCAAAGAACAGATCTATTCATTTGGTGGAGAAATTATCGAAACCCCCAAAG
AAAACTTCTTAAAGGGTGCTGTAAAAGCAGCAACTGAATACTCAAATCACCAAAAAAACATATTCTTTCTCAATCAATCT
GACACCACCTTAAATAAAGATGCGTGGCATAGTTGTGGTGAAGAAATTGTCAGAAAAATGAAAGAGATAAATAAAAAACC
TGATTACTTTATTTGTTCAATCGGAACGGGAGGTACATTTTCGGGTATTGCGGAAATTTTGAAGAAAGCCTACCCACGAA
TCCATACGGTGGGTATTGAAGTTGATCAATCGGCCCCGATCTATTCACAGCGACATGGTCTTAACTTTCATCATAAACAT
CATAATCTTATGGGGCTAGGTGCTGGTGTTATTTCAGTGAATACCCTTTTAGATTTGATCGATGAGGTAAGGGTTGTTAA
TGGCAAAGCGGCTTGGGAAAGGATGAAAAGCTTCATCGAAAAGGAGCGCTTAGGAATTGGGCCAACATGTGGAGCTAACT
TGTTGATTACGGAAGATATAATGCAAGAAGTTAACGGGAAAGTGATTGTCACTCTATTCTTTGATAGTGCATGGAAATAT
AAAAGTTGCTGGGATGGAGTTTACCCTGGATATAAGGAAACCCAATGA

Upstream 100 bases:

>100_bases
GCGAAATCAACCAAGAAATATATATTGAAATTATTAACTACAAAATAATATATGCACCTATAAATAGTATTTAAAATAAT
TCAAAAAATTAAATTACACA

Downstream 100 bases:

>100_bases
TTTTATTAAAGAATGTGTATAAAAATGCTCAGGTAGTGAACTCAGGAAAAGCATTAACCACCGTCAATGAATTTACAGAC
CAGTTGCCTGCCCTCAGACC

Product: pyridoxal-phosphate dependent protein

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 335; Mature: 335

Protein sequence:

>335_residues
MIFTLREIYVLLCTSIKKECVMELKDIGNTELIELKNLSINNNSLFSKCEFNNPTGSHKDRTFLHILNILEEENKIIPGM
TLIDCSTGNGGAALAWIGQKKGYKIKIFMPEGMTEERKEQIYSFGGEIIETPKENFLKGAVKAATEYSNHQKNIFFLNQS
DTTLNKDAWHSCGEEIVRKMKEINKKPDYFICSIGTGGTFSGIAEILKKAYPRIHTVGIEVDQSAPIYSQRHGLNFHHKH
HNLMGLGAGVISVNTLLDLIDEVRVVNGKAAWERMKSFIEKERLGIGPTCGANLLITEDIMQEVNGKVIVTLFFDSAWKY
KSCWDGVYPGYKETQ

Sequences:

>Translated_335_residues
MIFTLREIYVLLCTSIKKECVMELKDIGNTELIELKNLSINNNSLFSKCEFNNPTGSHKDRTFLHILNILEEENKIIPGM
TLIDCSTGNGGAALAWIGQKKGYKIKIFMPEGMTEERKEQIYSFGGEIIETPKENFLKGAVKAATEYSNHQKNIFFLNQS
DTTLNKDAWHSCGEEIVRKMKEINKKPDYFICSIGTGGTFSGIAEILKKAYPRIHTVGIEVDQSAPIYSQRHGLNFHHKH
HNLMGLGAGVISVNTLLDLIDEVRVVNGKAAWERMKSFIEKERLGIGPTCGANLLITEDIMQEVNGKVIVTLFFDSAWKY
KSCWDGVYPGYKETQ
>Mature_335_residues
MIFTLREIYVLLCTSIKKECVMELKDIGNTELIELKNLSINNNSLFSKCEFNNPTGSHKDRTFLHILNILEEENKIIPGM
TLIDCSTGNGGAALAWIGQKKGYKIKIFMPEGMTEERKEQIYSFGGEIIETPKENFLKGAVKAATEYSNHQKNIFFLNQS
DTTLNKDAWHSCGEEIVRKMKEINKKPDYFICSIGTGGTFSGIAEILKKAYPRIHTVGIEVDQSAPIYSQRHGLNFHHKH
HNLMGLGAGVISVNTLLDLIDEVRVVNGKAAWERMKSFIEKERLGIGPTCGANLLITEDIMQEVNGKVIVTLFFDSAWKY
KSCWDGVYPGYKETQ

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=308, Percent_Identity=29.5454545454545, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI295821200, Length=308, Percent_Identity=29.5454545454545, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI4557415, Length=308, Percent_Identity=29.5454545454545, Blast_Score=117, Evalue=2e-26,
Organism=Escherichia coli, GI2367138, Length=313, Percent_Identity=27.4760383386581, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI1788754, Length=305, Percent_Identity=29.5081967213115, Blast_Score=101, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI17535051, Length=301, Percent_Identity=32.2259136212625, Blast_Score=132, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI17562970, Length=299, Percent_Identity=28.7625418060201, Blast_Score=120, Evalue=9e-28,
Organism=Caenorhabditis elegans, GI32566674, Length=299, Percent_Identity=28.7625418060201, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI115535073, Length=299, Percent_Identity=28.4280936454849, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17561720, Length=302, Percent_Identity=29.1390728476821, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI25147552, Length=207, Percent_Identity=30.4347826086957, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17534315, Length=118, Percent_Identity=35.5932203389831, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI32566672, Length=215, Percent_Identity=24.6511627906977, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17539800, Length=240, Percent_Identity=26.25, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6321594, Length=309, Percent_Identity=29.4498381877023, Blast_Score=108, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6321449, Length=333, Percent_Identity=26.7267267267267, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24643623, Length=204, Percent_Identity=33.3333333333333, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI20129101, Length=204, Percent_Identity=33.3333333333333, Blast_Score=108, Evalue=6e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 37780; Mature: 37780

Theoretical pI: Translated: 7.26; Mature: 7.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIFTLREIYVLLCTSIKKECVMELKDIGNTELIELKNLSINNNSLFSKCEFNNPTGSHKD
CEEEHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECEECCCCCEEEEECCCCCCCCCC
RTFLHILNILEEENKIIPGMTLIDCSTGNGGAALAWIGQKKGYKIKIFMPEGMTEERKEQ
HHHHHHHHHHHHCCCCCCCEEEEEECCCCCCEEEEEEECCCCEEEEEECCCCCCHHHHHH
IYSFGGEIIETPKENFLKGAVKAATEYSNHQKNIFFLNQSDTTLNKDAWHSCGEEIVRKM
HHHCCCHHCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHH
KEINKKPDYFICSIGTGGTFSGIAEILKKAYPRIHTVGIEVDQSAPIYSQRHGLNFHHKH
HHHCCCCCEEEEECCCCCCHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHCCCCEECCC
HNLMGLGAGVISVNTLLDLIDEVRVVNGKAAWERMKSFIEKERLGIGPTCGANLLITEDI
CCEEECCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEHHH
MQEVNGKVIVTLFFDSAWKYKSCWDGVYPGYKETQ
HHHCCCCEEEEEEECCCCCHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MIFTLREIYVLLCTSIKKECVMELKDIGNTELIELKNLSINNNSLFSKCEFNNPTGSHKD
CEEEHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECEECCCCCEEEEECCCCCCCCCC
RTFLHILNILEEENKIIPGMTLIDCSTGNGGAALAWIGQKKGYKIKIFMPEGMTEERKEQ
HHHHHHHHHHHHCCCCCCCEEEEEECCCCCCEEEEEEECCCCEEEEEECCCCCCHHHHHH
IYSFGGEIIETPKENFLKGAVKAATEYSNHQKNIFFLNQSDTTLNKDAWHSCGEEIVRKM
HHHCCCHHCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHH
KEINKKPDYFICSIGTGGTFSGIAEILKKAYPRIHTVGIEVDQSAPIYSQRHGLNFHHKH
HHHCCCCCEEEEECCCCCCHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHCCCCEECCC
HNLMGLGAGVISVNTLLDLIDEVRVVNGKAAWERMKSFIEKERLGIGPTCGANLLITEDI
CCEEECCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEHHH
MQEVNGKVIVTLFFDSAWKYKSCWDGVYPGYKETQ
HHHCCCCEEEEEEECCCCCHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA